LOCUS       NM_033601               1835 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Mus musculus B cell leukemia/lymphoma 3 (Bcl3), mRNA.
ACCESSION   NM_033601
VERSION     NM_033601.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1835)
  AUTHORS   Liu,S., Wang,H., Li,J., Gao,J., Yu,L., Wei,X., Cui,M., Zhao,Y.,
            Liang,Y. and Wang,H.
  TITLE     Loss of Bcl-3 regulates macrophage polarization by promoting
            macrophage glycolysis
  JOURNAL   Immunol Cell Biol 102 (7), 605-617 (2024)
   PUBMED   38804132
  REMARK    GeneRIF: Loss of Bcl-3 regulates macrophage polarization by
            promoting macrophage glycolysis.
REFERENCE   2  (bases 1 to 1835)
  AUTHORS   Daly,A.E., Yeh,G., Soltero,S. and Smale,S.T.
  TITLE     Selective regulation of a defined subset of inflammatory and
            immunoregulatory genes by an NF-kappaB p50-IkappaBzeta pathway
  JOURNAL   Genes Dev 38 (11-12), 536-553 (2024)
   PUBMED   38918046
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1835)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 1835)
  AUTHORS   Jaffery,H., Huesa,C., Chilaka,S., Cole,J., Doonan,J., Akbar,M.,
            Dunning,L., Tanner,K.E., van 't Hof,R.J., McInnes,I.B.,
            Carmody,R.J. and Goodyear,C.S.
  TITLE     IkB Protein BCL3 as a Controller of Osteogenesis and Bone Health
  JOURNAL   Arthritis Rheumatol 75 (12), 2148-2160 (2023)
   PUBMED   37410754
  REMARK    GeneRIF: IkB Protein BCL3 as a Controller of Osteogenesis and Bone
            Health.
REFERENCE   5  (bases 1 to 1835)
  AUTHORS   Qian,G., Jiang,W., Sun,D., Sun,Z., Chen,A., Fang,H., Wang,J.,
            Liu,Y., Yin,Z., Wei,H., Fang,H. and Zhang,X.
  TITLE     B-cell-derived IL-10 promotes allergic sensitization in asthma
            regulated by Bcl-3
  JOURNAL   Cell Mol Immunol 20 (11), 1313-1327 (2023)
   PUBMED   37653127
  REMARK    GeneRIF: B-cell-derived IL-10 promotes allergic sensitization in
            asthma regulated by Bcl-3.
REFERENCE   6  (bases 1 to 1835)
  AUTHORS   Franzoso,G., Carlson,L., Scharton-Kersten,T., Shores,E.W.,
            Epstein,S., Grinberg,A., Tran,T., Shacter,E., Leonardi,A.,
            Anver,M., Love,P., Sher,A. and Siebenlist,U.
  TITLE     Critical roles for the Bcl-3 oncoprotein in T cell-mediated
            immunity, splenic microarchitecture, and germinal center reactions
  JOURNAL   Immunity 6 (4), 479-490 (1997)
   PUBMED   9133427
REFERENCE   7  (bases 1 to 1835)
  AUTHORS   Schwarz,E.M., Krimpenfort,P., Berns,A. and Verma,I.M.
  TITLE     Immunological defects in mice with a targeted disruption in Bcl-3
  JOURNAL   Genes Dev 11 (2), 187-197 (1997)
   PUBMED   9009202
REFERENCE   8  (bases 1 to 1835)
  AUTHORS   Huppi,K., Siwarski,D., Pisegna,J.R. and Wank,S.
  TITLE     Chromosomal localization of the gastric and brain receptors for
            cholecystokinin (CCKAR and CCKBR) in human and mouse
  JOURNAL   Genomics 25 (3), 727-729 (1995)
   PUBMED   7759110
REFERENCE   9  (bases 1 to 1835)
  AUTHORS   Wulczyn,F.G., Naumann,M. and Scheidereit,C.
  TITLE     Candidate proto-oncogene bcl-3 encodes a subunit-specific inhibitor
            of transcription factor NF-kappa B
  JOURNAL   Nature 358 (6387), 597-599 (1992)
   PUBMED   1501714
REFERENCE   10 (bases 1 to 1835)
  AUTHORS   Bhatia,K., Huppi,K., McKeithan,T., Siwarski,D., Mushinski,J.F. and
            Magrath,I.
  TITLE     Mouse bcl-3: cDNA structure, mapping and stage-dependent expression
            in B lymphocytes
  JOURNAL   Oncogene 6 (9), 1569-1573 (1991)
   PUBMED   1923524
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY749796.1, AF067774.1 and AI528691.1.
            
            On Jan 11, 2008 this sequence version replaced NM_033601.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF067774.1, AK155016.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849388 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                BY749796.1         2-56
            56-1473             AF067774.1         17-1434
            1474-1835           AI528691.1         3-364               c
FEATURES             Location/Qualifiers
     source          1..1835
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 9.95 cM"
     gene            1..1835
                     /gene="Bcl3"
                     /gene_synonym="Bcl-3"
                     /note="B cell leukemia/lymphoma 3"
                     /db_xref="GeneID:12051"
                     /db_xref="MGI:MGI:88140"
     exon            1..319
                     /gene="Bcl3"
                     /gene_synonym="Bcl-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..1425
                     /gene="Bcl3"
                     /gene_synonym="Bcl-3"
                     /note="B-cell CLL/lymphoma 3"
                     /codon_start=1
                     /product="B-cell lymphoma 3 protein homolog"
                     /protein_id="NP_291079.2"
                     /db_xref="CCDS:CCDS20914.2"
                     /db_xref="GeneID:12051"
                     /db_xref="MGI:MGI:88140"
                     /translation="MPRCPAGAMDEGPVDLRTRPKGTPGAALPLRKRPLRPASPEPAT
                     TRSPAGPLDALRSGCDVPVVPGPPHCVARPEALYYQGPLMPIYSTPTMAPHFPLLNLP
                     THPYSMICPMEHPLSADIAMATRVDEDGDTPLHIAVVQNNIAAVYRILSLFKLGSREV
                     DVHNNLRQTPLHLAVITTLPDMVRLLVTAGASPMALDRHGQTAIHLACEHRSPSCLQA
                     LLDSATSGSVDLEVRNYEGLTALHVAVNTGCQEAVLLLLERGADIDAVDIKSGRSPLI
                     HAVENNSLNMVQLLLLHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSGLKN
                     CHNDTPLMVARSRRVIDILRGKASRAASGSQPEPSPDQSATNSPESSSRLSSNGLQSS
                     PSSSPSLSPPKDAPGFPATPQNFFLPTTSTPAFLPFPGVLRGPGRPVPPSPAPGSS"
     exon            320..473
                     /gene="Bcl3"
                     /gene_synonym="Bcl-3"
                     /inference="alignment:Splign:2.1.0"
     exon            474..582
                     /gene="Bcl3"
                     /gene_synonym="Bcl-3"
                     /inference="alignment:Splign:2.1.0"
     exon            583..787
                     /gene="Bcl3"
                     /gene_synonym="Bcl-3"
                     /inference="alignment:Splign:2.1.0"
     exon            788..876
                     /gene="Bcl3"
                     /gene_synonym="Bcl-3"
                     /inference="alignment:Splign:2.1.0"
     exon            877..954
                     /gene="Bcl3"
                     /gene_synonym="Bcl-3"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1122
                     /gene="Bcl3"
                     /gene_synonym="Bcl-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1240
                     /gene="Bcl3"
                     /gene_synonym="Bcl-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1835
                     /gene="Bcl3"
                     /gene_synonym="Bcl-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1814..1819
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bcl3"
                     /gene_synonym="Bcl-3"
                     /note="hexamer: AATAAA"
     polyA_site      1835
                     /gene="Bcl3"
                     /gene_synonym="Bcl-3"
                     /note="major polyA site"
ORIGIN      
        1 aggggaagtc ccgctgcccg gcgagaccgc cttcccgtgc cgagctcgcc gcacgccccg
       61 gcgtctccgg gcggcccgat gccccgatgc cccgcggggg ccatggacga ggggcccgtg
      121 gacctgcgca cccggcccaa gggcaccccg ggcgccgcgc tgccactccg caaacgcccg
      181 ctgcgccccg cgtccccaga gcccgcaacc acgcgcagcc ccgctggacc cctggacgcc
      241 ctgcgcagcg gctgcgacgt cccggttgtc cctgggcccc cccactgtgt ggccaggccg
      301 gaggcccttt actaccaggg acctttgatg cccatttact ctaccccgac gatggccccc
      361 cactttccgc tgctgaacct gcctactcac ccctactcca tgatatgccc catggaacac
      421 cccctttcag ctgatattgc catggccact cgggtggatg aggatggaga cacgcctctc
      481 cacatcgctg tggtccagaa taacatagcc gctgtctacc gaatactcag ccttttcaag
      541 cttgggagcc gcgaagtaga cgtccataac aacctgcggc agaccccgct ccacctggct
      601 gtcatcacca cattaccaga catggtccgg ctcttggtga cagctggtgc cagccccatg
      661 gccctggatc gtcacggcca gactgcaatt cacctggcat gcgagcaccg cagccccagc
      721 tgcctgcagg ccctgctgga cagcgcaacc tcaggctccg tggacctgga ggttcgcaat
      781 tatgaagggc tcactgccct gcacgtggcc gtgaacaccg ggtgccagga ggctgttctg
      841 ctgctcctgg agcgtggcgc ggacatcgat gcagtggata tcaagagcgg ccgctcccca
      901 ctcatccacg ccgtggagaa caacagcctg aacatggtgc aactcctgct gctgcacggc
      961 gccaacgtga acgctcagat gtattctggc agctcggctc tgcattctgc gtctggccgc
     1021 gggcttctgc ctctggtgcg cacgctggtg cgcagcgggg ctgacagcgg cctcaagaac
     1081 tgtcacaatg acacacctct catggtggcg cgcagccgca gggtcattga tatcttaagg
     1141 gggaaggcct ctcgggctgc ttcagggtca cagcctgagc catccccaga ccaaagtgcc
     1201 accaactccc ccgagagcag cagtcgtctc agctccaatg gcctccagtc ctcgccaagc
     1261 tcctcaccct cgctgtctcc cccgaaagat gctcctggct tccccgcgac tccccaaaac
     1321 tttttccttc ccacaacatc tacacctgcc ttcctgccct tcccaggagt cctccgaggc
     1381 cctggccggc ccgtaccccc ttccccagct ccaggaagca gctgagacgg atgggggggc
     1441 agacccggac tcatgaggag gggcctccct gccctgtggg gaccactctt ctggaaactg
     1501 tgaggacctt gttctgcttc cccccgccca atcctcggga ccaggttttg caccaaggca
     1561 catgcacata ctactgagca cagatcctcc caatcgcgcc ccttgcccag gactctcagc
     1621 ccccacttaa tctcaggcac ccaggttccc tgtctggaat ccaccagata ctcaattctt
     1681 tgagtggagg aaccaaagga cagccagcct ctcctctgcc accctccacc ctgagggacc
     1741 cagagaaaca gaggggtctg ggagggcatt gatcacagtg taaattatta ggtttgggtc
     1801 agatttcttt tgtaataaac tatttttgta tcata
//
