LOCUS       NM_001289739            1220 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Mus musculus BCL2-like 1 (Bcl2l1), transcript variant 4, mRNA.
ACCESSION   NM_001289739
VERSION     NM_001289739.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1220)
  AUTHORS   Vier,J., Hacker,G. and Kirschnek,S.
  TITLE     Contribution of A1 to macrophage survival in cooperation with MCL-1
            and BCL-XL in a murine cell model of myeloid differentiation
  JOURNAL   Cell Death Dis 15 (9), 677 (2024)
   PUBMED   39285161
  REMARK    GeneRIF: Contribution of A1 to macrophage survival in cooperation
            with MCL-1 and BCL-XL in a murine cell model of myeloid
            differentiation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1220)
  AUTHORS   Shimora,H., Matsuda,M., Nakayama,Y., Maeyama,H., Tanioka,R.,
            Tanaka,Y., Kitatani,K. and Nabe,T.
  TITLE     Involvement of Janus kinase-dependent Bcl-xL overexpression in
            steroid resistance of group 2 innate lymphoid cells in asthma
  JOURNAL   Immunology 172 (4), 653-668 (2024)
   PUBMED   38786548
  REMARK    GeneRIF: Involvement of Janus kinase-dependent Bcl-xL
            overexpression in steroid resistance of group 2 innate lymphoid
            cells in asthma.
REFERENCE   3  (bases 1 to 1220)
  AUTHORS   Bodac,A., Mayet,A., Rana,S., Pascual,J., Bowler,A.D., Roh,V.,
            Fournier,N., Craciun,L., Demetter,P., Radtke,F. and Meylan,E.
  TITLE     Bcl-xL targeting eliminates ageing tumor-promoting neutrophils and
            inhibits lung tumor growth
  JOURNAL   EMBO Mol Med 16 (1), 158-184 (2024)
   PUBMED   38177532
  REMARK    GeneRIF: Bcl-xL targeting eliminates ageing tumor-promoting
            neutrophils and inhibits lung tumor growth.
REFERENCE   4  (bases 1 to 1220)
  AUTHORS   Moriishi,T., Kawai,Y., Fukuyama,R., Matsuo,Y., He,Y.W., Akiyama,H.,
            Asahina,I. and Komori,T.
  TITLE     Bcl2l1 Deficiency in Osteoblasts Reduces the Trabecular Bone Due to
            Enhanced Osteoclastogenesis Likely through Osteoblast Apoptosis
  JOURNAL   Int J Mol Sci 24 (24), 17319 (2023)
   PUBMED   38139148
  REMARK    GeneRIF: Bcl2l1 Deficiency in Osteoblasts Reduces the Trabecular
            Bone Due to Enhanced Osteoclastogenesis Likely through Osteoblast
            Apoptosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1220)
  AUTHORS   Yang,X.F., Weber,G.F. and Cantor,H.
  TITLE     A novel Bcl-x isoform connected to the T cell receptor regulates
            apoptosis in T cells
  JOURNAL   Immunity 7 (5), 629-639 (1997)
   PUBMED   9390687
REFERENCE   6  (bases 1 to 1220)
  AUTHORS   Grillot,D.A., Merino,R. and Nunez,G.
  TITLE     Bcl-XL displays restricted distribution during T cell development
            and inhibits multiple forms of apoptosis but not clonal deletion in
            transgenic mice
  JOURNAL   J Exp Med 182 (6), 1973-1983 (1995)
   PUBMED   7500043
REFERENCE   7  (bases 1 to 1220)
  AUTHORS   Wang,Z., Karras,J.G., Howard,R.G. and Rothstein,T.L.
  TITLE     Induction of bcl-x by CD40 engagement rescues sIg-induced apoptosis
            in murine B cells
  JOURNAL   J Immunol 155 (8), 3722-3725 (1995)
   PUBMED   7561075
REFERENCE   8  (bases 1 to 1220)
  AUTHORS   Chao,D.T., Linette,G.P., Boise,L.H., White,L.S., Thompson,C.B. and
            Korsmeyer,S.J.
  TITLE     Bcl-XL and Bcl-2 repress a common pathway of cell death
  JOURNAL   J Exp Med 182 (3), 821-828 (1995)
   PUBMED   7650488
REFERENCE   9  (bases 1 to 1220)
  AUTHORS   Broome,H.E., Dargan,C.M., Krajewski,S. and Reed,J.C.
  TITLE     Expression of Bcl-2, Bcl-x, and Bax after T cell activation and
            IL-2 withdrawal
  JOURNAL   J Immunol 155 (5), 2311-2317 (1995)
   PUBMED   7650367
REFERENCE   10 (bases 1 to 1220)
  AUTHORS   Gonzalez-Garcia,M., Perez-Ballestero,R., Ding,L., Duan,L.,
            Boise,L.H., Thompson,C.B. and Nunez,G.
  TITLE     bcl-XL is the major bcl-x mRNA form expressed during murine
            development and its product localizes to mitochondria
  JOURNAL   Development 120 (10), 3033-3042 (1994)
   PUBMED   7607090
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL731857.9.
            
            On Feb 21, 2023 this sequence version replaced NM_001289739.1.
            
            Summary: This gene encodes a member of the Bcl-2 family of
            apoptosis regulators. The encoded protein is localized to the inner
            and outer mitochondrial membranes and regulates the programmed cell
            death pathway during development and tissue homeostasis. This
            protein binds to voltage-dependent anion channels in the outer
            mitochondrial membrane to facilitate the uptake of calcium ions.
            Mice embryos lacking this gene survived for two weeks and exhibited
            cell death of immature hematopoietic cells and neurons. Alternative
            splicing results in multiple transcript variants. Additional
            alternatively spliced transcript variants of this gene have been
            described, but their full-length nature is not known. [provided by
            RefSeq, Jan 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U51277.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            NMD candidate                      :: PMID: 9390687
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               AL731857.9         33842-33943
            103-778             AL731857.9         34227-34902
            779-921             AL731857.9         96870-97012
            922-1030            AL731857.9         98566-98674
            1031-1220           AL731857.9         105408-105597
FEATURES             Location/Qualifiers
     source          1..1220
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 75.41 cM"
     gene            1..1220
                     /gene="Bcl2l1"
                     /gene_synonym="Bcl(X)L; bcl-x; Bcl-XL; bcl2-L-1; Bcl2l;
                     BclX"
                     /note="BCL2-like 1"
                     /db_xref="GeneID:12048"
                     /db_xref="MGI:MGI:88139"
     exon            1..102
                     /gene="Bcl2l1"
                     /gene_synonym="Bcl(X)L; bcl-x; Bcl-XL; bcl2-L-1; Bcl2l;
                     BclX"
                     /inference="alignment:Splign:2.1.0"
     exon            103..778
                     /gene="Bcl2l1"
                     /gene_synonym="Bcl(X)L; bcl-x; Bcl-XL; bcl2-L-1; Bcl2l;
                     BclX"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..922
                     /gene="Bcl2l1"
                     /gene_synonym="Bcl(X)L; bcl-x; Bcl-XL; bcl2-L-1; Bcl2l;
                     BclX"
                     /note="isoform b is encoded by transcript variant 4;
                     bcl-2-like protein 1; B-cell leukemia/lymphoma x;
                     anti-apoptosis regulatory protein; apoptosis regulator
                     Bcl-X"
                     /codon_start=1
                     /product="bcl-2-like protein 1 isoform b"
                     /protein_id="NP_001276668.1"
                     /db_xref="GeneID:12048"
                     /db_xref="MGI:MGI:88139"
                     /translation="MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEETEAE
                     RETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYR
                     RAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQ
                     VLVSRIASWMATYLNDHLEPWIQENGGWGVSGGTPLRSVFRRLVQVPGVAEHVCDPSL
                     WEVETEGSEVQGPPQLL"
     exon            779..921
                     /gene="Bcl2l1"
                     /gene_synonym="Bcl(X)L; bcl-x; Bcl-XL; bcl2-L-1; Bcl2l;
                     BclX"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1030
                     /gene="Bcl2l1"
                     /gene_synonym="Bcl(X)L; bcl-x; Bcl-XL; bcl2-L-1; Bcl2l;
                     BclX"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1220
                     /gene="Bcl2l1"
                     /gene_synonym="Bcl(X)L; bcl-x; Bcl-XL; bcl2-L-1; Bcl2l;
                     BclX"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgagttacc ggcgacccag ccaccacctc ctccccgacc tatgatacaa aagaccttcc
       61 gggggttgta cctgcttgct gtcgccggag atagatttga ataaccttat cttggctttg
      121 gatcctggaa gagaatcgct aaacacagag cagacccagt aagtgagcag gtgttttgga
      181 caatggactg gttgagccca tctctattat aaaaatgtct cagagcaacc gggagctggt
      241 ggtcgacttt ctctcctaca agctttccca gaaaggatac agctggagtc agtttagtga
      301 tgtcgaagag aataggactg aggccccaga agaaactgaa gcagagaggg agacccccag
      361 tgccatcaat ggcaacccat cctggcacct ggcggatagc ccggccgtga atggagccac
      421 tggccacagc agcagtttgg atgcgcggga ggtgattccc atggcagcag tgaagcaagc
      481 gctgagagag gcaggcgatg agtttgaact gcggtaccgg agagcgttca gtgatctaac
      541 atcccagctt cacataaccc cagggaccgc gtatcagagc tttgagcagg tagtgaatga
      601 actctttcgg gatggagtaa actggggtcg catcgtggcc tttttctcct ttggcggggc
      661 actgtgcgtg gaaagcgtag acaaggagat gcaggtattg gtgagtcgga ttgcaagttg
      721 gatggccacc tatctgaatg accacctaga gccttggatc caggagaacg gcggctgggg
      781 tgtgagtgga ggtacacccc tcagatctgt cttcagaagg cttgttcaag tgccaggagt
      841 ggcggagcac gtttgtgatc ccagcctttg ggaggtggaa acagaaggat cggaagttca
      901 aggccctcct cagctattat aggtttctct gtgtagccct ggctgtcctg taactcactc
      961 tgtagagcaa actggactca aactcagaga catgcctgcc tgatcttcat cgtgagtgct
     1021 ggaatcacag gctctaacat ggctatcggg agatgcgtgg accaggccta tggtggccct
     1081 tgacgcagcg tggtgcttca actcagacca agagacagag cagaaaatca acagagggga
     1141 caaaaagtgt ctgtgtgcca aggaccttat ctcaggagga cttcaggaag gacgctgacc
     1201 cttccttccc tcattccttc
//
