LOCUS       NM_001122683            3133 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus 3-hydroxybutyrate dehydrogenase, type 1 (Bdh1),
            transcript variant 2, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001122683
VERSION     NM_001122683.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3133)
  AUTHORS   Williams,A.S., Crown,S.B., Lyons,S.P., Koves,T.R., Wilson,R.J.,
            Johnson,J.M., Slentz,D.H., Kelly,D.P., Grimsrud,P.A., Zhang,G.F.
            and Muoio,D.M.
  TITLE     Ketone flux through BDH1 supports metabolic remodeling of skeletal
            and cardiac muscles in response to intermittent time-restricted
            feeding
  JOURNAL   Cell Metab 36 (2), 422-437 (2024)
   PUBMED   38325337
REFERENCE   2  (bases 1 to 3133)
  AUTHORS   Wan,S.R., Teng,F.Y., Fan,W., Xu,B.T., Li,X.Y., Tan,X.Z., Guo,M.,
            Gao,C.L., Zhang,C.X., Jiang,Z.Z. and Xu,Y.
  TITLE     BDH1-mediated betaOHB metabolism ameliorates diabetic kidney
            disease by activation of NRF2-mediated antioxidative pathway
  JOURNAL   Aging (Albany NY) 15 (22), 13384-13410 (2023)
   PUBMED   38015723
  REMARK    GeneRIF: BDH1-mediated betaOHB metabolism ameliorates diabetic
            kidney disease by activation of NRF2-mediated antioxidative
            pathway.
REFERENCE   3  (bases 1 to 3133)
  AUTHORS   Lin,J., Ren,Q., Zhang,F., Gui,J., Xiang,X. and Wan,Q.
  TITLE     D-beta-Hydroxybutyrate Dehydrogenase Mitigates Diabetes-Induced
            Atherosclerosis through the Activation of Nrf2
  JOURNAL   Thromb Haemost 123 (10), 1003-1015 (2023)
   PUBMED   37399841
  REMARK    GeneRIF: D-beta-Hydroxybutyrate Dehydrogenase Mitigates
            Diabetes-Induced Atherosclerosis through the Activation of Nrf2.
REFERENCE   4  (bases 1 to 3133)
  AUTHORS   Luda,K.M., Longo,J., Kitchen-Goosen,S.M., Duimstra,L.R., Ma,E.H.,
            Watson,M.J., Oswald,B.M., Fu,Z., Madaj,Z., Kupai,A., Dickson,B.M.,
            DeCamp,L.M., Dahabieh,M.S., Compton,S.E., Teis,R., Kaymak,I.,
            Lau,K.H., Kelly,D.P., Puchalska,P., Williams,K.S., Krawczyk,C.M.,
            Levesque,D., Boisvert,F.M., Sheldon,R.D., Rothbart,S.B.,
            Crawford,P.A. and Jones,R.G.
  TITLE     Ketolysis drives CD8+ T cell effector function through effects on
            histone acetylation
  JOURNAL   Immunity 56 (9), 2021-2035 (2023)
   PUBMED   37516105
REFERENCE   5  (bases 1 to 3133)
  AUTHORS   Tuomainen,T., Naumenko,N., Mutikainen,M., Shakirzyanova,A.,
            Sczelecki,S., Estall,J.L., Ruas,J.L. and Tavi,P.
  TITLE     PGC-1alpha4 Interacts with REST to Upregulate Neuronal Genes and
            Augment Energy Consumption in Developing Cardiomyocytes
  JOURNAL   Cells 11 (19), 2944 (2022)
   PUBMED   36230906
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3133)
  AUTHORS   Labialle,S., Marty,V., Bortolin-Cavaille,M.L., Hoareau-Osman,M.,
            Pradere,J.P., Valet,P., Martin,P.G. and Cavaille,J.
  TITLE     The miR-379/miR-410 cluster at the imprinted Dlk1-Dio3 domain
            controls neonatal metabolic adaptation
  JOURNAL   EMBO J 33 (19), 2216-2230 (2014)
   PUBMED   25124681
REFERENCE   7  (bases 1 to 3133)
  AUTHORS   Gineste,C., De Winter,J.M., Kohl,C., Witt,C.C., Giannesini,B.,
            Brohm,K., Le Fur,Y., Gretz,N., Vilmen,C., Pecchi,E., Jubeau,M.,
            Cozzone,P.J., Stienen,G.J., Granzier,H., Labeit,S.,
            Ottenheijm,C.A., Bendahan,D. and Gondin,J.
  TITLE     In vivo and in vitro investigations of heterozygous nebulin
            knock-out mice disclose a mild skeletal muscle phenotype
  JOURNAL   Neuromuscul Disord 23 (4), 357-369 (2013)
   PUBMED   23375831
REFERENCE   8  (bases 1 to 3133)
  AUTHORS   Kim,S.C., Sprung,R., Chen,Y., Xu,Y., Ball,H., Pei,J., Cheng,T.,
            Kho,Y., Xiao,H., Xiao,L., Grishin,N.V., White,M., Yang,X.J. and
            Zhao,Y.
  TITLE     Substrate and functional diversity of lysine acetylation revealed
            by a proteomics survey
  JOURNAL   Mol Cell 23 (4), 607-618 (2006)
   PUBMED   16916647
REFERENCE   9  (bases 1 to 3133)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   10 (bases 1 to 3133)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK145711.1, AK146962.1, AA789526.1 and BE979314.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146321.1, AK145711.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2057              AK145711.1         2-2058
            2058-2284           AK146962.1         2108-2334
            2285-2291           AA789526.1         87-93
            2292-3113           AK146962.1         2335-3156
            3114-3133           BE979314.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..3133
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 21.74 cM"
     gene            1..3133
                     /gene="Bdh1"
                     /gene_synonym="2310032J20Rik; Bdh"
                     /note="3-hydroxybutyrate dehydrogenase, type 1"
                     /db_xref="GeneID:71911"
                     /db_xref="MGI:MGI:1919161"
     exon            1..235
                     /gene="Bdh1"
                     /gene_synonym="2310032J20Rik; Bdh"
                     /inference="alignment:Splign:2.1.0"
     exon            236..361
                     /gene="Bdh1"
                     /gene_synonym="2310032J20Rik; Bdh"
                     /inference="alignment:Splign:2.1.0"
     CDS             279..1310
                     /gene="Bdh1"
                     /gene_synonym="2310032J20Rik; Bdh"
                     /EC_number="1.1.1.30"
                     /note="3-hydroxybutyrate dehydrogenase (heart,
                     mitochondrial); D-beta-hydroxybutyrate dehydrogenase,
                     mitochondrial; b-hydroxybutyrate dehydrogenase"
                     /codon_start=1
                     /product="D-beta-hydroxybutyrate dehydrogenase,
                     mitochondrial precursor"
                     /protein_id="NP_001116155.1"
                     /db_xref="CCDS:CCDS28106.1"
                     /db_xref="GeneID:71911"
                     /db_xref="MGI:MGI:1919161"
                     /translation="MLAARLSRPLSQLPGKALSVRDRENGTRHTLLFYPASFSPDTRR
                     TYASQADAASGKAILITGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGDAGVKELDSL
                     KSDRLRTIQLNVCNSEEVEKAVETIRSGLKDPEKGMWGLVNNAGISTFGEVEFTSMET
                     YKEVAEVNLWGTVRTTKSFLPLLRRAKGRVVNISSMLGRMANPARSPYCITKFGIEAF
                     SDCLRYEMHPLGVKVSVVEPGNFIAATSLYSPERIQAIAKKMWDDLPEVVRKDYGRKY
                     FDEKIAKMETYCNSGSTDTSSVINAVTHALTAATPYTRYHPMDYYWWLRMQIMTHFPG
                     AISDKIYIH"
     exon            362..434
                     /gene="Bdh1"
                     /gene_synonym="2310032J20Rik; Bdh"
                     /inference="alignment:Splign:2.1.0"
     exon            435..545
                     /gene="Bdh1"
                     /gene_synonym="2310032J20Rik; Bdh"
                     /inference="alignment:Splign:2.1.0"
     exon            546..687
                     /gene="Bdh1"
                     /gene_synonym="2310032J20Rik; Bdh"
                     /inference="alignment:Splign:2.1.0"
     exon            688..840
                     /gene="Bdh1"
                     /gene_synonym="2310032J20Rik; Bdh"
                     /inference="alignment:Splign:2.1.0"
     exon            841..3117
                     /gene="Bdh1"
                     /gene_synonym="2310032J20Rik; Bdh"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1694..1699
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bdh1"
                     /gene_synonym="2310032J20Rik; Bdh"
                     /note="hexamer: AGTAAA"
     polyA_site      1714
                     /gene="Bdh1"
                     /gene_synonym="2310032J20Rik; Bdh"
                     /note="major polyA site"
     regulatory      3096..3101
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bdh1"
                     /gene_synonym="2310032J20Rik; Bdh"
                     /note="hexamer: AATAAA"
     polyA_site      3117
                     /gene="Bdh1"
                     /gene_synonym="2310032J20Rik; Bdh"
                     /note="major polyA site"
ORIGIN      
        1 gtctgccgtc gggccccgcc cggcgcagcc ctaacgcacg caccggagtg tgtgtaaggc
       61 acatccgggt gtcagaagca ggaggccgcg gttttagggg tcgggagagg gtcttggaga
      121 gcctaggcaa cgagccaact ccaagccaga agcgcgagca cctgcagagc tacgggttca
      181 gacgagcgca cccgtccagc ccttgctgcg gagccccctg ccggcttgct ttgggagcca
      241 ccagaaggaa gcagagcgtc ttacaacttg gtgccacgat gctagctgcc cgtctctcca
      301 gacccctgtc acagctccca ggaaaagccc taagtgtccg tgacagagaa aatgggacaa
      361 gacacacact gttgttttat ccagcatcct tcagccctga cacccgtcgg acctacgcca
      421 gtcaggcaga tgcggctagt ggcaaagcta tcctgatcac aggctgtgac tctggatttg
      481 ggttctcact ggccaagcat ctgcactcaa aaggcttcct tgtatttgct ggctgtttga
      541 tgaaggacaa aggtgatgct ggggtcaagg aactggacag cttgaagagt gaccgactga
      601 gaaccatcca gctcaatgtc tgcaacagtg aagaggtgga gaaggcggtg gagacgatcc
      661 gctccggcct gaaagatcct gagaagggaa tgtggggcct ggttaacaac gcaggcatct
      721 caacgtttgg ggaggtggag ttcaccagca tggagacata taaggaggtg gctgaagtga
      781 acctctgggg aaccgtgcgc accacaaaat ccttccttcc ccttctccga agagccaaag
      841 gtcgcgtcgt taacatcagc agcatgctgg gccgcatggc caaccccgcc cgctcgccat
      901 actgcatcac caagtttggg atcgaggctt tctcggactg cctgcgctat gagatgcacc
      961 ctctgggtgt caaggtcagt gtggtggaac ctggcaactt catagcggcc accagtctct
     1021 acagccccga gcgcatccag gccatcgcca agaagatgtg ggatgacctg cctgaggtcg
     1081 tccgcaagga ctatggcagg aagtacttcg atgaaaagat tgccaagatg gaaacctact
     1141 gcaacagcgg ttccacagat acttcctctg tcatcaacgc tgtcacacac gccttgaccg
     1201 ccgccacccc gtatacccgc taccatccca tggactacta ctggtggctt cggatgcaga
     1261 tcatgaccca ttttcctgga gccatctctg acaagatcta catacactga agagctgaag
     1321 aggtcccttc ggtctccgcc agggaacctg gtgggaggga gaaagatgag gggagggagt
     1381 ttaccttttg attagctgtt gaggattacc cactgtctta ggaagaccta ttttaacctt
     1441 acgtgttcaa tgtggtgaat ggtttgggcc ttcacaaatt aggggggggg cgggcggagg
     1501 gcgcaggtgg gtggccctaa acctcagggc caatatggtg cttctatcta tctcgagttg
     1561 attttatata aagatttgtg gggaaatatc tttatattaa aagcaggtta ttggaataga
     1621 atccaaaatc attttccagc caaaacatcc attcgaaatc tgtatcccat ttgatcctta
     1681 tgtaagtctc atgagtaaac agaacagaat ttttttttct tgtgtgcatg aaagaatttg
     1741 cagatcgcag aggacatacg agacacctct ttcattgtgt ccacggagtc ccgccagtgt
     1801 tacggcaaag gcaaatcaca tttgtgtccc acagacactt gaacccatca gtccagtaac
     1861 cctgtgacca actctgtacc ttctcctgag ccagtcacac caaaggtcac tgtgtgctat
     1921 gtctctgtgc gtccgtagct ctgtgtgact ggtggccagc agtcagtgac tctctgctgg
     1981 ctccaggtgg gggaatccag agacttttca gctgagatct tgacattctc attaaagatt
     2041 cgagttaggt ctgggtgaag atgctgtccg gctaagagcg cagcttggtt ttgcctagga
     2101 caggattggt gctatgcttg gtgctgcaaa cagaccagtg gtgccaaggc tgggcactga
     2161 gacacttgcc cagcaatggg tctagatgcc tgttgtcttg tgtgctcatg tggtgctccc
     2221 acatgtgggt gcgtgtgtgc atgcactcac acacacacac acacatcaca cacacacaca
     2281 cacatcacac acacacacac acacctgctc catagacttc agggtggtca cctcttcttt
     2341 gtattgggaa cttcttttta attaaactga gacacagtta gagagcctgt gttctcaatc
     2401 aagggacttt tgcatttgaa ggctgcttgt ccctgaagtt tcctagggtc tcagtatttg
     2461 gatccaaacc aaatcccacc acgttccagg tggcagcaag tcttgggccg ggtatttaag
     2521 tgccagcttt acacacatct cagctttaca cttttgtgca tcttgttgca aagtctagga
     2581 ctgccactag agggcgcgct gccccctcaa ctggagcctg ctcaggcccg ggcgttttcg
     2641 ttcacacaaa cttggggtct tttcaagagt gtttgaccac ctacttggac actgccaggg
     2701 aacaaagaga agagcaaaga cccccttgga aaccgatcct acactcctgg cagtgtctag
     2761 cctgaaactg aagcccagcg ccaggagaaa gcaaaggaac ctggacagcc acaggcgggt
     2821 gcaggcagtg ctgagacaaa gagggtccca cagagagcga attcagcctg ccggtttggg
     2881 cttttaaccc ctctggatac aaacagaggt gcactgttct agctcctgtc ttcaaagcaa
     2941 agtagatagg gcctgagagg gaaggtgaga gggagccagg gccccagggt ccacgaattt
     3001 acctgacagc gggatgcatt tgtactgcag agcctgcctc ctgctggcgt ctttcagtgg
     3061 cattttacac cttgggagaa tttgtatccg tgtttaataa agagattggt cataacaaaa
     3121 aaaaaaaaaa aaa
//
