LOCUS       NM_175045               6857 bp    mRNA    linear   ROD 09-JUL-2024
DEFINITION  Mus musculus BCL6 interacting corepressor (Bcor), transcript
            variant c, mRNA.
ACCESSION   NM_175045
VERSION     NM_175045.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6857)
  AUTHORS   Takano,J., Ito,S., Dong,Y., Sharif,J., Nakajima-Takagi,Y.,
            Umeyama,T., Han,Y.W., Isono,K., Kondo,T., Iizuka,Y., Miyai,T.,
            Koseki,Y., Ikegaya,M., Sakihara,M., Nakayama,M., Ohara,O.,
            Hasegawa,Y., Hashimoto,K., Arner,E., Klose,R.J., Iwama,A.,
            Koseki,H. and Ikawa,T.
  TITLE     PCGF1-PRC1 links chromatin repression with DNA replication during
            hematopoietic cell lineage commitment
  JOURNAL   Nat Commun 13 (1), 7159 (2022)
   PUBMED   36443290
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6857)
  AUTHORS   Langouet,M., Jolicoeur,C., Javed,A., Mattar,P., Gearhart,M.D.,
            Daiger,S.P., Bertelsen,M., Tranebjaerg,L., Rendtorff,N.D.,
            Gronskov,K., Jespersgaard,C., Chen,R., Sun,Z., Li,H., Alirezaie,N.,
            Majewski,J., Bardwell,V.J., Sui,R., Koenekoop,R.K. and Cayouette,M.
  TITLE     Mutations in BCOR, a co-repressor of CRX/OTX2, are associated with
            early-onset retinal degeneration
  JOURNAL   Sci Adv 8 (36), eabh2868 (2022)
   PUBMED   36070393
REFERENCE   3  (bases 1 to 6857)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6857)
  AUTHORS   Sportoletti,P., Sorcini,D., Guzman,A.G., Reyes,J.M., Stella,A.,
            Marra,A., Sartori,S., Brunetti,L., Rossi,R., Papa,B.D., Adamo,F.M.,
            Pianigiani,G., Betti,C., Scialdone,A., Guarente,V., Spinozzi,G.,
            Tini,V., Martelli,M.P., Goodell,M.A. and Falini,B.
  TITLE     Bcor deficiency perturbs erythro-megakaryopoiesis and cooperates
            with Dnmt3a loss in acute erythroid leukemia onset in mice
  JOURNAL   Leukemia 35 (7), 1949-1963 (2021)
   PUBMED   33159179
  REMARK    GeneRIF: Bcor deficiency perturbs erythro-megakaryopoiesis and
            cooperates with Dnmt3a loss in acute erythroid leukemia onset in
            mice.
REFERENCE   5  (bases 1 to 6857)
  AUTHORS   Schmidt,C.R., Achille,N.J., Kuntimaddi,A., Boulton,A.M.,
            Leach,B.I., Zhang,S., Zeleznik-Le,N.J. and Bushweller,J.H.
  TITLE     BCOR Binding to MLL-AF9 Is Essential for Leukemia via Altered EYA1,
            SIX, and MYC Activity
  JOURNAL   Blood Cancer Discov 1 (2), 162-177 (2020)
   PUBMED   32954361
  REMARK    GeneRIF: BCOR Binding to MLL-AF9 Is Essential for Leukemia via
            Altered EYA1, SIX, and MYC Activity.
REFERENCE   6  (bases 1 to 6857)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   7  (bases 1 to 6857)
  AUTHORS   Srinivasan,R.S., de Erkenez,A.C. and Hemenway,C.S.
  TITLE     The mixed lineage leukemia fusion partner AF9 binds specific
            isoforms of the BCL-6 corepressor
  JOURNAL   Oncogene 22 (22), 3395-3406 (2003)
   PUBMED   12776190
REFERENCE   8  (bases 1 to 6857)
  AUTHORS   Tomsig,J.L., Snyder,S.L. and Creutz,C.E.
  TITLE     Identification of targets for calcium signaling through the copine
            family of proteins. Characterization of a coiled-coil
            copine-binding motif
  JOURNAL   J Biol Chem 278 (12), 10048-10054 (2003)
   PUBMED   12522145
REFERENCE   9  (bases 1 to 6857)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 6857)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK053309.1 and BC058656.1.
            
            On Dec 1, 2009 this sequence version replaced NM_175045.2.
            
            Transcript Variant: This variant (c) lacks a segment in the CDS, as
            compared to variant a. The resulting isoform (c) lacks an internal
            segment, as compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058656.1, AY161172.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-499               AK053309.1         2-500
            500-6857            BC058656.1         1-6358
FEATURES             Location/Qualifiers
     source          1..6857
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 6.83 cM"
     gene            1..6857
                     /gene="Bcor"
                     /gene_synonym="2900008C10Rik; 5830466J11Rik;
                     8430401K06Rik; BcorR; D930024N20Rik; mKIAA1575"
                     /note="BCL6 interacting corepressor"
                     /db_xref="GeneID:71458"
                     /db_xref="MGI:MGI:1918708"
     exon            1..736
                     /gene="Bcor"
                     /gene_synonym="2900008C10Rik; 5830466J11Rik;
                     8430401K06Rik; BcorR; D930024N20Rik; mKIAA1575"
                     /inference="alignment:Splign:2.1.0"
     exon            737..861
                     /gene="Bcor"
                     /gene_synonym="2900008C10Rik; 5830466J11Rik;
                     8430401K06Rik; BcorR; D930024N20Rik; mKIAA1575"
                     /inference="alignment:Splign:2.1.0"
     CDS             776..5953
                     /gene="Bcor"
                     /gene_synonym="2900008C10Rik; 5830466J11Rik;
                     8430401K06Rik; BcorR; D930024N20Rik; mKIAA1575"
                     /note="isoform c is encoded by transcript variant c; BCL-6
                     corepressor"
                     /codon_start=1
                     /product="BCL-6 corepressor isoform c"
                     /protein_id="NP_778210.2"
                     /db_xref="CCDS:CCDS30021.1"
                     /db_xref="GeneID:71458"
                     /db_xref="MGI:MGI:1918708"
                     /translation="MLSATPLYGNVHSWMNSERVRMCGTSEDRKIPVNDGDASKARLE
                     LREETPLSHSVVDTSGAHRIDGLAALSMDRTGLIREGLRVPGNIVYSGLCGLGSEKGR
                     EATPSSLSGLGFSSERNPEMQFKPNTPETVEASAVSGKPPNGFSAIYKTPPGIQKSAV
                     ATAESLGLDRPASDKQSPLNINGASYLRLPWVNPYMEGATPAIYPFLDSPNKYSLNMY
                     KALLPQQSYGLAQPLYSPVCTSGERFLYLPPPHYVNPHIPSSLASPMRLSTPSASAAI
                     PPLVHCSDKSLPWKMGVNPGNPVDSHSYPHIQNSKQPRVTSAKAVNSGLPGDTALLLP
                     PSPRPSARVHLPTQPAAETYSEFHKHYPRISTSPSVTLTKPYMTANSEFSTSRLSNGK
                     YPKALDGGDCAQSMPGHTRKTTVQDRKDGGSPPLLEKQTVTKDVTDKPLDLSSKVVDA
                     DASKGDHMKKMAPTVLVHSRAASGLVLSGSEIPKETLSPPGNGCSIYRSEIISTAPSS
                     WVVPGPSPNEENNGKSLSLKNKALDWAIPQQRSSSCPRMGGTDAVVTNVSGSVSSSGR
                     PASASPAPNANANADGTKTSRSSVDTTPSVIQHVGQPSSTPAKHGGSTSSKGAKANPE
                     PSFKASENGLPPTSIFLSPNEAFRSPAIPYPRSYLPYAAPEGIALSPLSLHGKGPVYP
                     HPVLLPNGSLFPGHLAPKPGLPYGLHTSRPEFVTYQDALGLGMVHPMLIPHTPIEITK
                     EEKPERRSRSHERARYEDPTLRSRFSEMLEASSTKLHPEVPTDKNLKPNSSWNQGKTG
                     VKSDKLVYVDLLREEADTKTDAGAPKAGLVAENVGQDTEATKPSADPVIQQRREFISL
                     REELGRITDFHESFTFKQASSQPVFSLGKDSGAAGTNKENLGVQVATPFLETALGSEG
                     PAVTFGKTQEDPKPFCVGGAPPNMDVTPAYTKEGTDEAESNDGKVLKPKPSKLAKRIA
                     NSAGYVGDRFKCVTTELYADSSQLSREQRALQMEGLQEDSILCLPAAYCERAMMRFSE
                     LEMKEREGSHPATKDSEVCKFSPADWERLKGNQEKKPKSVTLEEAIADQNDSERCEYS
                     TGNKHDLFEAPEDKDLPVEKYFLERPPVSEPPSDQGVVDTPHSPTLRLDRKRKLSGDS
                     THTETAVEELAEDPLKAKRRRISKGLHPKKQRHLLHLRERWEQQVSAAESKPGRQSRK
                     EVAQAVQPEVTSQGTNITEEKPGRKKAEAKGNRGWSEESLKSCDNEQGLPVLSGSPPM
                     KSLSSTNASGKKQTQPSCTPASRLPAKQQKIKESQKTDVLCTGEDEDCQAASPLQKYT
                     DNIEKPSGKRLCKTKHLIPQESRRSLQITGDYYVENTDTKMTVRRFRKRPEPSSDYDL
                     SPPAKQEPKPFDRLQQLLPATQATQLPRSNSPQETTQSRPMPPEARRLIVNKNAGETL
                     LQRAARLGYEEVVLYCLENKVCDVNHRDNAGYCALHEACARGWLNIVRHLLEYGADVN
                     CSAQDGTRPLHDAVENDHLEIVRLLLSYGADPTLATYSGRTIMKMTHSELMEKFLTDY
                     LNDLQGRSEDDTSGAWEFYGSSVCEPDDESGYDVLANPPGPEDPDEEEDTYSDLFEFE
                     FAESSLLPCYNIQVSVAQGPRNWLLLSDVLKKLKMSSRIFRSNFPNLEIVTIAEAEFY
                     RQVSTSLLFSCPKDLEAFNPESKELLDLVEFTNELQTLLGSSVEWLHPSDTGHENYW"
     exon            862..940
                     /gene="Bcor"
                     /gene_synonym="2900008C10Rik; 5830466J11Rik;
                     8430401K06Rik; BcorR; D930024N20Rik; mKIAA1575"
                     /inference="alignment:Splign:2.1.0"
     exon            941..3787
                     /gene="Bcor"
                     /gene_synonym="2900008C10Rik; 5830466J11Rik;
                     8430401K06Rik; BcorR; D930024N20Rik; mKIAA1575"
                     /inference="alignment:Splign:2.1.0"
     exon            3788..3841
                     /gene="Bcor"
                     /gene_synonym="2900008C10Rik; 5830466J11Rik;
                     8430401K06Rik; BcorR; D930024N20Rik; mKIAA1575"
                     /inference="alignment:Splign:2.1.0"
     exon            3842..4028
                     /gene="Bcor"
                     /gene_synonym="2900008C10Rik; 5830466J11Rik;
                     8430401K06Rik; BcorR; D930024N20Rik; mKIAA1575"
                     /inference="alignment:Splign:2.1.0"
     exon            4029..4286
                     /gene="Bcor"
                     /gene_synonym="2900008C10Rik; 5830466J11Rik;
                     8430401K06Rik; BcorR; D930024N20Rik; mKIAA1575"
                     /inference="alignment:Splign:2.1.0"
     exon            4287..4529
                     /gene="Bcor"
                     /gene_synonym="2900008C10Rik; 5830466J11Rik;
                     8430401K06Rik; BcorR; D930024N20Rik; mKIAA1575"
                     /inference="alignment:Splign:2.1.0"
     exon            4530..4855
                     /gene="Bcor"
                     /gene_synonym="2900008C10Rik; 5830466J11Rik;
                     8430401K06Rik; BcorR; D930024N20Rik; mKIAA1575"
                     /inference="alignment:Splign:2.1.0"
     exon            4856..5113
                     /gene="Bcor"
                     /gene_synonym="2900008C10Rik; 5830466J11Rik;
                     8430401K06Rik; BcorR; D930024N20Rik; mKIAA1575"
                     /inference="alignment:Splign:2.1.0"
     exon            5114..5280
                     /gene="Bcor"
                     /gene_synonym="2900008C10Rik; 5830466J11Rik;
                     8430401K06Rik; BcorR; D930024N20Rik; mKIAA1575"
                     /inference="alignment:Splign:2.1.0"
     exon            5281..5426
                     /gene="Bcor"
                     /gene_synonym="2900008C10Rik; 5830466J11Rik;
                     8430401K06Rik; BcorR; D930024N20Rik; mKIAA1575"
                     /inference="alignment:Splign:2.1.0"
     exon            5427..5504
                     /gene="Bcor"
                     /gene_synonym="2900008C10Rik; 5830466J11Rik;
                     8430401K06Rik; BcorR; D930024N20Rik; mKIAA1575"
                     /inference="alignment:Splign:2.1.0"
     exon            5505..5661
                     /gene="Bcor"
                     /gene_synonym="2900008C10Rik; 5830466J11Rik;
                     8430401K06Rik; BcorR; D930024N20Rik; mKIAA1575"
                     /inference="alignment:Splign:2.1.0"
     exon            5662..6842
                     /gene="Bcor"
                     /gene_synonym="2900008C10Rik; 5830466J11Rik;
                     8430401K06Rik; BcorR; D930024N20Rik; mKIAA1575"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6816..6821
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bcor"
                     /gene_synonym="2900008C10Rik; 5830466J11Rik;
                     8430401K06Rik; BcorR; D930024N20Rik; mKIAA1575"
                     /note="hexamer: AATAAA"
     polyA_site      6837
                     /gene="Bcor"
                     /gene_synonym="2900008C10Rik; 5830466J11Rik;
                     8430401K06Rik; BcorR; D930024N20Rik; mKIAA1575"
                     /note="major polyA site"
ORIGIN      
        1 agacggagcc tgagctccca gcggcaaggt gaggcagagc tgcgctccgg gccgaacggc
       61 gaccgagctc ttcggccgag ggggagacgc gccggaaccc agagcacgac cgagagcggg
      121 agcgaggcgg gcggcggtgg cggaggggga gcacgcgagc cgccgggcgg agagcccgag
      181 ccgcgctgtc gccgcggagg gacgacttgg ccaacacact cgctcacaca cactcacaca
      241 cacacccagc ccgagcgggc gctctcggcg aaccgtcaac atggcgctgg ggctcttgcc
      301 cgagcgcggg cggcagcggc ggcgcgggag ctgctgaggg tgacagagct cgggccagct
      361 gcgggaggag aggatcgcgc ggggccgtcg ccacctgccc tgaagctcgc agcccgcccc
      421 gccccgcccc acccccacgc ggcccagagc ccacccctcc gccgggccga ccccgagggc
      481 agcagagcgg ctgcagtcgg cggcgagcga gcgcggcgct gggagtggac tgcgggcacc
      541 agaggaagcc aaactttgct gctcgctgcg ctttcccggc cgggctcctt cacgtagccg
      601 ccctctcccg accccgcaca cattcaccca gccagccgcc cccggatctt cctcgccgcc
      661 tggactccgc tccggggaaa acttcaaagc gccggatcgc agggctccct gcctacttcc
      721 cgactgggga tttcagacta gacgcttgaa gccaagctgc catccaaggg gcgacatgct
      781 ttctgcaacc cctctgtatg ggaacgttca cagctggatg aacagcgaga gggtccgcat
      841 gtgtggaaca agtgaagaca ggaaaattcc tgtgaatgat ggcgacgctt caaaagccag
      901 gctggagctg agggaggaga ctcccctgag tcacagcgtg gtggatacca gtggagccca
      961 tcggatcgat ggcctggcag cactgagcat ggaccgcaca ggcctcatcc gggaagggct
     1021 ccgggtccct ggaaacatcg tttattctgg cttgtgtgga ttgggctcag aaaaaggtcg
     1081 ggaggctacc ccaagctctc tcagtggcct tgggttttct tcggaaagaa atccagagat
     1141 gcaattcaaa ccgaatactc ccgagacagt ggaggcttct gctgtctctg gaaaaccccc
     1201 aaatggcttc agtgctatat acaaaacacc gcctgggata caaaagagcg ctgtagctac
     1261 agcggaaagc ttgggtttgg ataggcctgc cagtgacaaa cagagccctc tcaacatcaa
     1321 tggtgctagt tacctgcggc tgccctgggt caacccttac atggaggggg ccactccagc
     1381 catataccct ttcctcgact cgccaaataa gtattcactg aatatgtaca aggccttgct
     1441 acctcagcag tcctacggct tggcccagcc actgtattct cctgtctgca ccagtgggga
     1501 acgcttcctc tacctgccac ccccacacta tgtcaaccct cacatcccct cctccttggc
     1561 ttcacccatg aggctctcca caccttcagc ctctgcggcc attccacctc tcgtccactg
     1621 ctcagacaaa agcctcccat ggaagatggg cgtcaaccct gggaacccag tagattccca
     1681 cagttacccc cacatccaaa acagtaaaca gccccgggtg acctctgcca aggcagtcaa
     1741 tagtggcctg ccaggggaca cagctctcct gttgcctcct tcacctcggc cctcagcccg
     1801 ggtccacctt ccaactcagc ccgctgcaga gacctactcc gagttccaca agcactatcc
     1861 caggatctcc acctctccct cagtcaccct gacgaagcca tacatgacag ccaatagcga
     1921 gttctctaca tccaggctgt ccaatggcaa gtaccccaag gctctagatg ggggcgactg
     1981 tgctcaatcc atgcctgggc acacccggaa gacaacggtt caagacagaa aagatggggg
     2041 ctcaccacct ctgttggaaa agcagaccgt taccaaagat gtcacagaca aaccacttga
     2101 cctgtcttct aaagtggtgg atgcggacgc ttccaaaggt gaccacatga aaaagatggc
     2161 tcccacagtc ctggttcaca gtcgggctgc aagtggctta gtgctctctg gaagtgagat
     2221 tccgaaagaa acactatctc ctccaggaaa tggatgttct atctatagat cagagatcat
     2281 cagcactgct ccctcatcct gggtggtgcc agggccaagt cctaatgaag agaacaatgg
     2341 caaaagtctg tcactgaaaa acaaggcttt ggactgggca ataccgcaac agcggagttc
     2401 ctcgtgtccc cgcatgggtg gcacagatgc cgtggtcact aatgtttcag ggtccgtgtc
     2461 cagctcagga cgcccagcct ctgcatcacc agcccccaac gccaacgcca atgcagatgg
     2521 caccaagacc agcaggagct cggtggatac cacgccatca gtcatccagc atgtgggcca
     2581 gccctcatcc acgcctgcca agcacggtgg cagcaccagc agcaagggag ccaaagccaa
     2641 cccagaaccg agcttcaaag cgagtgagaa tggcctcccg ccaacctcaa tatttctatc
     2701 tccaaatgaa gcattcaggt ccccagcaat tccctaccct aggagttacc tcccttacgc
     2761 agcaccagaa ggcatcgctc taagtcccct ctctttacat ggcaaaggac ctgtgtatcc
     2821 tcacccagtt ttgttaccca atggcagtct gtttcctggg caccttgccc caaagcctgg
     2881 cctgccttac gggctgcata cgagcaggcc agaatttgtg acctaccaag atgccctggg
     2941 cctgggcatg gtccatccca tgttgatccc acacacgccc attgagatca caaaagagga
     3001 gaagccggag agacgctccc gctcccatga gagagcccgt tatgaggacc caaccctccg
     3061 tagccggttt tctgagatgt tggaagctag cagcaccaaa ctgcatccag aagtccccac
     3121 tgacaagaac ctgaagccaa actctagctg gaatcaaggg aagactgggg tcaaaagcga
     3181 caaactggtc tacgtagacc ttctccgaga agaagcagac actaaaactg atgcaggggc
     3241 acccaaagca ggccttgtag ccgagaatgt aggtcaggac accgaggcca ccaagccctc
     3301 agctgaccct gtgatccaac aacgccgtga attcatctcc ctcagagagg agctgggccg
     3361 aatcactgac ttccatgaat ctttcacttt caaacaggcc tcaagccagc cagtgttcag
     3421 cttaggcaag gatagtggtg cagcaggaac caacaaagag aacctgggtg tgcaggtagc
     3481 aactccattc ttggagacag ctctgggcag tgagggccct gctgtgactt ttggtaaaac
     3541 ccaagaggat cccaaaccat tttgtgtggg cggtgcccct ccaaacatgg atgtcacccc
     3601 cgcctatacc aaagaaggaa ctgatgaggc cgaatccaac gatggcaaag ttctgaaacc
     3661 caagccatcc aagctggcaa agagaattgc taactcggca ggttatgtgg gcgaccgatt
     3721 caagtgtgtc accaccgaac tgtatgcaga ttccagtcag ctcagccgag agcagcgggc
     3781 attgcagatg gaaggattac aagaggacag tattttatgt ctacccgctg cttactgtga
     3841 gcgtgcaatg atgcgcttct cagagttgga gatgaaagag agagaaggta gccacccagc
     3901 aaccaaagac tccgaggtgt gcaaattcag cccagccgac tgggaaaggt tgaaaggaaa
     3961 tcaggaaaag aagccaaagt cagtcaccct ggaagaggcc attgccgacc agaatgacag
     4021 tgagagatgt gagtatagca ctggaaacaa acatgatctc tttgaagccc cagaggacaa
     4081 agatcttcct gtggaaaagt atttcttgga gaggccacct gtgagtgagc cacccagtga
     4141 ccagggggtg gtggacacgc cacacagccc caccctccgg ctagacagga aacgcaaact
     4201 gtcaggtgac agcacccaca ctgagaccgc tgtggaagag ctagctgagg accctctgaa
     4261 agccaagcga agacggatct ccaaagggct ccatcctaaa aagcaacgcc acttgctgca
     4321 ccttagagaa cggtgggagc agcaggtgtc ggcagccgag agcaaacctg gccggcaaag
     4381 caggaaggaa gtggcccagg ctgttcagcc tgaggtcacc tcccagggga ctaacatcac
     4441 tgaagagaag cctggcagga aaaaggcaga ggccaaaggc aacagaggct ggtctgaaga
     4501 gtcgctcaaa tcctgtgaca atgagcaagg cttgcctgtg ctctcaggct ctccgcccat
     4561 gaagagcctt tcatccacca atgcaagtgg caaaaagcag actcagccaa gctgcacgcc
     4621 agcctcaagg ctgcctgcca aacagcagaa aattaaagaa agccagaaga cagatgtgct
     4681 gtgcacaggg gaagacgagg attgccaggc tgcctccccg ctgcaaaaat acacagacaa
     4741 catcgagaag ccatccggga agagactgtg caaaaccaag cacttgatac ctcaggagtc
     4801 caggaggagc ttgcagatca caggcgacta ctatgtggag aacactgaca ctaagatgac
     4861 tgtgcggaga ttcagaaaac gacctgagcc cagttcggac tacgatttgt caccaccagc
     4921 caagcaggag ccaaagccct ttgaccgtct acaacaattg ctaccggcca cccaggccac
     4981 ccagctgcca cgctcaaatt ctcctcaaga gaccacccag tctcgcccca tgccgccaga
     5041 agctcggaga cttattgtca ataagaatgc tggcgagacc ctcctgcagc gggctgcccg
     5101 gctaggctat gaggaagtgg tcttatattg cctggagaac aaggtctgtg atgtcaatca
     5161 tcgagacaat gctggctact gtgctctgca tgaagcttgc gccaggggat ggctcaacat
     5221 cgtgcgccac ctccttgaat atggcgctga tgtcaactgc agtgcccagg atggaaccag
     5281 gcctctgcat gatgctgtgg agaatgacca cttagaaatt gtacgattgc ttctttccta
     5341 tggtgctgac cctactttgg ccacatactc agggagaacc atcatgaaaa tgacccacag
     5401 tgaacttatg gagaagtttt taacagacta tttaaatgac ctgcagggtc gcagtgaaga
     5461 tgacaccagc ggcgcttggg agttctatgg cagctctgtg tgtgaaccag atgacgaaag
     5521 tgggtacgat gttttggcta atcccccagg accagaagac ccagatgagg aagaggatac
     5581 ctatagcgat ttgtttgagt ttgagtttgc tgaaagctcc ctcttgccgt gttataacat
     5641 ccaagtgtct gtcgctcagg ggccacgaaa ctggcttctg ctctcagacg tgctcaagaa
     5701 gttgaaaatg tcctcccgga tattccgtag caattttccc aatctggaaa ttgtcaccat
     5761 tgcagaggcg gagttttacc gacaggtctc aacaagtctc ttgttctcct gccccaaaga
     5821 cctggaagcc ttcaatcctg aaagcaagga gctgttggat ctggtggaat tcaccaatga
     5881 gctccagaca ctgctgggct cctctgtgga gtggctccac cctagtgaca cgggccatga
     5941 aaactactgg tgagccacct gccccgccca cccactgtgt acagtgtgtt atagtgttaa
     6001 tccttgtgca tatgtgtcat aatacaacaa tttctgtaaa gaaaggacac tattacatat
     6061 gaaaatatct cttctttata taagagaagt tactccggtc agaagaaccc agaagcccgt
     6121 gttttctttc taaaatttta agtcagtttt tatgaagctg ttgaaatgtc tttatttttc
     6181 agtgtacaca tgctttgaaa tgtatgttcg tttttacttg gaacattttt cttttctgtt
     6241 cttttctaag gagaaaaaaa taaatgaata aatgaataaa tgaaaaggag ctctgtgctt
     6301 ggcgtaattt catacaaagc tctggtggcg ggccatgggt gtattgtgtg gtgaggacta
     6361 tgtgtttggt ttgctggagt gaattgggtg aaggcacttg gtggtggtat acttttatgt
     6421 tttgtttaca gagtacctgc tcacaccagg taaatgctat tggacgtgat ccagtggtat
     6481 gtaatataaa ttcaaaccat atccacacac aacaactaat tgtaagaaac ttttgtatcc
     6541 taatttaaaa gctgtgaaat tacttttcac acatcaaacc ggattgttta tatgtttaaa
     6601 cattttatgc tcttatttaa agaagacttt gagctatttt tttctgtact ctgtaaaata
     6661 ttgaaaacta acataatatg ttgaggttgc ttgaaaatgt acataaaact aaaattttct
     6721 gaattgtgtg tttatgtttg aaatctgtgt tttaactttg taagtaaatt ctctgccttt
     6781 gtatttatat tttacaaaaa tttttcttaa aaggcaataa acctgttgag gaaaggagca
     6841 aaaaaaaaaa aaaaaaa
//
