LOCUS       NM_009738               6209 bp    mRNA    linear   ROD 05-FEB-2024
DEFINITION  Mus musculus butyrylcholinesterase (Bche), mRNA.
ACCESSION   NM_009738
VERSION     NM_009738.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6209)
  AUTHORS   Veerakumar,A., Yung,A.R., Liu,Y. and Krasnow,M.A.
  TITLE     Molecularly defined circuits for cardiovascular and cardiopulmonary
            control
  JOURNAL   Nature 606 (7915), 739-746 (2022)
   PUBMED   35650438
REFERENCE   2  (bases 1 to 6209)
  AUTHORS   Spieker,J., Mudersbach,T., Vogel-Hopker,A. and Layer,P.G.
  TITLE     Endochondral Ossification Is Accelerated in
            Cholinesterase-Deficient Mice and in Avian Mesenchymal Micromass
            Cultures
  JOURNAL   PLoS One 12 (1), e0170252 (2017)
   PUBMED   28118357
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6209)
  AUTHORS   Darvesh,S. and Reid,G.A.
  TITLE     Reduced fibrillar beta-amyloid in subcortical structures in a
            butyrylcholinesterase-knockout Alzheimer disease mouse model
  JOURNAL   Chem Biol Interact 259 (Pt B), 307-312 (2016)
   PUBMED   27091549
  REMARK    GeneRIF: the absence of BChE leads to diminished fibrillar Abeta
            deposition in amygdala, hippocampal formation, thalamus and basal
            ganglia.
REFERENCE   4  (bases 1 to 6209)
  AUTHORS   Chen,V.P., Gao,Y., Geng,L., Stout,M.B., Jensen,M.D. and
            Brimijoin,S.
  TITLE     Butyrylcholinesterase Deficiency Promotes Adipose Tissue Growth and
            Hepatic Lipid Accumulation in Male Mice on High-Fat Diet
  JOURNAL   Endocrinology 157 (8), 3086-3095 (2016)
   PUBMED   27300766
  REMARK    GeneRIF: BChE strongly affects fat metabolism, has an important
            impact on fat accumulation and may be a promising tool for
            combating obesity.
REFERENCE   5  (bases 1 to 6209)
  AUTHORS   Maurice,T., Strehaiano,M., Simeon,N., Bertrand,C. and Chatonnet,A.
  TITLE     Learning performances and vulnerability to amyloid toxicity in the
            butyrylcholinesterase knockout mouse
  JOURNAL   Behav Brain Res 296, 351-360 (2016)
   PUBMED   26306824
REFERENCE   6  (bases 1 to 6209)
  AUTHORS   Adler,M., Manley,H.A., Purcell,A.L., Deshpande,S.S., Hamilton,T.A.,
            Kan,R.K., Oyler,G., Lockridge,O., Duysen,E.G. and Sheridan,R.E.
  TITLE     Reduced acetylcholine receptor density, morphological remodeling,
            and butyrylcholinesterase activity can sustain muscle function in
            acetylcholinesterase knockout mice
  JOURNAL   Muscle Nerve 30 (3), 317-327 (2004)
   PUBMED   15318343
  REMARK    GeneRIF: A possible mechanism for partial compensation of tetanic
            fade in acetylcholinesterase knockout mice is hydrolysis of
            acetylcholine by normal levels of endogenous butyrylcholinesterase.
REFERENCE   7  (bases 1 to 6209)
  AUTHORS   Rodriguez,J.A., Buzaleh,A.M., Fossati,M., Azcurra,J. and
            Batlle,A.M.
  TITLE     The effects of some porphyrinogenic drugs on the brain cholinergic
            system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 48 (1), 103-110 (2002)
   PUBMED   11929041
  REMARK    GeneRIF: The effects of porphyrinogenic drugs on the brain
            cholinergic system (Ache, Bche, and Chrm1 levels in various regions
            of the brain) were examined to establish a mechanism for
            neurological syndrome displayed in acute porphyrias.
REFERENCE   8  (bases 1 to 6209)
  AUTHORS   al-Fakhri,N. and Bogusch,G.
  TITLE     Activity of acetylcholinesterase and unspecific cholinesterase
            during differentiation of somites in mouse embryos
  JOURNAL   Anat Embryol (Berl) 192 (3), 257-264 (1995)
   PUBMED   8651510
REFERENCE   9  (bases 1 to 6209)
  AUTHORS   Arpagaus,M., Chatonnet,A., Masson,P., Newton,M., Vaughan,T.A.,
            Bartels,C.F., Nogueira,C.P., La Du,B.N. and Lockridge,O.
  TITLE     Use of the polymerase chain reaction for homology probing of
            butyrylcholinesterase from several vertebrates
  JOURNAL   J Biol Chem 266 (11), 6966-6974 (1991)
   PUBMED   2016308
REFERENCE   10 (bases 1 to 6209)
  AUTHORS   Rachinsky,T.L., Camp,S., Li,Y., Ekstrom,T.J., Newton,M. and
            Taylor,P.
  TITLE     Molecular cloning of mouse acetylcholinesterase: tissue
            distribution of alternatively spliced mRNA species
  JOURNAL   Neuron 5 (3), 317-327 (1990)
   PUBMED   2400605
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK050337.1, CK636839.1 and AC102340.10.
            
            [WARNING] On Mar 11, 2024 this sequence was replaced by
            NM_009738.4.
            
            On Feb 6, 2007 this sequence version replaced NM_009738.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099977.1, AK050337.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-876               AK050337.1         2-877
            877-883             CK636839.1         600-606
            884-3205            AK050337.1         885-3206
            3206-6209           AC102340.10        24618-27621
FEATURES             Location/Qualifiers
     source          1..6209
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 33.61 cM"
     gene            1..6209
                     /gene="Bche"
                     /gene_synonym="C730038G20Rik"
                     /note="butyrylcholinesterase"
                     /db_xref="GeneID:12038"
                     /db_xref="MGI:MGI:894278"
     exon            1..281
                     /gene="Bche"
                     /gene_synonym="C730038G20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            282..1809
                     /gene="Bche"
                     /gene_synonym="C730038G20Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             290..2101
                     /gene="Bche"
                     /gene_synonym="C730038G20Rik"
                     /EC_number="3.1.1.8"
                     /note="cholinesterase; choline esterase II;
                     pseudocholinesterase; butyrylcholine esterase; acylcholine
                     acylhydrolase"
                     /codon_start=1
                     /product="cholinesterase precursor"
                     /protein_id="NP_033868.3"
                     /db_xref="CCDS:CCDS17411.1"
                     /db_xref="GeneID:12038"
                     /db_xref="MGI:MGI:894278"
                     /translation="MQTQHTKVTQTHFLLWILLLCMPFGKSHTEEDFIITTKTGRVRG
                     LSMPVLGGTVTAFLGIPYAQPPLGSLRFKKPQPLNKWPDIHNATQYANSCYQNIDQAF
                     PGFQGSEMWNPNTNLSEDCLYLNVWIPVPKPKNATVMVWIYGGGFQTGTSSLPVYDGK
                     FLARVERVIVVSMNYRVGALGFLAFPGNPDAPGNMGLFDQQLALQWVQRNIAAFGGNP
                     KSITIFGESAGAASVSLHLLCPQSYPLFTRAILESGSSNAPWAVKHPEEARNRTLTLA
                     KFTGCSKENEMEMIKCLRSKDPQEILRNERFVLPSDSILSINFGPTVDGDFLTDMPHT
                     LLQLGKVKKAQILVGVNKDEGTAFLVYGAPGFSKDNDSLITRKEFQEGLNMYFPGVSR
                     LGKEAVLFYYVDWLGEQSPEVYRDALDDVIGDYNIICPALEFTKKFAELENNAFFYFF
                     EHRSSKLPWPEWMGVMHGYEIEFVFGLPLGRRVNYTRAEEIFSRSIMKTWANFAKYGH
                     PNGTQGNSTMWPVFTSTEQKYLTLNTEKSKIYSKLRAPQCQFWRLFFPKVLEMTGDID
                     ETEQEWKAGFHRWSNYMMDWQNQFNDYTSKKESCTAL"
     exon            1810..1976
                     /gene="Bche"
                     /gene_synonym="C730038G20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1977..6209
                     /gene="Bche"
                     /gene_synonym="C730038G20Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttctctcct gaagcctgcc tgcaatggtg gaggaagacc cacaaccctc tctgaagaag
       61 tcaccgctgc ttttgtgcga gcagatgtca gcctgggaag cctggccaga gccagatcaa
      121 gttgctgctg ccagctctcg cgagctttgt ctggaagagt tgactgaaat gtcagagtcc
      181 tgcaattcac aggcagggcg gcagctgcat cccgcgcgtc cccaaagcat tgcaagattg
      241 ccactttgca aacttcctca tcctttgctg cagtaattcc gaaatcaaca tgcagactca
      301 gcataccaag gtaacacaga cccacttcct cctatggatt cttctgctct gcatgccttt
      361 tgggaagtca cacactgaag aagacttcat aattacaacc aagaccggaa gggtccgagg
      421 gctgagcatg ccagttcttg gtggcacggt gactgccttt ctcggtatcc cctatgcaca
      481 acctcctctg ggtagcctaa gattcaaaaa gccgcaaccc ttaaacaaat ggcctgacat
      541 ccataatgcc actcaatatg caaattcttg ttatcagaac atagaccaag ccttcccagg
      601 cttccagggg tcagaaatgt ggaatccaaa cacaaacctc agtgaagact gcttgtatct
      661 gaatgtttgg attccagtac cgaagcctaa aaatgccact gtcatggtat ggatctatgg
      721 tggtggcttt caaactggga cctcttctct acctgtttac gatgggaagt ttctagctcg
      781 tgttgaaaga gttattgtag tttcgatgaa ctatagggta ggtgctctag gattcctagc
      841 ttttcccgga aatcccgatg ctccaggaaa catgggttta tttgatcaac agttggcact
      901 tcaatgggtc caaagaaata tagctgcttt tggagggaat cctaaaagta taacgatttt
      961 tggagaaagt gcaggggcag cttcagttag cttacatttg ctctgccccc aaagttatcc
     1021 tttgtttacc agagccattc ttgaaagtgg ctcctctaat gccccctggg cagtaaagca
     1081 tcctgaggaa gccagaaaca gaaccttgac cttagctaaa tttactggtt gctcaaagga
     1141 aaatgagatg gagatgatta aatgccttcg aagtaaagat cctcaggaaa ttcttcgcaa
     1201 tgaaaggttc gttctcccct ctgattccat cttatccata aattttggtc caacagtgga
     1261 tggcgatttt ctcaccgata tgccccacac actactccaa ctaggaaaag tgaaaaaagc
     1321 tcagatctta gtgggagtta acaaagatga agggacagct ttcctagtgt acggtgctcc
     1381 gggtttcagc aaagacaatg atagccttat cacaaggaag gaatttcaag aaggtttaaa
     1441 tatgtatttc cctggagtga gcagattggg caaggaagca gttcttttct actacgtgga
     1501 ctggttaggt gagcagtcac cagaagtcta ccgtgacgct ttggatgatg ttattggaga
     1561 ttacaacatc atctgccctg cactggagtt taccaagaaa tttgcagagc ttgaaaacaa
     1621 tgcttttttc tactttttcg aacatcgatc ttccaaacta ccttggccgg aatggatggg
     1681 agtgatgcat ggctatgaaa ttgaatttgt gtttggctta cctctgggaa gaagagttaa
     1741 ttatacgaga gctgaggaaa tctttagtcg atccataatg aaaacttggg caaattttgc
     1801 aaaatatgga catcccaatg ggacccaggg caatagcaca atgtggcctg tcttcacaag
     1861 tactgaacaa aaatacctaa cattgaacac agagaagtca aaaatatact ctaaacttcg
     1921 tgctccccaa tgtcagttct ggagactatt ttttccaaaa gtcttggaaa tgacaggaga
     1981 tattgatgaa acggagcaag agtggaaggc aggatttcat cgctggagca attacatgat
     2041 ggactggcaa aatcaattta acgattacac tagcaagaaa gagagctgta cagctctcta
     2101 attaatacat ttacccttta tagaatgttc attttactgt agatgaaggc aaatatacca
     2161 gtagctctct ccatatatac caagaatgct attacacagc agagaaatgc caaatgagac
     2221 tattgatttc ttatactttt cacttagtat tttgcctaat gcctcaaaac tgagtcatta
     2281 gaagttgttt ttttattaat tttcacaatg taaactttca gaattaatta catgctactt
     2341 tgttattact tttctgaata acattacagc tttcacctaa aagttacatc atctgcttct
     2401 attcaatcca gtattttcag agatacctat ataaaactat tgctaaaatc tgaattggat
     2461 tttgaagcaa tggatgttat aatttttatt actgttgcct ataatttatt tttaagtcta
     2521 gtatcaatat caaatagtaa aacaaaaagt tggctattca tatatgtaga ggcaagagag
     2581 aatttcaaag aaagagccac tgcgtctggg aaataaaata tggctatcaa caaatgcaag
     2641 gaatttcaag tactgttgaa aatcatgcca actggctctt ctgagagaga tttcatgctt
     2701 caggcatcat ttcatgagca tgatttgcta catgaatcat gttcaatcca gaattcaaca
     2761 gccaaagaaa atatgtggtt ctaatatgca caggaattct agaatagaat cctgggcctc
     2821 acactgtgct ataggatgga tcgcagaaat cagtgtctgg gaacacttgg agatctcatc
     2881 tttaacatat tcacagctga aacaatagtt tggcttaagt tattcataga ttaagtgtct
     2941 gcagacccaa actccacatt atatcagtct tccttagggt tagcacttga ggaaatgtaa
     3001 caccaaacaa agccattgaa ctgtcactta atttaggtga gtttgtatat cattctgaat
     3061 atatgacaaa aatgtatgct ttatattgta tataaataat tgttgatagt taaggcagat
     3121 cagaacatta ttttgatcat ctatttatat actgaaaaat gtttatgtta gcggtttata
     3181 agaactaaag taacaaatct cttccaaaaa agaatcttat tatattgaat tttcattttc
     3241 aaaaatagta tgatgaagtt tataatgatg aggataattt caaaagttat gtaattaaat
     3301 tcatgtcaat cataatttct ttgatggtta ttagtataat tttagcagtg acacacttag
     3361 ctcaatgact aataaatagg acaatctgca cattgatgaa gaaggacaag aaaatcaagc
     3421 tagcgaaatt ctatatcacg cttgtatgta ctgtactcaa cagtacctgt tctcatcaca
     3481 aacttgtttg caaaggcagt atgtagggtg agaggggctt tgcctaaata tagtgttatt
     3541 tgccattcct ttacactgaa ctgtaatcca tgagtaattt tccttaatct acaagtaact
     3601 taaatccaac tttgttacac taaggaaaaa agaaaagaac agttgactac ctgatctaag
     3661 atgcatacaa attggtatta gggttatctc aaggaacact gcagacaaaa tgaatacata
     3721 tattaaaaag gagtttattt gagtgcctta tggaatatag cctagtatta taacaatgtc
     3781 tgcctcaccc tggagaggcc tagagtatag aagttgttaa acacacatgt ttgaatgtgt
     3841 cagtagtcac aataaagtgc tataagccca gagaattcct ggagagcatc tgtccctgag
     3901 tttagtttgg catctcaaag aagtaggttc taatatcagt gaaggtatgc tactgcaaga
     3961 agatcaatga acttgacagc aagagttaga gcaaacagtt aaaaagcaaa tttcccttct
     4021 ttcatgtcct ttgatctatg aggccaccat gaggctcatc tcatgtttag gactcatctt
     4081 tctatttcaa atatcctcat caggaaaatc actcacagga atgccctgaa acttgcttgg
     4141 attaacttga atccagatgc tgtcaaggtg gcactgtaat tatccattac aaatccatcc
     4201 cttatcagca tgacacagag ctacattctc ttaaagtcat gcctttaatt tcaaaggtca
     4261 gtgcataatt ccacctaaca aactttaact atcccataca caactgcaag tgtgttgtgt
     4321 attttagaat agtcagcaaa gtttttcaaa gaatgcttag tcttgtagtg ccttataacc
     4381 taaatatgat aatatagatt tacacttaaa caatattatc tcaattgatt tatcaatgca
     4441 tgataaacat atagagggaa gaaaacacta gtaattgatt aatatatgta tatacatgta
     4501 aacatgtttt aacataagat aaaatcattt atatcaatga taatcatgtc ttcaacagaa
     4561 tctcgactgt atttacttac tatgcattat gtatacctgt agcaagaagc ttacctttac
     4621 agatttcctg gaatcatgtt aattaaatac tatacaacag gccatgcaaa actgactgtt
     4681 catattgttc actgcctatt tatgctagtt caaagccatt agtccttcca ggaaaggaca
     4741 ggaggaaggc taaaaataaa actctgcagc atgttaacat gatcctgagg gggaactggc
     4801 cttctcatca aggaattcta ggtcttctgg ctgacacaac tctggaaact gacaggcaaa
     4861 tattcttgat tgctagaagg aactttatca tttcctgctt ttattctaga gcatttctat
     4921 atacacagat gagacaacag ttagtaatct tctctttcat ccgtagaaat aaatatgctt
     4981 aactatccag taccaaaggt ccgtatgggt cagactatta cacatattgt tttgcctgta
     5041 ctgcccatta caataccata ctttctatgt ctttggaaat tcaatgatgc cacttgagct
     5101 ctgctacttt ggggaccaat tgaacctatt acaattaatt tatccactga gcattagaat
     5161 cttcagctct aaaaccagac agaagaacaa caatggctgt tcaaatgtac tgatatctct
     5221 ccaagcattt ggagtgttaa cattcttcac gttaccccct cactgttttc tgcagtgagt
     5281 gacaggtatt ctaggctctc ccacggtgaa ggattaggtt ttatacagtt tatctacttc
     5341 agcattccag attctgagtc ttaaaattcc cttcattaca ataaaccaag tgttatcaac
     5401 catttccagt tttttaaaat agaataacat ttgagaaata cacagcctac caatcaaata
     5461 aactcctttt aactgtgaaa gcttccatat taagtataga atagccatta aatggctcca
     5521 tattaataat ctcagcctga tccagtttta tgtttctttc accactatct tacacccttc
     5581 ggatctattc tcaaacattc gccagacttc catttgaatt gaagttcatt taaattcttt
     5641 aaaaagtgta gtatacctca cttctataag cctcctcacc ttgagactcc ttaaagatct
     5701 atagacaaca atttgtaggc accggtggac atctgtatta gcctccttgg catctccttc
     5761 agggaaggta attatgaatt ctgtgtgtaa tacagagtca attcccttag tcaaggatgg
     5821 agtgaacaat actgagtggc atatgcttgg atccgtcctc tcttctaagg gttgtgagcc
     5881 tactttctca gatgagaaaa tacagtggtg tgaatgagaa tgtcctccac gggctcacat
     5941 atttgaacac ttgatcacca gttggtgctg tttggagggt ttaagaggca cagccttcct
     6001 ggaaggagtg tatcactgtg aaaaggtgtt gagattacct agcatcacca gatatggttt
     6061 tcgctctttc cactttctac ttgtgtttga agatgtgaac tctcagcttt ctgttcaaat
     6121 caccatgcct gatgcttgct atcatacttc ccattgtgga ctgttatctc tctgaatcat
     6181 atgcacaaaa taaaaacttc cttgtataa
//
