LOCUS       NM_025392               1260 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus BRCA2 and CDKN1A interacting protein (Bccip), mRNA.
ACCESSION   NM_025392
VERSION     NM_025392.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1260)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1260)
  AUTHORS   Lu,H., Ye,C., Liu,J., Rabson,A.B., Verzi,M., De,S. and Shen,Z.
  TITLE     Requirement of Bccip for the Regeneration of Intestinal Progenitors
  JOURNAL   Am J Pathol 191 (1), 66-78 (2021)
   PUBMED   33039352
  REMARK    GeneRIF: Requirement of Bccip for the Regeneration of Intestinal
            Progenitors.
REFERENCE   3  (bases 1 to 1260)
  AUTHORS   Ye,C., Liu,B., Lu,H., Liu,J., Rabson,A.B., Jacinto,E., Pestov,D.G.
            and Shen,Z.
  TITLE     BCCIP is required for nucleolar recruitment of eIF6 and 12S
            pre-rRNA production during 60S ribosome biogenesis
  JOURNAL   Nucleic Acids Res 48 (22), 12817-12832 (2020)
   PUBMED   33245766
  REMARK    GeneRIF: BCCIP is required for nucleolar recruitment of eIF6 and
            12S pre-rRNA production during 60S ribosome biogenesis.
REFERENCE   4  (bases 1 to 1260)
  AUTHORS   Lu,H., Ye,C., Feng,X., Liu,J., Bhaumik,M., Xia,B., Liu,C. and
            Shen,Z.
  TITLE     Spontaneous Development of Hepatocellular Carcinoma and B-Cell
            Lymphoma in Mosaic and Heterozygous Brca2 and Cdkn1a Interacting
            Protein Knockout Mice
  JOURNAL   Am J Pathol 190 (6), 1175-1187 (2020)
   PUBMED   32201259
REFERENCE   5  (bases 1 to 1260)
  AUTHORS   Droz-Rosario,R., Lu,H., Liu,J., Liu,N.A., Ganesan,S., Xia,B.,
            Haffty,B.G. and Shen,Z.
  TITLE     Roles of BCCIP deficiency in mammary tumorigenesis
  JOURNAL   Breast Cancer Res 19 (1), 115 (2017)
   PUBMED   29047390
  REMARK    GeneRIF: We analyzed the BCCIP protein level in 470 cases of human
            breast cancer to determine the associations between BCCIP and
            53BP1, p53, and subtypes of breast cancer. We further constructed a
            unique BCCIP knockdown mouse model to determine whether a partial
            BCCIP deficiency leads to spontaneous breast cancer formation
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1260)
  AUTHORS   Huang,Y.Y., Dai,L., Gaines,D., Droz-Rosario,R., Lu,H., Liu,J. and
            Shen,Z.
  TITLE     BCCIP suppresses tumor initiation but is required for tumor
            progression
  JOURNAL   Cancer Res 73 (23), 7122-7133 (2013)
   PUBMED   24145349
  REMARK    GeneRIF: BCCIP represents a paradoxical class of modulators for
            tumorigenesis as a suppressor for initiation but a requisite for
            progression.
REFERENCE   7  (bases 1 to 1260)
  AUTHORS   Huang,Y.Y., Lu,H., Liu,S., Droz-Rosario,R. and Shen,Z.
  TITLE     Requirement of mouse BCCIP for neural development and progenitor
            proliferation
  JOURNAL   PLoS One 7 (1), e30638 (2012)
   PUBMED   22292003
  REMARK    GeneRIF: BCCIP and its anti-replication stress functions are
            essential for normal neural development by maintaining an orderly
            proliferation of neural progenitors.
REFERENCE   8  (bases 1 to 1260)
  AUTHORS   Lu,H., Huang,Y.Y., Mehrotra,S., Droz-Rosario,R., Liu,J.,
            Bhaumik,M., White,E. and Shen,Z.
  TITLE     Essential roles of BCCIP in mouse embryonic development and
            structural stability of chromosomes
  JOURNAL   PLoS Genet 7 (9), e1002291 (2011)
   PUBMED   21966279
  REMARK    GeneRIF: these data suggest a unique function of BCCIP, not only in
            repair of DNA damage, but also in resolving stalled replication
            forks and prevention of replication stress
REFERENCE   9  (bases 1 to 1260)
  AUTHORS   Corbo,J.C. and Cepko,C.L.
  TITLE     A hybrid photoreceptor expressing both rod and cone genes in a
            mouse model of enhanced S-cone syndrome
  JOURNAL   PLoS Genet 1 (2), e11 (2005)
   PUBMED   16110338
  REMARK    Erratum:[PLoS Genet. 2008 Jan;4(1):e18]
REFERENCE   10 (bases 1 to 1260)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD770748.1, BC048465.1 and BE947296.1.
            
            On Mar 23, 2007 this sequence version replaced NM_025392.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048465.1, AK003666.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 CD770748.1         5-12
            9-1240              BC048465.1         1-1232
            1241-1260           BE947296.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..1260
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 77.3 cM"
     gene            1..1260
                     /gene="Bccip"
                     /gene_synonym="1110013J05Rik; TOK-1"
                     /note="BRCA2 and CDKN1A interacting protein"
                     /db_xref="GeneID:66165"
                     /db_xref="MGI:MGI:1913415"
     exon            1..196
                     /gene="Bccip"
                     /gene_synonym="1110013J05Rik; TOK-1"
                     /inference="alignment:Splign:2.1.0"
     exon            197..271
                     /gene="Bccip"
                     /gene_synonym="1110013J05Rik; TOK-1"
                     /inference="alignment:Splign:2.1.0"
     exon            272..352
                     /gene="Bccip"
                     /gene_synonym="1110013J05Rik; TOK-1"
                     /inference="alignment:Splign:2.1.0"
     exon            353..442
                     /gene="Bccip"
                     /gene_synonym="1110013J05Rik; TOK-1"
                     /inference="alignment:Splign:2.1.0"
     exon            443..630
                     /gene="Bccip"
                     /gene_synonym="1110013J05Rik; TOK-1"
                     /inference="alignment:Splign:2.1.0"
     exon            631..805
                     /gene="Bccip"
                     /gene_synonym="1110013J05Rik; TOK-1"
                     /inference="alignment:Splign:2.1.0"
     exon            806..1244
                     /gene="Bccip"
                     /gene_synonym="1110013J05Rik; TOK-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1216..1221
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bccip"
                     /gene_synonym="1110013J05Rik; TOK-1"
                     /note="hexamer: AATAAA"
     polyA_site      1241
                     /gene="Bccip"
                     /gene_synonym="1110013J05Rik; TOK-1"
                     /note="major polyA site"
ORIGIN      
        1 gcgcaggcgc agtgtgaccg gcgacatggc atctaaggct aagaagcgag cggtgggaaa
       61 tggaattcag cggccgctgg gagccccggg ccagcgggag gaggaagaag aagaagagga
      121 tgaggtggag gatgaggaag aagacgagga cgacagtgac gaagaagagg atgaagttga
      181 cgaaatcgtg gacgaggaag tgaatattga gtttgaagcc tattccatct cagataacga
      241 ttatggcgga attaagaaat tactgcaaca gctttttcta aaagcccccg tgaacactgc
      301 cgagctgacg aatctcctga tgcagcagaa ccacattggg agtgtgatta agcaaacaga
      361 tgtttcagaa gacagtgatg atgaagtgga tgaagatgag atctttggct tcataagcct
      421 tttaaatttg actgaaagaa aggggactca gtgtgctgaa caaattaaag agttggttct
      481 aagcttctgt gagaagacct gtgagcagag catggttgaa cagctggaca agcttttgaa
      541 tgacaccagc aagcctgtgg gccttctgct aagtgaaaga ttcattaacg tccctccaca
      601 gattgccctg cccatgcacc agcagctcca gaaagaactg tctgaggcgc gaagaaccaa
      661 caagccatgt gggaaatgct gcttctacct gctgattagt aagacattta tggaagcagg
      721 aaagtccagt tccagaaaga ggcaggacag ccttcagcag ggggcactga tgtttgcaaa
      781 tgcagaggaa gagttcttct atgagaaggc aatcttgaag ttcagctact cggtgcaggg
      841 ggagagcgac actcgtctgg gaggcagatg gtccttcgat gatgttccga tgacgccttt
      901 gcggactgtg atggtaattc cagacgacag gatgaatgag atcatggaaa ccctgaaaga
      961 ccatctctcc gtctagtcca tttcccccag acagtgacag gcttgtttat gtgtaattac
     1021 caagaaaccc attgaagaga tactgaaaaa ctcattattt tattcagatt caagtcctct
     1081 acaaaaagta gggttctgtt ccatgtgtct gtgacacatt tacaaaatga tttttttctt
     1141 tattttggtc aaattatgaa tgattggtta aaaacttcca ataagaaaag catggaatag
     1201 taattttaag aacttaataa aactattttt ttattttaaa atcaaaaaaa aaaaaaaaaa
//
