LOCUS       NM_207680               5040 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus BCL2 like 11 (Bcl2l11), transcript variant 1, mRNA.
ACCESSION   NM_207680
VERSION     NM_207680.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5040)
  AUTHORS   Sheibani,N., Song,Y.S., Farnoodian,M., Inampudi,S., Hanna,B.,
            Wang,S., Darjatmoko,S.R. and Sorenson,C.M.
  TITLE     Bim Expression Influences Choroidal Endothelial Cell
            Characteristics and Their Response to Therapeutic Intervention
  JOURNAL   Int J Mol Sci 25 (19), 10254 (2024)
   PUBMED   39408582
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5040)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5040)
  AUTHORS   Soma,S., Murakami,K., Fukuchi,Y., Kunimoto,H. and Nakajima,H.
  TITLE     O-Linked N-Acetylglucosamine Transferase Ensures Survival of Mouse
            Fetal Liver Hematopoietic Progenitors Partly by Regulating Bcl-xL
            and Oxidative Phosphorylation
  JOURNAL   Stem Cells 42 (1), 55-63 (2024)
   PUBMED   37813816
REFERENCE   4  (bases 1 to 5040)
  AUTHORS   Ou,Q., Qiao,X., Li,Z., Niu,L., Lei,F., Cheng,R., Xie,T., Yang,N.,
            Liu,Y., Fu,L., Yang,J., Mao,X., Kou,X., Chen,C. and Shi,S.
  TITLE     Apoptosis releases hydrogen sulfide to inhibit Th17 cell
            differentiation
  JOURNAL   Cell Metab 36 (1), 78-89 (2024)
   PUBMED   38113886
REFERENCE   5  (bases 1 to 5040)
  AUTHORS   Lambrecht,R., Delgado,M.E., Gloe,V., Schuetz,K., Plazzo,A.P.,
            Franke,B., San Phan,T., Fleming,J., Mayans,O. and Brunner,T.
  TITLE     Liver receptor homolog-1 (NR5A2) orchestrates hepatic inflammation
            and TNF-induced cell death
  JOURNAL   Cell Rep 42 (12), 113513 (2023)
   PUBMED   38039134
REFERENCE   6  (bases 1 to 5040)
  AUTHORS   Bouillet,P., Zhang,L.C., Huang,D.C., Webb,G.C., Bottema,C.D.,
            Shore,P., Eyre,H.J., Sutherland,G.R. and Adams,J.M.
  TITLE     Gene structure alternative splicing, and chromosomal localization
            of pro-apoptotic Bcl-2 relative Bim
  JOURNAL   Mamm Genome 12 (2), 163-168 (2001)
   PUBMED   11210187
REFERENCE   7  (bases 1 to 5040)
  AUTHORS   Bouillet,P., Metcalf,D., Huang,D.C., Tarlinton,D.M., Kay,T.W.,
            Kontgen,F., Adams,J.M. and Strasser,A.
  TITLE     Proapoptotic Bcl-2 relative Bim required for certain apoptotic
            responses, leukocyte homeostasis, and to preclude autoimmunity
  JOURNAL   Science 286 (5445), 1735-1738 (1999)
   PUBMED   10576740
REFERENCE   8  (bases 1 to 5040)
  AUTHORS   Puthalakath,H., Huang,D.C., O'Reilly,L.A., King,S.M. and
            Strasser,A.
  TITLE     The proapoptotic activity of the Bcl-2 family member Bim is
            regulated by interaction with the dynein motor complex
  JOURNAL   Mol Cell 3 (3), 287-296 (1999)
   PUBMED   10198631
REFERENCE   9  (bases 1 to 5040)
  AUTHORS   Reed,J.C.
  TITLE     Bcl-2 family proteins
  JOURNAL   Oncogene 17 (25), 3225-3236 (1998)
   PUBMED   9916985
  REMARK    Review article
REFERENCE   10 (bases 1 to 5040)
  AUTHORS   O'Connor,L., Strasser,A., O'Reilly,L.A., Hausmann,G., Adams,J.M.,
            Cory,S. and Huang,D.C.
  TITLE     Bim: a novel member of the Bcl-2 family that promotes apoptosis
  JOURNAL   EMBO J 17 (2), 384-395 (1998)
   PUBMED   9430630
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK037885.1, AK082613.1, CB521709.1, CA321725.1, AA881651.1 and
            BE136124.1.
            
            On Mar 21, 2006 this sequence version replaced NM_207680.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK082613.1, AK011490.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AK037885.1         2-14
            14-3716             AK082613.1         10-3712
            3717-3942           CB521709.1         434-659
            3943-4076           CA321725.1         66-199
            4077-4637           AA881651.1         55-615
            4638-5040           BE136124.1         1-403               c
FEATURES             Location/Qualifiers
     source          1..5040
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 62.23 cM"
     gene            1..5040
                     /gene="Bcl2l11"
                     /gene_synonym="1500006F24Rik; bcl2-L-11; Bim; Bod"
                     /note="BCL2 like 11"
                     /db_xref="GeneID:12125"
                     /db_xref="MGI:MGI:1197519"
     exon            1..215
                     /gene="Bcl2l11"
                     /gene_synonym="1500006F24Rik; bcl2-L-11; Bim; Bod"
                     /inference="alignment:Splign:2.1.0"
     exon            216..610
                     /gene="Bcl2l11"
                     /gene_synonym="1500006F24Rik; bcl2-L-11; Bim; Bod"
                     /inference="alignment:Splign:2.1.0"
     CDS             229..819
                     /gene="Bcl2l11"
                     /gene_synonym="1500006F24Rik; bcl2-L-11; Bim; Bod"
                     /note="isoform 1 is encoded by transcript variant 1;
                     bcl-2-like protein 11; bcl2-interacting mediator of cell
                     death; Bcl2 interacting mediator of cell death; BCL2-like
                     11 (apoptosis facilitator)"
                     /codon_start=1
                     /product="bcl-2-like protein 11 isoform 1"
                     /protein_id="NP_997563.1"
                     /db_xref="CCDS:CCDS16713.1"
                     /db_xref="GeneID:12125"
                     /db_xref="MGI:MGI:1197519"
                     /translation="MAKQPSDVSSECDREGGQLQPAERPPQLRPGAPTSLQTEPQGNP
                     DGEGDRCPHGSPQGPLAPPASPGPFATRSPLFIFVRRSSLLSRSSSGYFSFDTDRSPA
                     PMSCDKSTQTPSPPCQAFNHYLSAMASIRQSQEEPEDLRPEIRIAQELRRIGDEFNET
                     YTRRVFANDYREAEDHPQMVILQLLRFIFRLVWRRH"
     exon            611..720
                     /gene="Bcl2l11"
                     /gene_synonym="1500006F24Rik; bcl2-L-11; Bim; Bod"
                     /inference="alignment:Splign:2.1.0"
     exon            721..5037
                     /gene="Bcl2l11"
                     /gene_synonym="1500006F24Rik; bcl2-L-11; Bim; Bod"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1023..1028
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bcl2l11"
                     /gene_synonym="1500006F24Rik; bcl2-L-11; Bim; Bod"
                     /note="hexamer: AGTAAA"
     polyA_site      1047
                     /gene="Bcl2l11"
                     /gene_synonym="1500006F24Rik; bcl2-L-11; Bim; Bod"
                     /note="major polyA site"
     regulatory      5014..5019
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bcl2l11"
                     /gene_synonym="1500006F24Rik; bcl2-L-11; Bim; Bod"
                     /note="hexamer: AATAAA"
     polyA_site      5037
                     /gene="Bcl2l11"
                     /gene_synonym="1500006F24Rik; bcl2-L-11; Bim; Bod"
                     /note="major polyA site"
ORIGIN      
        1 acttcgctcc ccgcaggcac tgggtcacca gctggttgga gctctgcggt ccttgccatc
       61 gtcgccgtca ccggattcct gcagccgctc tgcgagctgt gttccacttg gattcacacc
      121 acctccgctg ctcccgccgc caccgcctcg gcgcccttcc cctggccctc gtccacccaa
      181 tgtctgactc tgattctcgg actgagaaac gcaagaaaaa aagaccaaat ggccaagcaa
      241 ccttctgatg taagttctga gtgtgacaga gaaggtggac aattgcagcc tgctgagagg
      301 cctccccagc tcaggcctgg ggcccctacc tccctacaga cagaaccgca aggtaatccc
      361 gacggcgaag gggaccgctg cccccacggc agccctcagg gcccgctggc cccaccggcc
      421 agccctggcc cttttgctac cagatcccca cttttcatct ttgtgagaag atcttctctg
      481 ctgtcccggt cctccagtgg gtatttctct tttgacacag acaggagccc ggcacccatg
      541 agttgtgaca agtcaacaca aaccccaagt cctccttgcc aggccttcaa ccactatctc
      601 agtgcaatgg cttccatacg acagtctcag gaggaacctg aagatctgcg cccggagata
      661 cggattgcac aggagctgcg gcggatcgga gacgagttca acgaaactta cacaaggagg
      721 gtgtttgcaa atgattaccg cgaggctgaa gaccaccctc aaatggttat cttacaactg
      781 ttacgcttta tcttccgtct ggtatggaga aggcattgac aggatctaca tgcagccagg
      841 atacgtggcg gacatggctc ttgttcagac tgggagaacc cccacgcgtc atgtccctct
      901 cttggtgctg cgacagtgtg tccagtggtt ctatcccaga gagatgtgct gagcatggac
      961 agcgctctgc actgtgtcga tgtgaacgga acctctgttc atcaccacat ggccgagttt
     1021 tcagtaaata tttgttgtga atgtaaacaa gggagggctt ttctcttttt aatgtacaga
     1081 tcctaggaac agagaaatat gcaagagagg tgtttacatg tggcgtgtta atttttttaa
     1141 acccactttc tttgataact gtttttgggg tttttttttt ttgtctcatt ttctttcaga
     1201 aagtaaagct ttttagccaa tttatggatg atttttatac tcaaattctt aacccactac
     1261 ctactcagag gattccataa ccctgcagtg ggaactgagc cagctgattt ataaggctgc
     1321 cttagtttat ttttagaaat tactgtacag aattttttaa acaggaagag tatggtgttg
     1381 ccctctctcc tctgccatgg cctctttgag tttccttttg agttattact accaaaacag
     1441 ttcttaggaa atggaatgag ttcgagcggc agaggttctg ttctggtacg ccacttccac
     1501 tttgtaaata tttacctcct tagctcagtt gctcctgtag cagaaattca cacttttcct
     1561 gcttccctca actcctcaga cccctcggtc tgtctccaca cggatgcgca gcttcagccc
     1621 agggtatctt caagtgtatt gtgtcagcaa gggctagggg ctgcccggat tgtgcccagc
     1681 tccatcaatc aagctgactc acgggaaggg ctctcgtgcg cttcactgca ctgcggtggc
     1741 tgtgtttgcc tcttttatcc tgagaggacg tgggctcaca caccgcttgc tgaagccgct
     1801 agctccactg gttgctggct ttgctgccgc cacaggctct gctttgctgt gtgtatcagg
     1861 tgagctggag cccacgcttt ctcggggact ggccaggtca tttcaggagc aaggagctca
     1921 ggtgatcctt ttccatgctt cttgggatgt agccctgctc accccacctg gcctgtgatt
     1981 cctgaatttc atctctattc ccttgagtta ggggctggct ctacttccat cagttcccag
     2041 acataggaag cttccattat gccgagtaaa gcacttgtct tccacaagat gtctgcctgc
     2101 tttgctctct ccattttctt aatacttgga tcttgttggg cttacttgtg tctggggtgg
     2161 gggtgaggtg ctctttcttg gtccctgccc cttaggacca cagcccagac atttggtcag
     2221 ttatttcaag accaggcagg actggaagtg cacagcctgg tggaggagca ctttctaacc
     2281 tgtggagagc tgtggcccag ctccagctcc tcccaaaaca aacggcacac gtgtaggcag
     2341 acagccaggg gagatacaaa aaaggaccaa gaggaaagag catgggagga gtggggatgg
     2401 caagccctct cacttctgag aacttcagac gtcaggcagc ttgctcagga agctttatga
     2461 gtttcctcgc aagtcagcag tgccaacgac tgtttgcttt tggcctgtag aaagccagtg
     2521 gtttttctta tgttatgaag tagagaaatc cgtttgttca tactttcctc tgtgtgtgtg
     2581 tgcatgtgtg tgtgtgtgtg catatgcgtg gttgtgtgtg tttatatgta tatgtatatt
     2641 acctataagc ttccttctag attgagatca tctgattcca aatatcctta tacatttccc
     2701 agcttcgtta gatttggtgt ggtttgaaag ctgttttggc attctcctcc tttcctgatg
     2761 tattgagcct gctcatggtt cccatgaggc cctgtggtta ttataagttg gtgttaaaac
     2821 tgcaaccatg gctctcacac acacacacac acacacacac acacaccaaa gacatacttg
     2881 gtcctgggcc atgcccccct cctaggacct ccattctcat gtgccagtct ccccgactgg
     2941 agcactttac tgtctcagcc ccatggctct gtggcagtgc ctgagcaggt gcagaagctc
     3001 cagagccagg tcccagtgac atgtgtggcc cccaacgcat gcttacctcc agcctggggc
     3061 tggccgctga agcagctcat agggaaataa gagattctat gaattgtaga agtattcaag
     3121 aacaggatgc ggcacccaga acgtaaacat gactggatgt ccctgtactg tatctgtttg
     3181 ttagagtgca aacgtcgcct gcagacagac agtgcccctg cttactgtgg gtaggccttt
     3241 gtacttaaat atattctctc tcgtttttgg taggacagaa actagatctc cctccccctc
     3301 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt aaacataatg
     3361 cgggttttgt gccttgacaa cctccccatg tgaggtttgt aaatagtgtc ctgtgacttc
     3421 acctcaagtt gtaataaaca tacaaaatgg tgtcctgagt gattcttcaa atttcttttc
     3481 cagaaaagaa ttgatgaatt gggggaaggg gcaggggtct gaaaaatcag tttaaagtct
     3541 ctctattaaa gtatgtaatg ggtaatgtct gcttctccta tttccttcca gtgttgtata
     3601 tattttgact atttattaga ttagaaagtc atgtttcact cgtcaactga gccaaatgtc
     3661 tctgtgcaat tgtgttccct ttacctttct ttgtaaaata ttgtacagca taaatgagta
     3721 aaaaaaaaaa aatcactgtt tttccaaact tctcataatt aaggatttgt aaataccata
     3781 ggttcttctt ctgtgtaatg tgccctactg tttcataatg ctgtaacttg tagagatgtt
     3841 gtatatttat tttccgctta tttaaatgtc ttaagttctt gaaagtgttg acatccctat
     3901 ccctgacagc cctgccatgc catgaattgc ttcagctcct gataaaggag gggtagtggc
     3961 tggttctctt cccacaaggc ggcttctgct ttggcttctg gcattcagtg cttgggttct
     4021 gccgcctttc tgatgaaatg agtgttttgc tgccggtgag ataccctaag atgctagcct
     4081 ggaagattgg actctaagaa aatacccatc aaacccattt ttgaagcagc tggcttctga
     4141 gaaaaatcag actcaccagt aagttggcca catctttaga gaagtattag cagcagatgg
     4201 ggaagaattt ttttttcctt aaattgaaag agtatctttg acaactcagt gttgagagaa
     4261 atattatcct gctgcctctt gaggtactgc tgaatggctg tcctgggtaa gagaagggct
     4321 ggtgggacct gtttctagag catttgccaa ggccacttgt gtcaccagga cactcgctgg
     4381 ctaccgtccc cacctgctgt gtgcttccta gtttgaggtc tgtggactga acttacctat
     4441 accattcggc tcccttcccg ttcactgctt taggccagcc cactcctgct tccctctaca
     4501 gaggttctgg cacccacgtc aagatggctc actgaagctc tagagccatg tgacttcatg
     4561 gaaatggttt tgtcttcctg ctgattcagc ctggtgcctg tgtgtgtcca tccgctcagc
     4621 acgtctgcat gcgggtcctg tccacacgtg tcgctaaatc ggcggggaat tgcctctcaa
     4681 acagcgttgc acaaagcacc ctcaagttcc cagcaaagta cttgatctct ttcaaatgtg
     4741 tgttattgtc taggttctgt gaccactggt ttctgtaccc agacctgtca ggtatccttt
     4801 agtgaacagc actgatctct gtatagtccc catcactaat gtcagaaccc agcgtatgta
     4861 gcatttgtat tgcagtttcc ctggcttcct ttacgttttg cactgatgaa ttttgacagg
     4921 gtaattgcca ctgtacctgt gcaatactgc tgtaaataac tgcagatttt tttaagaaac
     4981 tcaatctttt atgttcttaa tgaattttat ataaataaaa cttgcgacta gctttcaaaa
//
