LOCUS       NM_009741               7209 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus B cell leukemia/lymphoma 2 (Bcl2), transcript variant
            1, mRNA.
ACCESSION   NM_009741 XM_001476583
VERSION     NM_009741.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7209)
  AUTHORS   Jasmine, Baraiya,D.H., Kavya,T.T., Mandal,A., Chakraborty,S.,
            Sathish,N., Francis,C.M.R. and Binoy Joseph,D.
  TITLE     Epithelial and mesenchymal compartments of the developing bladder
            and urethra display spatially distinct gene expression patterns
  JOURNAL   Dev Biol 520, 155-170 (2025)
   PUBMED   39798644
REFERENCE   2  (bases 1 to 7209)
  AUTHORS   Song,C., Chen,Q., Xu,J., He,K., Guo,Q., Teng,X., Xue,H., Xiao,L.,
            Tian,D., Jin,S., An,C. and Wu,Y.
  TITLE     H2S alleviated sepsis-induced acute kidney injury by inhibiting
            PERK/Bax-Bcl2 pathway
  JOURNAL   Nitric Oxide 152, 11-18 (2024)
   PUBMED   39271041
  REMARK    GeneRIF: H2S alleviated sepsis-induced acute kidney injury by
            inhibiting PERK/Bax-Bcl2 pathway.
REFERENCE   3  (bases 1 to 7209)
  AUTHORS   Luo,X., Zhang,D., Zheng,J., Liu,H., Sun,L., Guo,H., Wang,L. and
            Cui,S.
  TITLE     Casein kinase 1alpha mediates estradiol secretion via CYP19A1
            expression in mouse ovarian granulosa cells
  JOURNAL   BMC Biol 22 (1), 176 (2024)
   PUBMED   39183304
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7209)
  AUTHORS   Chen,D.F., Schneider,G.E., Martinou,J.C. and Tonegawa,S.
  TITLE     Bcl-2 promotes regeneration of severed axons in mammalian CNS
  JOURNAL   Nature 385 (6615), 434-439 (1997)
   PUBMED   9009190
REFERENCE   5  (bases 1 to 7209)
  AUTHORS   Nakayama,K., Nakayama,K., Negishi,I., Kuida,K., Shinkai,Y.,
            Louie,M.C., Fields,L.E., Lucas,P.J., Stewart,V., Alt,F.W. et al.
  TITLE     Disappearance of the lymphoid system in Bcl-2 homozygous mutant
            chimeric mice
  JOURNAL   Science 261 (5128), 1584-1588 (1993)
   PUBMED   8372353
REFERENCE   6  (bases 1 to 7209)
  AUTHORS   Chin,H., Krall,M., Kim,H.L., Kozak,C.A. and Mock,B.
  TITLE     The gene for the alpha 1 subunit of the skeletal muscle
            dihydropyridine-sensitive calcium channel (Cchl1a3) maps to mouse
            chromosome 1
  JOURNAL   Genomics 14 (4), 1089-1091 (1992)
   PUBMED   1335956
REFERENCE   7  (bases 1 to 7209)
  AUTHORS   Acton,D., Domen,J., Jacobs,H., Vlaar,M., Korsmeyer,S. and Berns,A.
  TITLE     Collaboration of pim-1 and bcl-2 in lymphomagenesis
  JOURNAL   Curr Top Microbiol Immunol 182, 293-298 (1992)
   PUBMED   1337029
REFERENCE   8  (bases 1 to 7209)
  AUTHORS   Sentman,C.L., Shutter,J.R., Hockenbery,D., Kanagawa,O. and
            Korsmeyer,S.J.
  TITLE     bcl-2 inhibits multiple forms of apoptosis but not negative
            selection in thymocytes
  JOURNAL   Cell 67 (5), 879-888 (1991)
   PUBMED   1835668
REFERENCE   9  (bases 1 to 7209)
  AUTHORS   Copeland,N.G., Silan,C.M., Kingsley,D.M., Jenkins,N.A.,
            Cannizzaro,L.A., Croce,C.M., Huebner,K. and Sims,J.E.
  TITLE     Chromosomal location of murine and human IL-1 receptor genes
  JOURNAL   Genomics 9 (1), 44-50 (1991)
   PUBMED   1672292
REFERENCE   10 (bases 1 to 7209)
  AUTHORS   Strasser,A., Harris,A.W., Bath,M.L. and Cory,S.
  TITLE     Novel primitive lymphoid tumours induced in transgenic mice by
            cooperation between myc and bcl-2
  JOURNAL   Nature 348 (6299), 331-333 (1990)
   PUBMED   2250704
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC122842.3, BC095964.1 and
            AC162916.3.
            
            On Sep 23, 2015 this sequence version replaced NM_009741.4.
            
            Summary: This gene encodes a member of the B cell lymphoma 2
            protein family. Members of this family regulate cell death in
            multiple cell types and can have either proapoptotic or
            antiapoptotic activities. The protein encoded by this gene inhibits
            mitochondrial-mediated apoptosis. This protein is an integral outer
            mitochondrial membrane protein that functions as part of signaling
            pathway that controls mitochondrial permeability in response to
            apoptotic stimuli. This protein may also play a role in neuron cell
            survival and autophagy. Abnormal expression and chromosomal
            translocations of this gene are associated with cancer progression
            in numerous tissues. Alternate splicing results in multiple
            transcript variants. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (isoform 1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC095964.1, AK049473.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1339              AC122842.3         120977-122315       c
            1340-3667           BC095964.1         996-3323
            3668-7209           AC162916.3         134829-138370       c
FEATURES             Location/Qualifiers
     source          1..7209
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 49.76 cM"
     gene            1..7209
                     /gene="Bcl2"
                     /gene_synonym="Bcl-2; C430015F12Rik; D630044D05Rik;
                     D830018M01Rik"
                     /note="B cell leukemia/lymphoma 2"
                     /db_xref="GeneID:12043"
                     /db_xref="MGI:MGI:88138"
     exon            1..1986
                     /gene="Bcl2"
                     /gene_synonym="Bcl-2; C430015F12Rik; D630044D05Rik;
                     D830018M01Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             1411..2121
                     /gene="Bcl2"
                     /gene_synonym="Bcl-2; C430015F12Rik; D630044D05Rik;
                     D830018M01Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     apoptosis regulator Bcl-2"
                     /codon_start=1
                     /product="apoptosis regulator Bcl-2 isoform 1"
                     /protein_id="NP_033871.2"
                     /db_xref="CCDS:CCDS15209.1"
                     /db_xref="GeneID:12043"
                     /db_xref="MGI:MGI:88138"
                     /translation="MAQAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDADAAPLGAAP
                     TPGIFSFQPESNPMPAVHRDMAARTSPLRPLVATAGPALSPVPPVVHLTLRRAGDDFS
                     RRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVN
                     REMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLL
                     SLALVGACITLGAYLGHK"
     exon            1987..7209
                     /gene="Bcl2"
                     /gene_synonym="Bcl-2; C430015F12Rik; D630044D05Rik;
                     D830018M01Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7182..7187
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bcl2"
                     /gene_synonym="Bcl-2; C430015F12Rik; D630044D05Rik;
                     D830018M01Rik"
                     /note="hexamer: AATAAA"
     polyA_site      7207
                     /gene="Bcl2"
                     /gene_synonym="Bcl-2; C430015F12Rik; D630044D05Rik;
                     D830018M01Rik"
                     /note="major polyA site"
ORIGIN      
        1 gtccgggtcc ccgccgagcc gccgccgcca acaccgaggt gcccaggccc tccccagccg
       61 cagccgtcac cgtggaacgg gctgcgcggc gcaagcacga ggaggcggcc gccagcgccg
      121 cccgcagcgg aggaggagaa agggtgcgca gcccggaggc ggggtgcgcc ggtggggtgc
      181 agcggaagag gggaccaggg ggggacttcg tagcagtcat cctttttagg aaaaagaggg
      241 ggggcaaacc ctcccccacc acctccttct cccgcagcgc accacacaca gtgcgcgggc
      301 tgctccttgg gcacccgcgg ccccagcgcg tccgtgcctg catttagcaa gctgcttttt
      361 ttcccgtttc ggaaagcgcg ttggcccttc ggagtttaat cagaagagga ttccggtccc
      421 ggtcccccag ctcctccatc gtccccttgg cgtgtctctc tgccctggag gtctgaagcg
      481 gtccggtgga tacggatcca tgcctgcgct ccagcgtgtg tgtgcaagtg taaattgccg
      541 agaagaaggg agaatcacag gacttctgca aatgctggac tgaaaaattg taattcatct
      601 gccgccgccg ccgctgcctt tttgccccgc tgcggtgctc ttgagatctc tggttgggat
      661 tcctacggat tgacattctc agtgaagccg gagtgtgagg acccaatctg gaaaccctcc
      721 tgatttttcc tccacctagc ccccagaccc caactcccga ttcattgcaa gttgtaaaga
      781 agcttataca aggagacttc tgaagatcga tggtgtggtt gccttatgta tttgtttggg
      841 ttttaccaaa aaagggtaaa cttgacagaa gatcatgccg tccttagaaa atacagtaag
      901 ttctttgcac aggaattttg tttaatataa ctttccatgg acgcgtttga aatatttttt
      961 tacttcaagt gcattcaagc aaatttcatt tccagacagt ttaatgcatt tttaaacgtg
     1021 taacttgtag cggatatacc tttcttaccc taaatatata aaggaaaaca cacctgattt
     1081 taacttccta ggtcgtcccg cctcttcacc tttcagcatt gcggaggaag tagactgata
     1141 ttaacaaagc ttaataaata atgtacctca tgaaataaaa agcagaaagg aatttgaata
     1201 aaaatttcct gcatctcatg ccaacgggga aacaccagaa tcaagtgttc ggtgtaacta
     1261 aagacacccc ttcatccaag aatgcaaagc acatccaata aaagagctgg attataacta
     1321 ttcttttttt tttttttttc tttcggggcc gtggggcggg agtcgggact tgaagtgcca
     1381 ttggtacctg cagcttcttt tcggggaagg atggcgcaag ccgggagaac agggtatgat
     1441 aaccgggaga tcgtgatgaa gtacatacat tataagctgt cacagagggg ctacgagtgg
     1501 gatgctggag atgcggacgc ggcgcccctg ggggctgccc ccacccctgg catcttctcc
     1561 ttccagcctg agagcaaccc aatgcccgct gtgcaccggg acatggctgc caggacgtct
     1621 cctctcaggc ccctcgttgc caccgctggg cctgcgctca gccctgtgcc acctgtggtc
     1681 catctgaccc tccgccgggc tggggatgac ttctctcgtc gctaccgtcg tgacttcgca
     1741 gagatgtcca gtcagctgca cctgacgccc ttcaccgcga ggggacgctt tgccacggtg
     1801 gtggaggaac tcttcaggga tggggtgaac tgggggagga ttgtggcctt ctttgagttc
     1861 ggtggggtca tgtgtgtgga gagcgtcaac agggagatgt cacccctggt ggacaacatc
     1921 gccctgtgga tgactgagta cctgaaccgg catctgcaca cctggatcca ggataacgga
     1981 ggctgggatg cctttgtgga actatatggc cccagcatgc gacctctgtt tgatttctcc
     2041 tggctgtctc tgaagaccct gctcagcctg gccctggtcg gggcctgcat cactctgggt
     2101 gcatacctgg gccacaagtg aggtcgacaa acctgcccca aacaaatatg caaaaggttc
     2161 actaaagcag tagaaattat atgcattatc aatgatgtac catgaaacaa agttgtgatc
     2221 tttttttaaa gcagaacaca cacacacaca cacacacaca cacacacaca cacacacaca
     2281 cacacacaca ttcaggcaaa tggtcgaatc agctatttac tgccaaaggg aaatatcatt
     2341 tattttttac attatttagg aaaaaaaaga tttatttatt taagacagtt ccaccgaaac
     2401 tccaggcttt gaaaaccgaa ccaggaattg ccaagaaacg tgtggctcca cctgctggcc
     2461 tgtgcctgtg gtcatggatc tgttttcaat attggccaaa ctggcccacc atctaaagag
     2521 caagtggcac aggaccctga cggctgggga agcctgcagt ctggctgcta gaagctttga
     2581 agaaggcttc aatgtgatct ctatatactg gccctggggg ccaggatgct agaaggagca
     2641 ggtgcctaca agaaagcctg gtcttccatg gactggagaa gggacttttg tatatgactc
     2701 acatggtaca tacccagtca gaggacaaag gctggaaact tcagatgaac ttggtaccca
     2761 ctgagacttc cctgctgaaa gacagtggtg ggaaaatgcc cttaatcata ggaaattatt
     2821 tttttaagct accaattgtg ccgagaagca ttttagcagt ttatacaata tcatccagta
     2881 ccttaagccc tgactgtaga taatcatata ttttggatac gcacaccccc tcctccaata
     2941 ctcactctgt ctgaggagga aacaaaggct tctggattcc aggaagtgga tgtgtgacga
     3001 cttcttcagc atcaggaaga atggggtcac ctagcgcttc aggcagccac aagtgcctgc
     3061 tttatggaga ccaacatctg cagaacctcc ctgtggctca gcaacttggc ctgggcagcc
     3121 tgccctgagt gtggccctca ccagcctcct caccgggttt ggaacagagc agctggtctc
     3181 tgagctcaga cttacccagt aagaaagagc aatataatag agactcacca gggtctgcta
     3241 ccctcaggcc ctccaggctg ggcctgtctg gagcaggaga actgctcttt ctaagacact
     3301 tgccactgta gagaggagaa cgcaggtagt gcccatcctg cctgagggca tagtgaaggc
     3361 aggaagacca ccacacagaa gaagaagccc ggcggagctt taggtggcca caggtacctg
     3421 ctggcagtgc tgtcacattt aaggcaaggc tttaagttac tttggccaaa aatcctaagg
     3481 aggcagtgaa gcgaggctca cggagtcgat gacccgtgtc tatggattta catgtaaaac
     3541 attatcttgt agtttggttc tatttgaaaa tctgacagag agagagaata aaaagtttca
     3601 ggaatgtatg gaatgtggag attatctata catcctgggg ccaaaaaaaa aaaaaaaaaa
     3661 aaaaaaagat ggtatattat ggaggaataa caaaagaagt gatgaaattt ccagctaatg
     3721 aaaggggaac cactttttcc ccaagttcag aattagcatg ggggtatttg tggaattacc
     3781 tttggggcat tatcacaccc tgtaccattc atctgtatta acgttggaat gtacttcact
     3841 caatgtttat tgctgtggtt gatatttcaa aagctgcttt caaaaagaat ccatgcatct
     3901 cagcattgtt taaattgtat ttagttatga cctctagaat gtttgttagt cacacaaaca
     3961 gaaaaagata ctttttccat ttgaggtatt tgtctcttga ttcttcaaaa gcatttctga
     4021 aaaggtggga acagctttag agagatgcga ggaaccgatg gagctgggct tgcctgttcc
     4081 ctccgctgtg ctgttggagc ctacccctct gccgggacag accctgggat tgcttatcat
     4141 gatggatata gctgttgccc actcgacctt gtttcttcca ggtttacttg tccctggacg
     4201 attcagcatt taactcaagt tacctaggat ttcatgcatg tttggttaaa cccatgatgt
     4261 tcattcactt agaaatccag atgggaagca gagcaagggg ttaggacctg gctctagcag
     4321 ctgggccttc agagggttgc tttgtgtggc ctgttgggca tagatgtgtc aggactcctc
     4381 ttatcccctg tcccccaggc ctgcctccct gtgcagagag agagagaaca agggagagag
     4441 caggagagcc agaactcccc agtaggtctc agagaacagg atgatcagaa cttttcaagt
     4501 tattctagtt tttaagcgaa atattatcct gtgaaaggtt tacattctcc acgcgatgaa
     4561 tatggaataa gaaaccctgt gctgctatcc tgccaagatc attgtaatgg aggagtcggt
     4621 ttgcagtaca caccaagtga ccggctcctt caagctgctt cttgaagtaa cgatgaagaa
     4681 cacagacatt tattttaaat ataaaacctg tttctctttt gtttttgttg ctattgttca
     4741 aacttggatt tgtagagtat ttgaaaaaaa tgtatataca tttaaaagaa gaagcagcag
     4801 cagctcatag gagtccttca ggtgtgggat tttgttttct gatttgaatg gcaaattctc
     4861 caagtccctg gaccctagaa ctggacagta ttgtggctgc atttgctcta aaagtagttg
     4921 gtgatgcaat tttttttctt gttaaaaaca tgttagaagc aaagagtata catagaatct
     4981 gacttgacta gcctttttct tcctcttttt ttttaataac ctcaattatt ttgcaatcag
     5041 acaacagaga gccatctgca tgtagttcat atttcagaag ggcttcacac ccaaatctca
     5101 cctcctctgt aagctttgaa atctctccat caatcaaagc caagcagacg tagaagtggg
     5161 ctgagagact cagagagagc catcgagaag agcagcccaa tgccctccag agccccagta
     5221 cccgcccagg ctctctgaga gatggcaaaa aaaacagaga ggttgatctt cagtgattcc
     5281 tcagggcctg aacttgcgtg aaggcttgag atgtccatga gagccacagt taagggagca
     5341 ctttcatgta gttcaagtaa aaccctccat cctgtccagc tcgcttgtct ctggatgttt
     5401 gggtgtggcc tttattcata catacataca ttttttccac aggcatattc ttatttatta
     5461 catctaagag cattgctggg tctaggaaag ggggaagcag ggtttaggaa gtgctcataa
     5521 gccaggaggg attataataa tcaggactga atgtagataa tgggtggcag tacccacatg
     5581 tgtaggtccc acactgaata gaataggcag aattgtgaat agcccgtgtt tgtaatggag
     5641 cctagactaa aacaactcat aaatgtgagc ttcaactcta actgtgcttt gaaggtgatg
     5701 ggtgtctcta tacttcctta tcagttacag ttagaaatgt acacctaccc tatcaggaaa
     5761 aaataacagg aaaaggttga aatataagcc agtctaagga aattagggag ccactaaagt
     5821 tctcttctga gcttatacta tggtctctat tgcagctcag acaaatatga tcacacactt
     5881 tttaagaaat acaattctcc attgtcgggc ccatgaaggc tctgatctga tctgtattgt
     5941 tgcccaattt gggtctttca gggatttttc tatgccatta ttatagggac aaaggacact
     6001 tgttatgagg tgggagagat gaagaattct tacatgagta gaacatttcc tagattgggc
     6061 cagggtgtga aggtcttcag caaaatcaag gctgtgagaa gtgagggacc tttatggggg
     6121 tcaaagttat gttcgcctga ggactttttg caagaagcaa ggaagctcta tggtacattt
     6181 atactccagg gacattgacc tagttcaaag tctggcttaa tatggtcaag caatagcata
     6241 tgtttcaagt tggatatggc taatgagtgt ttaaacagta agtttgacat tttaaccaac
     6301 agggtattta aacaacaact ttccagttgg tagggacatc tgtttctctc tgtttattat
     6361 acacaacata gaaaaaattc aataagattg aattaagtaa aacattgtga gactgagtta
     6421 ggtaaacgat tgtggcagtc ccttagcctt ggccagggaa ttattcaatc cgctatagac
     6481 atctgtgcac tgtgcatctc tccaggcatg aagaaaacca ggtagagggc agatggcacc
     6541 tgagcacttc atcctggata tctaagaaga ataacataaa gccagtgttc catgcaccaa
     6601 gtccagtaca gaagacaaaa agagtcacag aagatggaaa agctagctaa tcagaaatcc
     6661 tgggaatgtt aagtgtgccg gccatgtggc tatgcggcaa tgcctgtacc ttcccacttg
     6721 ggaacctgca gtgggccctc cagctggctc ccttcatgaa atcctcccct ccgagataac
     6781 atctgaagga ttgatggcag attcagtttc cattaggaga tattttcctt tggagacagg
     6841 ggttctctat taaaatatct tcttaggttt tcagctaaac tttgctttgg cttcagctat
     6901 agtggggttc tttctaagta aagtaatgtt caaataagtg ttttgtattg gaagctttgt
     6961 tatcaagatt ttcatactta tatccatggg ctgcttttaa ggttgatact tttaggcgtg
     7021 gctgatgcct atagcactgt acatacaaga aatatataag tgtatttggc atacttaagg
     7081 taaaataagt ctccagttgg ctactgttac atataatggc tctttgtttg tgttgttaga
     7141 aaacattaca ttgccattaa ctccccatgt ctgtctgaaa aaataaaata aaatacagtg
     7201 agcagcacc
//
