LOCUS       NM_021486               2327 bp    mRNA    linear   ROD 11-JUN-2024
DEFINITION  Mus musculus beta-carotene oxygenase 1 (Bco1), transcript variant
            1, mRNA.
ACCESSION   NM_021486
VERSION     NM_021486.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2327)
  AUTHORS   Miller,A.P., Hornero-Mendez,D., Bandara,S., Parra-Rivero,O.,
            Limon,M.C., von Lintig,J., Avalos,J. and Amengual,J.
  TITLE     Bioavailability and provitamin A activity of neurosporaxanthin in
            mice
  JOURNAL   Commun Biol 6 (1), 1068 (2023)
   PUBMED   37864015
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2327)
  AUTHORS   Moon,J., Ramkumar,S. and von Lintig,J.
  TITLE     Genetic tuning of beta-carotene oxygenase-1 activity rescues cone
            photoreceptor function in STRA6-deficient mice
  JOURNAL   Hum Mol Genet 32 (5), 798-809 (2023)
   PUBMED   36150025
  REMARK    GeneRIF: Genetic tuning of beta-carotene oxygenase-1 activity
            rescues cone photoreceptor function in STRA6-deficient mice.
REFERENCE   3  (bases 1 to 2327)
  AUTHORS   Coronel,J., Yu,J., Pilli,N., Kane,M.A. and Amengual,J.
  TITLE     The conversion of beta-carotene to vitamin A in adipocytes drives
            the anti-obesogenic effects of beta-carotene in mice
  JOURNAL   Mol Metab 66, 101640 (2022)
   PUBMED   36400405
REFERENCE   4  (bases 1 to 2327)
  AUTHORS   Miller,A.P., Black,M. and Amengual,J.
  TITLE     Fenretinide inhibits vitamin A formation from beta-carotene and
            regulates carotenoid levels in mice
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1867 (2), 159070 (2022)
   PUBMED   34742949
REFERENCE   5  (bases 1 to 2327)
  AUTHORS   Amengual,J., Coronel,J., Marques,C., Aradillas-Garcia,C.,
            Morales,J.M.V., Andrade,F.C.D., Erdman,J.W. and Teran-Garcia,M.
  TITLE     beta-Carotene Oxygenase 1 Activity Modulates Circulating
            Cholesterol Concentrations in Mice and Humans
  JOURNAL   J Nutr 150 (8), 2023-2030 (2020)
   PUBMED   32433733
  REMARK    GeneRIF: beta-Carotene Oxygenase 1 Activity Modulates Circulating
            Cholesterol Concentrations in Mice and Humans.
REFERENCE   6  (bases 1 to 2327)
  AUTHORS   Boulanger,A., McLemore,P., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A., Yu,S.S., Gentleman,S. and Redmond,T.M.
  TITLE     Identification of beta-carotene 15, 15'-monooxygenase as a
            peroxisome proliferator-activated receptor target gene
  JOURNAL   FASEB J 17 (10), 1304-1306 (2003)
   PUBMED   12759335
  REMARK    GeneRIF: Transcriptional activation of the beta-carotene 15,
            15'-monooxygenase gene by peroxisome proliferator-activated
            receptor (beta-carotene 15, 15'-monooxygenase).
REFERENCE   7  (bases 1 to 2327)
  AUTHORS   Paik,J., During,A., Harrison,E.H., Mendelsohn,C.L., Lai,K. and
            Blaner,W.S.
  TITLE     Expression and characterization of a murine enzyme able to cleave
            beta-carotene. The formation of retinoids
  JOURNAL   J Biol Chem 276 (34), 32160-32168 (2001)
   PUBMED   11418584
REFERENCE   8  (bases 1 to 2327)
  AUTHORS   Wyss,A., Wirtz,G.M., Woggon,W.D., Brugger,R., Wyss,M.,
            Friedlein,A., Riss,G., Bachmann,H. and Hunziker,W.
  TITLE     Expression pattern and localization of beta,beta-carotene
            15,15'-dioxygenase in different tissues
  JOURNAL   Biochem J 354 (Pt 3), 521-529 (2001)
   PUBMED   11237856
REFERENCE   9  (bases 1 to 2327)
  AUTHORS   Redmond,T.M., Gentleman,S., Duncan,T., Yu,S., Wiggert,B., Gantt,E.
            and Cunningham,F.X. Jr.
  TITLE     Identification, expression, and substrate specificity of a
            mammalian beta-carotene 15,15'-dioxygenase
  JOURNAL   J Biol Chem 276 (9), 6560-6565 (2001)
   PUBMED   11092891
REFERENCE   10 (bases 1 to 2327)
  AUTHORS   Yan,W., Jang,G.F., Haeseleer,F., Esumi,N., Chang,J., Kerrigan,M.,
            Campochiaro,M., Campochiaro,P., Palczewski,K. and Zack,D.J.
  TITLE     Cloning and characterization of a human
            beta,beta-carotene-15,15'-dioxygenase that is highly expressed in
            the retinal pigment epithelium
  JOURNAL   Genomics 72 (2), 193-202 (2001)
   PUBMED   11401432
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC108436.5, AEKQ02009580.1 and
            AC121116.7.
            
            On Jul 30, 2020 this sequence version replaced NM_021486.3.
            
            Summary: Vitamin A metabolism is important for vital processes such
            as vision, embryonic development, cell differentiation, and
            membrane and skin protection. The protein encoded by this gene is a
            key enzyme in beta-carotene metabolism to vitamin A. It catalyzes
            the oxidative cleavage of beta,beta-carotene into two retinal
            molecules. Two alternatively spliced variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Jul
            2009].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript but encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146472.1, AF294899.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-230               AC108436.5         151310-151539
            231-359             AC108436.5         153005-153133
            360-489             AC108436.5         161105-161234
            490-637             AC108436.5         164080-164227
            638-785             AEKQ02009580.1     1382-1529
            786-1009            AEKQ02009580.1     3873-4096
            1010-1267           AC108436.5         172837-173094
            1268-1373           AC108436.5         182884-182989
            1374-1468           AC108436.5         184620-184714
            1469-1580           AC121116.7         194784-194895       c
            1581-2327           AC121116.7         191773-192519       c
FEATURES             Location/Qualifiers
     source          1..2327
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 63.61 cM"
     gene            1..2327
                     /gene="Bco1"
                     /gene_synonym="Bcdo; Bcdo1; Bcmo1; beta-CD; betaCMOOX;
                     CMO1; Cmoi"
                     /note="beta-carotene oxygenase 1"
                     /db_xref="GeneID:63857"
                     /db_xref="MGI:MGI:1926923"
     exon            1..230
                     /gene="Bco1"
                     /gene_synonym="Bcdo; Bcdo1; Bcmo1; beta-CD; betaCMOOX;
                     CMO1; Cmoi"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..1867
                     /gene="Bco1"
                     /gene_synonym="Bcdo; Bcdo1; Bcmo1; beta-CD; betaCMOOX;
                     CMO1; Cmoi"
                     /EC_number="1.13.11.63"
                     /note="isoform 1 is encoded by transcript variant 1;
                     beta-carotene 15, 15'-dioxygenase 1; beta,beta-carotene
                     15,15'-dioxygenase; beta,beta-carotene
                     15,15'-monooxygenase; carotenoid-15,15'-oxygenase;
                     beta-carotene cleavage enzyme; beta-carotene 15,15'
                     dioxygenase; beta-carotene dioxygenase 1"
                     /codon_start=1
                     /product="beta,beta-carotene 15,15'-dioxygenase isoform 1"
                     /protein_id="NP_067461.2"
                     /db_xref="CCDS:CCDS22697.1"
                     /db_xref="GeneID:63857"
                     /db_xref="MGI:MGI:1926923"
                     /translation="MEIIFGQNKKEQLEPVQAKVTGSIPAWLQGTLLRNGPGMHTVGE
                     SKYNHWFDGLALLHSFSIRDGEVFYRSKYLQSDTYIANIEANRIVVSEFGTMAYPDPC
                     KNIFSKAFSYLSHTIPDFTDNCLINIMKCGEDFYATTETNYIRKIDPQTLETLEKVDY
                     RKYVAVNLATSHPHYDEAGNVLNMGTSVVDKGRTKYVIFKIPATVPDSKKKGKSPVKH
                     AEVFCSISSRSLLSPSYYHSFGVTENYVVFLEQPFKLDILKMATAYMRGVSWASCMSF
                     DREDKTYIHIIDQRTRKPVPTKFYTDPMVVFHHVNAYEEDGCVLFDVIAYEDSSLYQL
                     FYLANLNKDFEEKSRLTSVPTLRRFAVPLHVDKDAEVGSNLVKVSSTTATALKEKDGH
                     VYCQPEVLYEGLELPRINYAYNGKPYRYIFAAEVQWSPVPTKILKYDILTKSSLKWSE
                     ESCWPAEPLFVPTPGAKDEDDGVILSAIVSTDPQKLPFLLILDAKSFTELARASVDAD
                     MHLDLHGLFIPDADWNAVKQTPAETQEVENSDHPTDPTAPELSHSENDFTAGHGGSSL
                     "
     exon            231..359
                     /gene="Bco1"
                     /gene_synonym="Bcdo; Bcdo1; Bcmo1; beta-CD; betaCMOOX;
                     CMO1; Cmoi"
                     /inference="alignment:Splign:2.1.0"
     exon            360..489
                     /gene="Bco1"
                     /gene_synonym="Bcdo; Bcdo1; Bcmo1; beta-CD; betaCMOOX;
                     CMO1; Cmoi"
                     /inference="alignment:Splign:2.1.0"
     exon            490..637
                     /gene="Bco1"
                     /gene_synonym="Bcdo; Bcdo1; Bcmo1; beta-CD; betaCMOOX;
                     CMO1; Cmoi"
                     /inference="alignment:Splign:2.1.0"
     exon            638..785
                     /gene="Bco1"
                     /gene_synonym="Bcdo; Bcdo1; Bcmo1; beta-CD; betaCMOOX;
                     CMO1; Cmoi"
                     /inference="alignment:Splign:2.1.0"
     exon            786..1009
                     /gene="Bco1"
                     /gene_synonym="Bcdo; Bcdo1; Bcmo1; beta-CD; betaCMOOX;
                     CMO1; Cmoi"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1267
                     /gene="Bco1"
                     /gene_synonym="Bcdo; Bcdo1; Bcmo1; beta-CD; betaCMOOX;
                     CMO1; Cmoi"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1373
                     /gene="Bco1"
                     /gene_synonym="Bcdo; Bcdo1; Bcmo1; beta-CD; betaCMOOX;
                     CMO1; Cmoi"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1468
                     /gene="Bco1"
                     /gene_synonym="Bcdo; Bcdo1; Bcmo1; beta-CD; betaCMOOX;
                     CMO1; Cmoi"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1580
                     /gene="Bco1"
                     /gene_synonym="Bcdo; Bcdo1; Bcmo1; beta-CD; betaCMOOX;
                     CMO1; Cmoi"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..2327
                     /gene="Bco1"
                     /gene_synonym="Bcdo; Bcdo1; Bcmo1; beta-CD; betaCMOOX;
                     CMO1; Cmoi"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggcagaagc accggtcagc ttggggaagg gacacagagg aagagacgga gtgtacaggg
       61 accaaggatg atgtcaagga gcaaagagca ggaagacagg aggctttgag cacacacggc
      121 tttgtctatt ccagtaacaa cccccttgct gccgctcacc ggttccatgg agataatatt
      181 tggccagaat aagaaagaac agctggagcc agttcaggcc aaagtgacag gcagcattcc
      241 agcatggctg caggggaccc tgctccgaaa cgggcccggg atgcacacag tgggagagag
      301 caagtacaac cattggtttg atggcctggc ccttctccac agtttctcca tcagagatgg
      361 ggaggtcttc tacaggagca aatacctgca gagtgacacc tacatcgcca acattgaggc
      421 caacagaatc gtggtgtctg agttcggaac catggcctac ccggacccct gcaaaaacat
      481 cttttccaaa gctttctcct acttgtctca caccatcccc gacttcacag acaactgtct
      541 gatcaacatc atgaaatgtg gagaagactt ctatgcaacc acggagacca actacatcag
      601 gaaaatcgac ccccagaccc tagagacctt ggagaaggtt gattaccgga agtatgtggc
      661 ggtaaacctg gctacctcgc accctcatta tgacgaggct gggaatgtcc ttaacatggg
      721 cacatccgtc gtggacaaag ggaggacaaa atacgtgata tttaagatcc ctgccacagt
      781 gccagacagc aagaagaaag ggaagagtcc cgtgaagcac gcggaagttt tctgctccat
      841 ttcctcccgc tcgctgctct ctcccagcta ctaccacagc tttggtgtca cggagaacta
      901 tgtggtgttt ctggagcagc cttttaagtt ggatatcctc aagatggcca ccgcatacat
      961 gaggggagtg agctgggctt cctgtatgtc attcgacagg gaggacaaga catacattca
     1021 tatcatcgac cagaggacca ggaagcctgt gcctaccaag ttctacacag atcccatggt
     1081 ggtcttccat catgtcaatg cctacgagga ggacggctgt gtgctgtttg atgtgatcgc
     1141 ctatgaggac agcagcctct atcagctctt ctacctggcc aacctgaaca aggacttcga
     1201 ggagaagtcc aggctgacct cagtgcctac cctcaggagg tttgctgtgc ccctccatgt
     1261 ggacaaggat gcagaagtgg gctcaaattt agtcaaggtg tcatctacaa ctgcaacagc
     1321 cctgaaggag aaagacggcc atgtctattg ccagcccgag gtcctctacg aaggcctaga
     1381 gctccctcgg ataaattatg cttacaacgg gaagccatat cgctacatct ttgcagctga
     1441 agtacagtgg agtccagtcc caaccaagat actgaaatat gacattctca caaagtcctc
     1501 cttaaagtgg tctgaggaga gctgctggcc agcagagcct ctgtttgttc ccacgccagg
     1561 tgcgaaggat gaagatgatg gagtcatttt atcagccatc gtctctacgg atccccaaaa
     1621 gctgcctttt ttactcattc tggatgccaa aagttttacg gaactggctc gcgcctctgt
     1681 tgatgcggac atgcacctgg accttcatgg tttatttatc ccagatgcag actggaatgc
     1741 agtgaagcag actccagctg aaacgcaaga ggttgaaaac tcagatcatc ccacagatcc
     1801 gacagcacca gaactgagcc acagtgaaaa tgacttcaca gcgggtcatg gtggctcaag
     1861 tctttaatcc taacactcaa ggcagaggca agcagatctc tgagttcaca acggacagcc
     1921 tgggacagcc ggggctacac agagaaatcc tatcttgaaa atgaaaggaa gaaaggaaga
     1981 gagagagaga gagagagaga gagggagaga gagagagaga gaagggaagg aaggaaggaa
     2041 ggaaggaagg aagaaagaaa gaaagaaaga aagaaagaaa gaaagaaaga aagaaagaaa
     2101 gcaagcaagc aagctagcta gcttcattgg tagaacttag ttgttgacac tgtcaacgtg
     2161 gacagcattt aggatctctt aagaaacaaa cttctgagcc tgtctgtgag aaagtttctt
     2221 tattgtgtta actggacaag gaagatccaa ccagaacatg ggcagcacca tctcatcctt
     2281 tgaacatcct ttatttcctg aataaaaagg aaagaacctg tcgctgg
//
