LOCUS       NM_025778               2220 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus BCL2 like 14 (Bcl2l14), transcript variant 1, mRNA.
ACCESSION   NM_025778 XM_132904
VERSION     NM_025778.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2220)
  AUTHORS   Soma,S., Murakami,K., Fukuchi,Y., Kunimoto,H. and Nakajima,H.
  TITLE     O-Linked N-Acetylglucosamine Transferase Ensures Survival of Mouse
            Fetal Liver Hematopoietic Progenitors Partly by Regulating Bcl-xL
            and Oxidative Phosphorylation
  JOURNAL   Stem Cells 42 (1), 55-63 (2024)
   PUBMED   37813816
REFERENCE   2  (bases 1 to 2220)
  AUTHORS   Nguyen,P.M., Dagley,L.F., Preaudet,A., Lam,N., Giam,M., Fung,K.Y.,
            Aizel,K., van Duijneveldt,G., Tan,C.W., Hirokawa,Y., Yip,H.Y.K.,
            Love,C.G., Poh,A.R., Cruz,A., Burstroem,C., Feltham,R.,
            Abdirahman,S.M., Meiselbach,K., Low,R.R.J., Palmieri,M., Ernst,M.,
            Webb,A.I., Burgess,T., Sieber,O.M., Bouillet,P. and Putoczki,T.L.
  TITLE     Loss of Bcl-G, a Bcl-2 family member, augments the development of
            inflammation-associated colorectal cancer
  JOURNAL   Cell Death Differ 27 (2), 742-757 (2020)
   PUBMED   31296963
REFERENCE   3  (bases 1 to 2220)
  AUTHORS   Gu,Y., He,Y., Zhang,X., Shi,Y., Yang,Q., Yu,L., Sun,Z., Zhang,H.,
            Wang,J., Gao,X. and Wang,J.
  TITLE     Deficiency of monoclonal non-specific suppressor factor beta
            (MNSFB) promotes pregnancy loss in mice
  JOURNAL   Mol Reprod Dev 82 (6), 475-488 (2015)
   PUBMED   26031240
REFERENCE   4  (bases 1 to 2220)
  AUTHORS   Nakamura,M., Nakagawa,M. and Watanabe,J.
  TITLE     Ubiquitin-like protein MNSFbeta negatively regulates T cell
            function and survival
  JOURNAL   Immunol Invest 44 (1), 1-12 (2015)
   PUBMED   25180634
  REMARK    GeneRIF: CD3/CD28-inducible MNSFbeta-Bcl-G complex may be involved
            in the regulation of T cell function and survival.
REFERENCE   5  (bases 1 to 2220)
  AUTHORS   Watanabe,J., Nakagawa,M., Watanabe,N. and Nakamura,M.
  TITLE     Ubiquitin-like protein MNSFbeta covalently binds to Bcl-G and
            enhances lipopolysaccharide/interferon gamma-induced apoptosis in
            macrophages
  JOURNAL   FEBS J 280 (5), 1281-1293 (2013)
   PUBMED   23298187
REFERENCE   6  (bases 1 to 2220)
  AUTHORS   Giam,M., Okamoto,T., Mintern,J.D., Strasser,A. and Bouillet,P.
  TITLE     Bcl-2 family member Bcl-G is not a proapoptotic protein
  JOURNAL   Cell Death Dis 3 (10), e404 (2012)
   PUBMED   23059823
  REMARK    GeneRIF: The Bcl-G interacts specifically with proteins of the
            transport particle protein complex.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2220)
  AUTHORS   Giam,M., Mintern,J.D., Rautureau,G.J., Hinds,M.G., Strasser,A. and
            Bouillet,P.
  TITLE     Detection of Bcl-2 family member Bcl-G in mouse tissues using new
            monoclonal antibodies
  JOURNAL   Cell Death Dis 3 (8), e378 (2012)
   PUBMED   22914326
  REMARK    GeneRIF: Bcl-G is expressed highly in mature spermatids in the
            testis, CD8(+) conventional dendritic cells (DCs) in hematopoietic
            tissues and diverse epithelial cell types, including those lining
            the gastrointestinal and respiratory tracts.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2220)
  AUTHORS   Reed,J.C., Doctor,K., Rojas,A., Zapata,J.M., Stehlik,C.,
            Fiorentino,L., Damiano,J., Roth,W., Matsuzawa,S., Newman,R.,
            Takayama,S., Marusawa,H., Xu,F., Salvesen,G. and Godzik,A.
  CONSRTM   RIKEN GER Group; GSL Members
  TITLE     Comparative analysis of apoptosis and inflammation genes of mice
            and humans
  JOURNAL   Genome Res 13 (6B), 1376-1388 (2003)
   PUBMED   12819136
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155838.7.
            
            On Apr 29, 2007 this sequence version replaced NM_025778.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK016670.1, AK016997.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                AC155838.7         134417-134507       c
            92-241              AC155838.7         132045-132194       c
            242-693             AC155838.7         106774-107225       c
            694-858             AC155838.7         103376-103540       c
            859-929             AC155838.7         100700-100770       c
            930-1196            AC155838.7         98424-98690         c
            1197-2220           AC155838.7         92112-93135         c
FEATURES             Location/Qualifiers
     source          1..2220
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 65.22 cM"
     gene            1..2220
                     /gene="Bcl2l14"
                     /gene_synonym="4930452K23Rik; 4933405K19Rik;
                     9030625M01Rik; Bcl-G; Bclg"
                     /note="BCL2 like 14"
                     /db_xref="GeneID:66813"
                     /db_xref="MGI:MGI:1914063"
     exon            1..91
                     /gene="Bcl2l14"
                     /gene_synonym="4930452K23Rik; 4933405K19Rik;
                     9030625M01Rik; Bcl-G; Bclg"
                     /inference="alignment:Splign:2.1.0"
     exon            92..241
                     /gene="Bcl2l14"
                     /gene_synonym="4930452K23Rik; 4933405K19Rik;
                     9030625M01Rik; Bcl-G; Bclg"
                     /inference="alignment:Splign:2.1.0"
     exon            242..693
                     /gene="Bcl2l14"
                     /gene_synonym="4930452K23Rik; 4933405K19Rik;
                     9030625M01Rik; Bcl-G; Bclg"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..1235
                     /gene="Bcl2l14"
                     /gene_synonym="4930452K23Rik; 4933405K19Rik;
                     9030625M01Rik; Bcl-G; Bclg"
                     /note="apoptosis regulator BCL-G; BCL2-like 14 (apoptosis
                     facilitator)"
                     /codon_start=1
                     /product="apoptosis facilitator Bcl-2-like protein 14"
                     /protein_id="NP_080054.1"
                     /db_xref="CCDS:CCDS20636.1"
                     /db_xref="GeneID:66813"
                     /db_xref="MGI:MGI:1914063"
                     /translation="MCSTSVYDLEDIPLEDDDPNSIEFKILAFYARHHVFKNTPAVFS
                     PKLSRTRSLSQKALGTWSTDSWTQVSLPCRGSPSSEKNISLGKKKSSWRTLFRVAEKE
                     EGLPSSPKEIRAQGPQGPFPVERQSGFHNQHWPRSLSSVEQRLESEVVDSKVACIANR
                     VAEIVYSWPPPDVIHSQGGSKLKERVSEILYFRFEGPCDSKNKDGEDQIISKIVELLK
                     FSGDQLGREIKKDKALMSSFQDGLSYSTFKTITDLFLRDVDTRGESEVKARGFKAALA
                     IDAIAKLTAIDNHPMNRMLGFGTKYLREYFSPWVQQNGGWEKILGISHEEVD"
     exon            694..858
                     /gene="Bcl2l14"
                     /gene_synonym="4930452K23Rik; 4933405K19Rik;
                     9030625M01Rik; Bcl-G; Bclg"
                     /inference="alignment:Splign:2.1.0"
     exon            859..929
                     /gene="Bcl2l14"
                     /gene_synonym="4930452K23Rik; 4933405K19Rik;
                     9030625M01Rik; Bcl-G; Bclg"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1196
                     /gene="Bcl2l14"
                     /gene_synonym="4930452K23Rik; 4933405K19Rik;
                     9030625M01Rik; Bcl-G; Bclg"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..2220
                     /gene="Bcl2l14"
                     /gene_synonym="4930452K23Rik; 4933405K19Rik;
                     9030625M01Rik; Bcl-G; Bclg"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1591..1596
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bcl2l14"
                     /gene_synonym="4930452K23Rik; 4933405K19Rik;
                     9030625M01Rik; Bcl-G; Bclg"
                     /note="hexamer: GATAAA"
     polyA_site      1610
                     /gene="Bcl2l14"
                     /gene_synonym="4930452K23Rik; 4933405K19Rik;
                     9030625M01Rik; Bcl-G; Bclg"
                     /note="major polyA site"
ORIGIN      
        1 actttagctt aaccctacta gttaaatggc ctctcctggc ctaatctggc aaaacccacc
       61 accatgaaga acatcggcac aagagggaaa tgcaaacagg gtcaaggcag agaccaagtc
      121 agtagactgt aatgcagaag accaataagt actgaaagat gcactccaaa cctatgaagg
      181 gacagtgtgt ggaacagtga gccagcctac cttgcagggc ctgtcaacgc ttctgaagga
      241 gacccagcat gtgcagcacc agtgtgtatg acctggaaga cattcccctg gaggatgatg
      301 atccaaacag catagagttc aaaatcctgg ccttctacgc cagacaccat gtcttcaaga
      361 acaccccggc tgtcttctcg cccaagctct ccagaacaag gagtctgtcc cagaaagccc
      421 tggggacttg gtcaactgat tcctggacac aggtatcatt gccttgcaga ggttccccct
      481 ccagcgaaaa gaacatcagc ttgggcaaga agaagtcttc ttggagaaca ctcttcaggg
      541 tggccgagaa ggaggaaggc ctgccgagct ccccaaagga gatccgagct cagggtcctc
      601 agggcccctt cccggtagag cggcagagtg gcttccacaa ccagcactgg cccaggtctc
      661 tgagcagtgt ggagcagcgc ctggagagtg aagttgtgga ttccaaagtg gcttgtattg
      721 ccaacagagt ggctgaaatt gtttactcct ggccaccacc agatgtcatc cacagccagg
      781 gaggaagcaa gctcaaagag agggtctcgg agattctgta cttcaggttt gaaggacctt
      841 gtgactctaa gaataaagat ggagaagacc aaataataag caagattgtt gagctgctga
      901 aattctcggg ggatcagttg ggaagagaga taaagaaaga caaggctttg atgagcagct
      961 tccaggacgg gctgtcctac tcaacgttca agaccatcac agacctgttc ctgagggacg
     1021 tggacaccag aggagaatca gaggtcaaag ctcggggctt caaggctgcc cttgcaatag
     1081 acgccatcgc caagctcacg gccatcgaca accacccaat gaatagaatg ctgggcttcg
     1141 ggaccaagta cctaagagag tacttctccc cctgggttca gcagaatggc ggatgggaaa
     1201 aaatacttgg gatctcacat gaagaagtag actgaaatag ccaaagacct gtcgcctgga
     1261 aggtcccttg tgcaacagtg gttctgtgtg cccaccactc ttaccataga cttcaggaga
     1321 aagttaaaac atacccagca gacagtgtct agagaaccat ctttcctttg actcaagagg
     1381 catcgggaga ggccttgctc tcttcagctc atagaactca gtagcacgga cttcgctgag
     1441 ggcactcgag tcctccactg aatgtgtgag gggctccata aagataagtg attgttttac
     1501 ctctaaatgt tgagaacgga aaccatcctg ttgctacacc agtggaagca ttcgttcggc
     1561 acgtgtctgt cggtctcatg gaggtgaaac gataaatatg tgtgtgctta ctttttagtc
     1621 tctaacacta tttgttcctt atactgcacc tgggatgccc tgattactgt ctcgtgtcaa
     1681 gcttaccctc aggaagacag ccctattcat gtcagagaga aaaacctgag tttgctgtta
     1741 tgtctagcta gcttaagtct tgctaacccg tcctctcaaa aactactgtg gtaccttgac
     1801 aaagtccatt tggtacaaag ccatcttcac agatttctct gtgtgatata cctgcacccc
     1861 accacatcag tgcgatcgag agcaagggca cacaggtacc acaagaagat acagaggtca
     1921 acctcgggtg ctagttttca tcttcctctt tgtgcatagc ttcttaccca ggctggatca
     1981 ctcctgagcg tctgggagtg tcccgcctcc gcctcctccc ttacagccac agcactaggg
     2041 ttgcaggtgt accctgtgac acgcagcgtt ttaggtcggt gctgtggatt caaatccagg
     2101 tcctcacact tctgtggcta gcactttacc cacagtgcta cctccccagc ctgagctctg
     2161 gactattagg accccttaga agtagcataa tggttggtaa ttaataaaat aaataaattg
//
