LOCUS       NM_013867               3332 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus breast cancer anti-estrogen resistance 3 (Bcar3),
            transcript variant 1, mRNA.
ACCESSION   NM_013867
VERSION     NM_013867.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3332)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3332)
  AUTHORS   Zeng,C., Wang,Q., Liu,X., Wang,K., Wang,C., Ju,X., Wang,T.,
            Zhou,Q., Fu,X., Yu,J. and Wang,Y.
  TITLE     Localized Administration of Bcar3 siRNA via Nano-Self-Assembly to
            Treat Idiopathic Pulmonary Fibrosis by Disrupting
            Macrophage-Fibroblast Crosstalk
  JOURNAL   Int J Nanomedicine 19, 1827-1842 (2024)
   PUBMED   38414524
  REMARK    GeneRIF: Localized Administration of Bcar3 siRNA via
            Nano-Self-Assembly to Treat Idiopathic Pulmonary Fibrosis by
            Disrupting Macrophage-Fibroblast Crosstalk.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3332)
  AUTHORS   Kondo,T., Nakamori,T., Nagai,H., Takeshita,A., Kusakabe,K.T. and
            Okada,T.
  TITLE     A novel spontaneous mutation of BCAR3 results in extrusion
            cataracts in CF#1 mouse strain
  JOURNAL   Mamm Genome 27 (9-10), 451-459 (2016)
   PUBMED   27364350
  REMARK    GeneRIF: The first spontaneous mutation in the Bcar3 gene
            associated with lens extrusion cataracts.
REFERENCE   4  (bases 1 to 3332)
  AUTHORS   Lumayag,S., Haldin,C.E., Corbett,N.J., Wahlin,K.J., Cowan,C.,
            Turturro,S., Larsen,P.E., Kovacs,B., Witmer,P.D., Valle,D.,
            Zack,D.J., Nicholson,D.A. and Xu,S.
  TITLE     Inactivation of the microRNA-183/96/182 cluster results in
            syndromic retinal degeneration
  JOURNAL   Proc Natl Acad Sci U S A 110 (6), E507-E516 (2013)
   PUBMED   23341629
REFERENCE   5  (bases 1 to 3332)
  AUTHORS   Sun,G., Cheng,S.Y., Chen,M., Lim,C.J. and Pallen,C.J.
  TITLE     Protein tyrosine phosphatase alpha phosphotyrosyl-789 binds BCAR3
            to position Cas for activation at integrin-mediated focal adhesions
  JOURNAL   Mol Cell Biol 32 (18), 3776-3789 (2012)
   PUBMED   22801373
REFERENCE   6  (bases 1 to 3332)
  AUTHORS   Garron,M.L., Arsenieva,D., Zhong,J., Bloom,A.B., Lerner,A.,
            O'Neill,G.M. and Arold,S.T.
  TITLE     Structural insights into the association between BCAR3 and Cas
            family members, an atypical complex implicated in anti-oestrogen
            resistance
  JOURNAL   J Mol Biol 386 (1), 190-203 (2009)
   PUBMED   19103205
  REMARK    GeneRIF: study presents a pluridisciplinary approach, including
            small-angle X-ray scattering, that provides first insights into the
            structure of the complex formed between BCAR3 and human enhancer of
            filamentation 1 (HEF1)
REFERENCE   7  (bases 1 to 3332)
  AUTHORS   Near,R.I., Smith,R.S., Toselli,P.A., Freddo,T.F., Bloom,A.B.,
            Vanden Borre,P., Seldin,D.C. and Lerner,A.
  TITLE     Loss of AND-34/BCAR3 expression in mice results in rupture of the
            adult lens
  JOURNAL   Mol Vis 15, 685-699 (2009)
   PUBMED   19365570
  REMARK    GeneRIF: AND-34-mediated signaling is required for maintenance of
            the structural integrity of the adult ocular lens.
REFERENCE   8  (bases 1 to 3332)
  AUTHORS   Cai,D., Felekkis,K.N., Near,R.I., O'Neill,G.M., van Seventer,J.M.,
            Golemis,E.A. and Lerner,A.
  TITLE     The GDP exchange factor AND-34 is expressed in B cells, associates
            with HEF1, and activates Cdc42
  JOURNAL   J Immunol 170 (2), 969-978 (2003)
   PUBMED   12517963
  REMARK    GeneRIF: p130Cas- and HEF1-associated AND-34 may regulate B cell
            adhesion and motility through a Cdc42-mediated signaling pathway.
REFERENCE   9  (bases 1 to 3332)
  AUTHORS   Gotoh,T., Cai,D., Tian,X., Feig,L.A. and Lerner,A.
  TITLE     p130Cas regulates the activity of AND-34, a novel Ral, Rap1, and
            R-Ras guanine nucleotide exchange factor
  JOURNAL   J Biol Chem 275 (39), 30118-30123 (2000)
   PUBMED   10896938
REFERENCE   10 (bases 1 to 3332)
  AUTHORS   Cai,D., Clayton,L.K., Smolyar,A. and Lerner,A.
  TITLE     AND-34, a novel p130Cas-binding thymic stromal cell protein
            regulated by adhesion and inflammatory cytokines
  JOURNAL   J Immunol 163 (4), 2104-2112 (1999)
   PUBMED   10438950
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138720.5, AF179566.1 and AV223564.1.
            
            On Sep 14, 2017 this sequence version replaced NM_013867.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC023930.1, AF179566.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-287               AC138720.5         134485-134771       c
            288-3324            AF179566.1         213-3249
            3325-3332           AV223564.1         263-270
FEATURES             Location/Qualifiers
     source          1..3332
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 53.41 cM"
     gene            1..3332
                     /gene="Bcar3"
                     /gene_synonym="AND-34"
                     /note="breast cancer anti-estrogen resistance 3"
                     /db_xref="GeneID:29815"
                     /db_xref="MGI:MGI:1352501"
     exon            1..427
                     /gene="Bcar3"
                     /gene_synonym="AND-34"
                     /inference="alignment:Splign:2.1.0"
     exon            428..737
                     /gene="Bcar3"
                     /gene_synonym="AND-34"
                     /inference="alignment:Splign:2.1.0"
     CDS             439..2901
                     /gene="Bcar3"
                     /gene_synonym="AND-34"
                     /note="isoform 1 is encoded by transcript variant 1;
                     p130Cas-binding protein AND-34; breast cancer
                     anti-estrogen resistance protein 3 homolog"
                     /codon_start=1
                     /product="breast cancer anti-estrogen resistance protein 3
                     homolog isoform 1"
                     /protein_id="NP_038895.1"
                     /db_xref="CCDS:CCDS17810.1"
                     /db_xref="GeneID:29815"
                     /db_xref="MGI:MGI:1352501"
                     /translation="MAAGKFASLPRNMPVNHQFPLASSMDLLSSKSPLAERRTDAYQD
                     VSIHGTLPRKKKGPPSIRSCDNAGHSKSPRQSSPLTQDIIQENPLQDRKGENFIFRDP
                     YLLDPTLEYVKFSKERHIMDRTPERLKKELEEELLLSSEDLRSHAWYHGRIPRQVSEN
                     LVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESF
                     DSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVPLWCLEERYGTSPGRGREGSLAEGR
                     PDVVKRLSLTTGSSIQAREHSLPRGNLLRNKEKSGSQPACLDHVQDRKALTLKAHQSE
                     SHLPIGCKLPPQSPSMDTSPCPSSPVFRTGSEPTLSPALVRRFSSDARTGEALRGSDS
                     QLCPKPPPKPCKVPFLKTPPSPSPWLTSEANYCELNPAFAVGCDRGAKLPMQAHDSHE
                     MLLTAKQNGPSGPRNSGINYMILDGDDQARHWDPLAVQTDEGQEDKTKFVPPLMETVS
                     SFRPNDFESKLLPPENKPLETAMLKHAKELFTNHDARVIAQHMLSVDCKVARILEVSE
                     DRKRSMGVSSGLELITLPHGRQLRLDIIERHNTMAIGIAVDILGCTGTLENRAGTLNK
                     IIQVAVELKDAMGDLYAFSAIMKALEMPQITRLEKTWTALRHHYTQTAILYEKQLKPF
                     SKILHEGRESTYVPASNVSVPLLMPLVTLMERQAVTFEGTDMWENNDESCEILLNHLA
                     TARFMAEASESYRMNAERILADFQPDEEMTEILRTEFQMRLLWGSKGAEVNQNERYDK
                     FNQILTALSRKLEPPSGKQAEL"
     exon            738..777
                     /gene="Bcar3"
                     /gene_synonym="AND-34"
                     /inference="alignment:Splign:2.1.0"
     exon            778..906
                     /gene="Bcar3"
                     /gene_synonym="AND-34"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1352
                     /gene="Bcar3"
                     /gene_synonym="AND-34"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1456
                     /gene="Bcar3"
                     /gene_synonym="AND-34"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..2109
                     /gene="Bcar3"
                     /gene_synonym="AND-34"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2225
                     /gene="Bcar3"
                     /gene_synonym="AND-34"
                     /inference="alignment:Splign:2.1.0"
     exon            2226..2397
                     /gene="Bcar3"
                     /gene_synonym="AND-34"
                     /inference="alignment:Splign:2.1.0"
     exon            2398..2509
                     /gene="Bcar3"
                     /gene_synonym="AND-34"
                     /inference="alignment:Splign:2.1.0"
     exon            2510..2722
                     /gene="Bcar3"
                     /gene_synonym="AND-34"
                     /inference="alignment:Splign:2.1.0"
     exon            2723..3332
                     /gene="Bcar3"
                     /gene_synonym="AND-34"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3306..3311
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bcar3"
                     /gene_synonym="AND-34"
                     /note="hexamer: AATATA"
     polyA_site      3327
                     /gene="Bcar3"
                     /gene_synonym="AND-34"
                     /note="major polyA site"
ORIGIN      
        1 gctgtccggt tgagtgaggt tcagtaagga agaggttgag ctacacttga agtctagctt
       61 ctcgggggaa gataaggggg agtcaaaact ctcaaatccg ggcggaggag agccagacga
      121 ggtcaccgaa tgtaaaagtc gccggggttc ggctcagccc ggcgaatcgg ctgggcgggg
      181 tggggccgcg aagccgcaaa tcaccagttg agggccagag agcgcgctgc cggctcagag
      241 ctgagcctgc agccgcccgg ccaggcagca gccggagcgg gacagccgtg cacacccgcc
      301 agccgcacca gcctcttggc ggacgcccgc ggaccatgag ccgcccgagc tccgagagca
      361 gctgcggtga ggtgagagca gcccggcgct gaaccgcaat cccggactcc gaacgcggcg
      421 cggggagagt taagaatcat ggctgcggga aagtttgcaa gccttcccag aaacatgcct
      481 gtgaatcacc agttcccctt ggcctcgtcc atggacctcc tgagcagcaa gtcccctctt
      541 gctgagcgtc gcacagatgc ctatcaagac gtgtctatac atggcactct tccacggaag
      601 aaaaagggcc ctccttccat acggtcctgt gacaatgctg gccactccaa atccccacga
      661 cagagctcac ctctgaccca ggacatcatc caggaaaacc cactgcaaga ccggaaaggg
      721 gaaaacttca tcttcaggga tccatatctt ctggacccaa ctctggaata cgtgaagttc
      781 tccaaggaga ggcacatcat ggacaggacc cctgagaggc tgaaaaagga attggaggag
      841 gagctgctgc tgagcagcga agacctacgc agccacgcct ggtaccacgg ccggatcccc
      901 cgacaggtgt ctgaaaacct tgtgcagcgg gatggggact tcctggttcg cgactccctg
      961 tcgagccccg gaaactttgt cctgacctgt cagtggaaga acctcgctca gcactttaag
     1021 atcaaccgga ctgtcctgcg gctcagcgag gcctacagcc gtgtgcagta ccaattcgag
     1081 atggagagct ttgactccat cccggggctg gtccgctgct acgtgggcaa ccggcggccc
     1141 atctcccaac agagtggtgc catcatcttc cagcccatca ataggacagt gcccctctgg
     1201 tgtctggagg agcgttatgg cacctccccg ggccgaggcc gggagggcag cctggctgag
     1261 ggaaggccag acgtggtgaa gaggctgagc ctcaccacag gcagcagcat ccaggctcgg
     1321 gaacacagcc tgccccgagg aaacctcctc aggaataaag agaagagtgg cagccagccc
     1381 gcctgcctgg atcacgtgca ggacaggaag gccttaaccc tcaaagctca ccagtcggag
     1441 agtcacctgc caataggctg caagctgccc ccccagtctc cgagtatgga cacaagccct
     1501 tgccccagct ctcccgtgtt caggactggc agcgagccca ctctgagtcc agcactggta
     1561 cgaaggttct cttcagatgc taggacaggg gaggcgcttc ggggatcaga cagccagctg
     1621 tgccccaagc cacccccgaa gccctgcaag gtgcccttcc tcaagactcc cccctctcca
     1681 tctccctggc tcacctcaga ggccaactac tgtgaactga accctgcttt tgctgtgggc
     1741 tgtgacaggg gagccaagct tcccatgcaa gcccacgaca gccacgagat gctgctgaca
     1801 gccaaacaga atgggccatc gggtccccgg aactctggca tcaactacat gatccttgat
     1861 ggggatgacc aggcgagaca ttgggatcca ctggcagtgc agacggatga aggtcaggag
     1921 gacaagacca agtttgtgcc acctctcatg gagaccgtgt cgtcattcag acccaatgac
     1981 tttgagtcca agcttcttcc tccagagaac aaacccctgg aaacggccat gctgaagcac
     2041 gcgaaagaac tgttcaccaa ccacgatgcc agggtcattg cgcagcacat gctgagcgtg
     2101 gactgcaagg ttgctaggat actcgaagtc tctgaagaca ggaagaggag catgggtgtg
     2161 agctctgggt tggagctcat tactttacct catggacggc agctgcgcct ggacatcatc
     2221 gagaggcaca acaccatggc cattggcatt gctgtggaca ttctgggctg cacaggcaca
     2281 ctggagaacc gagcgggtac cctcaataag atcatccagg tggcggtgga actgaaggat
     2341 gccatgggag acctctatgc tttctctgcc atcatgaaag ccctggagat gcctcagatc
     2401 acaaggttag agaaaacatg gacggctctg aggcaccact acacgcagac agccatcctc
     2461 tatgagaagc agttgaagcc ctttagcaaa atcctgcatg aaggcagaga gtctacatat
     2521 gtcccagcaa gcaatgtgtc agtccctctg ctgatgccac tggtgacctt aatggaacgc
     2581 caggctgtca cttttgaagg gaccgacatg tgggaaaaca atgacgagag ctgtgaaatt
     2641 ctgctgaatc acttggcaac agccaggttc atggctgagg cttctgagag ctacaggatg
     2701 aatgctgaga ggatcctggc agatttccaa ccagatgaag aaatgactga gatcttaagg
     2761 actgagttcc agatgagatt gttatggggc agcaagggcg ccgaagtcaa ccagaacgag
     2821 agatacgaca agttcaacca gatcctaaca gccctctcac ggaaactaga acctccctct
     2881 ggaaagcagg ccgagctgtg agaaccagct ggagggcctt ggggcactcc agtcccactg
     2941 ggcatgcctg tcaactctaa gtaataacga gcagatctaa caggatacaa gccgctaaca
     3001 tccacaggat agtaaatgtg taaactgcac agagcacact tatttatgaa ttgtttaaaa
     3061 ttactactga tttttaaatg aatggtaatt tattattaag ataactattg ctaatgttga
     3121 tcagcaaact taagacatag ctatgttgct ggttgtttag tatcatggca tttgaccatc
     3181 ttagttttaa ttccttgtca gataaatgta aatagaggca tttaaaagaa aagcatgaaa
     3241 catggaagaa ggtatcagtt atatgatatt ctttgaatat gaaactgtaa atagttatga
     3301 atggaaatat atctttttgt gaaataattg ta
//
