LOCUS       NM_029815               3090 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus brain enriched myelin associated protein 1 (Bcas1),
            transcript variant 1, mRNA.
ACCESSION   NM_029815
VERSION     NM_029815.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3090)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3090)
  AUTHORS   Waldhauser,V., Baroti,T., Frob,F. and Wegner,M.
  TITLE     PBAF Subunit Pbrm1 Selectively Influences the Transition from
            Progenitors to Pre-Myelinating Cells during Oligodendrocyte
            Development
  JOURNAL   Cells 12 (12), 1556 (2023)
   PUBMED   37371026
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3090)
  AUTHORS   Li,L., Jin,J. and Yang,X.J.
  TITLE     Histone Deacetylase 3 Governs Perinatal Cerebral Development via
            Neural Stem and Progenitor Cells
  JOURNAL   iScience 20, 148-167 (2019)
   PUBMED   31569049
REFERENCE   4  (bases 1 to 3090)
  AUTHORS   Loo,L., Simon,J.M., Xing,L., McCoy,E.S., Niehaus,J.K., Guo,J.,
            Anton,E.S. and Zylka,M.J.
  TITLE     Single-cell transcriptomic analysis of mouse neocortical
            development
  JOURNAL   Nat Commun 10 (1), 134 (2019)
   PUBMED   30635555
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3090)
  AUTHORS   Fard,M.K., van der Meer,F., Sanchez,P., Cantuti-Castelvetri,L.,
            Mandad,S., Jakel,S., Fornasiero,E.F., Schmitt,S., Ehrlich,M.,
            Starost,L., Kuhlmann,T., Sergiou,C., Schultz,V., Wrzos,C.,
            Bruck,W., Urlaub,H., Dimou,L., Stadelmann,C. and Simons,M.
  TITLE     BCAS1 expression defines a population of early myelinating
            oligodendrocytes in multiple sclerosis lesions
  JOURNAL   Sci Transl Med 9 (419) (2017)
   PUBMED   29212715
REFERENCE   6  (bases 1 to 3090)
  AUTHORS   Ishimoto,T., Ninomiya,K., Inoue,R., Koike,M., Uchiyama,Y. and
            Mori,H.
  TITLE     Mice lacking BCAS1, a novel myelin-associated protein, display
            hypomyelination, schizophrenia-like abnormal behaviors, and
            upregulation of inflammatory genes in the brain
  JOURNAL   Glia 65 (5), 727-739 (2017)
   PUBMED   28230289
  REMARK    GeneRIF: that the loss of BCAS1 specifically induced
            hypomyelination and the expression of inflammation-related genes in
            the brain
REFERENCE   7  (bases 1 to 3090)
  AUTHORS   Lauridsen,J.B., Johansen,J.L., Rekling,J.C., Thirstrup,K., Moerk,A.
            and Sager,T.N.
  TITLE     Regulation of the Bcas1 and Baiap3 transcripts in the subthalamic
            nucleus in mice recovering from MPTP toxicity
  JOURNAL   Neurosci Res 70 (3), 269-276 (2011)
   PUBMED   21514331
  REMARK    GeneRIF: Two transcripts with regulation from days 7 to 28 in the
            1-methyl-4-phenyl-tetrahydropyridine treated groups, are
            identified: brain specific angiogenesis inhibitor associated
            protein 3 (Baiap3) and breast carcinoma amplified sequence 1
            (Bcas1).
REFERENCE   8  (bases 1 to 3090)
  AUTHORS   Beardsley,D.I., Kowbel,D., Lataxes,T.A., Mannino,J.M., Xin,H.,
            Kim,W.J., Collins,C. and Brown,K.D.
  TITLE     Characterization of the novel amplified in breast cancer-1 (NABC1)
            gene product
  JOURNAL   Exp Cell Res 290 (2), 402-413 (2003)
   PUBMED   14567997
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY720653.1, AL935134.10, AK008957.1 and AL928812.11.
            
            On Sep 1, 2009 this sequence version replaced NM_029815.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY219233.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-470               BY720653.1         3-472
            471-595             AL935134.10        8740-8864           c
            596-2744            AK008957.1         2-2150
            2745-3090           AL928812.11        146240-146585       c
FEATURES             Location/Qualifiers
     source          1..3090
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 91.41 cM"
     gene            1..3090
                     /gene="Bcas1"
                     /gene_synonym="2210416M21Rik; 9030223A09Rik; NABC1"
                     /note="brain enriched myelin associated protein 1"
                     /db_xref="GeneID:76960"
                     /db_xref="MGI:MGI:1924210"
     exon            1..100
                     /gene="Bcas1"
                     /gene_synonym="2210416M21Rik; 9030223A09Rik; NABC1"
                     /inference="alignment:Splign:2.1.0"
     exon            101..177
                     /gene="Bcas1"
                     /gene_synonym="2210416M21Rik; 9030223A09Rik; NABC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..2007
                     /gene="Bcas1"
                     /gene_synonym="2210416M21Rik; 9030223A09Rik; NABC1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     breast carcinoma-amplified sequence 1 homolog; amplified
                     in breast cancer 1; novel amplified in breast cancer 1
                     homolog; breast carcinoma amplified sequence 1"
                     /codon_start=1
                     /product="breast carcinoma-amplified sequence 1 homolog
                     isoform 1"
                     /protein_id="NP_084091.2"
                     /db_xref="CCDS:CCDS17121.1"
                     /db_xref="GeneID:76960"
                     /db_xref="MGI:MGI:1924210"
                     /translation="MGNQMSVPLRPGDQEHDPGADTCKVTSDNECVQNGNPVVLSTRV
                     IQHYEEVDLGISSSKDNVATSSPKTMEAQAVGDASGKNLGKEAKTKAPAARSHFFLTL
                     SRPVPGRPGDQGTDSSAASGRFDVSPSAAPENKDPSEHGALPVAAAPGQAPDKTPGCP
                     EAKQQTLPATGPLAPSPPESQAEAPAQDKDFGFLNRFFKLDKGRESAPVNSQPKEAKG
                     SEDPEQATEAPAVPGNPHGVSAGEDIVDSEQRGQDVDTLSYSVPGDPEVPGTTKEDPQ
                     VVDTTENSSSIMSFFKTLVSPNKTETKKDPEDTKATKADSVCDGHAAGQKMSETQAKS
                     KKKRLDSPRLGLSFRKLFRHKDTENSPTTSANLKSDKANFTPQETRGKTKATKSCSPP
                     PPPPEPTSEGRDSGKEKAGPTSLPLGKLFWKKSVKEDTLSTGAEENAVCESPVETVRL
                     EEVESSLQTVDLSEETQPEPTDVKVKEESKPRKTPLMAFLRQMSVRSSEGIPRSEESN
                     VKDSSCQTSNSVEKTPSPPEPEPAGTAQKNKETSSSKDKKSVDKKSATENSKQKNGKQ
                     EVREPAPCVQPPTVEANAMQTGDKTPKKSEKRRQSLGGFLKGLGPKRMSDAQVQTDPV
                     SIGPVGKSK"
     exon            178..256
                     /gene="Bcas1"
                     /gene_synonym="2210416M21Rik; 9030223A09Rik; NABC1"
                     /inference="alignment:Splign:2.1.0"
     exon            257..831
                     /gene="Bcas1"
                     /gene_synonym="2210416M21Rik; 9030223A09Rik; NABC1"
                     /inference="alignment:Splign:2.1.0"
     exon            832..987
                     /gene="Bcas1"
                     /gene_synonym="2210416M21Rik; 9030223A09Rik; NABC1"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1032
                     /gene="Bcas1"
                     /gene_synonym="2210416M21Rik; 9030223A09Rik; NABC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1170
                     /gene="Bcas1"
                     /gene_synonym="2210416M21Rik; 9030223A09Rik; NABC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1377
                     /gene="Bcas1"
                     /gene_synonym="2210416M21Rik; 9030223A09Rik; NABC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1419
                     /gene="Bcas1"
                     /gene_synonym="2210416M21Rik; 9030223A09Rik; NABC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1584
                     /gene="Bcas1"
                     /gene_synonym="2210416M21Rik; 9030223A09Rik; NABC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1650
                     /gene="Bcas1"
                     /gene_synonym="2210416M21Rik; 9030223A09Rik; NABC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1932
                     /gene="Bcas1"
                     /gene_synonym="2210416M21Rik; 9030223A09Rik; NABC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1933..3090
                     /gene="Bcas1"
                     /gene_synonym="2210416M21Rik; 9030223A09Rik; NABC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2911..2916
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bcas1"
                     /gene_synonym="2210416M21Rik; 9030223A09Rik; NABC1"
                     /note="hexamer: AATAAA"
     polyA_site      2935
                     /gene="Bcas1"
                     /gene_synonym="2210416M21Rik; 9030223A09Rik; NABC1"
                     /note="major polyA site"
ORIGIN      
        1 agtctgagac tgggcagcaa ccgctgaaga cgcaggaccc tgagcagaac caactgttgg
       61 aaactgtggg ggacccaaga tactcccacc gacttaccag gaacaatggg aaaccagatg
      121 agcgtcccac taaggcctgg agaccaggag cacgacccag gagcagacac ttgcaaggtg
      181 acgtcagaca atgagtgtgt tcagaatggg aacccagttg tgctgtccac tcgtgtaatt
      241 caacactatg aggaagtcga cttgggaatc agcagctcca aggataatgt ggctacttct
      301 tcccccaaga caatggaggc ccaggctgtg ggcgatgcca gcggaaagaa tcttgggaaa
      361 gaagccaaga ccaaggcacc agctgctaga tcccattttt tcttgacact ctctcggcct
      421 gtaccaggac gtcccgggga ccaaggcacg gattcatcgg ctgcatcagg gaggtttgat
      481 gtcagcccaa gcgcagcgcc tgagaacaaa gacccaagtg agcacggggc acttccggtg
      541 gcagctgcac cagggcaggc tccagataaa accccagggt gccccgaggc caagcagcag
      601 accctccctg ccaccggccc attggcaccc tcaccacctg agtcccaggc agaagccccg
      661 gcccaggaca aggatttcgg ctttttgaac agattcttta aactggacaa aggaagagaa
      721 agcgcgccgg tgaacagcca gcccaaagaa gcgaaaggct cggaagaccc agaacaggcc
      781 acagaggctc ctgccgtgcc agggaatccc catggtgtct ctgcagggga ggacatagtc
      841 gacagcgagc agagaggaca agacgttgac actctgagtt attctgtccc tggggatcca
      901 gaggtgccgg ggaccacgaa ggaggacccg caggtggtcg ataccacaga gaacagcagc
      961 tccatcatga gcttcttcaa gacactggtt tcacctaaca agactgaaac aaagaaggac
     1021 ccagaagaca cgaaggcaac caaggcagac agtgtctgtg atggacacgc tgctggccag
     1081 aagatgtcgg agacgcaggc taaaagcaag aagaagcgcc tggacagccc caggctagga
     1141 ctctccttta gaaagctctt taggcacaag gatactgaga actcacccac gacttcagcc
     1201 aatctcaagt cggacaaagc caacttcaca ccccaggaga cccgagggaa gacaaaggct
     1261 accaaaagct gcagcccccc accgccacct cctgaaccca ccagcgaagg gagagacagc
     1321 ggcaaggaga aggcagggcc cacctcacta ccgctgggaa agttgttttg gaagaagtca
     1381 gttaaggagg atacactttc cacaggtgca gaggagaacg cggtgtgtga gtcaccagta
     1441 gagaccgtaa ggcttgagga agtagaatcc agcttacaaa ctgtggatct cagtgaagag
     1501 acccagcctg aacccacaga cgtaaaagtc aaagaagaaa gcaaaccccg gaagacccct
     1561 ctgatggcgt ttctcagaca aatgtcagtg agatcgagcg aagggatccc ccgctcggaa
     1621 gaaagtaacg tgaaagactc cagctgccaa acgtcaaact ccgtggaaaa gacgccctca
     1681 cccccagagc cagagcccgc gggaacagct cagaaaaaca aggagacctc ctcctcgaag
     1741 gacaagaaat cagtggacaa gaagtcagcg actgagaaca gcaagcagaa gaacggcaaa
     1801 caggaagtca gagagccggc gccgtgtgtg cagccgccca cagtggaggc aaacgcaatg
     1861 cagactgggg acaagacccc aaagaagtct gagaagcggc gacagtccct cgggggcttc
     1921 ctgaagggcc tgggaccaaa gcggatgtcg gatgctcagg tgcaaacgga cccggtctcc
     1981 atcggaccag ttggaaaatc caagtaaaca aaatcaccca gttcccactg ggttctcctc
     2041 ccactccatc tactgtccag acccacactg tgtatatatt tttcttcttc ttcttctggt
     2101 cagccaatga aattctgcct acaacttcaa cctgaattgt tgtagatcga ggtgtattat
     2161 ttacgtctct ggtccagtct ttcctggcat ttaagtgtaa aaatggctta gcaggttgac
     2221 cagttgatcc aagggagctg gtgagtgcca ggtgggggag gaagtaggta gataaaggca
     2281 tttgtgttaa gttatgaaaa aatggcaggt atccagtaag atgcagaaga aaagtgctta
     2341 tgagacaaag aatatctgga tttgtagcca ctcttgccac atcctctaag cctgaagagg
     2401 ggaagggaag actggtttat ttcatttcac acttggggga aggaggactc agggcaggca
     2461 tctacgctgg gcgtctgcca acttttggaa caggatgtgt gggctgtaaa gaagaatggg
     2521 caagaattgg ttttcaaata gggtccttgg aagttatcag tgaatgggga agtgatttgc
     2581 tggagagggc ttgctaggat ttggggaaac aattacttct ggggcacagg gacaagggca
     2641 tgaattccca acttcaaaag ggaaacagca aaatgaaata aaggtgcagg ttcattttgc
     2701 aacacaaggg ggcgccagga tctctgcttt ttccctttgc atccggtacc cctaacaaag
     2761 atttgtttct gcactatttc attattaatg tttctcagat ggctgaggga cttgcttcat
     2821 ctgttcggtc tgacgcttat ctcacgcctg tctgtaatgt cctaatgttt tcataatgtg
     2881 ctctgataaa aaccctcccc taacccagtt aataaaaatt gacagattat gcgaatactt
     2941 gaggtggttt ttttttttta attcttgtac agagaactga attggactgt gaatccatta
     3001 agatggaatt gccaagtacc atatgattga ctgatagtca tctgtattgt acctttcttt
     3061 tcccaattta ataaaaaaat attacatttt
//
