LOCUS       NM_009740               1959 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus B cell leukemia/lymphoma 10 (Bcl10), mRNA.
ACCESSION   NM_009740
VERSION     NM_009740.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1959)
  AUTHORS   Wang,B., Jiang,B., Li,G.W., Dong,F., Luo,Z., Cai,B., Wei,M.,
            Huang,J., Wang,K., Feng,X., Tong,F., Wang,S., Wang,Q., Han,Q.,
            Li,C., Zhang,X., Yang,L. and Bao,L.
  TITLE     Somatosensory neurons express specific sets of lincRNAs, and
            lincRNA CLAP promotes itch sensation in mice
  JOURNAL   EMBO Rep 24 (2), e54313 (2023)
   PUBMED   36524339
  REMARK    GeneRIF: Somatosensory neurons express specific sets of lincRNAs,
            and lincRNA CLAP promotes itch sensation in mice.
REFERENCE   2  (bases 1 to 1959)
  AUTHORS   Yang,D., Pei,G., Dong,S., Zhang,W., Deng,H., Zhao,X., Li,P. and
            Lin,X.
  TITLE     Bcl10 phosphorylation-dependent droplet-like condensation
            positively regulates DNA virus-induced innate immune signaling
  JOURNAL   Sci China Life Sci 66 (2), 283-297 (2023)
   PUBMED   36115893
  REMARK    GeneRIF: Bcl10 phosphorylation-dependent droplet-like condensation
            positively regulates DNA virus-induced innate immune signaling.
REFERENCE   3  (bases 1 to 1959)
  AUTHORS   Sugisawa,E., Kondo,T., Kumagai,Y., Kato,H., Takayama,Y.,
            Isohashi,K., Shimosegawa,E., Takemura,N., Hayashi,Y., Sasaki,T.,
            Martino,M.M., Tominaga,M. and Maruyama,K.
  TITLE     Nociceptor-derived Reg3gamma prevents endotoxic death by targeting
            kynurenine pathway in microglia
  JOURNAL   Cell Rep 38 (10), 110462 (2022)
   PUBMED   35263589
REFERENCE   4  (bases 1 to 1959)
  AUTHORS   Kurgyis,Z., Vornholz,L., Pechloff,K., Kemeny,L.V., Wartewig,T.,
            Muschaweckh,A., Joshi,A., Kranen,K., Hartjes,L., Mockel,S.,
            Steiger,K., Hameister,E., Volz,T., Mellett,M., French,L.E.,
            Biedermann,T., Korn,T. and Ruland,J.
  TITLE     Keratinocyte-intrinsic BCL10/MALT1 activity initiates and amplifies
            psoriasiform skin inflammation
  JOURNAL   Sci Immunol 6 (65), eabi4425 (2021)
   PUBMED   34826258
  REMARK    GeneRIF: Keratinocyte-intrinsic BCL10/MALT1 activity initiates and
            amplifies psoriasiform skin inflammation.
REFERENCE   5  (bases 1 to 1959)
  AUTHORS   Campanello,L., Traver,M.K., Shroff,H., Schaefer,B.C. and Losert,W.
  TITLE     Signaling through polymerization and degradation: Analysis and
            simulations of T cell activation mediated by Bcl10
  JOURNAL   PLoS Comput Biol 17 (5), e1007986 (2021)
   PUBMED   34014917
  REMARK    GeneRIF: Signaling through polymerization and degradation: Analysis
            and simulations of T cell activation mediated by Bcl10.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1959)
  AUTHORS   Srinivasula,S.M., Ahmad,M., Lin,J.H., Poyet,J.L.,
            Fernandes-Alnemri,T., Tsichlis,P.N. and Alnemri,E.S.
  TITLE     CLAP, a novel caspase recruitment domain-containing protein in the
            tumor necrosis factor receptor pathway, regulates NF-kappaB
            activation and apoptosis
  JOURNAL   J Biol Chem 274 (25), 17946-17954 (1999)
   PUBMED   10364242
REFERENCE   7  (bases 1 to 1959)
  AUTHORS   Yan,M., Lee,J., Schilbach,S., Goddard,A. and Dixit,V.
  TITLE     mE10, a novel caspase recruitment domain-containing proapoptotic
            molecule
  JOURNAL   J Biol Chem 274 (15), 10287-10292 (1999)
   PUBMED   10187815
REFERENCE   8  (bases 1 to 1959)
  AUTHORS   Thome,M., Martinon,F., Hofmann,K., Rubio,V., Steiner,V.,
            Schneider,P., Mattmann,C. and Tschopp,J.
  TITLE     Equine herpesvirus-2 E10 gene product, but not its cellular
            homologue, activates NF-kappaB transcription factor and c-Jun
            N-terminal kinase
  JOURNAL   J Biol Chem 274 (15), 9962-9968 (1999)
   PUBMED   10187771
REFERENCE   9  (bases 1 to 1959)
  AUTHORS   Koseki,T., Inohara,N., Chen,S., Carrio,R., Merino,J.,
            Hottiger,M.O., Nabel,G.J. and Nunez,G.
  TITLE     CIPER, a novel NF kappaB-activating protein containing a caspase
            recruitment domain with homology to Herpesvirus-2 protein E10
  JOURNAL   J Biol Chem 274 (15), 9955-9961 (1999)
   PUBMED   10187770
REFERENCE   10 (bases 1 to 1959)
  AUTHORS   Willis,T.G., Jadayel,D.M., Du,M.Q., Peng,H., Perry,A.R.,
            Abdul-Rauf,M., Price,H., Karran,L., Majekodunmi,O., Wlodarska,I.,
            Pan,L., Crook,T., Hamoudi,R., Isaacson,P.G. and Dyer,M.J.
  TITLE     Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and
            mutated in multiple tumor types
  JOURNAL   Cell 96 (1), 35-45 (1999)
   PUBMED   9989495
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU707261.1, AK150883.1, AK140179.1 and AC123684.8.
            
            On Aug 13, 2013 this sequence version replaced NM_009740.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156890.1, BC024379.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               BU707261.1         1-100
            101-1875            AK150883.1         2-1776
            1876-1949           AK140179.1         1748-1821
            1950-1959           AC123684.8         90721-90730         c
FEATURES             Location/Qualifiers
     source          1..1959
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 71.03 cM"
     gene            1..1959
                     /gene="Bcl10"
                     /gene_synonym="BCL-10; CARMEN; cE10; CIPER; CLAP; ME10"
                     /note="B cell leukemia/lymphoma 10"
                     /db_xref="GeneID:12042"
                     /db_xref="MGI:MGI:1337994"
     exon            1..254
                     /gene="Bcl10"
                     /gene_synonym="BCL-10; CARMEN; cE10; CIPER; CLAP; ME10"
                     /inference="alignment:Splign:2.1.0"
     CDS             198..899
                     /gene="Bcl10"
                     /gene_synonym="BCL-10; CARMEN; cE10; CIPER; CLAP; ME10"
                     /note="cellular-E10; B-cell CLL/lymphoma 10; CARD-like
                     apoptotic protein; cellular homolog of vCARMEN;
                     CARD-containing molecule enhancing NF-kappa-B; mammalian
                     CARD-containing adapter molecule E10; CED-3/ICH-1
                     prodomain homologous E10-like regulator"
                     /codon_start=1
                     /product="B-cell lymphoma/leukemia 10"
                     /protein_id="NP_033870.1"
                     /db_xref="CCDS:CCDS17897.1"
                     /db_xref="GeneID:12042"
                     /db_xref="MGI:MGI:1337994"
                     /translation="MEAPAPSLTEEDLTEVKKDALENLRVYLCEKIIAERHFDHLRAK
                     KILSREDTEEISCRTSSRKRAGKLLDYLQENPRGLDTLVESIRREKTQSFLIQKITDE
                     VLKLRNIKLEHLKGLKCSSCEPFAAGATNNLSRCNSDESNLSEKQRASTVMYHPEGES
                     STAPFFSMASSLNLPVLEVGRTENSSFSSATLPRPGDPGAPPLPPDLRLEEGGSCGNS
                     SEMFLPLRSRALSRQ"
     exon            255..543
                     /gene="Bcl10"
                     /gene_synonym="BCL-10; CARMEN; cE10; CIPER; CLAP; ME10"
                     /inference="alignment:Splign:2.1.0"
     exon            544..1959
                     /gene="Bcl10"
                     /gene_synonym="BCL-10; CARMEN; cE10; CIPER; CLAP; ME10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1858..1863
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bcl10"
                     /gene_synonym="BCL-10; CARMEN; cE10; CIPER; CLAP; ME10"
                     /note="hexamer: AATAAA"
     polyA_site      1877
                     /gene="Bcl10"
                     /gene_synonym="BCL-10; CARMEN; cE10; CIPER; CLAP; ME10"
                     /note="major polyA site"
     regulatory      1936..1941
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bcl10"
                     /gene_synonym="BCL-10; CARMEN; cE10; CIPER; CLAP; ME10"
                     /note="hexamer: AATATA"
     polyA_site      1959
                     /gene="Bcl10"
                     /gene_synonym="BCL-10; CARMEN; cE10; CIPER; CLAP; ME10"
ORIGIN      
        1 gctgagcgcg gcaccgctgg ccccaggggc ggagccggaa gtggggcgtt gaggtctcca
       61 cctcctcgtc cgtgagccgg ccgttccccc gcttctgttc ctagtccccc cgaagtcaca
      121 gcctgattcc cggaggcccg agcccttagt ctgggcgggg tggcgcgggc cggaaggacg
      181 ccatcccggc ctgggccatg gaggctcccg caccgtccct cacggaggag gatttgactg
      241 aagtgaagaa ggacgcttta gagaatttac gtgtttacct gtgtgagaaa atcatagctg
      301 agagacattt tgatcatcta cgtgcaaaaa aaatactaag tagagaagac acagaagaaa
      361 tttcttgccg aacttcaagt agaaaacggg ctgggaagtt gttagactac ttacaggaga
      421 accccagggg cctggacacc ctggtggaat ccatccgcag ggagaaaaca cagagcttcc
      481 tgattcagaa gataacggat gaggtgctaa agcttcggaa tataaaactg gagcacctca
      541 aaggcctgaa gtgcagcagc tgtgagccct ttgcagccgg agccaccaac aacctctcta
      601 ggtgcaattc cgatgagagc aatctctctg agaaacagag agcatccact gtcatgtacc
      661 acccggaggg agagtccagc acggctccct tcttctctat ggcgtcgtcc ctgaacttgc
      721 cagtcctgga agttggcagg actgaaaaca gcagcttctc ttcagccact cttcctcgac
      781 ctggggaccc tggggctccc cctttgcccc cagaccttcg gttggaagag gggggaagtt
      841 gtggaaactc aagtgagatg tttctcccct tacggtcacg ggctctttca cgccaatgat
      901 acatcaccgc ctagttgttt tactagtgat gcaaaatgct gtgaaggagg ccatctttct
      961 atacaaacca cggtgacagg tcactcacat tcgatgcgtg cctttaaaat cagtgtacac
     1021 attctctgta aataggattt gttagggtaa agaagcgctc tggggcggcg tggtgtaaat
     1081 catggtggtc gtgacttttc cataatgtcc tttctttttt attattttta ggtgtttgcg
     1141 tattttgaac ttttcataag attaatttta tcggaatatt tctcaatttg agaaaacaac
     1201 ttgtggattg ggaataatgt ttttagcaca tttatgctac aaattttcag tctgattgtt
     1261 tttcccactg atctggcagt atattttagc agtaagctgt tgtgtttcag gaaagctgga
     1321 cacgggaaag ctgccgacac actcagcagt gtcccactcc ttagttctga gaagccgtcg
     1381 ggttctgagg agacacctgg tggcactgag cctggtgacc tcagtgggcc aaaatttgtt
     1441 ttatactcac cctgccagcg tgagtgtctt actttcacag gccttgtgtc ctcagtctta
     1501 tcttaaagga tgttatcttg gcagggcatc acttgtaatt aatggatgat acttgtaatt
     1561 gactaaagtc ctcgctctga gccgtttgtt ctggctccga gagcgctgac atgtgaagca
     1621 tggtgagcag cgagggaact gacaggatgt ggccgtggcc agtgtggctt tagtgtttgc
     1681 atcaggcagc caccagctcc atccgtgttc ttactgcttt acaaagtttg actaacttta
     1741 cacattttaa aaatgctgat tgtcttcgtt taaattataa ttttacctat ttcttgacat
     1801 ctaactccta ttcatttcta ttatttaaaa attaagaaat gaaaatttgc tattaacaat
     1861 aaagtttttt taatgtagtg atgtgtctga gtcagaaatt caaaatgtct gattttcaaa
     1921 tgtctaacgc tttttaatat actggtttta aaaagaaaa
//
