LOCUS       NM_007534                764 bp    mRNA    linear   ROD 06-AUG-2023
DEFINITION  Mus musculus B cell leukemia/lymphoma 2 related protein A1b
            (Bcl2a1b), mRNA.
ACCESSION   NM_007534
VERSION     NM_007534.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 764)
  AUTHORS   Tan L, Sandrock I, Odak I, Aizenbud Y, Wilharm A, Barros-Martins J,
            Tabib Y, Borchers A, Amado T, Gangoda L, Herold MJ,
            Schmidt-Supprian M, Kisielow J, Silva-Santos B, Koenecke C, Hovav
            AH, Krebs C, Prinz I and Ravens S.
  TITLE     Single-Cell Transcriptomics Identifies the Adaptation of Scart1+
            Vgamma6+ T Cells to Skin Residency as Activated Effector Cells
  JOURNAL   Cell Rep 27 (12), 3657-3671 (2019)
   PUBMED   31216482
REFERENCE   2  (bases 1 to 764)
  AUTHORS   Mensink M, Anstee NS, Robati M, Schenk RL, Herold MJ, Cory S and
            Vandenberg CJ.
  TITLE     Anti-apoptotic A1 is not essential for lymphoma development in
            Emicro-Myc mice but helps sustain transplanted Emicro-Myc tumour
            cells
  JOURNAL   Cell Death Differ 25 (4), 797-808 (2018)
   PUBMED   29339775
REFERENCE   3  (bases 1 to 764)
  AUTHORS   Carrington EM, Zhan Y, Brady JL, Zhang JG, Sutherland RM, Anstee
            NS, Schenk RL, Vikstrom IB, Delconte RB, Segal D, Huntington ND,
            Bouillet P, Tarlinton DM, Huang DC, Strasser A, Cory S, Herold MJ
            and Lew AM.
  TITLE     Anti-apoptotic proteins BCL-2, MCL-1 and A1 summate collectively to
            maintain survival of immune cell populations both in vitro and in
            vivo
  JOURNAL   Cell Death Differ 24 (5), 878-888 (2017)
   PUBMED   28362427
REFERENCE   4  (bases 1 to 764)
  AUTHORS   Schenk RL, Tuzlak S, Carrington EM, Zhan Y, Heinzel S, Teh CE, Gray
            DH, Tai L, Lew AM, Villunger A, Strasser A and Herold MJ.
  TITLE     Characterisation of mice lacking all functional isoforms of the
            pro-survival BCL-2 family member A1 reveals minor defects in the
            haematopoietic compartment
  JOURNAL   Cell Death Differ 24 (3), 534-545 (2017)
   PUBMED   28085150
REFERENCE   5  (bases 1 to 764)
  AUTHORS   Sochalska M, Tuzlak S, Egle A and Villunger A.
  TITLE     Lessons from gain- and loss-of-function models of pro-survival Bcl2
            family proteins: implications for targeted therapy
  JOURNAL   FEBS J 282 (5), 834-849 (2015)
   PUBMED   25559680
  REMARK    Review article
REFERENCE   6  (bases 1 to 764)
  AUTHORS   Mandal M, Borowski C, Palomero T, Ferrando AA, Oberdoerffer P, Meng
            F, Ruiz-Vela A, Ciofani M, Zuniga-Pflucker JC, Screpanti I, Look
            AT, Korsmeyer SJ, Rajewsky K, von Boehmer H and Aifantis I.
  TITLE     The BCL2A1 gene as a pre-T cell receptor-induced regulator of
            thymocyte survival
  JOURNAL   J Exp Med 201 (4), 603-614 (2005)
   PUBMED   15728238
REFERENCE   7  (bases 1 to 764)
  AUTHORS   Nishimura M, Yokoi N, Miki T, Horikawa Y, Yoshioka H, Takeda J,
            Ohara O and Seino S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   8  (bases 1 to 764)
  AUTHORS   Hatakeyama S, Hamasaki A, Negishi I, Loh DY, Sendo F, Nakayama K
            and Nakayama K.
  TITLE     Multiple gene duplication and expression of mouse bcl-2-related
            genes, A1
  JOURNAL   Int Immunol 10 (5), 631-637 (1998)
   PUBMED   9645611
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT030686.6 and BC100462.1.
            
            On Oct 3, 2009 this sequence version replaced NM_007534.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC116241.1, AK138369.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                CT030686.6         161796-161818
            24-751              BC100462.1         1-728
            752-764             CT030686.6         170349-170361
FEATURES             Location/Qualifiers
     source          1..764
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 47.24 cM"
     gene            1..764
                     /gene="Bcl2a1b"
                     /gene_synonym="A1-b"
                     /note="B cell leukemia/lymphoma 2 related protein A1b"
                     /db_xref="GeneID:12045"
                     /db_xref="MGI:MGI:1278326"
     exon            1..507
                     /gene="Bcl2a1b"
                     /gene_synonym="A1-b"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..606
                     /gene="Bcl2a1b"
                     /gene_synonym="A1-b"
                     /note="anti-apoptotic protein A1-b"
                     /codon_start=1
                     /product="B-cell leukemia/lymphoma 2 related protein A1b"
                     /protein_id="NP_031560.2"
                     /db_xref="CCDS:CCDS23393.1"
                     /db_xref="GeneID:12045"
                     /db_xref="MGI:MGI:1278326"
                     /translation="MAEYEFMYIHSLAEHYLQYVLQVPAFESAPSKACRVLQRVAFSV
                     QKEVEKNLKSYLDDFHVESIDTARIIFNQVMEKEFEDGIINWGRIVTIFAFGGVLLKK
                     LPQEQIALDVGAYKQVSSFVAEFIINNTGEWIRRNGGWEDGFIKKFEPKSGWLTFLQM
                     TGQFWEMLFLLK"
     exon            508..764
                     /gene="Bcl2a1b"
                     /gene_synonym="A1-b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggttcctcc cctgacaaga cctatctttg cagtctttgc ctccttggcc tctaggtggg
       61 cagcagcagt cagctctgcc agggaagatg gctgagtacg agttcatgta tatccactcc
      121 ctggctgagc actatcttca gtatgtgcta caggtacccg cctttgagtc ggctccaagc
      181 aaagcatgca gagtgctaca aagagttgct ttctccgttc agaaggaagt tgaaaagaat
      241 ctgaagtcat acttggatga ctttcacgtg gaatccatag ataccgccag aataatattc
      301 aaccaagtga tggaaaaaga gtttgaagat ggcatcatta actggggaag gattgtgact
      361 atatttgcct ttgggggtgt tctcctcaaa aaacttccgc aagagcagat tgccctggat
      421 gtaggtgctt acaaacaagt ttccagtttt gtggcagaat tcataatcaa taacacagga
      481 gaatggatac ggcggaatgg aggttgggaa gatggcttca taaagaagtt tgaacccaaa
      541 tctggctggc tgacttttct gcagatgaca ggacagttct gggaaatgct ctttctcctc
      601 aagtaacact acggaccaga gagaaccttg gctcccacga gaatggttat cagcacttgg
      661 catttccatt tacaaacatg aaacttgtct ttccagagtt gcagatattt tgtttcaact
      721 ttaatgaata aattactagt atttgtttct gtacatgttt catg
//
