LOCUS       NM_001348026            4685 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus B cell leukemia/lymphoma 6 (Bcl6), transcript variant
            2, mRNA.
ACCESSION   NM_001348026
VERSION     NM_001348026.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4685)
  AUTHORS   Osum,K.C., Becker,S.H., Krueger,P.D., Mitchell,J.S., Hong,S.W.,
            Magill,I.R. and Jenkins,M.K.
  TITLE     A minority of Th1 and Tfh effector cells express survival genes
            shared by memory cell progeny that require IL-7 or TCR signaling to
            persist
  JOURNAL   Cell Rep 44 (1), 115111 (2025)
   PUBMED   39723889
REFERENCE   2  (bases 1 to 4685)
  AUTHORS   Fahlquist-Hagert,C., Wittenborn,T.R., Pedersen,M.K., Jensen,L. and
            Degn,S.E.
  TITLE     T-follicular regulatory cells expand to control germinal center
            plasma cell output but fail to curb autoreactivity
  JOURNAL   iScience 27 (10), 110887 (2024)
   PUBMED   39319261
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4685)
  AUTHORS   Li,X., Sun,W., Huang,M., Gong,L., Zhang,X., Zhong,L., Calderon,V.,
            Bian,Z., He,Y., Suh,W.K., Li,Y., Song,T., Zou,Y., Lian,Z.X. and
            Gu,H.
  TITLE     Deficiency of CBL and CBLB ubiquitin ligases leads to hyper T
            follicular helper cell responses and lupus by reducing BCL6
            degradation
  JOURNAL   Immunity 57 (7), 1603-1617 (2024)
   PUBMED   38761804
  REMARK    GeneRIF: Deficiency of CBL and CBLB ubiquitin ligases leads to
            hyper T follicular helper cell responses and lupus by reducing BCL6
            degradation.
REFERENCE   4  (bases 1 to 4685)
  AUTHORS   Li,Y., Ramirez-Suastegui,C., Harris,R., Castaneda-Castro,F.E.,
            Ascui,G., Perez-Jeldres,T., Diaz,A., Morong,C., Giles,D.A.,
            Chai,J., Seumois,G., Sanchez-Elsner,T., Cummings,F., Kronenberg,M.
            and Vijayanand,P.
  TITLE     Stem-like T cells are associated with the pathogenesis of
            ulcerative colitis in humans
  JOURNAL   Nat Immunol 25 (7), 1231-1244 (2024)
   PUBMED   38898157
REFERENCE   5  (bases 1 to 4685)
  AUTHORS   Dent,A.L., Shaffer,A.L., Yu,X., Allman,D. and Staudt,L.M.
  TITLE     Control of inflammation, cytokine expression, and germinal center
            formation by BCL-6
  JOURNAL   Science 276 (5312), 589-592 (1997)
   PUBMED   9110977
REFERENCE   6  (bases 1 to 4685)
  AUTHORS   Bernardin,F., Collyn-d'Hooghe,M., Quief,S., Bastard,C., Leprince,D.
            and Kerckaert,J.P.
  TITLE     Small deletions occur in highly conserved regions of the LAZ3/BCL6
            major translocation cluster in one case of non-Hodgkin's lymphoma
            without 3q27 translocation
  JOURNAL   Oncogene 14 (7), 849-855 (1997)
   PUBMED   9047392
REFERENCE   7  (bases 1 to 4685)
  AUTHORS   Yoshida,T., Fukuda,T., Okabe,S., Hatano,M., Miki,T., Hirosawa,S.,
            Miyasaka,N., Isono,K. and Tokuhisa,T.
  TITLE     The BCL6 gene is predominantly expressed in keratinocytes at their
            terminal differentiation stage
  JOURNAL   Biochem Biophys Res Commun 228 (1), 216-220 (1996)
   PUBMED   8912662
REFERENCE   8  (bases 1 to 4685)
  AUTHORS   Liao,X., Gilbert,D.J., Dent,A., Staudt,L.M., Jenkins,N.A. and
            Copeland,N.G.
  TITLE     Mapping of the mouse Bcl6 gene to chromosome 16
  JOURNAL   Mamm Genome 7 (8), 621-622 (1996)
   PUBMED   8678989
REFERENCE   9  (bases 1 to 4685)
  AUTHORS   Allman,D., Jain,A., Dent,A., Maile,R.R., Selvaggi,T., Kehry,M.R.
            and Staudt,L.M.
  TITLE     BCL-6 expression during B-cell activation
  JOURNAL   Blood 87 (12), 5257-5268 (1996)
   PUBMED   8652841
REFERENCE   10 (bases 1 to 4685)
  AUTHORS   Fukuda,T., Miki,T., Yoshida,T., Hatano,M., Ohashi,K., Hirosawa,S.
            and Tokuhisa,T.
  TITLE     The murine BCL6 gene is induced in activated lymphocytes as an
            immediate early gene
  JOURNAL   Oncogene 11 (8), 1657-1663 (1995)
   PUBMED   7478591
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158397.2.
            
            On Feb 13, 2023 this sequence version replaced NM_001348026.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.204404.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1438              AC158397.2         100313-101750       c
            1439-1477           AC158397.2         99075-99113         c
            1478-1649           AC158397.2         98039-98210         c
            1650-1871           AC158397.2         95337-95558         c
            1872-2846           AC158397.2         92769-93743         c
            2847-3031           AC158397.2         91939-92123         c
            3032-3199           AC158397.2         90430-90597         c
            3200-3330           AC158397.2         88831-88961         c
            3331-3468           AC158397.2         88584-88721         c
            3469-4685           AC158397.2         85576-86792         c
FEATURES             Location/Qualifiers
     source          1..4685
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 15.26 cM"
     gene            1..4685
                     /gene="Bcl6"
                     /gene_synonym="Bcl5"
                     /note="B cell leukemia/lymphoma 6"
                     /db_xref="GeneID:12053"
                     /db_xref="MGI:MGI:107187"
     exon            1..1438
                     /gene="Bcl6"
                     /gene_synonym="Bcl5"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1477
                     /gene="Bcl6"
                     /gene_synonym="Bcl5"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1649
                     /gene="Bcl6"
                     /gene_synonym="Bcl5"
                     /inference="alignment:Splign:2.1.0"
     CDS             1489..3612
                     /gene="Bcl6"
                     /gene_synonym="Bcl5"
                     /note="isoform 1 is encoded by transcript variant 2;
                     B-cell lymphoma 6 protein homolog; B-cell
                     leukemia/lymphoma 5"
                     /codon_start=1
                     /product="B-cell lymphoma 6 protein homolog isoform 1"
                     /protein_id="NP_001334955.1"
                     /db_xref="CCDS:CCDS28082.1"
                     /db_xref="GeneID:12053"
                     /db_xref="MGI:MGI:107187"
                     /translation="MASPADSCIQFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFR
                     AHKTVLMACSGLFYSIFTDQLKCNLSVINLDPEISPEGFCILLDFMYTSRLNLREGNI
                     MAVMTTAMYLQMEHVVDTCRKFIKASEAEMAPALKPPREEFLNSRMLMPHDIMAYRGR
                     EVVENNMPLRNTPGCESRAFAPPLYSGLSTPPASYPMYSHLPLSTFLFSDEELRDAPR
                     MPVANPFPKERALPCDSARQVPNEYSRPAMEVSPSLCHSNIYSPKEAVPEEARSDIHY
                     SVPEGPKPAVPSARNAPYFPCDKASKEEERPSSEDEIALHFEPPNAPLNRKGLVSPQS
                     PQKSDCQPNSPTESCSSKNACILQASGSPPAKSPTDPKACNWKKYKFIVLNSLNQNAK
                     PEGSEQAELGRLSPRAYPAPPACQPPMEPANLDLQSPTKLSASGEDSTIPQASRLNNL
                     VNRSLAGSPRSSSESHSPLYMHPPKCTSCGSQSPQHTEMCLHTAGPTFPEEMGETQSE
                     YSDSSCENGTFFCNECDCRFSEEASLKRHTLQTHSDKPYKCDRCQASFRYKGNLASHK
                     TVHTGEKPYRCNICGAQFNRPANLKTHTRIHSGEKPYKCETCGARFVQVAHLRAHVLI
                     HTGEKPYPCEICGTRFRHLQTLKSHLRIHTGEKPYHCEKCNLHFRHKSQLRLHLRQKH
                     GAITNTKVQYRVSAADLPPELPKAC"
     exon            1650..1871
                     /gene="Bcl6"
                     /gene_synonym="Bcl5"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..2846
                     /gene="Bcl6"
                     /gene_synonym="Bcl5"
                     /inference="alignment:Splign:2.1.0"
     exon            2847..3031
                     /gene="Bcl6"
                     /gene_synonym="Bcl5"
                     /inference="alignment:Splign:2.1.0"
     exon            3032..3199
                     /gene="Bcl6"
                     /gene_synonym="Bcl5"
                     /inference="alignment:Splign:2.1.0"
     exon            3200..3330
                     /gene="Bcl6"
                     /gene_synonym="Bcl5"
                     /inference="alignment:Splign:2.1.0"
     exon            3331..3468
                     /gene="Bcl6"
                     /gene_synonym="Bcl5"
                     /inference="alignment:Splign:2.1.0"
     exon            3469..4685
                     /gene="Bcl6"
                     /gene_synonym="Bcl5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4667..4672
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bcl6"
                     /gene_synonym="Bcl5"
                     /note="hexamer: AATAAA"
     polyA_site      4685
                     /gene="Bcl6"
                     /gene_synonym="Bcl5"
                     /note="major polyA site"
ORIGIN      
        1 acagtcctac cactcggccc cggccgaaac ttccctggct tcgaagtgga tgggcagcag
       61 tgccagccga tcgccagggg gtgggcggtc ccaggaagac aggtacagct aggtgcggcg
      121 agcgagtctg cgcaagcttg cctggcatca gggctggggt ttgtgcgggt gtgtgtgaac
      181 aggctagcgc ggctgccact ccactcccct ccccaaaggg aaagaaagga gcattggctc
      241 tagtgctctt ttcccctcga ctctcagatt ctctctccct ctctctttct gtctctcttc
      301 cttcccactg gaaactcctt acttgaagct gccttattca aagcacacta ggaaagtgcc
      361 ccagggaggg aaaggatgca tggatgggtt agtttacgtc tcagttgggg attactgagg
      421 ctggacccgg cattagaggg aaacccattc tggttcagct gtccttgccg gtctgactct
      481 ccttggggtt gtttgcatag gactttattg gagaattgtt ttgagatctt gggcaagagc
      541 ttgttttggg agcctcagtt tcctttatag tgaatcctgg ccgttataaa gatgtggtcc
      601 aatgatgagc gggagaggga agagtgattt gtccaagcca gctgaatggg gtagggcttt
      661 cctatctgca gtgtctggaa ggaagtagca ttcagctcca gagttagccc ccaccctagg
      721 gagttgtgga acctgctgag accatttggc tgacagagaa gtgaatcttt tgagaggggg
      781 tgattccaaa gagcagtctg ccctcctgtg tgcttgggct ttgttgatgg agaggggctt
      841 aaggtaaaaa gcccaaggcc agcctgtcag agtacataga agggctacct ttgttggttg
      901 gtttgtttgt ttgttcgttt gcctcgttcc ttgtctggag tgagtcatta ccacttgtcc
      961 gtcccggtga aacggcaaat ctgggcttcc cgtggttcca aaagtctgtg actggaaagc
     1021 cacaagtgag ctggtggttg aagctcagcc cgacgattcc agaagggctt gtggagctct
     1081 tccacaggaa gcaggagaga gttagtaaat aaacttcacg tgtcttcagc atttattttc
     1141 aaaagagaca gtcattggac ctgggtgagg accaagtgaa ctcttttttg ctcactctga
     1201 gtcaggacgg gttcaagaag aaatcagttc cttttgtctt tttctgtcct ctctccccct
     1261 ccatttccta ccccagaccc actcactcac tcactcactc actcactcac tcactcgcac
     1321 gaatgtaata accttgaagc tgaagagatt gagtgactgg ctcttaagac cacagagaaa
     1381 tatctgaggg tttggttaca gagtcaaaga aacctcacat tttaaagtgc acatttggtt
     1441 ttaaagcaaa attttggact gtgaagcaag gcactgggca aacacaacat ggcctccccg
     1501 gctgacagct gtatccagtt tacccggcac gctagtgatg ttcttctcaa ccttaatcgc
     1561 ctccggagtc gggacatctt gacggacgtt gtcatcgtgg tgagccgtga gcagtttaga
     1621 gcccataaga cagtgctcat ggcctgcagc ggcctgttct acagtatctt cactgaccag
     1681 ttgaaatgca accttagtgt aatcaatcta gatcctgaaa tcagccctga ggggttttgc
     1741 atcctcctgg acttcatgta cacatctagg ctcaacctga gggaaggcaa tatcatggcg
     1801 gtgatgacca cagccatgta cctgcagatg gagcatgttg tcgacacatg caggaagttc
     1861 atcaaggcca gtgaagcaga aatggcccct gcacttaaac ctccccgtga agagttcctg
     1921 aacagccgga tgctgatgcc ccatgacatc atggcctacc gaggtcgtga ggtcgtggag
     1981 aacaatatgc cactgagaaa tactcccggg tgtgagagca gagcttttgc tcctcctctg
     2041 tacagtggcc tgtcaacacc accagcctct tatcccatgt acagccatct cccgctcagc
     2101 accttcctct tctctgatga ggagctccga gatgcccccc gaatgcctgt ggccaaccct
     2161 tttcccaagg agcgtgccct cccctgcgac agtgccaggc aagtccctaa tgagtatagc
     2221 aggccagcca tggaggtgtc ccccagtttg tgtcacagca acatctactc gcccaaggag
     2281 gcagtcccag aggaggctcg gagtgacata cactacagtg tgcctgaggg ccccaagcct
     2341 gctgtccctt ctgctcggaa tgctccatac ttcccctgtg acaaagccag caaagaagaa
     2401 gagagacctt cttcggagga tgagattgcc ctgcatttcg agccccccaa tgcacccttg
     2461 aaccggaagg gtctggttag tccccagagt ccccagaaat ccgactgcca gcccaactca
     2521 cccacagagt cctgcagcag caagaacgcc tgcatccttc aggcctctgg ctctccgcca
     2581 gccaagagcc ccactgaccc gaaagcctgc aactggaaga agtataagtt catcgttctc
     2641 aacagcctca atcagaatgc caaacccgag ggctctgagc aggcagagct gggtcgcctc
     2701 tcccctcgag cctaccctgc accgcccgct tgccagccgc ctatggagcc cgcgaacctt
     2761 gatctccagt ccccgaccaa gctcagtgcc agtggggagg actctaccat cccccaagcc
     2821 agccggctca ataatctcgt gaacaggtcc ctggcaggct ccccccgaag cagcagtgag
     2881 agtcactcac cactctacat gcacccccca aagtgcacat cctgcggctc tcagtcccca
     2941 cagcatacag agatgtgcct ccatactgct gggcccacgt tcccggagga gatgggggaa
     3001 acccagtcag agtattcgga ttctagctgt gagaatggga ccttcttctg caacgaatgt
     3061 gactgccgtt tctctgagga ggcctcgctc aagaggcaca cgctgcagac gcacagtgac
     3121 aaaccataca aatgtgatcg ctgccaggcc tccttccgct acaagggcaa cctcgccagc
     3181 cacaagactg tccacacggg tgagaaaccc tatcgctgta acatttgtgg agcgcagttc
     3241 aatcggccag ccaacctgaa gacccacact cgaattcact ctggagaaaa gccctacaaa
     3301 tgtgaaacct gtggggccag gtttgttcag gtggcccacc tccgtgccca cgtgctcatc
     3361 cacactggag agaagccgta cccctgtgaa atctgtggca ctcgcttccg gcaccttcag
     3421 actctgaaga gccatctgcg catccacaca ggagagaaac cttaccattg tgagaagtgt
     3481 aacctgcact ttcgtcacaa aagccaactg cgacttcatt tgcgccagaa gcacggcgcc
     3541 atcaccaaca ccaaggtgca ataccgcgtg tcggccgctg acctgcctcc ggagctcccc
     3601 aaagcctgct gaatgaagca tggagtgttc ctcgcccttt cctctccagc cccttctcag
     3661 aatctaccca aaggatgctg taacacttta tacaaaggtc atcccatgat gtagtgcctc
     3721 tctcatccac tagtgcaaat catagttggg gtgggggtgg gggtggggtt tgcgggaccg
     3781 ggagccaagg cagctcccct tcccacactg ccataaaaca ttaagaaaat actattgctt
     3841 cttctcctat gtgtaaggca aaccctgtca gcaaaaagca aattcatttt ctatatcaaa
     3901 gtaggggaga atgcagaagt tctgacttga caggttgcaa ccgaggaatg taaatgatgt
     3961 gtgggaacag aggtctcttt tgtatgtaaa tgtgtattgt tttaaaagac aagacttcag
     4021 tatgctgtca aagagaaggc tttaattttt ttaaccaaag gtgaaggaat atatggcaga
     4081 gttgtaaata tataaatata tatatatata atataaatat ataaacctaa aaagatatat
     4141 tgaaaatata aaactgtgtt aaaggctcga ttttgtatct gcaggcagac acggatctga
     4201 gaatctttat tgagaaagag cacttaagag actattttaa gtattgcgtc tgtataagta
     4261 agaaaatatt ttgtctaaaa tgcctccgtg tatttgtatt tttttgcaag tgaaggttta
     4321 caaatttaca aagtgtgtat taaaaacaaa aagaacaaaa aaaaaagctg cagaaggaga
     4381 aatgtatact tttgttccag ttttcagttt gtacatacct gtaatgtgtc ctcacggtgc
     4441 ctttttacac ggaagttttc aatgatggac gggtgtgcgc catccctttt tgaagtgtag
     4501 gcagacacag ggacttgaag ttgtcactaa ctaaactctc tttgggaatg tttgactcct
     4561 cccacattct gcgtcatgct tgtcgttata attactccgg agacagggtt tggctgtgtc
     4621 taaactgcat tagtgcgttg taaaatagag ctgtacaaaa cataagaata aaacattgaa
     4681 aagtc
//
