LOCUS       NM_007539               1421 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus bradykinin receptor, beta 1 (Bdkrb1), mRNA.
ACCESSION   NM_007539
VERSION     NM_007539.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1421)
  AUTHORS   Branquinho,J., Neves,R.L., Martin,R.P., Arata,J.G.,
            Bittencourt,C.A., Araujo,R.C., Icimoto,M.Y. and Pesquero,J.B.
  TITLE     Kinin B1 receptor deficiency promotes enhanced adipose tissue
            thermogenic response to beta3-adrenergic stimulation
  JOURNAL   Inflamm Res 73 (9), 1565-1579 (2024)
   PUBMED   39017739
  REMARK    GeneRIF: Kinin B1 receptor deficiency promotes enhanced adipose
            tissue thermogenic response to beta3-adrenergic stimulation.
REFERENCE   2  (bases 1 to 1421)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1421)
  AUTHORS   Fernandes Gregnani,M., Budu,A., Batista,R.O., Ornellas,F.H.,
            Estrela,G.R., Arruda,A.C., Freitas Lima,L.C., Kremer,J.L., Favaroni
            Mendes,L.A., Casarini,D.E., Lotfi,C.F.P., Oyama,L.M., Bader,M. and
            Araujo,R.C.
  TITLE     Kinin B1 receptor modulates glucose homeostasis and physical
            exercise capacity by altering adrenal catecholamine synthesis and
            secretion
  JOURNAL   Mol Cell Endocrinol 579, 112085 (2024)
   PUBMED   37827227
REFERENCE   4  (bases 1 to 1421)
  AUTHORS   Alves-Silva,T., Hungaro,T.G.R., Freitas-Lima,L.C., de Melo
            Arthur,G., Arruda,A.C., Santos,R.B., Oyama,L.M., Mori,M.A.S.,
            Bader,M. and Araujo,R.C.
  TITLE     Kinin B1 receptor controls maternal adiponectin levels and
            influences offspring weight gain
  JOURNAL   iScience 26 (12), 108409 (2023)
   PUBMED   38058311
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1421)
  AUTHORS   Martins,L., Amorim,W.W., Gregnani,M.F., de Carvalho Araujo,R.,
            Qadri,F., Bader,M. and Pesquero,J.B.
  TITLE     Kinin receptors regulate skeletal muscle regeneration: differential
            effects for B1 and B2 receptors
  JOURNAL   Inflamm Res 72 (8), 1583-1601 (2023)
   PUBMED   37464053
  REMARK    GeneRIF: Kinin receptors regulate skeletal muscle regeneration:
            differential effects for B1 and B2 receptors.
REFERENCE   6  (bases 1 to 1421)
  AUTHORS   Leeb-Lundberg,L.M., Kang,D.S., Lamb,M.E. and Fathy,D.B.
  TITLE     The human B1 bradykinin receptor exhibits high ligand-independent,
            constitutive activity. Roles of residues in the fourth
            intracellular and third transmembrane domains
  JOURNAL   J Biol Chem 276 (12), 8785-8792 (2001)
   PUBMED   11134011
REFERENCE   7  (bases 1 to 1421)
  AUTHORS   Pesquero,J.B., Araujo,R.C., Heppenstall,P.A., Stucky,C.L.,
            Silva,J.A. Jr., Walther,T., Oliveira,S.M., Pesquero,J.L.,
            Paiva,A.C., Calixto,J.B., Lewin,G.R. and Bader,M.
  TITLE     Hypoalgesia and altered inflammatory responses in mice lacking
            kinin B1 receptors
  JOURNAL   Proc Natl Acad Sci U S A 97 (14), 8140-8145 (2000)
   PUBMED   10859349
REFERENCE   8  (bases 1 to 1421)
  AUTHORS   Rupniak,N.M., Boyce,S., Webb,J.K., Williams,A.R., Carlson,E.J.,
            Hill,R.G., Borkowski,J.A. and Hess,J.F.
  TITLE     Effects of the bradykinin B1 receptor antagonist
            des-Arg9[Leu8]bradykinin and genetic disruption of the B2 receptor
            on nociception in rats and mice
  JOURNAL   Pain 71 (1), 89-97 (1997)
   PUBMED   9200178
REFERENCE   9  (bases 1 to 1421)
  AUTHORS   Pesquero,J.B., Pesquero,J.L., Oliveira,S.M., Roscher,A.A.,
            Metzger,R., Ganten,D. and Bader,M.
  TITLE     Molecular cloning and functional characterization of a mouse
            bradykinin B1 receptor gene
  JOURNAL   Biochem Biophys Res Commun 220 (1), 219-225 (1996)
   PUBMED   8602848
  REMARK    Erratum:[Biochem Biophys Res Commun. 1996 Jul 5;224(1):281. doi:
            10.1006/bbrc.1996.1020.. PMID: 8694827]
REFERENCE   10 (bases 1 to 1421)
  AUTHORS   McIntyre,P., Phillips,E., Skidmore,E., Brown,M. and Webb,M.
  TITLE     Cloned murine bradykinin receptor exhibits a mixed B1 and B2
            pharmacological selectivity
  JOURNAL   Mol Pharmacol 44 (2), 346-355 (1993)
   PUBMED   8394991
  REMARK    Erratum:[Mol Pharmacol 1994 Mar;45(3):561]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC068459.9.
            
            On Dec 23, 2016 this sequence version replaced NM_007539.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC120684.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1421              AC068459.9         143802-145222
FEATURES             Location/Qualifiers
     source          1..1421
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 55.81 cM"
     gene            1..1421
                     /gene="Bdkrb1"
                     /gene_synonym="B1BKR; B1R; Bdkrb; BKR1; BRADYB1"
                     /note="bradykinin receptor, beta 1"
                     /db_xref="GeneID:12061"
                     /db_xref="MGI:MGI:88144"
     exon            1..1421
                     /gene="Bdkrb1"
                     /gene_synonym="B1BKR; B1R; Bdkrb; BKR1; BRADYB1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgtgtgccaa taaaacttta ttgtctggga tagaccacag ctgggcttgg cctcctatac
       61 tctctgtcaa tttcaggttc ctgtggatgg cgtcccaggc ctcgctgaag ctacagcctt
      121 ctaaccaaag ccagcaggcc cctcccaaca tcacctcctg cgagggcgcc ccggaagcct
      181 gggatctgct gtgtcgggtg ctgccagggt ttgtcatcac tgtctgtttc tttggcctcc
      241 tggggaacct tttagtcctg tccttcttcc ttttgccttg gcgacgatgg tggcagcagc
      301 ggcggcagcg cctaaccata gcagaaatct acctggctaa cttggcagct tctgatctgg
      361 tgtttgtgct gggcctgccc ttctgggcag agaacgttgg gaaccgtttc aactggccct
      421 ttggaagtga cctctgccgg gtggtcagcg gggtcatcaa ggccaacctg ttcatcagca
      481 tcttcctggt ggtggccatc agtcaggacc gctacaggtt gctggtatac cccatgacca
      541 gctgggggaa ccggcggcga cggcaagccc aagtgacctg cctgctcatc tgggtagctg
      601 ggggcctctt gagcaccccc acgttccttc tgcgttccgt caaagtcgtc cctgatctga
      661 acatctctgc ctgcatcctg cttttccccc acgaagcttg gcactttgta aggatggtgg
      721 agttgaacgt tttgggtttc ctcctcccat tggctgccat cctctacttc aactttcaca
      781 tcctggcctc cctgagagga cagaaggagg ccagcagaac ccggtgtggg ggacccaagg
      841 acagcaagac aatggggctg atcctcacac tggtagcctc cttcctggtc tgctgggccc
      901 cttaccactt ctttgccttc ctggatttcc tggtccaggt gagagtgatc caggactgct
      961 tctggaagga gctcacagac ctgggcctgc agctggccaa cttctttgct tttgtcaaca
     1021 gctgcctgaa cccactgatt tatgtctttg caggccggct ctttaagacc agggttctgg
     1081 gaactttata agtgatgcac ctctttataa aatgccggta ttgcccagta ggaaagaact
     1141 cttccaactg tcctgctgga attgaaacag cattgagcca agaagcctgg cttcttgacc
     1201 aaccgtctct gctatcatag ggaccatctg gttggctgag ccacagccca caaagatgcc
     1261 ggaggacaga gtaatcggag gacagggtag ccggaggaca gggtagccgg gacctcgcag
     1321 atgcacttaa taaggatccg gagattaggc tgatcctgaa gcttttcaga ggcagagcga
     1381 gaacagccac agaggtcctt ttaagatggg attagaaagg g
//
