LOCUS       NM_001417493            3661 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus BCL2-like 2 (Bcl2l2), transcript variant 4, mRNA.
ACCESSION   NM_001417493
VERSION     NM_001417493.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3661)
  AUTHORS   Tang,S.X., Camara,C.M., Franco,J.A., Pazyra-Murphy,M.F., Li,Y.,
            Godes,M., Moyer,B.M., Bird,G.H., Segal,R.A. and Walensky,L.D.
  TITLE     Dissecting the neuroprotective interaction between the BH4 domain
            of BCL-w and the IP3 receptor
  JOURNAL   Cell Chem Biol 31 (10), 1815-1826 (2024)
   PUBMED   39067448
  REMARK    GeneRIF: Dissecting the neuroprotective interaction between the BH4
            domain of BCL-w and the IP3 receptor.
REFERENCE   2  (bases 1 to 3661)
  AUTHORS   Soma,S., Murakami,K., Fukuchi,Y., Kunimoto,H. and Nakajima,H.
  TITLE     O-Linked N-Acetylglucosamine Transferase Ensures Survival of Mouse
            Fetal Liver Hematopoietic Progenitors Partly by Regulating Bcl-xL
            and Oxidative Phosphorylation
  JOURNAL   Stem Cells 42 (1), 55-63 (2024)
   PUBMED   37813816
REFERENCE   3  (bases 1 to 3661)
  AUTHORS   Wu,B., Wu,B., Benkaci,S., Shi,L., Lu,P., Park,T., Morrow,B.E.,
            Wang,Y. and Zhou,B.
  TITLE     Crk and Crkl Are Required in the Endocardial Lineage for Heart
            Valve Development
  JOURNAL   J Am Heart Assoc 12 (18), e029683 (2023)
   PUBMED   37702066
REFERENCE   4  (bases 1 to 3661)
  AUTHORS   Diepstraten,S.T., La Marca,J.E., Chang,C., Young,S., Strasser,A.
            and Kelly,G.L.
  TITLE     BCL-W makes only minor contributions to MYC-driven lymphoma
            development
  JOURNAL   Oncogene 42 (37), 2776-2781 (2023)
   PUBMED   37567974
REFERENCE   5  (bases 1 to 3661)
  AUTHORS   El-Saafin,F., Bergamasco,M.I., Chen,Y., May,R.E., Esakky,P.,
            Hediyeh-Zadeh,S., Dixon,M., Wilcox,S., Davis,M.J., Strasser,A.,
            Smyth,G.K., Thomas,T. and Voss,A.K.
  TITLE     Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic
            neuronal cell death
  JOURNAL   Cell Death Differ 29 (5), 1013-1027 (2022)
   PUBMED   35361962
REFERENCE   6  (bases 1 to 3661)
  AUTHORS   Moser,M., Pscherer,A., Roth,C., Becker,J., Mucher,G., Zerres,K.,
            Dixkens,C., Weis,J., Guay-Woodford,L., Buettner,R. and Fassler,R.
  TITLE     Enhanced apoptotic cell death of renal epithelial cells in mice
            lacking transcription factor AP-2beta
  JOURNAL   Genes Dev 11 (15), 1938-1948 (1997)
   PUBMED   9271117
REFERENCE   7  (bases 1 to 3661)
  AUTHORS   Gibson,L., Holmgreen,S.P., Huang,D.C., Bernard,O., Copeland,N.G.,
            Jenkins,N.A., Sutherland,G.R., Baker,E., Adams,J.M. and Cory,S.
  TITLE     bcl-w, a novel member of the bcl-2 family, promotes cell survival
  JOURNAL   Oncogene 13 (4), 665-675 (1996)
   PUBMED   8761287
REFERENCE   8  (bases 1 to 3661)
  AUTHORS   Tuscano,J.M., Druey,K.M., Riva,A., Pena,J., Thompson,C.B. and
            Kehrl,J.H.
  TITLE     Bcl-x rather than Bcl-2 mediates CD40-dependent centrocyte survival
            in the germinal center
  JOURNAL   Blood 88 (4), 1359-1364 (1996)
   PUBMED   8695854
REFERENCE   9  (bases 1 to 3661)
  AUTHORS   Avraham,S., London,R., Fu,Y., Ota,S., Hiregowdara,D., Li,J.,
            Jiang,S., Pasztor,L.M., White,R.A., Groopman,J.E. et al.
  TITLE     Identification and characterization of a novel related adhesion
            focal tyrosine kinase (RAFTK) from megakaryocytes and brain
  JOURNAL   J Biol Chem 270 (46), 27742-27751 (1995)
   PUBMED   7499242
REFERENCE   10 (bases 1 to 3661)
  AUTHORS   Swendeman,S.L., Spielholz,C., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G. and Sheffery,M.
  TITLE     Characterization of the genomic structure, chromosomal location,
            promoter, and development expression of the alpha-globin
            transcription factor CP2
  JOURNAL   J Biol Chem 269 (15), 11663-11671 (1994)
   PUBMED   8157699
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116591.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784644.855493.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-262               AC116591.4         19399-19660         c
            263-350             AC116591.4         19219-19306         c
            351-813             AC116591.4         18290-18752         c
            814-3661            AC116591.4         14872-17719         c
FEATURES             Location/Qualifiers
     source          1..3661
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 27.98 cM"
     gene            1..3661
                     /gene="Bcl2l2"
                     /gene_synonym="Bcl-w; bclw; c98; Gtrgal2; Gtrosa41"
                     /note="BCL2-like 2"
                     /db_xref="GeneID:12050"
                     /db_xref="MGI:MGI:108052"
     exon            1..262
                     /gene="Bcl2l2"
                     /gene_synonym="Bcl-w; bclw; c98; Gtrgal2; Gtrosa41"
                     /inference="alignment:Splign:2.1.0"
     exon            263..350
                     /gene="Bcl2l2"
                     /gene_synonym="Bcl-w; bclw; c98; Gtrgal2; Gtrosa41"
                     /inference="alignment:Splign:2.1.0"
     exon            351..813
                     /gene="Bcl2l2"
                     /gene_synonym="Bcl-w; bclw; c98; Gtrgal2; Gtrosa41"
                     /inference="alignment:Splign:2.1.0"
     CDS             382..963
                     /gene="Bcl2l2"
                     /gene_synonym="Bcl-w; bclw; c98; Gtrgal2; Gtrosa41"
                     /note="isoform 1 is encoded by transcript variant 4;
                     bcl-2-like protein 2; apoptosis regulator Bcl-W"
                     /codon_start=1
                     /product="bcl-2-like protein 2 isoform 1"
                     /protein_id="NP_001404422.1"
                     /db_xref="GeneID:12050"
                     /db_xref="MGI:MGI:108052"
                     /translation="MATPASTPDTRALVADFVGYKLRQKGYVCGAGPGEGPAADPLHQ
                     AMRAAGDEFETRFRRTFSDLAAQLHVTPGSAQQRFTQVSDELFQGGPNWGRLVAFFVF
                     GAALCAESVNKEMEPLVGQVQDWMVAYLETRLADWIHSSGGWAEFTALYGDGALEEAR
                     RLREGNWASVRTVLTGAVALGALVTVGAFFASK"
     exon            814..3661
                     /gene="Bcl2l2"
                     /gene_synonym="Bcl-w; bclw; c98; Gtrgal2; Gtrosa41"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3631..3636
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bcl2l2"
                     /gene_synonym="Bcl-w; bclw; c98; Gtrgal2; Gtrosa41"
                     /note="hexamer: AATAAA"
     polyA_site      3644
                     /gene="Bcl2l2"
                     /gene_synonym="Bcl-w; bclw; c98; Gtrgal2; Gtrosa41"
                     /note="major polyA site"
ORIGIN      
        1 ccctccctcc cagctcctcc accaggaaac aaccggattc cggatcccgg ctgcggcctg
       61 acccgtgaga ttccttaacc tggctggcgg gcggggttgg agaccagcta agggtggggg
      121 aatgggagga gctgggcctt tgggctgctc ttgggggtac cgggaataga gatggtgtcg
      181 gcaggaagcc cgtggtcccg ggtttcccaa gagggcagtc attaaacacg gaatcggtcc
      241 cacagctggc aaagctttgg agggctccac tctagccggg aggatgaaag gcctcagctg
      301 ggggctccct gccaccagca ctgggtccta agagctgcca tccaggctgg tctgtcatcc
      361 ttgccccttt cagccgcccg gatggcgacc ccagcctcaa ccccagacac acgggctcta
      421 gtggctgact ttgtaggcta taagctgagg cagaagggtt atgtctgtgg agctggccct
      481 ggggaaggcc cagccgccga cccgctgcac caagccatgc gggctgctgg agacgagttt
      541 gagacccgtt tccgccgcac cttctctgac ctggccgctc agctacacgt gaccccaggc
      601 tcagcccagc aacgcttcac ccaggtttcc gacgaacttt tccaaggggg ccctaactgg
      661 ggccgtcttg tggcattctt tgtctttggg gctgccctgt gtgctgagag tgtcaacaaa
      721 gaaatggagc ctttggtggg acaagtgcag gattggatgg tggcctacct ggagacacgt
      781 ctggctgact ggatccacag cagtgggggc tgggcggagt tcacagctct atacggggac
      841 ggggccctgg aggaggcacg gcgtctgcgg gaggggaact gggcatcagt gaggacagtg
      901 ctgacggggg ccgtggcact gggggccctg gtaactgtag gggccttttt tgctagcaag
      961 tgagaaagtc tagggccagg tggggctagg tgtggctagg ggccaggaga gctggaacaa
     1021 tagcgaatgc ccttggaaga aactggatgg tcacggaaca gagaaaggca ggggaaggta
     1081 gtgtgtgtgg gagcccagca tgccaggcag gtggcaggga gaatgagttg gaaacattaa
     1141 ggaatgtttc aaggccaaga acccagagag tggagtcatc ccacggcttg gggggtgggg
     1201 gtggggaggt gggaggaatc atgcccatat cgcgggcaca caactacccg gaacatggct
     1261 tgtagctcca aggacggtga gcttacttca aagatctgtg tctcgactag atgaatggga
     1321 tttagggagc ctagaattca cttccctttg ggatggaagc ttggtgatca ggtgactggg
     1381 tgaaatggct gtggctgtgg gctgcatggg cacacctgtg catgtatgtg cacatgcaag
     1441 catgctcatg tgcatgctgg gctgtctgtc gaatctggtg gtggggtact tagagaaaac
     1501 attccttctt gctatggcaa gaacaagggc cagttcactg cccttctcct ctctgcccct
     1561 tcccttgacc ttacgcctcc aggctgaggg aggaacactg tatctagact agggctctgg
     1621 tgctgccgag agttgttggc agggctttgg agagaagagt tctgcagctg gccttgttct
     1681 tcatcatccc cctgttgtgt gcatctgtgc acctgggctg aaaaagggta aggctgtgga
     1741 gcctgggtgg gtagaagctt tggtagttgg acttgcctgt caccttcccc tccaacggtg
     1801 gcacaatggt gcctaaagtg ttgcctgttt ctagggtctc tctatccagc tgagtctaaa
     1861 ttggggatct agttttcctt tagaagatac gggcataaat gctgatctac aattcagttt
     1921 agttcctgaa ctgtctcagt gagactgcgg ataccttgag aggaccattc cagctctgag
     1981 tcccttggga gtgatgggga caggtactcc ttgactggcc tgttctgggt ggtgggtttt
     2041 tggtgctgct gctctatcag gggccaggga tatgggttct agagtacctg ccatgaccta
     2101 acgcgttttc ttttgaagcc atgctctttg cataggttgt caacactcga gtctctgaag
     2161 atggtcacat tagaactcac agtccagtcc cctagaacaa atccagactc tagccttttc
     2221 ttttgaggga ggaaatgatt cactccaaat gcatgccctg agccagacct cactgctgca
     2281 cttcccaagg tgctaacatt gctgctcttt aatgctgact tcgttcccag tgctctagaa
     2341 ccctacctgc ctctcctgag cactgaccag cttggctaga ccacagctga cccacctctt
     2401 cacttggtcc tagaatgtgg catcatatcg tgcttgctag aatgtgggac caaattggcc
     2461 tcaggtgttt tagtccagac tttggctttt gagagaaggt tgcacttttt catagtgtct
     2521 atgggggatg tgggaggctg catgtgccag ttggtctgtt ttgagggtga tgatctaaga
     2581 gactcggagc tgtctgtgac aagcagtcag agtgggaggc tctgacttgc tcaggacaaa
     2641 ctaggccagt ggttttcaaa ctgcttggca gagccccgaa gtgtcctagg ggttgcctca
     2701 ggagtcctta gggagatgag ggagtggagg gctgggcagt ttgccctcaa acagaacagc
     2761 tcccccttgt agctgtctta tgtatcgggg ttcagggtaa gattttattt gtggtaaggg
     2821 ctttgctgct gaaaaaagtt agaaaaccac tgactagacc atcagctcca tctggagcct
     2881 gtgctcctcc acgtccaggg aagtctctgc tctacccttc ccatgggaca cctacctaag
     2941 gtagcattcc tggggccctt tagcaaacag gagcagcagg aaccagggtc aggttaccaa
     3001 catgctctgc tagcagacct tcagccaggt gggaggagag gctgtgctag gacaggctaa
     3061 agggttggtc ttggtctgga ttctcagaag cttagatggg accacagtgg agagttgtga
     3121 cctgttctgc ccttcgtttt aagggccagt ggaaacccag agactcttct gtcagggaaa
     3181 accagggact gtcttttaga gccatatagt tccttgggat tagctcttgg ccaagaaggc
     3241 tgagtatggc tcccaacttt taaatccatt tcattttttt taaatgaggg aaatggatat
     3301 aatttttcag atactaagta gctggagagg atgttcttgc tctccaaagc ccaaagggac
     3361 aaatagggac tttgcttagg ccaaggcaag agcgcaagtg ggcactcagt cctgcagtta
     3421 ccagtcctac tccccactta cactagggca tacatatact attttacttt tttaaatcat
     3481 aaacggcagg agaacagatt tggttagttt agaagaaaag aaaaagctct ataaatataa
     3541 atatatattc ctgtattttt atttaataat ttataaatgc caagttcatt tgacttttat
     3601 ttttgtgtaa tatgtaatgg tcgtattaaa aataaataaa taaagcccag aaatttaatg
     3661 a
//
