LOCUS       NM_026602               1478 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus BCAS2 pre-mRNA processing factor (Bcas2), transcript
            variant 1, mRNA.
ACCESSION   NM_026602
VERSION     NM_026602.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1478)
  AUTHORS   Yao,X., Wang,C., Yu,W., Sun,L., Lv,Z., Xie,X., Tian,S., Yan,L.,
            Li,L. and Liu,J.
  TITLE     BCAS2 regulates oocyte meiotic prophase I by participating in mRNA
            alternative splicing
  JOURNAL   FASEB J 38 (1), e23361 (2024)
   PUBMED   38085152
  REMARK    GeneRIF: BCAS2 regulates oocyte meiotic prophase I by participating
            in mRNA alternative splicing.
REFERENCE   2  (bases 1 to 1478)
  AUTHORS   Chen,X., Xie,X., Li,J., Sun,L., Lv,Z., Yao,X., Li,L., Jin,H.,
            Cui,S. and Liu,J.
  TITLE     BCAS2 Participates in Insulin Synthesis and Secretion via mRNA
            Alternative Splicing in Mice
  JOURNAL   Endocrinology 165 (1) (2023)
   PUBMED   37820033
  REMARK    GeneRIF: BCAS2 Participates in Insulin Synthesis and Secretion via
            mRNA Alternative Splicing in Mice.
            Erratum:[Endocrinology. 2024 Jul 26;165(9):bqae096. doi:
            10.1210/endocr/bqae096.. PMID: 39092924]
REFERENCE   3  (bases 1 to 1478)
  AUTHORS   Yao,X., Wang,C., Sun,L., Yan,L., Chen,X., Lv,Z., Xie,X., Tian,S.,
            Liu,W., Li,L., Zhang,H. and Liu,J.
  TITLE     BCAS2 regulates granulosa cell survival by participating in mRNA
            alternative splicing
  JOURNAL   J Ovarian Res 16 (1), 104 (2023)
   PUBMED   37248466
  REMARK    GeneRIF: BCAS2 regulates granulosa cell survival by participating
            in mRNA alternative splicing.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1478)
  AUTHORS   Chen,H.H., Lu,H.Y., Chang,C.H., Lin,S.H., Huang,C.W., Wei,P.H.,
            Chen,Y.W., Lin,Y.R., Huang,H.S., Wang,P.Y., Tsao,Y.P. and Chen,S.L.
  TITLE     Breast carcinoma-amplified sequence 2 regulates adult neurogenesis
            via beta-catenin
  JOURNAL   Stem Cell Res Ther 13 (1), 160 (2022)
   PUBMED   35410459
  REMARK    GeneRIF: Breast carcinoma-amplified sequence 2 regulates adult
            neurogenesis via beta-catenin.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1478)
  AUTHORS   Zhang,J., Liu,W., Li,G., Xu,C., Nie,X., Qin,D., Wang,Q., Lu,X.,
            Liu,J. and Li,L.
  TITLE     BCAS2 is involved in alternative splicing and mouse oocyte
            development
  JOURNAL   FASEB J 36 (2), e22128 (2022)
   PUBMED   34972250
  REMARK    GeneRIF: BCAS2 is involved in alternative splicing and mouse oocyte
            development.
REFERENCE   6  (bases 1 to 1478)
  AUTHORS   Huang,C.W., Chen,Y.W., Lin,Y.R., Chen,P.H., Chou,M.H., Lee,L.J.,
            Wang,P.Y., Wu,J.T., Tsao,Y.P. and Chen,S.L.
  TITLE     Conditional Knockout of Breast Carcinoma Amplified Sequence 2
            (BCAS2) in Mouse Forebrain Causes Dendritic Malformation via
            beta-catenin
  JOURNAL   Sci Rep 6, 34927 (2016)
   PUBMED   27713508
  REMARK    GeneRIF: BCAS2 is an upstream regulator of beta-catenin gene
            expression and plays a role in dendrite growth at least partly
            through beta-catenin in the forebrain.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1478)
  AUTHORS   Xu,Q., Wang,F., Xiang,Y., Zhang,X., Zhao,Z.A., Gao,Z., Liu,W.,
            Lu,X., Liu,Y., Yu,X.J., Wang,H., Huang,J., Yi,Z., Gao,S. and Li,L.
  TITLE     Maternal BCAS2 protects genomic integrity in mouse early embryonic
            development
  JOURNAL   Development 142 (22), 3943-3953 (2015)
   PUBMED   26428007
  REMARK    GeneRIF: Maternal BCAS2 protects genomic integrity in mouse early
            embryonic development.
REFERENCE   8  (bases 1 to 1478)
  AUTHORS   Liao,S., Du,R., Wang,L., Qu,Z., Cui,X., Li,C., Liu,F., Huang,M.,
            Wang,J., Chen,J., Gao,M., Yu,S., Tang,Z., Li,D.W., Jiang,T. and
            Liu,M.
  TITLE     BCAS2 interacts with HSF4 and negatively regulates its protein
            stability via ubiquitination
  JOURNAL   Int J Biochem Cell Biol 68, 78-86 (2015)
   PUBMED   26319152
  REMARK    GeneRIF: BCAS2 interacts with HSF4 and negatively regulates its
            protein stability via ubiquitination.
REFERENCE   9  (bases 1 to 1478)
  AUTHORS   Chanarat,S. and Strasser,K.
  TITLE     Splicing and beyond: the many faces of the Prp19 complex
  JOURNAL   Biochim Biophys Acta 1833 (10), 2126-2134 (2013)
   PUBMED   23742842
  REMARK    Review article
REFERENCE   10 (bases 1 to 1478)
  AUTHORS   Lee,S., Ha,S., Chung,M., Kim,Y. and Choi,Y.
  TITLE     Mouse DAM1 regulates pro-apoptotic activity of BLK in mammary
            epithelial cells
  JOURNAL   Cancer Lett 188 (1-2), 121-126 (2002)
   PUBMED   12406557
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC150894.4.
            
            On Sep 29, 2017 this sequence version replaced NM_026602.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK153513.1, AK166967.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-211               AC150894.4         40671-40881         c
            212-304             AC150894.4         40496-40588         c
            305-375             AC150894.4         39191-39261         c
            376-537             AC150894.4         38035-38196         c
            538-588             AC150894.4         36867-36917         c
            589-669             AC150894.4         35117-35197         c
            670-1478            AC150894.4         33373-34181         c
FEATURES             Location/Qualifiers
     source          1..1478
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 45.25 cM"
     gene            1..1478
                     /gene="Bcas2"
                     /gene_synonym="6430539P16Rik"
                     /note="BCAS2 pre-mRNA processing factor"
                     /db_xref="GeneID:68183"
                     /db_xref="MGI:MGI:1915433"
     exon            1..211
                     /gene="Bcas2"
                     /gene_synonym="6430539P16Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..796
                     /gene="Bcas2"
                     /gene_synonym="6430539P16Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     pre-mRNA-splicing factor SPF27; DNA amplified in mammary
                     carcinoma 1 protein; breast carcinoma-amplified sequence 2
                     homolog; breast carcinoma amplified sequence 2"
                     /codon_start=1
                     /product="pre-mRNA-splicing factor SPF27 isoform 1"
                     /protein_id="NP_080878.2"
                     /db_xref="CCDS:CCDS17691.1"
                     /db_xref="GeneID:68183"
                     /db_xref="MGI:MGI:1915433"
                     /translation="MAGTGLVAGEVVVDALPYFDQGYEAPGVREAAAALVEEETRRYR
                     PTKNYLSYLTAPDYSAFETDIMRNEFERLAARQPIELLSMKRYELPAPSSGQKNDITA
                     WQECVNNSMAQLEHQAVRIENLELMSQHGCNAWKVYNENLVHMIEHAQKELQKLRKHI
                     QDLNWQRKNMQLTAGSKLREMESNWVSLVSKNYEIERTIVQLENEIYQIKQQHGEANK
                     ENIRQDF"
     exon            212..304
                     /gene="Bcas2"
                     /gene_synonym="6430539P16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            305..375
                     /gene="Bcas2"
                     /gene_synonym="6430539P16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            376..537
                     /gene="Bcas2"
                     /gene_synonym="6430539P16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            538..588
                     /gene="Bcas2"
                     /gene_synonym="6430539P16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            589..669
                     /gene="Bcas2"
                     /gene_synonym="6430539P16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            670..1478
                     /gene="Bcas2"
                     /gene_synonym="6430539P16Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1122..1127
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bcas2"
                     /gene_synonym="6430539P16Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1143
                     /gene="Bcas2"
                     /gene_synonym="6430539P16Rik"
                     /note="major polyA site"
     polyA_site      1274
                     /gene="Bcas2"
                     /gene_synonym="6430539P16Rik"
ORIGIN      
        1 ccgaatcgaa gccccaaagg cagcggcgtg tgtgacgtca ttccaggcgc aggcgcagtg
       61 gaattagaac cgaggctgcg cagactcaga aggcgctctt gaagcctagt gccgcgcgat
      121 ggcgggcacg ggcttggtag ccggagaggt ggtggtagat gcgctaccat attttgacca
      181 aggctatgag gcacccggcg tgcgggaagc ggcggcggcc ctggtggagg aggagacgcg
      241 cagataccga cctaccaaga actacctgag ctacctgacg gccccggatt attctgcctt
      301 tgaaacagac ataatgagaa atgaatttga aagactcgct gctcgacaac cgattgaatt
      361 actcagcatg aaacgatatg aacttccagc cccttcctca ggtcaaaaaa atgacattac
      421 tgcatggcaa gaatgtgtaa acaattctat ggctcagttg gagcaccagg cggtccggat
      481 cgagaatctg gagctgatgt cacagcatgg atgcaatgcc tggaaggtgt acaatgaaaa
      541 tcttgttcat atgattgaac atgcacagaa agagcttcag aagttaagga aacatattca
      601 agatttgaac tggcagcgaa agaacatgca gcttacagct ggatctaagc tgagagaaat
      661 ggagtcaaac tgggtgtcgc tggtgagtaa gaactatgag attgagcgga cgattgtcca
      721 gctggagaac gagatctatc agatcaagca gcagcacggg gaggccaaca aggaaaacat
      781 ccgccaagac ttctaatgac tcaggcgacg tgggctccgc agactcagcg gggactttct
      841 cggagcgact gtggtggtta catggttaga gaccatggac tatgtaaact gttgtattgc
      901 ttctgtgtga gtgtcttagc aaaataaagt tgtcaacatg ttgctgtttt tatgctataa
      961 aaacctggtt ttcagaatga gtatgacttt agaataattt tgacatattt tgtagcagaa
     1021 tttttttttt aaggcttcaa attttgtaat gaagctcctt tatttttaag gcatccaaca
     1081 tgttctggaa gctggaaacc ttgaatttgt gttttttgtt gaataaagtt acagttctaa
     1141 gcatttttat gtgtggctat agtgaacttt attgatggta ttcaaaagaa tgaggctccc
     1201 ttctagggat ctatgataga aataggtgta gtgagaattg tggaattttg gattcttttt
     1261 taaaaatgca gaaatataag aatatgtttt gggctggtga gatggctcag cgggtaagag
     1321 cacccgactg ctcttccgaa ggtccggagt tcaaatccca gcaaccacat agtggctcac
     1381 aaccacccgt aatgagatct gattccctct tctggagtgt ctgaagacag ctacagtgta
     1441 cttacatata ataaataaat aaatcttaaa aaaaaaaa
//
