LOCUS       NM_001403496            1253 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus BCL2 like 12 (Bcl2l12), transcript variant 2, mRNA.
ACCESSION   NM_001403496
VERSION     NM_001403496.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1253)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1253)
  AUTHORS   Soma,S., Murakami,K., Fukuchi,Y., Kunimoto,H. and Nakajima,H.
  TITLE     O-Linked N-Acetylglucosamine Transferase Ensures Survival of Mouse
            Fetal Liver Hematopoietic Progenitors Partly by Regulating Bcl-xL
            and Oxidative Phosphorylation
  JOURNAL   Stem Cells 42 (1), 55-63 (2024)
   PUBMED   37813816
REFERENCE   3  (bases 1 to 1253)
  AUTHORS   Yang,G., Liu,J.Q., Mo,L.H., Luo,X.Q., Li,J., Liu,Z.Q., Liu,D.B.,
            Liu,Z.G., Yang,P.C. and Shi,J.B.
  TITLE     Bcl2 like protine-12 (Bcl2L12) facilitates experimental airway
            allergic inflammation by inducing autocrine eotaxin in eosinophils
  JOURNAL   Immunol Lett 228, 93-102 (2020)
   PUBMED   33132183
  REMARK    GeneRIF: Bcl2 like protine-12 (Bcl2L12) facilitates experimental
            airway allergic inflammation by inducing autocrine eotaxin in
            eosinophils.
REFERENCE   4  (bases 1 to 1253)
  AUTHORS   Zheng,P.Y., Geng,X.R., Hong,J.Y., Yang,G., Liu,J.Q., Mo,L.H.,
            Feng,Y., Zhang,Y.Y., Liu,T., Ran,P., Liu,Z.G. and Yang,P.C.
  TITLE     Regulating Bcl2L12 expression in mast cells inhibits food allergy
  JOURNAL   Theranostics 9 (17), 4982-4992 (2019)
   PUBMED   31410196
  REMARK    GeneRIF: Regulating Bcl2L12 expression in mast cells inhibits food
            allergy.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1253)
  AUTHORS   Chen,X., Zeng,X.H., Wang,M., Chen,L., Zhang,N., Rao,M., Yang,P.C.
            and Song,J.
  TITLE     Bcl2-Like Protein 12 Is Required for the Aberrant T Helper-2
            Polarization in the Heart by Enhancing Interleukin-4 Expression and
            Compromising Apoptotic Machinery in CD4+ T Cells
  JOURNAL   Circulation 138 (22), 2559-2568 (2018)
   PUBMED   30571346
REFERENCE   6  (bases 1 to 1253)
  AUTHORS   Beisner,D.R., Ch'en,I.L., Kolla,R.V., Hoffmann,A. and Hedrick,S.M.
  TITLE     Cutting edge: innate immunity conferred by B cells is regulated by
            caspase-8
  JOURNAL   J Immunol 175 (6), 3469-3473 (2005)
   PUBMED   16148088
REFERENCE   7  (bases 1 to 1253)
  AUTHORS   Honda,K., Yanai,H., Negishi,H., Asagiri,M., Sato,M., Mizutani,T.,
            Shimada,N., Ohba,Y., Takaoka,A., Yoshida,N. and Taniguchi,T.
  TITLE     IRF-7 is the master regulator of type-I interferon-dependent immune
            responses
  JOURNAL   Nature 434 (7034), 772-777 (2005)
   PUBMED   15800576
REFERENCE   8  (bases 1 to 1253)
  AUTHORS   O'Connell,R.M., Saha,S.K., Vaidya,S.A., Bruhn,K.W., Miranda,G.A.,
            Zarnegar,B., Perry,A.K., Nguyen,B.O., Lane,T.F., Taniguchi,T.,
            Miller,J.F. and Cheng,G.
  TITLE     Type I interferon production enhances susceptibility to Listeria
            monocytogenes infection
  JOURNAL   J Exp Med 200 (4), 437-445 (2004)
   PUBMED   15302901
REFERENCE   9  (bases 1 to 1253)
  AUTHORS   Reed,J.C., Doctor,K., Rojas,A., Zapata,J.M., Stehlik,C.,
            Fiorentino,L., Damiano,J., Roth,W., Matsuzawa,S., Newman,R.,
            Takayama,S., Marusawa,H., Xu,F., Salvesen,G. and Godzik,A.
  CONSRTM   RIKEN GER Group; GSL Members
  TITLE     Comparative analysis of apoptosis and inflammation genes of mice
            and humans
  JOURNAL   Genome Res 13 (6B), 1376-1388 (2003)
   PUBMED   12819136
REFERENCE   10 (bases 1 to 1253)
  AUTHORS   Sato,M., Suemori,H., Hata,N., Asagiri,M., Ogasawara,K., Nakao,K.,
            Nakaya,T., Katsuki,M., Noguchi,S., Tanaka,N. and Taniguchi,T.
  TITLE     Distinct and essential roles of transcription factors IRF-3 and
            IRF-7 in response to viruses for IFN-alpha/beta gene induction
  JOURNAL   Immunity 13 (4), 539-548 (2000)
   PUBMED   11070172
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155806.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14777535.3372961.1,
                                           SRR13861905.1585351.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-383               AC155806.3         196336-196718       c
            384-526             AC155806.3         196002-196144       c
            527-640             AC155806.3         193821-193934       c
            641-732             AC155806.3         193638-193729       c
            733-1020            AC155806.3         192202-192489       c
            1021-1253           AC155806.3         190680-190912       c
FEATURES             Location/Qualifiers
     source          1..1253
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.07 cM"
     gene            1..1253
                     /gene="Bcl2l12"
                     /gene_synonym="2810475P17Rik; 5430429M05Rik; Bcl-L12;
                     Bcl2-L12"
                     /note="BCL2 like 12"
                     /db_xref="GeneID:75736"
                     /db_xref="MGI:MGI:1922986"
     exon            1..383
                     /gene="Bcl2l12"
                     /gene_synonym="2810475P17Rik; 5430429M05Rik; Bcl-L12;
                     Bcl2-L12"
                     /inference="alignment:Splign:2.1.0"
     CDS             277..1071
                     /gene="Bcl2l12"
                     /gene_synonym="2810475P17Rik; 5430429M05Rik; Bcl-L12;
                     Bcl2-L12"
                     /note="isoform a is encoded by transcript variant 2;
                     BCL2-like 12 (proline rich)"
                     /codon_start=1
                     /product="bcl-2-like protein 12 isoform a"
                     /protein_id="NP_001390425.1"
                     /db_xref="GeneID:75736"
                     /db_xref="MGI:MGI:1922986"
                     /translation="MAGSEELGLREDTLKVLTAFLKRGEVAGSPVPTPPRSPAQEETT
                     DFLSRLRRCLPCPLGRGAPPTESSRPHFLPLRPCYGSEPESVAASFCSGPASSEFYAL
                     VAQRLEQLVQEQLKSPPSSEFQGPPPTEKEALLRRLVALLEEEAEVINQKLASDPALH
                     RKLARLSAGSFARLVELFSSRESSSSPNCSSPSLPCPGPPPPSPDPLARLALAMELSR
                     RVAGLGGPLANLSVEHVHSFLPWVQAHGGWAGILASSPVDLNLPLD"
     exon            384..526
                     /gene="Bcl2l12"
                     /gene_synonym="2810475P17Rik; 5430429M05Rik; Bcl-L12;
                     Bcl2-L12"
                     /inference="alignment:Splign:2.1.0"
     exon            527..640
                     /gene="Bcl2l12"
                     /gene_synonym="2810475P17Rik; 5430429M05Rik; Bcl-L12;
                     Bcl2-L12"
                     /inference="alignment:Splign:2.1.0"
     exon            641..732
                     /gene="Bcl2l12"
                     /gene_synonym="2810475P17Rik; 5430429M05Rik; Bcl-L12;
                     Bcl2-L12"
                     /inference="alignment:Splign:2.1.0"
     exon            733..1020
                     /gene="Bcl2l12"
                     /gene_synonym="2810475P17Rik; 5430429M05Rik; Bcl-L12;
                     Bcl2-L12"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1253
                     /gene="Bcl2l12"
                     /gene_synonym="2810475P17Rik; 5430429M05Rik; Bcl-L12;
                     Bcl2-L12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1228..1233
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bcl2l12"
                     /gene_synonym="2810475P17Rik; 5430429M05Rik; Bcl-L12;
                     Bcl2-L12"
                     /note="hexamer: ATTAAA"
     polyA_site      1253
                     /gene="Bcl2l12"
                     /gene_synonym="2810475P17Rik; 5430429M05Rik; Bcl-L12;
                     Bcl2-L12"
                     /note="major polyA site"
ORIGIN      
        1 attctctacg gtcttcgagc cttctttggc gctgctagct gagagggaac tccaaacccc
       61 cttcccgctc cttcctgcaa gagttcaagc actcatttac ctcctttctt agactcagta
      121 attcagaccg tttctcctca actgaatcaa ctgccccact ggcccttaaa aaccaccttt
      181 tccttggagt taggcgccct cttcattcag tgattcagaa gtttgagtta tccctgcact
      241 tgggtgcatc ctctgtcttc tgcctcaggt acccccatgg ccggctctga agagttgggt
      301 ctccgagagg acacactgaa ggttctgacg gccttcctta agcgcggtga agtcgctggg
      361 tcccctgtcc caactccacc caggagtcct gcccaagagg agacaacaga tttcctgagc
      421 cgcctccgaa gatgcctccc ttgtcccctg gggagaggag ctccccccac ggagtcctct
      481 aggccccact tccttcccct ccgcccctgc tatggttccg agcctgaaag cgtcgctgct
      541 tctttctgct caggcccagc ctcttccgag ttctatgccc tggttgccca gcggctggaa
      601 caattggtgc aggagcaact gaagtccccg cccagttcag agttccaggg acccccaccc
      661 acggagaagg aagccctgct aaggcggctg gtagccttgc tggaggaaga ggcagaagtc
      721 atcaaccaaa agctggcatc tgacccggct ctgcatcgta aactggcccg cctgtccgca
      781 ggctctttcg cccgccttgt ggaactcttc tctagccggg aaagcagctc ctccccaaat
      841 tgctccagcc cgtctctgcc gtgcccgggg cccccaccgc catccccgga tcctctggca
      901 cgcctggcac tagccatgga attgagccgg cgtgtggctg ggcttggggg tcccctggcc
      961 aacctcagtg ttgagcatgt acacagcttc ctgccttggg tccaggccca tgggggatgg
     1021 gcaggcatcc tggcctcctc acctgtggac ttgaacttgc ccttggactg aacgtttcct
     1081 ctgacccagc atagatgact gaaatatgac gacacacaca tcagggctgt agggtggtgg
     1141 ttgccctacc ttttttatgt ttttattttt tgtttgtttg ttttttgttt ttttttttgc
     1201 caaaaagact gtttaaaatg tgtctgtatt aaaaactttg ttctttaact aga
//
