LOCUS       NM_001166643            3561 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus BCAS3 microtubule associated cell migration factor
            (Bcas3), transcript variant 3, mRNA.
ACCESSION   NM_001166643
VERSION     NM_001166643.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3561)
  AUTHORS   Shetty,R., Joshi,D., Jain,M., Vasudevan,M., Paul,J.C., Bhat,G.,
            Banerjee,P., Abe,T., Kiyonari,H., VijayRaghavan,K. and Inamdar,M.S.
  TITLE     Rudhira/BCAS3 is essential for mouse development and cardiovascular
            patterning
  JOURNAL   Sci Rep 8 (1), 5632 (2018)
   PUBMED   29618843
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3561)
  AUTHORS   Jain,M., Bhat,G.P., Vijayraghavan,K. and Inamdar,M.S.
  TITLE     Rudhira/BCAS3 is a cytoskeletal protein that controls Cdc42
            activation and directional cell migration during angiogenesis
  JOURNAL   Exp Cell Res 318 (6), 753-767 (2012)
   PUBMED   22300583
REFERENCE   3  (bases 1 to 3561)
  AUTHORS   Gobert,R.P., Joubert,L., Curchod,M.L., Salvat,C., Foucault,I.,
            Jorand-Lebrun,C., Lamarine,M., Peixoto,H., Vignaud,C., Fremaux,C.,
            Jomotte,T., Francon,B., Alliod,C., Bernasconi,L., Abderrahim,H.,
            Perrin,D., Bombrun,A., Zanoguera,F., Rommel,C. and Hooft van
            Huijsduijnen,R.
  TITLE     Convergent functional genomics of oligodendrocyte differentiation
            identifies multiple autoinhibitory signaling circuits
  JOURNAL   Mol Cell Biol 29 (6), 1538-1553 (2009)
   PUBMED   19139271
REFERENCE   4  (bases 1 to 3561)
  AUTHORS   Munton,R.P., Tweedie-Cullen,R., Livingstone-Zatchej,M.,
            Weinandy,F., Waidelich,M., Longo,D., Gehrig,P., Potthast,F.,
            Rutishauser,D., Gerrits,B., Panse,C., Schlapbach,R. and Mansuy,I.M.
  TITLE     Qualitative and quantitative analyses of protein phosphorylation in
            naive and stimulated mouse synaptosomal preparations
  JOURNAL   Mol Cell Proteomics 6 (2), 283-293 (2007)
   PUBMED   17114649
REFERENCE   5  (bases 1 to 3561)
  AUTHORS   Siva,K. and Inamdar,M.S.
  TITLE     Rudhira is a cytoplasmic WD40 protein expressed in mouse embryonic
            stem cells and during embryonic erythropoiesis
  JOURNAL   Gene Expr Patterns 6 (2), 225-234 (2006)
   PUBMED   16099728
  REMARK    GeneRIF: expressed at high levels in embryonic stem cells and is
            restricted to blood islands and the erythroid lineage during
            embryonic development
REFERENCE   6  (bases 1 to 3561)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   7  (bases 1 to 3561)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY116917.1, BC086693.1, AL604024.7 and BC060690.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR and
            lacks an alternate in-frame exon compared to variant 1. The
            resulting isoform (b) has the same N- and C-termini but is shorter
            compared to isoform a. Variants 2 and 3 both encode the same
            isoform.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086693.1, SRR7345562.2980986.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                BY116917.1         2-34
            34-1309             BC086693.1         1-1276
            1310-1311           AL604024.7         99134-99135         c
            1312-3519           BC086693.1         1277-3484
            3520-3561           BC060690.1         3766-3807
FEATURES             Location/Qualifiers
     source          1..3561
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 51.34 cM"
     gene            1..3561
                     /gene="Bcas3"
                     /gene_synonym="1500019F07Rik; 2610028P08Rik; K20D4; Phaf2;
                     rudhira"
                     /note="BCAS3 microtubule associated cell migration factor"
                     /db_xref="GeneID:192197"
                     /db_xref="MGI:MGI:2385848"
     exon            1..70
                     /gene="Bcas3"
                     /gene_synonym="1500019F07Rik; 2610028P08Rik; K20D4; Phaf2;
                     rudhira"
                     /inference="alignment:Splign:2.1.0"
     exon            71..158
                     /gene="Bcas3"
                     /gene_synonym="1500019F07Rik; 2610028P08Rik; K20D4; Phaf2;
                     rudhira"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..2817
                     /gene="Bcas3"
                     /gene_synonym="1500019F07Rik; 2610028P08Rik; K20D4; Phaf2;
                     rudhira"
                     /note="isoform b is encoded by transcript variant 3;
                     breast carcinoma-amplified sequence 3 homolog; protein
                     rudhira; breast carcinoma amplified sequence 3"
                     /codon_start=1
                     /product="BCAS3 microtubule associated cell migration
                     factor isoform b"
                     /protein_id="NP_001160115.1"
                     /db_xref="CCDS:CCDS48873.1"
                     /db_xref="GeneID:192197"
                     /db_xref="MGI:MGI:2385848"
                     /translation="MNETMATDSPRRPSRCTGGVVVRPQAVTEQSYMESVVTFLQDVV
                     PQAYSGSPLTEEKEKIVWVRFENADLNDTSRNLEFHELHSTGNEPPLLVMIGYSDGMQ
                     VWGIPISGEAQELFSVRHGPVRAARILPAPQLGAQKCDNFAEKRPLLGVCKSIGSSGT
                     TPPYCCVDLYSLRTGEMVKSIQFKTPIYDLHCNKRILVVVLQEKIAAFDSCTFTKKFF
                     VTSCYPCPGPNMNPIALGSRWLAYAENKLIRCHQSRGGACGDNIQSYTATVLSAAKTL
                     KSGLTMVGKVVTQLTGTLPSGVTEDDVALHCNSRRSPLVPGIITVIDTETVGEGQVLV
                     SEDSDSDGIVAHFPAHEKPVCCMAFNTSGMLLVTTDTLGHDFHVFQILTHPWSSSQCA
                     VHHLYTLHRGETEAKVQDICFSHDCRWVVVSTLRGTSHVFPINPYGGQPCVRTHMSPR
                     VVNRMSRFQKSAGLEEIEQELTSKQGGRCSPVPGLSSSPSGSPLHGKLTSQDSYNNFT
                     NNNPGNPRLSPLPSLMVVTPLAQIKQPMTLGTITKRTGKVKSPPQISPSKSMGGEFCV
                     AAVFGTSRSWFANNAGLKREKDQSKQVVVESLYIISCYGTLVEHMIEPRPISTAPKIS
                     DDTPLEIMTSPRASWTLVRTPQWNELQPPFNANHPLLLAAEAVQYYQLLLAGSLPPGS
                     PGPITRHGSYDSLASDHSGQEDEEWLSQVEIVTHTGPHRRLWMGPQFHFKTIQTSGQT
                     TVISTSSSVLQSHGPSDTPQPLLDFDTDDLDLNSLRIQPVRSDPVSMPGSSRAVSDRR
                     GVSTVTDAASGTFDRSVTLLEVCGSWPEGFGLRHMSSMEHSEEGLRERLADAMAESPS
                     RDVVGSGTELQREGSIETLSNSSGSTSGSIPRNFDGYRSPLPTNESQPLSLFPTGFP"
     exon            159..213
                     /gene="Bcas3"
                     /gene_synonym="1500019F07Rik; 2610028P08Rik; K20D4; Phaf2;
                     rudhira"
                     /inference="alignment:Splign:2.1.0"
     exon            214..289
                     /gene="Bcas3"
                     /gene_synonym="1500019F07Rik; 2610028P08Rik; K20D4; Phaf2;
                     rudhira"
                     /inference="alignment:Splign:2.1.0"
     exon            290..396
                     /gene="Bcas3"
                     /gene_synonym="1500019F07Rik; 2610028P08Rik; K20D4; Phaf2;
                     rudhira"
                     /inference="alignment:Splign:2.1.0"
     exon            397..478
                     /gene="Bcas3"
                     /gene_synonym="1500019F07Rik; 2610028P08Rik; K20D4; Phaf2;
                     rudhira"
                     /inference="alignment:Splign:2.1.0"
     exon            479..551
                     /gene="Bcas3"
                     /gene_synonym="1500019F07Rik; 2610028P08Rik; K20D4; Phaf2;
                     rudhira"
                     /inference="alignment:Splign:2.1.0"
     exon            552..659
                     /gene="Bcas3"
                     /gene_synonym="1500019F07Rik; 2610028P08Rik; K20D4; Phaf2;
                     rudhira"
                     /inference="alignment:Splign:2.1.0"
     exon            660..736
                     /gene="Bcas3"
                     /gene_synonym="1500019F07Rik; 2610028P08Rik; K20D4; Phaf2;
                     rudhira"
                     /inference="alignment:Splign:2.1.0"
     exon            737..813
                     /gene="Bcas3"
                     /gene_synonym="1500019F07Rik; 2610028P08Rik; K20D4; Phaf2;
                     rudhira"
                     /inference="alignment:Splign:2.1.0"
     exon            814..897
                     /gene="Bcas3"
                     /gene_synonym="1500019F07Rik; 2610028P08Rik; K20D4; Phaf2;
                     rudhira"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1068
                     /gene="Bcas3"
                     /gene_synonym="1500019F07Rik; 2610028P08Rik; K20D4; Phaf2;
                     rudhira"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1162
                     /gene="Bcas3"
                     /gene_synonym="1500019F07Rik; 2610028P08Rik; K20D4; Phaf2;
                     rudhira"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1296
                     /gene="Bcas3"
                     /gene_synonym="1500019F07Rik; 2610028P08Rik; K20D4; Phaf2;
                     rudhira"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1561
                     /gene="Bcas3"
                     /gene_synonym="1500019F07Rik; 2610028P08Rik; K20D4; Phaf2;
                     rudhira"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1712
                     /gene="Bcas3"
                     /gene_synonym="1500019F07Rik; 2610028P08Rik; K20D4; Phaf2;
                     rudhira"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1837
                     /gene="Bcas3"
                     /gene_synonym="1500019F07Rik; 2610028P08Rik; K20D4; Phaf2;
                     rudhira"
                     /inference="alignment:Splign:2.1.0"
     exon            1838..2003
                     /gene="Bcas3"
                     /gene_synonym="1500019F07Rik; 2610028P08Rik; K20D4; Phaf2;
                     rudhira"
                     /inference="alignment:Splign:2.1.0"
     exon            2004..2104
                     /gene="Bcas3"
                     /gene_synonym="1500019F07Rik; 2610028P08Rik; K20D4; Phaf2;
                     rudhira"
                     /inference="alignment:Splign:2.1.0"
     exon            2105..2205
                     /gene="Bcas3"
                     /gene_synonym="1500019F07Rik; 2610028P08Rik; K20D4; Phaf2;
                     rudhira"
                     /inference="alignment:Splign:2.1.0"
     exon            2206..2402
                     /gene="Bcas3"
                     /gene_synonym="1500019F07Rik; 2610028P08Rik; K20D4; Phaf2;
                     rudhira"
                     /inference="alignment:Splign:2.1.0"
     exon            2403..2500
                     /gene="Bcas3"
                     /gene_synonym="1500019F07Rik; 2610028P08Rik; K20D4; Phaf2;
                     rudhira"
                     /inference="alignment:Splign:2.1.0"
     exon            2501..2668
                     /gene="Bcas3"
                     /gene_synonym="1500019F07Rik; 2610028P08Rik; K20D4; Phaf2;
                     rudhira"
                     /inference="alignment:Splign:2.1.0"
     exon            2669..3525
                     /gene="Bcas3"
                     /gene_synonym="1500019F07Rik; 2610028P08Rik; K20D4; Phaf2;
                     rudhira"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3499..3504
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bcas3"
                     /gene_synonym="1500019F07Rik; 2610028P08Rik; K20D4; Phaf2;
                     rudhira"
                     /note="hexamer: AATAAA"
     polyA_site      3525
                     /gene="Bcas3"
                     /gene_synonym="1500019F07Rik; 2610028P08Rik; K20D4; Phaf2;
                     rudhira"
                     /note="major polyA site"
ORIGIN      
        1 gtcaatcacg agggagactc caaacagtga gcctgaagct ggagaacagc gtttaccggc
       61 ggagcggccg gtctcatgaa tgaaacaatg gctacagatt ctcctcggag acccagtcgt
      121 tgtactggcg gagtcgtggt ccgccctcag gccgtcacgg agcagtccta catggagagc
      181 gtcgtgactt ttctgcagga tgttgtgcca caggcttaca gtgggtctcc cctaacagaa
      241 gaaaaggaga agatagtctg ggtcagattt gagaatgcag atctgaacga cacatcacgg
      301 aatctagaat ttcatgaact gcatagcact ggaaatgagc ctcctctgct ggttatgatc
      361 ggctacagtg acggaatgca ggtctggggc atccctatca gcggggaagc ccaggagctc
      421 ttctctgtac gacatggtcc agtccgagca gctagaatct tgcctgctcc acagttgggt
      481 gcccaaaagt gtgataactt tgctgagaaa agacctcttc ttggtgtttg taagagcatt
      541 ggatcttcag gcacgacacc accgtactgc tgtgtggatc tgtattcact ccggactggg
      601 gaaatggtca agtccattca gtttaaaaca cccatttatg atcttcactg taacaagcgg
      661 atcctcgtcg tagtcttgca ggagaaaatt gctgcctttg atagctgtac tttcacaaaa
      721 aaattttttg tcacaagttg ttatccttgt cctgggccaa acatgaatcc cattgctctt
      781 gggagccgct ggcttgctta tgcagaaaat aagctgattc gctgtcacca gtcccgtgga
      841 ggagcctgtg gagacaacat tcagtcttac actgccactg tccttagtgc tgctaaaaca
      901 ctgaaaagtg gcctgacgat ggttgggaaa gtggtgactc aactgacagg cacactgccc
      961 tcaggggtga cagaagatga cgttgcccta cactgcaact caagacggag ccccttggtt
     1021 ccaggcatca tcacagtcat agacactgag acggttggag agggccaggt gcttgtaagt
     1081 gaggactcgg acagtgatgg cattgtggcc cacttccctg cccatgagaa gccagtatgc
     1141 tgtatggctt ttaatactag tggaatgctt ttagtcacaa cagatactct tggccatgac
     1201 tttcatgtct tccaaatcct gactcatcct tggtcatcat cacagtgtgc tgtccatcat
     1261 ctgtacacac ttcacagggg agagaccgag gccaaagttc aggacatctg tttcagccat
     1321 gattgtcgtt gggtggtggt cagtaccctc cggggtacgt cccacgtttt ccccatcaat
     1381 ccttatggtg gccagccttg tgtccgcaca cacatgtcac cacgagtagt caatcgcatg
     1441 agccgtttcc agaaaagtgc tgggctggaa gagattgaac aagagctgac atctaagcaa
     1501 ggcggccgct gtagtcctgt tccaggcctg tccagcagcc cttctggctc cccgctgcat
     1561 gggaagctga ccagccaaga ctcttacaat aactttacaa acaacaaccc tggcaatccc
     1621 cggctttctc ccctccccag cttgatggta gtgacgcctc ttgcgcaaat caaacagcca
     1681 atgacactgg gaaccatcac gaagcgaaca ggcaaagtta aatcacctcc acaaatttct
     1741 ccaagcaaat caatgggcgg tgagttttgc gtggctgcag tgtttgggac ttccaggtcg
     1801 tggtttgcaa acaacgctgg tctgaaacgg gaaaaagatc agtccaaaca agttgtagtt
     1861 gaatctcttt acatcatcag ctgctacggg accttagtgg agcacatgat tgagccccgg
     1921 ccgatcagta ctgctcccaa gataagtgac gacacaccac tggagataat gacgtcaccc
     1981 cgtgccagct ggacacttgt tagaacgcct cagtggaatg aactgcagcc gccattcaat
     2041 gcgaatcacc ctctgctcct cgctgcagaa gcagtgcagt attaccagct cctgctggcc
     2101 ggctctcttc cccctggaag tcctggcccc attactcgac atgggtccta tgacagctta
     2161 gcctctgacc atagtggaca ggaagatgaa gaatggcttt cccaggttga aattgtgaca
     2221 cacaccggac cccacaggcg cctgtggatg ggcccacaat tccatttcaa aaccatccaa
     2281 acctcaggcc agaccacggt catatcaact agttcttctg tgttacaatc gcacggacct
     2341 agcgacacac cacagccgct cttggacttt gatacggatg atctagatct taacagcctc
     2401 aggatccagc ctgtccgctc tgacccagtc agcatgccag ggtcatcccg tgctgtctct
     2461 gatcggaggg gagtttccac agtgaccgat gctgcctcag gtacctttga ccggagcgtg
     2521 accctgctgg aggtgtgtgg gagctggcct gagggcttcg ggctgcggca tatgtcctcc
     2581 atggagcact cagaggaggg cctccgggaa cggcttgcag atgccatggc cgagtcacca
     2641 agccgagacg ttgtgggatc tggaacagaa cttcagcgag agggaagcat cgagactctg
     2701 agtaacagct ccggctccac cagcggcagc atcccaagaa acttcgatgg ctaccgatct
     2761 ccgctcccta ccaacgagag ccagccgctc agcctcttcc ccactggctt cccctaggca
     2821 ccagccacct gcttctgact ggctggcccg ctcaccccta gagggactga ctgggagggg
     2881 ggagtacccc catctcccta caccaccacc accacccctg tcccgcacgc ctctgttccc
     2941 acccttttca gtctcctcaa ccccaccttc cctaagctta gtggcaacag ctgttcatcc
     3001 caaactggac gagaagagac cttcagaaca cctcggtaca ccctgacctc ccccactcct
     3061 gtcagtgggg gctgtggccc aaagagactg cagaaactca gtcccttctc tctttgcaca
     3121 caacgtcccg cactggatcc gcttttgtat tttctaacta ctcacagggg actggaacag
     3181 gggccagatc ttagggcctc tggtagggga gagttgaaag atccagccag gcattttggt
     3241 ggacatcagc cctagcccag ttcaggctgg gatgcacatt gcccccaggt acccctgctc
     3301 agttctaaaa caggagtgaa ctgagaccta gagcgataga gaggaagaag gaaagaggcc
     3361 tccccttgcc cttgcttccc tgttggctca tggagagatt tgtctgtctt atctttaagc
     3421 ccttgtcccc tggtcctgta ctgttccatg aagggaagtg cagttaccga ggccgtgtca
     3481 aaagtgcacg tcttgtccaa taaatctcgc tgcaattggt gttcaaaaaa aaaaaaaaaa
     3541 aaaaaaaaaa aaaaaaaaaa a
//
