LOCUS       NM_001172055            1172 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus 3-hydroxybutyrate dehydrogenase, type 2 (Bdh2),
            transcript variant 1, mRNA.
ACCESSION   NM_001172055
VERSION     NM_001172055.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1172)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1172)
  AUTHORS   Yang,B., Hou,S., Zhao,J. and Li,Y.
  TITLE     3-hydroxy butyrate dehydrogenase 2 deficiency aggravates systemic
            lupus erythematosus progression in a mouse model by promoting CD40
            ligand demethylation
  JOURNAL   Bioengineered 13 (2), 2685-2695 (2022)
   PUBMED   35001849
  REMARK    GeneRIF: 3-hydroxy butyrate dehydrogenase 2 deficiency aggravates
            systemic lupus erythematosus progression in a mouse model by
            promoting CD40 ligand demethylation.
REFERENCE   3  (bases 1 to 1172)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1172)
  AUTHORS   Liu,Z., Ciocea,A. and Devireddy,L.
  TITLE     Endogenous siderophore 2,5-dihydroxybenzoic acid deficiency
            promotes anemia and splenic iron overload in mice
  JOURNAL   Mol Cell Biol 34 (13), 2533-2546 (2014)
   PUBMED   24777603
  REMARK    GeneRIF: these findings demonstrate a key role for BDH2 in
            erythropoiesis.
REFERENCE   5  (bases 1 to 1172)
  AUTHORS   Liu,Z., Reba,S., Chen,W.D., Porwal,S.K., Boom,W.H., Petersen,R.B.,
            Rojas,R., Viswanathan,R. and Devireddy,L.
  TITLE     Regulation of mammalian siderophore 2,5-DHBA in the innate immune
            response to infection
  JOURNAL   J Exp Med 211 (6), 1197-1213 (2014)
   PUBMED   24863067
REFERENCE   6  (bases 1 to 1172)
  AUTHORS   Liu,Z., Velpula,K.K. and Devireddy,L.
  TITLE     3-Hydroxybutyrate dehydrogenase-2 and ferritin-H synergistically
            regulate intracellular iron
  JOURNAL   FEBS J 281 (10), 2410-2421 (2014)
   PUBMED   24673886
  REMARK    GeneRIF: 3-hydroxybutyrate dehydrogenase-2 catalyzes a
            rate-limiting step in the biogenesis of the mammalian siderophore.
REFERENCE   7  (bases 1 to 1172)
  AUTHORS   Thiagarajan,R.D., Georgas,K.M., Rumballe,B.A., Lesieur,E.,
            Chiu,H.S., Taylor,D., Tang,D.T., Grimmond,S.M. and Little,M.H.
  TITLE     Identification of anchor genes during kidney development defines
            ontological relationships, molecular subcompartments and regulatory
            pathways
  JOURNAL   PLoS One 6 (2), e17286 (2011)
   PUBMED   21386911
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1172)
  AUTHORS   Devireddy,L.R., Hart,D.O., Goetz,D.H. and Green,M.R.
  TITLE     A mammalian siderophore synthesized by an enzyme with a bacterial
            homolog involved in enterobactin production
  JOURNAL   Cell 141 (6), 1006-1017 (2010)
   PUBMED   20550936
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104874.11.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.674207.1,
                                           SRR5189676.64385.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               AC104874.11        115491-115638
            149-301             AC104874.11        119785-119937
            302-380             AC104874.11        122531-122609
            381-477             AC104874.11        123825-123921
            478-586             AC104874.11        125264-125372
            587-647             AC104874.11        129498-129558
            648-761             AC104874.11        131090-131203
            762-820             AC104874.11        134944-135002
            821-913             AC104874.11        135832-135924
            914-1172            AC104874.11        138438-138696
FEATURES             Location/Qualifiers
     source          1..1172
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 62.55 cM"
     gene            1..1172
                     /gene="Bdh2"
                     /gene_synonym="1810026B04Rik; Dhrs6"
                     /note="3-hydroxybutyrate dehydrogenase, type 2"
                     /db_xref="GeneID:69772"
                     /db_xref="MGI:MGI:1917022"
     exon            1..148
                     /gene="Bdh2"
                     /gene_synonym="1810026B04Rik; Dhrs6"
                     /inference="alignment:Splign:2.1.0"
     exon            149..301
                     /gene="Bdh2"
                     /gene_synonym="1810026B04Rik; Dhrs6"
                     /inference="alignment:Splign:2.1.0"
     exon            302..380
                     /gene="Bdh2"
                     /gene_synonym="1810026B04Rik; Dhrs6"
                     /inference="alignment:Splign:2.1.0"
     exon            381..477
                     /gene="Bdh2"
                     /gene_synonym="1810026B04Rik; Dhrs6"
                     /inference="alignment:Splign:2.1.0"
     exon            478..586
                     /gene="Bdh2"
                     /gene_synonym="1810026B04Rik; Dhrs6"
                     /inference="alignment:Splign:2.1.0"
     exon            587..647
                     /gene="Bdh2"
                     /gene_synonym="1810026B04Rik; Dhrs6"
                     /inference="alignment:Splign:2.1.0"
     exon            648..761
                     /gene="Bdh2"
                     /gene_synonym="1810026B04Rik; Dhrs6"
                     /inference="alignment:Splign:2.1.0"
     exon            762..820
                     /gene="Bdh2"
                     /gene_synonym="1810026B04Rik; Dhrs6"
                     /inference="alignment:Splign:2.1.0"
     exon            821..913
                     /gene="Bdh2"
                     /gene_synonym="1810026B04Rik; Dhrs6"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1172
                     /gene="Bdh2"
                     /gene_synonym="1810026B04Rik; Dhrs6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1146..1151
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bdh2"
                     /gene_synonym="1810026B04Rik; Dhrs6"
                     /note="hexamer: AATAAA"
     polyA_site      1172
                     /gene="Bdh2"
                     /gene_synonym="1810026B04Rik; Dhrs6"
                     /note="major polyA site"
ORIGIN      
        1 acttaacagg cattagcaaa aggactcgga ggggacctga actccacctc ccagcgtgca
       61 ttaatcagca tgtgacttct cctgcgcaga gatctgaagt ttgtctcctg aaggaatctg
      121 gaggactgtg tggactcact cttctaaaac gttaccacct gcacaactgg ttttctacaa
      181 cttgagccat taagggtcta tgtctttgga ttgtgccgca ggatccacta tgggccgact
      241 ggacggcaaa gttattgtcc tgacagctgc cgctcaaggg attggacggg catccgcatt
      301 agcttttgca agagaaggag ccaaagtcat agccacagat atcaacgagt ccaaactcca
      361 ggagctggaa agttaccgag gtattcaaac tcgagtcctt gatgtcacaa agaagagaca
      421 gattgatcag tttgcctcag aaatcgagag aattgatgtt ctctttaatg ttgctggttt
      481 tgtccaccac ggaaccatcc tggattgcga ggaaaaagac tgggacttct caatgaatct
      541 caacgtccgc agcatgttcc tgatgatcaa agcattcctt cccaaaatgc ttgctcagaa
      601 gtcaggcaac attatcaaca tgtcgtctgt ggcctccagc atcaaagggg tggagaacag
      661 atgtgtgtac agtgctacca aggcggctgt gatcggtctc accaagtccg tggctgcaga
      721 cttcatccaa cagggcatca gatgcaactg tgtgtgtcca ggaacggttg acaccccatc
      781 tctgcaagaa agaatacaag ccagagacaa tcccaaagag gcactgaaaa ctttcctaaa
      841 cagacaaaag acgggaaggt ttgcgtcggc cgaagaggtc gctctgctct gcgtatacct
      901 ggcctcggac gagtcagcct atgtaactgg caaccctgtc atcattgatg ggggctggag
      961 cctgtgaccg cgaggatccc tgctgggaag acaggccctt cctagccacg gagcaaagca
     1021 agctgcctgg gtgatcatct cttctgagag tgacattcat gaaaataagc cctttagtga
     1081 ttgttcccga gagtgtgact ctttaatagt ctctcgtctc ttctgaagct gtggtaaata
     1141 aatcaaataa aatgtattga ttttgtggca aa
//
