LOCUS       NP_001398929             419 aa            linear   ROD 13-MAY-2024
DEFINITION  branched-chain-amino-acid aminotransferase, mitochondrial isoform 3
            [Mus musculus].
ACCESSION   NP_001398929
VERSION     NP_001398929.1
DBSOURCE    REFSEQ: accession NM_001412000.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 419)
  AUTHORS   Wang,Y., Zhao,N., Meng,Y., Chen,J., Qi,C., Hu,X., Zhu,H., Yang,D.,
            Zhang,X., Ma,H., Zhao,J., Di,T., Li,P. and Wang,Y.
  TITLE     Bcat2-Mediated Branched-Chain Amino Acid Catabolism Is Linked to
            the Aggravated Inflammation in Obese with Psoriasis Mice
  JOURNAL   Mol Nutr Food Res 68 (8), e2300720 (2024)
   PUBMED   38581348
  REMARK    GeneRIF: Bcat2-Mediated Branched-Chain Amino Acid Catabolism Is
            Linked to the Aggravated Inflammation in Obese with Psoriasis Mice.
REFERENCE   2  (residues 1 to 419)
  AUTHORS   Portero,V., Nicol,T., Podliesna,S., Marchal,G.A., Baartscheer,A.,
            Casini,S., Tadros,R., Treur,J.L., Tanck,M.W.T., Cox,I.J.,
            Probert,F., Hough,T.A., Falcone,S., Beekman,L., Muller-Nurasyid,M.,
            Kastenmuller,G., Gieger,C., Peters,A., Kaab,S., Sinner,M.F.,
            Blease,A., Verkerk,A.O., Bezzina,C.R., Potter,P.K. and Remme,C.A.
  TITLE     Chronically elevated branched chain amino acid levels are
            pro-arrhythmic
  JOURNAL   Cardiovasc Res 118 (7), 1742-1757 (2022)
   PUBMED   34142125
REFERENCE   3  (residues 1 to 419)
  AUTHORS   Uddin,G.M., Karwi,Q.G., Pherwani,S., Gopal,K., Wagg,C.S.,
            Biswas,D., Atnasious,M., Wu,Y., Wu,G., Zhang,L., Ho,K.L.,
            Pulinilkunnil,T., Ussher,J.R. and Lopaschuk,G.D.
  TITLE     Deletion of BCATm increases insulin-stimulated glucose oxidation in
            the heart
  JOURNAL   Metabolism 124, 154871 (2021)
   PUBMED   34478752
  REMARK    GeneRIF: Deletion of BCATm increases insulin-stimulated glucose
            oxidation in the heart.
REFERENCE   4  (residues 1 to 419)
  AUTHORS   Li,J.T., Yin,M., Wang,D., Wang,J., Lei,M.Z., Zhang,Y., Liu,Y.,
            Zhang,L., Zou,S.W., Hu,L.P., Zhang,Z.G., Wang,Y.P., Wen,W.Y.,
            Lu,H.J., Chen,Z.J., Su,D. and Lei,Q.Y.
  TITLE     BCAT2-mediated BCAA catabolism is critical for development of
            pancreatic ductal adenocarcinoma
  JOURNAL   Nat Cell Biol 22 (2), 167-174 (2020)
   PUBMED   32029896
REFERENCE   5  (residues 1 to 419)
  AUTHORS   Koike,H., Zhang,R.R., Ueno,Y., Sekine,K., Zheng,Y.W., Takebe,T. and
            Taniguchi,H.
  TITLE     Nutritional modulation of mouse and human liver bud growth through
            a branched-chain amino acid metabolism
  JOURNAL   Development 144 (6), 1018-1024 (2017)
   PUBMED   28219950
REFERENCE   6  (residues 1 to 419)
  AUTHORS   Wu,J.Y., Kao,H.J., Li,S.C., Stevens,R., Hillman,S., Millington,D.
            and Chen,Y.T.
  TITLE     ENU mutagenesis identifies mice with mitochondrial branched-chain
            aminotransferase deficiency resembling human maple syrup urine
            disease
  JOURNAL   J Clin Invest 113 (3), 434-440 (2004)
   PUBMED   14755340
REFERENCE   7  (residues 1 to 419)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   8  (residues 1 to 419)
  AUTHORS   Ben-Yosef,T., Eden,A. and Benvenisty,N.
  TITLE     Characterization of murine BCAT genes: Bcat1, a c-Myc target, and
            its homolog, Bcat2
  JOURNAL   Mamm Genome 9 (7), 595-597 (1998)
   PUBMED   9657861
REFERENCE   9  (residues 1 to 419)
  AUTHORS   Bledsoe,R.K., Dawson,P.A. and Hutson,S.M.
  TITLE     Cloning of the rat and human mitochondrial branched chain
            aminotransferases (BCATm)
  JOURNAL   Biochim Biophys Acta 1339 (1), 9-13 (1997)
   PUBMED   9165094
REFERENCE   10 (residues 1 to 419)
  AUTHORS   Bassett,D.E. Jr., Boguski,M.S., Spencer,F., Reeves,R., Kim,S.,
            Weaver,T. and Hieter,P.
  TITLE     Genome cross-referencing and XREFdb: implications for the
            identification and analysis of genes mutated in human disease
  JOURNAL   Nat Genet 15 (4), 339-344 (1997)
   PUBMED   9090377
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC151602.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253011.5875257.1,
                                           SRR17253013.4374743.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..419
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.36 cM"
     Protein         1..419
                     /product="branched-chain-amino-acid aminotransferase,
                     mitochondrial isoform 3"
                     /EC_number="2.6.1.42"
                     /note="branched-chain-amino-acid aminotransferase,
                     mitochondrial"
                     /calculated_mol_wt=46608
     Region          114..409
                     /region_name="BCAT_beta_family"
                     /note="Branched-chain aminotransferase catalyses the
                     transamination of the branched-chain amino acids leusine,
                     isoleucine and valine to their respective alpha-keto
                     acids, alpha-ketoisocaproate,
                     alpha-keto-beta-methylvalerate and alpha-ketoisovalerate.
                     The...; cd01557"
                     /db_xref="CDD:238798"
     Site            order(114..118,121..125,127,129,160,197,199,205..207,211,
                     218,258,263,265,269,283)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:238798"
     Site            order(124,129,153,209,256,261,291,323..324,367)
                     /site_type="active"
                     /note="substrate-cofactor binding pocket [active]"
                     /db_xref="CDD:238798"
     Site            256
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:238798"
     CDS             1..419
                     /gene="Bcat2"
                     /gene_synonym="Bcat(m); Bcat-2; Eca40"
                     /coded_by="NM_001412000.1:28..1287"
                     /note="isoform 3 is encoded by transcript variant 4"
                     /db_xref="GeneID:12036"
                     /db_xref="MGI:MGI:1276534"
ORIGIN      
        1 maaatlgqec sltcslslvv vpsklstscg qsslvwarkl lpvpwllcgs krcvssifka
       61 adlqiqmtke pqkkpapsqa llfgktftdh mlmvewnnka gwgppriqpf qnltlhpacs
      121 glhyslqlfe glkaykggdq qvrlfrpwln mdrmlrsarr lclpdfdkqe llecirqlie
      181 vdkdwvpdgn gtslyvrpvl ignepslgvg mvtqallyvi lcpvgsyfpg dsmtpvslla
      241 dpsfvrawig gvgdcklggn ygptvavqre aqkrgceqvl wlygpdhqlt evgtmnifvy
      301 wthedgvlel vtpplngvil pgvvrqslld lartwgefrv aerkvtmkel kraleegrvr
      361 evfgsgtacq vcpvhqilye gkqlhiptme ngpelilrfq kelkaiqyga sahdwmfrv
//
