LOCUS       NM_007528               3426 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus B cell CLL/lymphoma 6, member B (Bcl6b), mRNA.
ACCESSION   NM_007528
VERSION     NM_007528.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3426)
  AUTHORS   Tanaka,M., Nakamura,S., Sakaue,T., Yamamoto,T., Maekawa,M.,
            Nishinaka,A., Yasuda,H., Yunoki,K., Sato,Y., Sawa,M., Yoshino,K.,
            Shimazawa,M., Hatano,M., Tokuhisa,T., Higashiyama,S. and Hara,H.
  TITLE     BCL6B Contributes to Ocular Vascular Diseases via Notch Signal
            Silencing
  JOURNAL   Arterioscler Thromb Vasc Biol 43 (6), 927-942 (2023)
   PUBMED   37078291
  REMARK    GeneRIF: BCL6B Contributes to Ocular Vascular Diseases via Notch
            Signal Silencing.
REFERENCE   2  (bases 1 to 3426)
  AUTHORS   Nakagawa,T., Jorg,D.J., Watanabe,H., Mizuno,S., Han,S., Ikeda,T.,
            Omatsu,Y., Nishimura,K., Fujita,M., Takahashi,S., Kondoh,G.,
            Simons,B.D., Yoshida,S. and Nagasawa,T.
  TITLE     A multistate stem cell dynamics maintains homeostasis in mouse
            spermatogenesis
  JOURNAL   Cell Rep 37 (3), 109875 (2021)
   PUBMED   34686326
REFERENCE   3  (bases 1 to 3426)
  AUTHORS   Medeiros de Araujo,J.A., Barao,S., Mateos-White,I., Espinosa,A.,
            Costa,M.R., Gil-Sanz,C. and Muller,U.
  TITLE     ZBTB20 is crucial for the specification of a subset of callosal
            projection neurons and astrocytes in the mammalian neocortex
  JOURNAL   Development 148 (16) (2021)
   PUBMED   34351428
REFERENCE   4  (bases 1 to 3426)
  AUTHORS   Cai,W.Y., Lin,L.Y., Wang,L., Yang,L., Ye,G.D., Zeng,Q., Cheng,J.,
            Xie,Y.Y., Chen,M.L. and Luo,Q.C.
  TITLE     Inhibition of Bcl6b promotes gastric cancer by amplifying
            inflammation in mice
  JOURNAL   Cell Commun Signal 17 (1), 72 (2019)
   PUBMED   31288844
  REMARK    GeneRIF: Epigenetic inactivation of Bcl6b promotes gastric cancer
            through amplification of the gastric inflammatory response in vivo
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3426)
  AUTHORS   Nakajima,R., Okano,H. and Noce,T.
  TITLE     JMJD1C Exhibits Multiple Functions in Epigenetic Regulation during
            Spermatogenesis
  JOURNAL   PLoS One 11 (9), e0163466 (2016)
   PUBMED   27649575
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3426)
  AUTHORS   Takamori,M., Hatano,M., Arima,M., Sakamoto,A., Fujimura,L.,
            Hartatik,T., Kuriyama,T. and Tokuhisa,T.
  TITLE     BAZF is required for activation of naive CD4 T cells by TCR
            triggering
  JOURNAL   Int Immunol 16 (10), 1439-1449 (2004)
   PUBMED   15314041
REFERENCE   7  (bases 1 to 3426)
  AUTHORS   Takenaga,M., Hatano,M., Takamori,M., Yamashita,Y., Okada,S.,
            Kuroda,Y. and Tokuhisa,T.
  TITLE     Bcl6-dependent transcriptional repression by BAZF
  JOURNAL   Biochem Biophys Res Commun 303 (2), 600-608 (2003)
   PUBMED   12659862
  REMARK    GeneRIF: represses Bcl6-dependent transcription.
REFERENCE   8  (bases 1 to 3426)
  AUTHORS   Sakashita,C., Fukuda,T., Okabe,S., Kobayashi,H., Hirosawa,S.,
            Tokuhisa,T., Miyasaka,N., Miura,O. and Miki,T.
  TITLE     Cloning and characterization of the human BAZF gene, a homologue of
            the BCL6 oncogene
  JOURNAL   Biochem Biophys Res Commun 291 (3), 567-573 (2002)
   PUBMED   11855826
REFERENCE   9  (bases 1 to 3426)
  AUTHORS   Hartatik,T., Okada,S., Okabe,S., Arima,M., Hatano,M. and
            Tokuhisa,T.
  TITLE     Binding of BAZF and Bc16 to STAT6-binding DNA sequences
  JOURNAL   Biochem Biophys Res Commun 284 (1), 26-32 (2001)
   PUBMED   11374866
  REMARK    GeneRIF: DNA-binding protein; gene expression regulation; binds
            STAT6 elements; binding site specificity
REFERENCE   10 (bases 1 to 3426)
  AUTHORS   Okabe,S., Fukuda,T., Ishibashi,K., Kojima,S., Okada,S., Hatano,M.,
            Ebara,M., Saisho,H. and Tokuhisa,T.
  TITLE     BAZF, a novel Bcl6 homolog, functions as a transcriptional
            repressor
  JOURNAL   Mol Cell Biol 18 (7), 4235-4244 (1998)
   PUBMED   9632807
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY730334.1, BC090998.1 and AL669869.10.
            
            On Apr 20, 2010 this sequence version replaced NM_007528.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156733.1, AB011665.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                BY730334.1         1-40
            41-1860             BC090998.1         1-1820
            1861-3426           AL669869.10        89569-91134         c
FEATURES             Location/Qualifiers
     source          1..3426
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.99 cM"
     gene            1..3426
                     /gene="Bcl6b"
                     /gene_synonym="Bazf"
                     /note="B cell CLL/lymphoma 6, member B"
                     /db_xref="GeneID:12029"
                     /db_xref="MGI:MGI:1278332"
     exon            1..89
                     /gene="Bcl6b"
                     /gene_synonym="Bazf"
                     /inference="alignment:Splign:2.1.0"
     exon            90..280
                     /gene="Bcl6b"
                     /gene_synonym="Bazf"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..1526
                     /gene="Bcl6b"
                     /gene_synonym="Bazf"
                     /note="BcL6-associated zinc finger protein"
                     /codon_start=1
                     /product="B-cell CLL/lymphoma 6 member B protein"
                     /protein_id="NP_031554.1"
                     /db_xref="CCDS:CCDS24939.1"
                     /db_xref="GeneID:12029"
                     /db_xref="MGI:MGI:1278332"
                     /translation="MGSTAAPEGALGYVREFTRHSSDVLSNLNELRLRGILTDVTLLV
                     GGQPLRAHKAVLIACSGFFYSIFRGRAGLGVDVLSLPGGPEARGFAPLLDFMYTSRLR
                     LSPATAPAVLAAATYLQMEHVVQACHRFIQASYEPLGISLRPVEVEPPRPPTVAPPGS
                     PRRSEGHPDPPTESRSCSQGSPSPASPDPKACNWKKYKFIVLNSQTSQAGSLVGESSG
                     QPCPQARLPSGDEACSSSSSSEEGTTPGLQSRLSLATTTARFKCGALANNSYLFTPRA
                     QETSLPASKQANPPPGSEFFSCQNCEAVAGCSSGLELLAPGDEDKPYKCQLCRSAFRY
                     KGNLASHRTVHTGEKPYRCSICGARFNRPANLKTHSRIHSGEKPYKCETCGSRFVQVA
                     HLRAHVLIHTGEKPYPCPTCGTRFRHLQTLKSHVRIHTGEKPYHCDPCGLHFRHKSQL
                     RLHLRQKHGAATNTKVRYHILGGP"
     exon            281..502
                     /gene="Bcl6b"
                     /gene_synonym="Bazf"
                     /inference="alignment:Splign:2.1.0"
     exon            503..850
                     /gene="Bcl6b"
                     /gene_synonym="Bazf"
                     /inference="alignment:Splign:2.1.0"
     exon            851..975
                     /gene="Bcl6b"
                     /gene_synonym="Bazf"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1140
                     /gene="Bcl6b"
                     /gene_synonym="Bazf"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1271
                     /gene="Bcl6b"
                     /gene_synonym="Bazf"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1409
                     /gene="Bcl6b"
                     /gene_synonym="Bazf"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..3426
                     /gene="Bcl6b"
                     /gene_synonym="Bazf"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3402..3407
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bcl6b"
                     /gene_synonym="Bazf"
                     /note="hexamer: AATAAA"
     polyA_site      3426
                     /gene="Bcl6b"
                     /gene_synonym="Bazf"
                     /note="major polyA site"
ORIGIN      
        1 atcccggctg aataaaggag cagagaccga aagaggagag agaccccgcc cccctcgaga
       61 agagaagccg cagcccctgc gggacagggg cttaggtcgc tatgggttcc acagcggccc
      121 cagagggagc tctgggctac gtccgagagt tcacccgcca ctcctccgac gtgcttagca
      181 atctgaatga gctgcgcctg cgcgggatcc tcactgacgt cacgctgctg gttggcgggc
      241 aacccctaag agcgcacaag gcagttctta tcgcttgcag tggcttcttc tattcaattt
      301 tccggggccg agcgggactc ggggtggatg tactctctct gccggggggg ccagaagcca
      361 gaggctttgc tcctcttctg gacttcatgt atacttcaag gcttcgcctc tctccagcca
      421 ctgccccagc tgtcctcgca gctgccacct atttgcagat ggaacacgta gtccaggcgt
      481 gtcaccgttt catccaagcc agctatgaac ctctaggcat ctccttgcga cctgtggagg
      541 tagaaccccc aagaccccca acagtcgctc caccaggcag tcccaggcgc tcagaaggac
      601 acccagaccc acctactgag tctcgaagct gcagtcaagg ttccccaagt ccagccagcc
      661 cagaccccaa ggcctgcaac tggaaaaaat acaaatttat tgtgctaaat tctcagacct
      721 cacaagcagg aagcctggtt ggggagagtt caggtcaacc ttgtccccag gccaggctcc
      781 ctagtggaga tgaagcctgt agcagcagca gcagcagtga agaaggaacc acgcctggtc
      841 tccaaagcag actatctcta gctactacca ctgcacgatt caagtgtgga gctctagcaa
      901 ataactccta cctcttcaca ccccgggctc aagagacttc tctgccagct tctaagcagg
      961 ctaatccacc gccaggaagt gagtttttca gctgccagaa ctgtgaggct gtggctgggt
     1021 gctcatcggg gctggagctc ttagctccag gggacgagga caagccctat aaatgccagc
     1081 tgtgccgatc tgccttccgt tataagggca acttggctag tcaccgcacg gtgcacacag
     1141 gggaaaagcc ctaccgctgc tccatctgcg gagcacgttt taaccgacct gctaacctaa
     1201 aaacacacag ccgcatccat tccggagaga aaccgtacaa gtgtgagacc tgcggctcgc
     1261 gttttgttca ggtggcacac ctacgcgcac acgtgctcat ccacaccgga gagaagccct
     1321 atccgtgtcc cacctgcgga acccgcttcc gccatctaca gaccctcaaa agccacgttc
     1381 gcatccacac cggggagaag ccataccact gtgacccctg cggcctgcat tttcggcaca
     1441 agagtcaact gcggctgcat ctgcgtcaga aacacggggc agctaccaac actaaagtgc
     1501 gctaccacat cctcggggga ccatagctga gttccccccc acccccagcc aaacttcgct
     1561 ccctaggggc agtgaaagct gtaggctcag gcttgatttc cctgatggtc ctgatatggg
     1621 ggtgtgccgg gttaccctgg tattagaaac tgctgacacc ttaattttgt actggggaag
     1681 agcgggaggt ggcagatcct ggctagatct gcctctgttt tgctggtcaa aacctcttcc
     1741 tcataatcca gattgggtag ctaggggctt ggggggttgg gggggacttg ctctctttaa
     1801 gggaacttcc ccctccattt caaatggttt atctgtaaat ataatttatt gaggcctgta
     1861 gttggtacca gggcctttat tctgtttgca tttccgactt tcttcttcca caagtgtgat
     1921 caaaaaagac tggaaacaca gaaggggagg gcaccactct gctggcagag atacctagtg
     1981 cttggctctc tcctttggct tgagtgtctt acattgtttt gttttgtttt ttcccccccc
     2041 ttttcctttc taacttttct ttctggaatt gtcctgtctt tccctccctt tgtttgcttg
     2101 ttggtttctc tccagttcta gaactggatc ctttagtttt cctgggctta gccctgagaa
     2161 tatcgaaggt tgggtaattt tggtattttg gatgatgaaa gccctgtagc aggccagaca
     2221 tggaaagaaa cctttcagct ttttgagggt gatgggaacc ttttgtaatg aacccaaaat
     2281 gtagataata aactccccct gaaggctggg aaggtgggag ccagagcccg catcttccta
     2341 aatggaggtg agttgtctcc accaaggagg cccagcatca acggtttgcc tgggttcgaa
     2401 tgcactaagt tcatccatca gaccaagctt gcctaagggt ttgtattaaa cccataatcc
     2461 tctcaccggg cctgacttag tatctcctga agatccttac tagagactac aggaccgttt
     2521 cttatctgtc tgggttctga gaatgctatg acctagagag aattaatggc attccttgac
     2581 tcggagtctg agtcctttac tgcatgaaca gctgggtttg aatgtccctt ggccctcctt
     2641 ctttgaatgt gttttttgtt tgtttgtttg ttttgtgttt ggacagcttc tggcaagtgt
     2701 ccagattcca aaacgttcat ctttcatggg tgcttggtag ctttcttaac ttagaaaatc
     2761 tgggtctgag actcagacta cccaacattc cattcctgtc tgggaccagt gaatgtacta
     2821 ggactttaca ccggaagaaa agagggctgc cttcaatgct gcatttgttg tcattgggga
     2881 ttgttgctgg gattatatac ttaaaagcct ttgatggatt ggccaaaggc cccttccact
     2941 tgaacaagtt accagagagt gttacaaggt tggtgagggc tgcattttct ggtgtggaac
     3001 atggtagata aagatgttag ggatggagtt tcatggttag acggagtgtc tggaatgtta
     3061 gtatttggga gcctcgatgt acagtcctgc tcctgctgcc ctgggaccta tttgattata
     3121 gtacttgggt aaacggtaaa acgacttaaa tttataggac agagactcct gaatgaaggt
     3181 ggtccctgtg gccagcagct ggggacaggt gagaaagcca ttcattcttc ctgttcccat
     3241 ctaactgccc tatcacctga atgcagactt gaactgtgtg tgggctgggg gcgccgacag
     3301 aggagacatg agaaggtggt ttgatttctg tttagcagac tggctgggca cgtgggaagc
     3361 gccagggtga gatgttagat gctgcaagat cagattcttg gaataaagaa gcccttcttt
     3421 gtgcca
//
