LOCUS       NM_001081412            6537 bp    mRNA    linear   ROD 19-DEC-2022
DEFINITION  Mus musculus BCR activator of RhoGEF and GTPase (Bcr), mRNA.
ACCESSION   NM_001081412 XM_983429
VERSION     NM_001081412.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6537)
  AUTHORS   Borza CM, Bolas G, Bock F, Zhang X, Akabogu FC, Zhang MZ, de
            Caestecker M, Yang M, Yang H, Lee E, Gewin L, Fogo AB, McDonald WH,
            Zent R and Pozzi A.
  TITLE     DDR1 contributes to kidney inflammation and fibrosis by promoting
            the phosphorylation of BCR and STAT3
  JOURNAL   JCI Insight 7 (3), e150887 (2022)
   PUBMED   34941574
  REMARK    GeneRIF: DDR1 contributes to kidney inflammation and fibrosis by
            promoting the phosphorylation of BCR and STAT3.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6537)
  AUTHORS   Xiao Y, Sun Y, Lu Y, Du J, Tian X, Cai W and Wang Y.
  TITLE     Loss function of Bcr mutation causes gastrointestinal dysmotility
            and brain developmental defects
  JOURNAL   Neurogastroenterol Motil 33 (12), e14190 (2021)
   PUBMED   34190380
  REMARK    GeneRIF: Loss function of Bcr mutation causes gastrointestinal
            dysmotility and brain developmental defects.
REFERENCE   3  (bases 1 to 6537)
  AUTHORS   Lee J, Robinson ME, Ma N, Artadji D, Ahmed MA, Xiao G, Sadras T,
            Deb G, Winchester J, Cosgun KN, Geng H, Chan LN, Kume K, Miettinen
            TP, Zhang Y, Nix MA, Klemm L, Chen CW, Chen J, Khairnar V, Wiita
            AP, Thomas-Tikhonenko A, Farzan M, Jung JU, Weinstock DM, Manalis
            SR, Diamond MS, Vaidehi N and Muschen M.
  TITLE     IFITM3 functions as a PIP3 scaffold to amplify PI3K signalling in B
            cells
  JOURNAL   Nature 588 (7838), 491-497 (2020)
   PUBMED   33149299
  REMARK    Erratum:[Nature. 2021 Apr;592(7852):E3. PMID: 33712811]
REFERENCE   4  (bases 1 to 6537)
  AUTHORS   Chong Y, Liu Y, Lu S, Cai B, Qin H, Chang CS, Ren M, Cowell JK and
            Hu T.
  TITLE     Critical individual roles of the BCR and FGFR1 kinase domains in
            BCR-FGFR1-driven stem cell leukemia/lymphoma syndrome
  JOURNAL   Int J Cancer 146 (8), 2243-2254 (2020)
   PUBMED   31525277
  REMARK    GeneRIF: Authors have deleted the STK domain and mutated the
            critical Y177 residue and demonstrate that the transforming
            activity of these mutated genes is reduced compared to the
            BCR-FGFR1 parental kinase. In addition, we demonstrate that
            deletion of the FGFR1 tyrosine kinase domain abrogates transforming
            ability, which is not compensated for by BCR STK activity.
REFERENCE   5  (bases 1 to 6537)
  AUTHORS   Faulkner J, Jiang P, Farris D, Walker R and Dai Z.
  TITLE     CRISPR/CAS9-mediated knockout of Abi1 inhibits p185Bcr-Abl-induced
            leukemogenesis and signal transduction to ERK and PI3K/Akt pathways
  JOURNAL   J Hematol Oncol 13 (1), 34 (2020)
   PUBMED   32276588
  REMARK    GeneRIF: CRISPR/CAS9-mediated knockout of Abi1 inhibits
            p185(Bcr-Abl)-induced leukemogenesis and signal transduction to ERK
            and PI3K/Akt pathways.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6537)
  AUTHORS   Wilkie TM, Gilbert DJ, Olsen AS, Chen XN, Amatruda TT, Korenberg
            JR, Trask BJ, de Jong P, Reed RR, Simon MI et al.
  TITLE     Evolution of the mammalian G protein alpha subunit multigene family
  JOURNAL   Nat Genet 1 (2), 85-91 (1992)
   PUBMED   1302014
  REMARK    Review article
REFERENCE   7  (bases 1 to 6537)
  AUTHORS   Haefliger JA, Bruzzone R, Jenkins NA, Gilbert DJ, Copeland NG and
            Paul DL.
  TITLE     Four novel members of the connexin family of gap junction proteins.
            Molecular cloning, expression, and chromosome mapping
  JOURNAL   J Biol Chem 267 (3), 2057-2064 (1992)
   PUBMED   1370487
REFERENCE   8  (bases 1 to 6537)
  AUTHORS   Zhu QS, Heisterkamp N and Groffen J.
  TITLE     Unique organization of the human BCR gene promoter
  JOURNAL   Nucleic Acids Res 18 (23), 7119-7125 (1990)
   PUBMED   2263470
REFERENCE   9  (bases 1 to 6537)
  AUTHORS   Justice MJ, Siracusa LD, Gilbert DJ, Heisterkamp N, Groffen J,
            Chada K, Silan CM, Copeland NG and Jenkins NA.
  TITLE     A genetic linkage map of mouse chromosome 10: localization of
            eighteen molecular markers using a single interspecific backcross
  JOURNAL   Genetics 125 (4), 855-866 (1990)
   PUBMED   1975791
REFERENCE   10 (bases 1 to 6537)
  AUTHORS   Heisterkamp N and Groffen J.
  TITLE     Duplication of the bcr and gamma-glutamyl transpeptidase genes
  JOURNAL   Nucleic Acids Res 16 (16), 8045-8056 (1988)
   PUBMED   2901712
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160402.8 and BC131682.1.
            
            [WARNING] On Apr 12, 2023 this sequence was replaced by
            NM_001081412.3.
            
            On Dec 29, 2007 this sequence version replaced NM_001081412.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060270.1, SRR1660819.87310.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-807               AC160402.8         147605-148411       c
            808-4568            BC131682.1         213-3973
            4569-6537           AC160402.8         24384-26352         c
FEATURES             Location/Qualifiers
     source          1..6537
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 38.49 cM"
     gene            1..6537
                     /gene="Bcr"
                     /gene_synonym="5133400C09Rik; mKIAA3017"
                     /note="BCR activator of RhoGEF and GTPase"
                     /db_xref="GeneID:110279"
                     /db_xref="MGI:MGI:88141"
     exon            1..1415
                     /gene="Bcr"
                     /gene_synonym="5133400C09Rik; mKIAA3017"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1588
                     /gene="Bcr"
                     /gene_synonym="5133400C09Rik; mKIAA3017"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1693
                     /gene="Bcr"
                     /gene_synonym="5133400C09Rik; mKIAA3017"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1879
                     /gene="Bcr"
                     /gene_synonym="5133400C09Rik; mKIAA3017"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..1987
                     /gene="Bcr"
                     /gene_synonym="5133400C09Rik; mKIAA3017"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2048
                     /gene="Bcr"
                     /gene_synonym="5133400C09Rik; mKIAA3017"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2101
                     /gene="Bcr"
                     /gene_synonym="5133400C09Rik; mKIAA3017"
                     /inference="alignment:Splign:2.1.0"
     exon            2102..2242
                     /gene="Bcr"
                     /gene_synonym="5133400C09Rik; mKIAA3017"
                     /inference="alignment:Splign:2.1.0"
     exon            2243..2364
                     /gene="Bcr"
                     /gene_synonym="5133400C09Rik; mKIAA3017"
                     /inference="alignment:Splign:2.1.0"
     exon            2365..2533
                     /gene="Bcr"
                     /gene_synonym="5133400C09Rik; mKIAA3017"
                     /inference="alignment:Splign:2.1.0"
     exon            2534..2653
                     /gene="Bcr"
                     /gene_synonym="5133400C09Rik; mKIAA3017"
                     /inference="alignment:Splign:2.1.0"
     exon            2654..2729
                     /gene="Bcr"
                     /gene_synonym="5133400C09Rik; mKIAA3017"
                     /inference="alignment:Splign:2.1.0"
     exon            2730..2834
                     /gene="Bcr"
                     /gene_synonym="5133400C09Rik; mKIAA3017"
                     /inference="alignment:Splign:2.1.0"
     exon            2835..2909
                     /gene="Bcr"
                     /gene_synonym="5133400C09Rik; mKIAA3017"
                     /inference="alignment:Splign:2.1.0"
     exon            2910..3007
                     /gene="Bcr"
                     /gene_synonym="5133400C09Rik; mKIAA3017"
                     /inference="alignment:Splign:2.1.0"
     exon            3008..3139
                     /gene="Bcr"
                     /gene_synonym="5133400C09Rik; mKIAA3017"
                     /inference="alignment:Splign:2.1.0"
     exon            3140..3199
                     /gene="Bcr"
                     /gene_synonym="5133400C09Rik; mKIAA3017"
                     /inference="alignment:Splign:2.1.0"
     exon            3200..3309
                     /gene="Bcr"
                     /gene_synonym="5133400C09Rik; mKIAA3017"
                     /inference="alignment:Splign:2.1.0"
     exon            3310..3449
                     /gene="Bcr"
                     /gene_synonym="5133400C09Rik; mKIAA3017"
                     /inference="alignment:Splign:2.1.0"
     exon            3450..3584
                     /gene="Bcr"
                     /gene_synonym="5133400C09Rik; mKIAA3017"
                     /inference="alignment:Splign:2.1.0"
     exon            3585..3690
                     /gene="Bcr"
                     /gene_synonym="5133400C09Rik; mKIAA3017"
                     /inference="alignment:Splign:2.1.0"
     exon            3691..3853
                     /gene="Bcr"
                     /gene_synonym="5133400C09Rik; mKIAA3017"
                     /inference="alignment:Splign:2.1.0"
     exon            3854..6537
                     /gene="Bcr"
                     /gene_synonym="5133400C09Rik; mKIAA3017"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttcgccgcc gcatccgcgg ggccatggga gccaccgggc tccccagccc gggcccggtg
       61 agaacgccgc gccgccgctg agccggactc cgggcgcgca gctcggcggc gcaggtgagc
      121 cggccgcgcc atggtggact cggtgggctt cgccgaggcg tggagggcgc agttcccgga
      181 ctcggagccg ccgcgcatgg agctgcgctc ggtgggtgac atcgagcagg agctggagcg
      241 ctgcaaggcc tccattaggc gcttggagca ggaggtgaac caggagcgct tccgcatgat
      301 ctacctgcag acgctgctgg ccaaggagaa gaagagctac gatcggcagc gctggggctt
      361 ccgccgtgca gcgcagcccc ccgacggcgc cgccgagccc cgagcgtccg ccccgcgccc
      421 gccgcccgcg cccgccgacg gcgcagaccc ggcgcccgtc gaggagtccg aggcgcggcc
      481 ggacggagag gggtcaccga gtaaggggcg gtcagcgtcc gcccgcaggc cagcggctgc
      541 tgcatcggcg gaccgggacg accgagggcc ccccaccagc gtggcggcgc tcagatccaa
      601 cttcgagaag atccgcaagg gacctgccca gcccggctct gccgacgccg agaagccctt
      661 ctacgtgaac gtcgagttcc accacgagcg cggcctggtg aaggtcaacg acaaagaggt
      721 gtccgaccga atcagttccc tgggcagcca ggccatgcaa atggagcgca agaagtccca
      781 gcagagcgcc gggcagggcc tgggggaagc acccagaccc cattaccgtg ggcgctcctc
      841 ggaaagcagt tgcggccttg acggtgacta tgaggatgca gagttgaatc cccgcttcct
      901 gaaggacaac ctaataaatg ccaacggcgg caacaggccc ccttggccgc ccctggagta
      961 ccaaccctac cagagcatct atgtcggagg catgatggtg gaaggggagg gcaagagccc
     1021 tctcctgcga agccagagca cttcagagca ggagaaacgc ctaacctggc ctcgcaggtc
     1081 ctactcgcct cggagtttcg aggacagcgg aggtggctac acgccggact gcagctccaa
     1141 cgagaacctc acctccagcg aggaggactt ttcctctggc cagtccagcc gcgtgtcacc
     1201 aagccccacc acctaccgca tgttccggga caagagccgc tcaccctcgc agaattcgca
     1261 gcagtccttt gacagcagca gccccccgac gccacagtgc cagaagcggc accggcagtg
     1321 ccaggttgtg gtgtctgagg ctaccatcgt gggtgtccgc aagactgggc agatctggcc
     1381 cagtgatggg gacagcacct ttcaagggga agcagattcc tcgtttggaa caccacctgg
     1441 atatggctgt gccgcagacc aggctgagga acagcgccgg caccaggacg ggctgcccta
     1501 catcgatgat tcaccttctt cctcgccaca cctcagcagc aaaggcagag gcagcctggc
     1561 ctcaggcgcc ctggatccca ccaaagtgag tgagctggat ctggaaaagg gcctggagat
     1621 gagaaagtgg gttttgtccg gaatcctggc cagcgaggag acgtacctga gccatctgga
     1681 ggccctgctg ctgcccatga agcctctgaa agccgctgcc accacctctc agcctgtgct
     1741 gaccagccag cagattgaga ccattttctt caaagtgcct gagctctacg agatccacaa
     1801 ggagttctac gatgggctgt tcccccgagt gcagcagtgg agccaccagc agcgtgtagg
     1861 ggacctcttc cagaagctgg ccagccagct gggtgtgtac cgagcctttg tggataacta
     1921 cggagtggcc atggaaactg cagagaagtg ctgtcaggcc aacgctcagt ttgcagaaat
     1981 ctctgagaac ctgcgagcca gaagcaacaa ggatgtcaag gactcaacta ccaagaactc
     2041 tttggaaact ctgctctaca aacctgtgga ccgggtgacg aggagcacgc tagtccttca
     2101 cgacttgcta aaacacaccc cgtccagcca tcccgaccat tccctgctgc aagacgccct
     2161 ccgaatctct cagaacttcc tgtccagcat caacgaggag atcacgcccc gccgacagtc
     2221 catgacggtg aaaaaaggag agcaccggca gctgctgaag gacagcttta tggtagagct
     2281 ggtggagggg gcccgcaagc tgcgtcacat cttcctgttc actgacctgc tcctctgcac
     2341 caagctgaag aagcaaagtg gaggcaaaac ccagcaatat gactgtaaat ggtacattcc
     2401 gctcacggac ctcagcttcc agatggtgga tgaattggag gcactaccca acatccctct
     2461 ggtgccagat gaggaactgg atgccttgaa gatcaaaatc tcccaaatca agagcgacat
     2521 ccaacgagag aagagagcaa ataagggcag caaggtcatg gagaggctga ggaagaagct
     2581 gtcagagcag gagtcactgc tgctgttaat gtctcccagc atggccttcc gcgttcacag
     2641 tcgcaacggc aagagttaca cgttccttat ttcctctgac tatgagcgag ccgagtggag
     2701 agaaagcatc cgagagcagc agaagaaatg tttcaaaagt ttctctctga catctgtgga
     2761 gctacaaatg ctgaccaact catgtgtaaa acttcagacg gttcaccaca ttccactgac
     2821 catcaacaaa gaagatgacg agtctcctgg actctacggc ttcctgcatg tcatcgtcca
     2881 ctcagccacc ggctttaagc agagctcaaa tctctactgc accctggagg tggattcctt
     2941 tggatatttt gtgaataaag caaagactcg agtctacagg gacacaactg agccaaactg
     3001 gaatgaggag tttgagatag agctagaagg ctcccagacc ctgcggatac tatgttatga
     3061 aaagtgttac aacaaaatga agatgacgaa ggaagatggt gagagcgcag acaagctcat
     3121 ggggaaaggc caggtccagc tggaccccca aaccctacag gacagagact ggcagcggac
     3181 tgtcatcgac atgaatggaa ttgaagtgaa actctccgtc aagttcacga gcagggagtt
     3241 cagcctgaag agaatgccct cccgcaaaca gacaggggtc ttcggtgtca agattgctgt
     3301 agtcacaaag agagagaggt ccaaggtacc ttacattgtg cgccagtgtg tggaagagat
     3361 cgagcgccgg ggtatggagg aggtgggcat ctaccgagtg tctggagtgg ccacagacat
     3421 ccaggcactg aaggcagcct ttgatgtcaa taacaaggat gtgtccgtga tgatgagcga
     3481 gatggacgtg aacgccattg ccggcacgct gaagctctac ttccgtgagc tgcccgagcc
     3541 cctcttcacg gatgagttct accctaactt cgcagaaggc attgctcttt cagaccccgt
     3601 cgcaaaggag agctgcatgc tgaacctgct gctgtccctc ccagaagcca acctgctcac
     3661 cttcctcttc ctcctggacc acctgaaaag ggtagctgaa aaggagacgg tgaacaagat
     3721 gtccctgcac aacctcgcca cggtctttgg ccccacactg cttcggccct cagagaagga
     3781 aagcaagctc cctgctaacc ccagccagcc catcaccatg actgacagct ggtccctgga
     3841 ggtcatgtcc caggtccaag tgttgctgta cttcctgcag ctggaggcca tccctgcccc
     3901 tgacagcaag agacagagca tcctgttttc cactgaagtc taaaagccag gcatcagtca
     3961 tctcattagg aggcccacag aatgacctgg aaaactggga cgagagaacc cgcccacaga
     4021 gtgggaatga gacccttcct gcggtgtaat ttagccattc cgaagctctg ggccatctgc
     4081 caagagacaa gtacccaaag cgaaaggcca aggggcctgc gagaatccag gtgtgtctgc
     4141 aagccccagg ctggccccca gactgtacct ttcccttgtt gccaccagag ggcaccccaa
     4201 gtcagcccat ctgcaagcct gcggacaagg gaaaagaggc ggagaagaga gtggttttta
     4261 cgaatctaat ttatcagagt tttaaaaaaa aaaaatctct actggatcat ttgttccgat
     4321 gcaccctctc tggggaatag ggacaccgtc agatccctta ctgttgtgtc ttgaataaac
     4381 actgctgctg cttcctattg tgggggccac agccatgtcc ctctgtttag gtggggatgc
     4441 cttcacgttc cctgacgtag aaattccgct gtgtgtgtga cagggtctga gatgctgact
     4501 cggcactgta acatcgtcag ccctggctgc ttgctccgtc ctcccagaag gatggatgta
     4561 tgtgcagaag caggtcaggc tcctgttctc tgatactctt gtctgggctc tctatgcacc
     4621 tctcaggagt gtgctcctcc acagcccaga agtgtcccag gacccagcac ggggaaggag
     4681 accctggtcg tcacgcacct tacaattcct tctgcaggga gagtggccga gcccactgat
     4741 ccttacagcc tcccttctgt cttacaaagg ctgtgatatc tccagcctgg ctctgactgc
     4801 tgtctctctc cctcgttgcc ccatctaaga gaccactccc ttcccttgct cccgtctgag
     4861 cagactcggt tacctttctc agccatctct gctccaagac agcagtttcc tctagtggct
     4921 tgttttaata ctttgatccg aaatagcttt tgatacttga atatttttaa gttttatacg
     4981 tagtttctaa tttttttttt cctaatgggt tcagacacct aataagatac tagaatgtac
     5041 accgtggaca ggccatgtcc aggcagggtt ttgtcttcct ttgagagccg gcttcctttt
     5101 gtttggagtc gtttctgatg cctccctcca gagcatcaga aatatgggaa gaaggctagg
     5161 aaagtcaggc ctggggatag gagcaagatg gaaagctagc ccacctgcgg ccctcccacc
     5221 tcaatccctg tcgctgggtg ggagtcggag tagttgtctc ttactggcca ccctagttag
     5281 caaagggaaa gggaaaacca ctgattgtct tcaagaagga atcccataaa cccttgcatc
     5341 atttcttaaa gggtagaatc ccacccttgg gtgacagagg cagagttgcc atgagctcag
     5401 gaccagcctt ggcagcatca tgcttatctg gacagccaag actactgtgt agggctggcg
     5461 tacaagtagc tggggagaga agaaaaaagg ctgacgagag acttgaatcc tgagctgctc
     5521 ctgcaggaag gcataatttt aggggtgtag actgcctgtc ccgtgaggac tcctgcaccc
     5581 ggtcacatac cccacagccc ctcccatgtc tggacggtgg gtatgcccac cgatggcatc
     5641 caccaacccc acagcacatg ggggacccct gagaggcaga gccatgtctt cccctcccgt
     5701 ctgctcttga acctgcctaa ggtattgggc aggaaacaaa agaccctaca gggtctctgt
     5761 ctgcatacag tgtttagttg gctttttttt ttcccctcag cagagctacc cattggtctg
     5821 ctcttgagca tttttggacc cactgggctc ctctagtttg gctgttcatc ccagtccatg
     5881 tcatggctct gaccctgtaa ggggagcact gctgagaaaa gctgagtaac ctcccagccc
     5941 cccactgttg tttctgcacc tcctcccctc ccctcccccc caacccattg tttgctttgt
     6001 gtctgtcacc ttgaactgga aagcaatata tcaatgtgcc aatgtgcatt ccctggccca
     6061 ccccctgcct cggttcactt tatttattta ggttatgtgt tatttgatga tggaatgagc
     6121 atccctgtgt cggtctaaaa agtgcccctc cgccatcggg ccacggcagc agtgactggg
     6181 gctgcctctc ttaccgcctc acgccttgca ggcctctaag ctggcaaaga aaatacatgg
     6241 cgttgtccag gaatgggggt gactcagctt taccctctgc aaagagaatg acggccccag
     6301 tccgttatga ccgcccacca ggcgtggctg ccagacgcta aaggaagaag tgatactttc
     6361 ttaccttggg acctgggtcc tgggcacagt gggcttggct ttcctggtgg tagcctggcc
     6421 tctgcagtgg gtggatggtc tcttagctgc gatcctgctt ttgaactcgg ctgtctgtac
     6481 taccactctg taccagaagg accacggaca ctctcattaa agtctcctga gactact
//
