LOCUS       NM_001242934            6122 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus BCL11 transcription factor A (Bcl11a), transcript
            variant 4, mRNA.
ACCESSION   NM_001242934
VERSION     NM_001242934.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6122)
  AUTHORS   Clemot-Dupont,S., Lourenco Fernandes,J.A., Larrigan,S., Sun,X.,
            Medisetti,S., Stanley,R., El Hankouri,Z., Joshi,S.V.,
            Picketts,D.J., Shekhar,K. and Mattar,P.
  TITLE     The chromatin remodeler ADNP regulates neurodevelopmental disorder
            risk genes and neocortical neurogenesis
  JOURNAL   Proc Natl Acad Sci U S A 122 (3), e2405981122 (2025)
   PUBMED   39808658
REFERENCE   2  (bases 1 to 6122)
  AUTHORS   Greig,L.C., Woodworth,M.B., Poulopoulos,A., Lim,S. and Macklis,J.D.
  TITLE     BEAM: A combinatorial recombinase toolbox for binary gene
            expression and mosaic genetic analysis
  JOURNAL   Cell Rep 43 (8), 114650 (2024)
   PUBMED   39159043
REFERENCE   3  (bases 1 to 6122)
  AUTHORS   Tan,R.L., Sciandra,F., Hubner,W., Bozzi,M., Reimann,J., Schoch,S.,
            Brancaccio,A. and Blaess,S.
  TITLE     The missense mutation C667F in murine beta-dystroglycan causes
            embryonic lethality, myopathy and blood-brain barrier
            destabilization
  JOURNAL   Dis Model Mech 17 (6) (2024)
   PUBMED   38616731
REFERENCE   4  (bases 1 to 6122)
  AUTHORS   Zheng,G. and Orkin,S.H.
  TITLE     Transcriptional Repressor BCL11A in Erythroid Cells
  JOURNAL   Adv Exp Med Biol 1459, 199-215 (2024)
   PUBMED   39017845
  REMARK    GeneRIF: Transcriptional Repressor BCL11A in Erythroid Cells.
            Review article
REFERENCE   5  (bases 1 to 6122)
  AUTHORS   Simbula,M., Manchinu,M.F., Mingoia,M., Pala,M., Asunis,I.,
            Caria,C.A., Perseu,L., Shah,M., Crossley,M., Moi,P. and
            Ristaldi,M.S.
  TITLE     miR-365-3p mediates BCL11A and SOX6 erythroid-specific
            coregulation: A new player in HbF activation
  JOURNAL   Mol Ther Nucleic Acids 34, 102025 (2023)
   PUBMED   37744176
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6122)
  AUTHORS   Liu,P., Jenkins,N.A. and Copeland,N.G.
  TITLE     A highly efficient recombineering-based method for generating
            conditional knockout mutations
  JOURNAL   Genome Res 13 (3), 476-484 (2003)
   PUBMED   12618378
REFERENCE   7  (bases 1 to 6122)
  AUTHORS   Saiki,Y., Yamazaki,Y., Yoshida,M., Katoh,O. and Nakamura,T.
  TITLE     Human EVI9, a homologue of the mouse myeloid leukemia gene, is
            expressed in the hematopoietic progenitors and down-regulated
            during myeloid differentiation of HL60 cells
  JOURNAL   Genomics 70 (3), 387-391 (2000)
   PUBMED   11161790
REFERENCE   8  (bases 1 to 6122)
  AUTHORS   Nakamura,T., Yamazaki,Y., Saiki,Y., Moriyama,M., Largaespada,D.A.,
            Jenkins,N.A. and Copeland,N.G.
  TITLE     Evi9 encodes a novel zinc finger protein that physically interacts
            with BCL6, a known human B-cell proto-oncogene product
  JOURNAL   Mol Cell Biol 20 (9), 3178-3186 (2000)
   PUBMED   10757802
REFERENCE   9  (bases 1 to 6122)
  AUTHORS   Avram,D., Fields,A., Pretty On Top,K., Nevrivy,D.J., Ishmael,J.E.
            and Leid,M.
  TITLE     Isolation of a novel family of C(2)H(2) zinc finger proteins
            implicated in transcriptional repression mediated by chicken
            ovalbumin upstream promoter transcription factor (COUP-TF) orphan
            nuclear receptors
  JOURNAL   J Biol Chem 275 (14), 10315-10322 (2000)
   PUBMED   10744719
REFERENCE   10 (bases 1 to 6122)
  AUTHORS   Nakamura,T., Largaespada,D.A., Shaughnessy,J.D. Jr., Jenkins,N.A.
            and Copeland,N.G.
  TITLE     Cooperative activation of Hoxa and Pbx1-related genes in murine
            myeloid leukaemias
  JOURNAL   Nat Genet 12 (2), 149-153 (1996)
   PUBMED   8563752
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY735002.1, BB649527.1, AK045556.1, AK140949.1, CB524780.1,
            BB662872.1, CD355476.1, AK164574.1 and BF731393.1.
            
            Transcript Variant: This variant (4) represents the longest
            transcript and encodes the longest protein (isoform 4).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK140949.1, SRR1660817.417638.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                BY735002.1         2-58
            58-485              BB649527.1         1-428
            486-965             AK045556.1         142-621
            966-3055            AK140949.1         911-3000
            3056-3563           CB524780.1         66-573
            3564-4830           AK140949.1         3508-4774
            4831-5315           BB662872.1         88-572
            5316-5612           CD355476.1         49-345
            5613-6085           AK164574.1         568-1040
            6086-6122           BF731393.1         1-37                c
FEATURES             Location/Qualifiers
     source          1..6122
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 14.41 cM"
     gene            1..6122
                     /gene="Bcl11a"
                     /gene_synonym="2810047E18Rik; BCL-11A; Ctip1;
                     D930021L15Rik; Evi9; Evi9a; Evi9b; Evi9c; mKIAA1809"
                     /note="BCL11 transcription factor A"
                     /db_xref="GeneID:14025"
                     /db_xref="MGI:MGI:106190"
     exon            1..390
                     /gene="Bcl11a"
                     /gene_synonym="2810047E18Rik; BCL-11A; Ctip1;
                     D930021L15Rik; Evi9; Evi9a; Evi9b; Evi9c; mKIAA1809"
                     /inference="alignment:Splign:2.1.0"
     CDS             336..2843
                     /gene="Bcl11a"
                     /gene_synonym="2810047E18Rik; BCL-11A; Ctip1;
                     D930021L15Rik; Evi9; Evi9a; Evi9b; Evi9c; mKIAA1809"
                     /note="isoform 4 is encoded by transcript variant 4;
                     COUP-TF interacting protein 1; B-cell lymphoma/leukemia
                     11A; EVI-9; B cell CLL/lymphoma 11A (zinc finger protein);
                     ecotropic viral integration site 9 protein; myeloid
                     leukemia; B-cell CLL/lymphoma 11A"
                     /codon_start=1
                     /product="B-cell lymphoma/leukemia 11A isoform 4"
                     /protein_id="NP_001229863.1"
                     /db_xref="CCDS:CCDS56764.1"
                     /db_xref="GeneID:14025"
                     /db_xref="MGI:MGI:106190"
                     /translation="MSRRKQGKPQHLSKREFSPEPLEAILTDDEPDHGPLGAPEGDHD
                     LLTCGQCQMNFPLGDILIFIEHKRKQCNGSLCLEKGVDKPPSPSPIEMKKASNPVEVG
                     IQVTPEDDDCLSTSSRGICPKQEHIADKLLHWRGLSSPRSAHGALIPTPGMSAEYAPQ
                     GICKDEPSSYTCTTCKQPFTSAWFLLQHAQNTHGLRIYLESEHGSPLTPRVGIPSGLG
                     AECPSQPPLHGIHIADNNPFNLLRIPGSVSREASGLAEGRFPPTPPLFSPPPRHHLDP
                     HRIERLGAEEMALATHHPSAFDRVLRLNPMAMEPPAMDFSRRLRELAGNTSSPPLSPG
                     RPSPMQRLLQPFQPGSKPPFLATPPLPPLQSAPPPSQPPVKSKSCEFCGKTFKFQSNL
                     VVHRRSHTGEKPYKCNLCDHACTQASKLKRHMKTHMHKSSPMTVKSDDGLSTASSPEP
                     GTSDLVGSASSALKSVVAKFKSENDPNLIPENGDEEEEEDDEEEEEEEEEEEEELTES
                     ERVDYGFGLSLEAARHHENSSRGAVVGVGDEGRALPDVMQGMVLSSMQHFSEAFHQVL
                     GEKHKRSHLAEAEGHRDTCDEDSVAGESDRIDDGTVNGRGCSPGESASGGLSKKLLLG
                     SPSSLSPFSKRIKLEKEFDLPPAAMPNTENVYSQWLAGYAASRQLKDPFLTFGDSRQS
                     PFASSSEHSSENGSLRFSTPPGELDGGISGRSGTGSGGSTPHISGPGPGRPSSKEGRR
                     SDTCEYCGKVFKNCSNLTVHRRSHTGERPYKCELCNYACAQSSKLTRHMKTHGQVGKD
                     VYKCEICKMPFSVYSTLEKHMKKWHSDRVLNNDIKTE"
     exon            391..720
                     /gene="Bcl11a"
                     /gene_synonym="2810047E18Rik; BCL-11A; Ctip1;
                     D930021L15Rik; Evi9; Evi9a; Evi9b; Evi9c; mKIAA1809"
                     /inference="alignment:Splign:2.1.0"
     exon            721..822
                     /gene="Bcl11a"
                     /gene_synonym="2810047E18Rik; BCL-11A; Ctip1;
                     D930021L15Rik; Evi9; Evi9a; Evi9b; Evi9c; mKIAA1809"
                     /inference="alignment:Splign:2.1.0"
     exon            823..6112
                     /gene="Bcl11a"
                     /gene_synonym="2810047E18Rik; BCL-11A; Ctip1;
                     D930021L15Rik; Evi9; Evi9a; Evi9b; Evi9c; mKIAA1809"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6092..6097
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bcl11a"
                     /gene_synonym="2810047E18Rik; BCL-11A; Ctip1;
                     D930021L15Rik; Evi9; Evi9a; Evi9b; Evi9c; mKIAA1809"
                     /note="hexamer: AATAAA"
     polyA_site      6112
                     /gene="Bcl11a"
                     /gene_synonym="2810047E18Rik; BCL-11A; Ctip1;
                     D930021L15Rik; Evi9; Evi9a; Evi9b; Evi9c; mKIAA1809"
                     /note="major polyA site"
ORIGIN      
        1 gacgttcaag ttcgcaggga cgtcacgtcc gcacttgaac ttgcagctca ggggggcttt
       61 tgccattttt ttcatctctc tctctccctc tatccctctt ctctcttcct ctctctcttt
      121 tttttcctta aaaaaaaaaa agccatgacg gctctcccac aattcatctt ccctgcgcca
      181 tctttgtatt atttctaatt tattttggat gtcaaaaggc actgatgaag atattttctc
      241 tggagtctcc ttctttctaa cccggctctc ccgatgtgaa ccgagccgtc gtccgcacgc
      301 cgccgccgcc gccgccgccc gccccgcagc ccaccatgtc tcgccgcaag caaggcaaac
      361 cccagcactt aagcaaacgg gaattctcgc ccgaacctct tgaagccatt cttacagatg
      421 atgaaccaga ccatggcccg ttgggagctc cagaagggga ccacgacctt ctcacctgtg
      481 ggcagtgcca gatgaatttc ccactggggg acattcttat ttttatcgag cacaaacgga
      541 aacaatgcaa tggcagcctc tgcttagaaa aaggtgtgga taagccgcct tccccttctc
      601 ccatcgagat gaaaaaggca tccaatcctg tggaggttgg catccaggtc acgccagagg
      661 atgacgattg tttatcaacg tcatctagag gaatttgccc caaacaggaa cacatagcag
      721 ataaacttct gcactggagg ggcctgtcct ctcctcggtc tgcacacgga gctctaatcc
      781 ccacgcccgg gatgagtgca gaatatgccc cgcagggtat ttgtaaagat gagcccagca
      841 gctacacatg tacaacttgc aaacagccat tcaccagtgc atggtttctc ttgcaacacg
      901 cacagaacac tcatggatta agaatctact tagaaagtga acacggaagt cccctgaccc
      961 cgcgggttgg tatcccttca ggactaggtg cagaatgtcc ttcccagcca cctctccatg
     1021 ggattcatat tgcagacaat aaccccttta acctgctaag aataccagga tcagtatcga
     1081 gagaggcttc cggcctggca gaagggcgct ttccacccac tccccccctg tttagtccac
     1141 caccgagaca tcacttggac ccccaccgca tagagcgcct gggggcggaa gagatggccc
     1201 tggccaccca tcacccgagt gcctttgaca gggtgctgcg gttgaatcca atggctatgg
     1261 agcctcccgc catggatttc tctaggagac ttagagagct ggcagggaac acgtctagtc
     1321 caccgctgtc cccaggccgg cccagtccta tgcaaaggtt actgcaacca ttccagccag
     1381 gtagcaagcc acccttcctg gcgacgcccc ccctccctcc tctgcaatcc gcccctcctc
     1441 cctcccaacc cccggtcaag tccaagtcat gcgagttctg cggcaagacg ttcaaatttc
     1501 agagcaactt ggtggttcac cgacgcagcc atactggtga gaagccctat aagtgcaacc
     1561 tgtgcgacca cgcgtgcaca caggccagca agctgaagcg tcacatgaag acacacatgc
     1621 acaaatcgtc ccccatgaca gtcaagtccg acgatggcct ctccacagcc agctccccgg
     1681 aacctggtac cagcgacctg gtgggcagcg ccagcagtgc gctcaagtca gtggtggcca
     1741 agttcaagag tgagaacgac cccaacttga tcccagagaa cggggatgag gaggaagagg
     1801 aggacgacga ggaagaagaa gaagaggagg aagaggagga ggaggagctg acggagagcg
     1861 agagggtgga ctacggcttc gggctgagcc tggaggctgc acgccaccat gagaacagct
     1921 ctcggggcgc agtggtgggc gtgggcgacg agggccgcgc cctgcccgat gtcatgcagg
     1981 gcatggtgct cagctccatg cagcacttca gcgaggcctt ccaccaggtc ctgggcgaaa
     2041 agcataagcg tagccacctg gccgaggccg agggccatag ggacacttgt gatgaagact
     2101 cggtggccgg tgagtcagac cgcatagacg atggcactgt taatggtcgt ggctgctccc
     2161 ccggcgaatc ggcttcgggg ggtctgtcca aaaagctgct gctgggtagc cccagctcgc
     2221 tgagcccctt ctccaagcgc atcaagctgg agaaggagtt tgacctgccc ccggccgcga
     2281 tgcctaacac ggagaacgtg tattcgcagt ggctcgctgg ctatgcggcc tccaggcagc
     2341 tcaaagatcc cttccttact ttcggagact ccagacaatc gccttttgcc tcctcatcag
     2401 agcactcctc ggagaacggg agcttgcgct tctccacacc gcccggggag ctggacggag
     2461 ggatctcagg gcgcagcggc acaggaagtg gagggagcac gccccatatt agtggtccgg
     2521 gcccgggcag gcccagctca aaagagggca gacgcagcga cacttgtgag tactgtggga
     2581 aagtcttcaa gaactgtagc aatctcactg tccacaggag aagccacacg ggcgaaaggc
     2641 cttataaatg cgagctgtgc aactatgcct gtgcccagag tagcaagctc accaggcaca
     2701 tgaaaacgca tggccaggtg gggaaggacg tttacaaatg tgaaatttgt aagatgcctt
     2761 ttagcgtgta cagtaccctg gagaaacaca tgaaaaaatg gcacagtgat cgagtgttga
     2821 ataatgatat aaaaactgaa tagaggtata ttaataccct ccctcactcc cacttgatgc
     2881 cccccttcca ccccttcccc attgtccttc cagccctact ccctgtagga tttttctagt
     2941 cccatgtgat caaacaaaca aacaaacaaa caacagaggt aatggaagct aagaatatga
     3001 atgagtgctt gtcaccagca cacctggttt tttgttttgt ttttcctttt ttttttcttt
     3061 ttcttcttct tttttttaaa ttttaaattc tttatgttct caccgtttga atgcatgttt
     3121 ggggcaatac tattgcattt tacgcaaact ttgagccttt ctcttgtgca ataatttaca
     3181 tgttgtgtat gtttttcccc ccttaactta gacagcatgt atggtatgtt acggctattt
     3241 taaattgtcc ctaattcatt atgagcaaac atgttgttgc tgtttccagt tccattctga
     3301 gagtgtgagg gagggagggt agaaaacaac gcatgctgca tacataattc tgtaatacag
     3361 atcatgtgca gctttatttt ataacacgag gagggaaacg gtgtctgggt tgactaaccc
     3421 tctgcagaca gagcagatag cagtgaaaaa aaggtgctaa atgtctgtct ctaaagggtt
     3481 acatgtatta attggagagg gaaaaaaggc cttgaattga caaattaaca gaagaacaag
     3541 tttattctat catttggctt ttaaaatgag tgccttggat ctattcaaac catgttgatg
     3601 gttttttttc tgcttgttat aaacttgtag tttaatctag cattgggtga ggtaataaac
     3661 tttaggacct agcatgtaat tctgtgttgt atttctcaca acaatggcta cctaaaaata
     3721 tgacccatta tgtcctagtt aatcattgat ttttgccttt aactttgtga acaaaactga
     3781 ttataccagt ataaaagcta ctttgctcct tgtgagagca taaaagaaat gggctgtttc
     3841 gcctaaagtt ttattttatt ttatttttaa atggttatca aattgaatgt gaaatgtgca
     3901 aaggccctgg aatgtgatga aatacattag caagaagttc atcttgtgac aatacttgtt
     3961 taaaatgatg catttaatga aattctggcg ccaaaagaag tagatccggc tctagttggt
     4021 tgttgagtgg acaataaaat gataaagccc tttagaggac atttgaaaga acaggctgat
     4081 atgatgagag agagagagag agacagaaaa cggtagtgat tggttagcac gatgtagtac
     4141 tgtttgccat ttgaaactag aacaggtgta taaggggcca gcgatacaat gatgattaac
     4201 tctgaagctc taagacttgc atttaatgtg acagtcttca aaaagaagag gaagaccttt
     4261 aagagcagca gtatctatgt ctgtgctccc tggaagttgt acttcatttc ttttccatac
     4321 actgtgtgct atttgtgtta acattgaaga ggatttgttt ttattttgtt ttattctttc
     4381 tttctttctt ttttcttcct tctttgtttt aagctagcat ctgccccagt tggtgttcaa
     4441 atagcacttg actctgccta tgatacctgt atcttttctc taatcagaga tacagaggtt
     4501 gagtataaaa taaacctgct cagataggac aattaagtgc actgtacagt tttcccagtt
     4561 tacaggtctt tattaaggga aacgttgcaa gaatgctgaa aacaattgaa cacaatctca
     4621 atgatgagca ttaaaaaata ataaaaaaaa acaagcaaac ctaaaaaaaa ctaagacaga
     4681 cgttgccagc cattgacttg actattgagc ttcctcactt ggatgcaaca ttgcaagcgc
     4741 tgtggatgga aacaacacac ttaacataga aacgaatgac tcctttgctt ctacagtgca
     4801 aggatttttg tacaaaactt ttttaagtat aaatgttaag aaaagaattt ttaaaaagac
     4861 acttcattat gtttaggggg gaacagcatt ttagggttcc attgtcttgg tggtgttaca
     4921 agacctgtta tccatttaaa aatggtagtg gaaattctat gccttggatc acacaccgct
     4981 cttcaggttg taaaaaaaaa tgaaaacaaa acaaaacaaa aaaaaaacat acatggggaa
     5041 aggtttaaga ttatatagta cttaaaaata ggaaaacgca cactcatgtt gattcctatg
     5101 ctaaaacaca gttatggtct tctttctgta tttctagaat ggtatttgaa ttaaatgttc
     5161 atctagtgtt aggcactata gtatttatat tgaagcttgt atttttaact gttgcttgtt
     5221 cactcaaaag gtatcaatgt acctttttgt tagtagaaaa aaaaagacag gctgccacag
     5281 tatatttttt taatttggca ggataatata gtgcaaatta tttgtatgct gagagagaga
     5341 gagagagaga gagagagaga gagagaggtg tgacattgta cagagaagcc atataatggc
     5401 ggtttgggga gcctgctaga atgtcacatg gatggctgtc ataggggttg tacatatcct
     5461 tttccccctt tcctgctgcc atgctgtacg cagcactgca agctaatagc gttggtttgt
     5521 tatgtagtgt gctttggccc ctcctccccg ctcacccgac attccagcat cttaccttca
     5581 tatgcagtaa aagaaagaaa gaaaaaaaaa aaggaaaaaa aaaacaacaa caatgttttg
     5641 cagttttttt cattgccaaa aactaaatgg tgctttatat ttagattgga gagaatttct
     5701 tatgcaaagc atattaaaga gaaagcccgc tttagtcaat acttttttgt aaatggcaat
     5761 gcagaatatt ttgttattgg ccttttctat tcctgtaatg aaagctgttt gtcgtaactt
     5821 gaaattttat cttttactat gggagtcact atttattatt gcttatatgc cctgttcaaa
     5881 acagaggcac ttaatttgat cttttatttt tctctgtttt tattattatt ttttttaatt
     5941 tggatgacca aaggtcattg caacctggct ttttactgta tttgtttctg gtctttgtta
     6001 agttctattg gaaaaaccac tgtctgtgtt tttttggcag ttgtctgcat taacctgttc
     6061 atacacccat tttgtccctt tattgaaaaa aaataaaaaa attaaagtac taaaaaaaaa
     6121 aa
//
