LOCUS       NP_031558                386 aa            linear   ROD 07-FEB-2025
DEFINITION  branched-chain-amino-acid aminotransferase, cytosolic isoform 2
            [Mus musculus].
ACCESSION   NP_031558
VERSION     NP_031558.3
DBSOURCE    REFSEQ: accession NM_007532.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 386)
  AUTHORS   Li,Q., Jiang,S., Lei,K., Han,H., Chen,Y., Lin,W., Xiong,Q., Qi,X.,
            Gan,X., Sheng,R., Wang,Y., Zhang,Y., Ma,J., Li,T., Lin,S., Zhou,C.,
            Chen,D. and Yuan,Q.
  TITLE     Metabolic rewiring during bone development underlies tRNA
            m7G-associated primordial dwarfism
  JOURNAL   J Clin Invest 134 (20), e177220 (2024)
   PUBMED   39255038
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 386)
  AUTHORS   You,H., Song,G., Xu,Z., Chen,S., Shen,W., Liu,H., Deng,B., Li,J.
            and Huang,G.
  TITLE     HuR promotes castration-resistant prostate cancer progression by
            altering ERK5 activation via posttranscriptional regulation of
            BCAT1
  JOURNAL   J Transl Med 22 (1), 178 (2024)
   PUBMED   38369471
  REMARK    GeneRIF: HuR promotes castration-resistant prostate cancer
            progression by altering ERK5 activation via posttranscriptional
            regulation of BCAT1.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 386)
  AUTHORS   Nishikawa,K., Mezawa,Y. and Kobayashi,T.
  TITLE     Bcat1 is controlled by Tsc2/mTORC1 pathway at expression levels and
            its deficiency together with Bcat2 inactivation suppresses the
            growth of a Tsc2-/- tumor cell line
  JOURNAL   Genes Cells 28 (6), 447-456 (2023)
   PUBMED   36965015
  REMARK    GeneRIF: Bcat1 is controlled by Tsc2/mTORC1 pathway at expression
            levels and its deficiency together with Bcat2 inactivation
            suppresses the growth of a Tsc2[-/-] tumor cell line.
REFERENCE   4  (residues 1 to 386)
  AUTHORS   Tan,L., Lu,J., Zhang,C., Meng,L. and Zhu,Q.
  TITLE     The proatherosclerotic function of BCAT1 in atherosclerosis
            development of aged-apolipoprotein E-deficient mice
  JOURNAL   Biochem Biophys Res Commun 631, 93-101 (2022)
   PUBMED   36182869
  REMARK    GeneRIF: The proatherosclerotic function of BCAT1 in
            atherosclerosis development of aged-apolipoprotein E-deficient
            mice.
REFERENCE   5  (residues 1 to 386)
  AUTHORS   Francois,L., Boskovic,P., Knerr,J., He,W., Sigismondo,G.,
            Schwan,C., More,T.H., Schlotter,M., Conway,M.E., Krijgsveld,J.,
            Hiller,K., Grosse,R., Lichter,P. and Radlwimmer,B.
  TITLE     BCAT1 redox function maintains mitotic fidelity
  JOURNAL   Cell Rep 41 (3), 111524 (2022)
   PUBMED   36260995
  REMARK    GeneRIF: BCAT1 redox function maintains mitotic fidelity.
            Erratum:[Cell Rep. 2023 Mar 28;42(3):112217. doi:
            10.1016/j.celrep.2023.112217.. PMID: 36862549]
REFERENCE   6  (residues 1 to 386)
  AUTHORS   Ben-Porath,I. and Benvenisty,N.
  TITLE     Characterization of a tumor-associated gene, a member of a novel
            family of genes encoding membrane glycoproteins
  JOURNAL   Gene 183 (1-2), 69-75 (1996)
   PUBMED   8996089
REFERENCE   7  (residues 1 to 386)
  AUTHORS   Schuldiner,O., Eden,A., Ben-Yosef,T., Yanuka,O., Simchen,G. and
            Benvenisty,N.
  TITLE     ECA39, a conserved gene regulated by c-Myc in mice, is involved in
            G1/S cell cycle regulation in yeast
  JOURNAL   Proc Natl Acad Sci U S A 93 (14), 7143-7148 (1996)
   PUBMED   8692959
REFERENCE   8  (residues 1 to 386)
  AUTHORS   Hutson,S.M., Bledsoe,R.K., Hall,T.R. and Dawson,P.A.
  TITLE     Cloning and expression of the mammalian cytosolic branched chain
            aminotransferase isoenzyme
  JOURNAL   J Biol Chem 270 (51), 30344-30352 (1995)
   PUBMED   8530459
REFERENCE   9  (residues 1 to 386)
  AUTHORS   Benvenisty,N., Leder,A., Kuo,A. and Leder,P.
  TITLE     An embryonically expressed gene is a target for c-Myc regulation
            via the c-Myc-binding sequence
  JOURNAL   Genes Dev 6 (12B), 2513-2523 (1992)
   PUBMED   1340466
REFERENCE   10 (residues 1 to 386)
  AUTHORS   Niwa,O., Kumazaki,T., Tsukiyama,T., Soma,G., Miyajima,N. and
            Yokoro,K.
  TITLE     A cDNA clone overexpressed and amplified in a mouse teratocarcinoma
            line
  JOURNAL   Nucleic Acids Res 18 (22), 6709 (1990)
   PUBMED   2251142
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY781109.1, AK167232.1, AC140416.2 and AW491045.1.
            
            On Nov 24, 2007 this sequence version replaced NP_031558.2.
            
            Transcript Variant: This variant (2) uses an alternate 5'-terminal
            exon, compared to variant 1. The resulting protein (isoform 2) has
            a shorter and unique N-terminus, compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK168249.1, AK166971.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..386
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 77.27 cM"
     Protein         1..386
                     /product="branched-chain-amino-acid aminotransferase,
                     cytosolic isoform 2"
                     /EC_number="2.6.1.42"
                     /note="branched-chain-amino-acid aminotransferase,
                     cytosolic; BCAT(c)"
                     /calculated_mol_wt=42660
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:P54687; propagated from
                     UniProtKB/Swiss-Prot (P24288.2)"
     Region          33..386
                     /region_name="PRK13357"
                     /note="branched-chain amino acid aminotransferase;
                     Provisional"
                     /db_xref="CDD:237363"
     CDS             1..386
                     /gene="Bcat1"
                     /gene_synonym="BCATc; Eca39"
                     /coded_by="NM_007532.5:264..1424"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS39703.1"
                     /db_xref="GeneID:12035"
                     /db_xref="MGI:MGI:104861"
ORIGIN      
        1 mkdcsngcsa pfagergsee vaetfrakdl iitpatvlke kpdpdslvfg atftdhmltv
       61 ewssasgwek phikpfgnlp ihpaasvlhy avelfeglka frgvdnkirl frpdlnmdrm
      121 crsavrttlp mfdkeellkc ilqllqidqe wvpystsasl yirptfigte pslgvkkpsk
      181 allfvilspv gpyfssgsft pvslwanpky irawkggtgd ckmggnygas llaqceaven
      241 gcqqvlwlyg kdnqitevgt mnlflywine dgeeelatpp ldgiilpgvt rqsilelaqq
      301 wgefkvcerh ltmddlatal egnrvkemfg sgtacvvcpv sdilykgqml hiptmengpk
      361 lasrilgklt diqygrvesd wtielp
//
