LOCUS       NM_009954               3209 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus breast cancer anti-estrogen resistance 1 (Bcar1),
            transcript variant 2, mRNA.
ACCESSION   NM_009954
VERSION     NM_009954.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3209)
  AUTHORS   Wong,W., Estep,J.A., Treptow,A.M., Rajabli,N., Jahncke,J.N.,
            Ubina,T., Wright,K.M. and Riccomagno,M.M.
  TITLE     An adhesion signaling axis involving Dystroglycan, beta1-Integrin,
            and Cas adaptor proteins regulates the establishment of the
            cortical glial scaffold
  JOURNAL   PLoS Biol 21 (8), e3002212 (2023)
   PUBMED   37540708
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3209)
  AUTHORS   Gao,J., Li,A., Fujii,S., Huang,F., Nakatomi,C., Nakamura,I.,
            Honda,H., Kiyoshima,T. and Jimi,E.
  TITLE     p130Cas is required for androgen-dependent postnatal development
            regulation of submandibular glands
  JOURNAL   Sci Rep 13 (1), 5144 (2023)
   PUBMED   36991029
  REMARK    GeneRIF: p130Cas is required for androgen-dependent postnatal
            development regulation of submandibular glands.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3209)
  AUTHORS   Wen,Y., Chelariu-Raicu,A., Umamaheswaran,S., Nick,A.M., Stur,E.,
            Hanjra,P., Jiang,D., Jennings,N.B., Chen,X., Corvigno,S.,
            Glassman,D., Lopez-Berestein,G., Liu,J., Hung,M.C. and Sood,A.K.
  TITLE     Endothelial p130cas confers resistance to anti-angiogenesis therapy
  JOURNAL   Cell Rep 38 (4), 110301 (2022)
   PUBMED   35081345
  REMARK    Erratum:[Cell Rep. 2022 Jun 21;39(12):110999. doi:
            10.1016/j.celrep.2022.110999.. PMID: 35732127]
REFERENCE   4  (bases 1 to 3209)
  AUTHORS   Inoue,A., Kiyoshima,T., Yoshizaki,K., Nakatomi,C., Nakatomi,M.,
            Ohshima,H., Shin,M., Gao,J., Tsuru,K., Okabe,K., Nakamura,I.,
            Honda,H., Matsuda,M., Takahashi,I. and Jimi,E.
  TITLE     Deletion of epithelial cell-specific p130Cas impairs the maturation
            stage of amelogenesis
  JOURNAL   Bone 154, 116210 (2022)
   PUBMED   34592494
  REMARK    GeneRIF: Deletion of epithelial cell-specific p130Cas impairs the
            maturation stage of amelogenesis.
REFERENCE   5  (bases 1 to 3209)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3209)
  AUTHORS   Casamassima,A. and Rozengurt,E.
  TITLE     Tyrosine phosphorylation of p130(cas) by bombesin, lysophosphatidic
            acid, phorbol esters, and platelet-derived growth factor. Signaling
            pathways and formation of a p130(cas)-Crk complex
  JOURNAL   J Biol Chem 272 (14), 9363-9370 (1997)
   PUBMED   9083073
REFERENCE   7  (bases 1 to 3209)
  AUTHORS   Lo,S.H., Yu,Q.C., Degenstein,L., Chen,L.B. and Fuchs,E.
  TITLE     Progressive kidney degeneration in mice lacking tensin
  JOURNAL   J Cell Biol 136 (6), 1349-1361 (1997)
   PUBMED   9087448
REFERENCE   8  (bases 1 to 3209)
  AUTHORS   Jucker,M., McKenna,K., da Silva,A.J., Rudd,C.E. and Feldman,R.A.
  TITLE     The Fes protein-tyrosine kinase phosphorylates a subset of
            macrophage proteins that are involved in cell adhesion and
            cell-cell signaling
  JOURNAL   J Biol Chem 272 (4), 2104-2109 (1997)
   PUBMED   8999909
REFERENCE   9  (bases 1 to 3209)
  AUTHORS   Polte,T.R. and Hanks,S.K.
  TITLE     Interaction between focal adhesion kinase and Crk-associated
            tyrosine kinase substrate p130Cas
  JOURNAL   Proc Natl Acad Sci U S A 92 (23), 10678-10682 (1995)
   PUBMED   7479864
REFERENCE   10 (bases 1 to 3209)
  AUTHORS   Shaffer,J.B., Sutton,R.B. and Bewley,G.C.
  TITLE     Isolation of a cDNA clone for murine catalase and analysis of an
            acatalasemic mutant
  JOURNAL   J Biol Chem 262 (27), 12908-12911 (1987)
   PUBMED   3654595
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY733553.1 and BC057578.1.
            
            On Nov 10, 2010 this sequence version replaced NM_009954.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and 5'
            coding region, compared to variant 1, and encodes isoform B.
            Isoforms A and B are the same length but differ by 4 N-terminal
            amino acids.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK167516.1, AK090315.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                BY733553.1         2-41
            41-3209             BC057578.1         1-3169
FEATURES             Location/Qualifiers
     source          1..3209
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 57.98 cM"
     gene            1..3209
                     /gene="Bcar1"
                     /gene_synonym="Cas; Crkas"
                     /note="breast cancer anti-estrogen resistance 1"
                     /db_xref="GeneID:12927"
                     /db_xref="MGI:MGI:108091"
     exon            1..161
                     /gene="Bcar1"
                     /gene_synonym="Cas; Crkas"
                     /inference="alignment:Splign:2.1.0"
     exon            162..794
                     /gene="Bcar1"
                     /gene_synonym="Cas; Crkas"
                     /inference="alignment:Splign:2.1.0"
     exon            795..956
                     /gene="Bcar1"
                     /gene_synonym="Cas; Crkas"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1073
                     /gene="Bcar1"
                     /gene_synonym="Cas; Crkas"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..2171
                     /gene="Bcar1"
                     /gene_synonym="Cas; Crkas"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2261
                     /gene="Bcar1"
                     /gene_synonym="Cas; Crkas"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..3182
                     /gene="Bcar1"
                     /gene_synonym="Cas; Crkas"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3161..3166
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bcar1"
                     /gene_synonym="Cas; Crkas"
                     /note="hexamer: AATAAA"
     polyA_site      3182
                     /gene="Bcar1"
                     /gene_synonym="Cas; Crkas"
                     /note="major polyA site"
ORIGIN      
        1 ggccggactg tccggtggcg gcggaaagca gccggcagga cagcggagaa cgccgggacc
       61 ccgcgccggg ggctgtgagc ggcgcgggcc caccgagccc gagctagccc gcgccgctgc
      121 tgcagggctc cgggggggcg gcggccaaga tgaccgtgcc gaacgtgctg gccaaagccc
      181 tctatgacaa tgttgctgaa tccccggatg agctctcctt ccgaaagggt gacatcatga
      241 cagtgctcga gcgggacact cagggcctgg atggctggtg gctctgctca ctgcatgggc
      301 gccagggcat tgtgcctggt aaccgcctca agattctggt tggcatgtat gataagaagc
      361 cagtaggacc tggaccaggc ccacctgcca ccccacccca gccccagccc agccttcccc
      421 agggcgtcca tgctccggta cctccagctt cccagtacag tcccatgctc cccactgcgt
      481 accagcccca gtctgacaat gtgtacctgg tacccactcc cagcaagact cagcaaggtc
      541 tctaccaagc ccctgggccc aacccacagt tccagtcacc cccagccaaa cagacgtcca
      601 cattctccaa gcaaacacct catcactcat ttcccagccc agccacggac ctttaccagg
      661 tgcccccagg gcctggaagt ccagcccagg acatttatca ggtgccacct tccgctggca
      721 tagggcatga catctaccaa gttcctccat ctctggacac tcgcggatgg gagggaacaa
      781 agccaccggc aaaggtggtg gttcctacgc gagtgggaca gggctatgtg tatgaggccg
      841 ctcagacgga gcaggatgag tacgacaccc cacgccacct gctggcccca ggtccccagg
      901 acatctatga tgtgccccct gttcgaggac tgcttcctaa ccagtatggc caggaggtat
      961 atgacacgcc ccctatggca gtcaaaggcc ccaatggccg agacccattg ttggatgtgt
     1021 atgacgtgcc ccctagtgtg gagaaaggcc tgctctcgtc cagccatcat tcggtgtatg
     1081 atgttcctcc ttctgtgagc aaggatgtgc ccgatggccc actgctgcgt gaggaaacct
     1141 atgatgtacc tcctgccttc gccaagccca agccctttga tcccacccga cacccactga
     1201 tccttgctgc gcctcctccc gactccccag cagctgagga tgtatatgat gtgccccccc
     1261 ctgctcccga cctctatgat gtgccccctg gtttgcggcg gcctggccct ggaacactgt
     1321 atgacgtgcc tcgcgagcgc gtgctccctc ctgaggtggc tgatgggagt gtagttgacg
     1381 atggtgtgta tgctgtgccc ccaccagccg agcgagaggc cccaacggat ggcaagcgcc
     1441 tgtcggcctc tagcacgggc agcacgcgca gcagccaatc ggcatcttcc ttggaggtgg
     1501 tggtgccagg ccgggagccc ctggaactgg aggttgctgt ggagtccctg gctcggctgc
     1561 agcaaggcgt gagcaccacc gtagcccacc ttctggacct ggtgggcagt gccagtgggc
     1621 ctgggggctg gcgtggtacc tctgagcctc aggagcctcc cgcacaggac ctgaaagccg
     1681 cagtggcggc agttcacggg gcagtccatg agctcctgga gttcgcccgc ggagctgtga
     1741 gcaatgccac ccacacttct gaccgcacct tgcatgccaa gcttagccgg caactacaga
     1801 agatggagga tgtgtaccag acactggtgg tccacggtca ggtccttgac agtggccgag
     1861 gaagtccagg attcactccg gaagacctgg accgcctggt ggcctgctct cgggctgtgc
     1921 ccgaggatgc caagcagcta gcttcctttt tgcatggcaa tgcctcgctg cttttcagac
     1981 ggaccaaagc ccctggccca gggcctgagg gaagcagctc cctgcaccca aaccccactg
     2041 ataaagccag tagcatccag tcacgccctc tcccctcacc tccaaagttc acctcccagg
     2101 actctccaga cggccagtat gagaacagtg aagggggttg gatggaggac tatgactacg
     2161 tccatctgca ggggaaggag gaatttgaga agacccagaa ggagctgcta gaaaggggta
     2221 acatcatgcg gcagggaaag ggccaactgg agttgcagca gctgaaacag tttgagcgac
     2281 tggagcagga ggtgtctcgt ccaatagacc acgacctggc caactggaca ccagcccagc
     2341 ccctggtgcc gggccggaca gggggcctgg ggccttcaga ccgacagctg ctgctcttct
     2401 acttggagca gtgcgaggcc aacctgacca cactgacaga tgcagtggac gccttcttca
     2461 ctgcggtggc caccaaccaa ccacccaaga tctttgtggc acacagcaag tttgtcattc
     2521 tcagtgccca caagcttgtg ttcattgggg acacactgtc acggcaggca aaggcagctg
     2581 atgtccgaag ccaagtgacc cactacagca atctgctgtg tgacctcctg cgtggcattg
     2641 tggccaccac caaggctgct gccctgcagt acccatcccc ttccgctgcc caggacatgg
     2701 tggacagggt caaggagcta ggccacagca ctcagcagtt ccgccgcgtc ctgggccagc
     2761 tagctgctgc ctgagagcag aggaccagga tgtgaggctg gggatgggca gcgatgctct
     2821 gagctaccca gcattcattc ctcttgaaaa cggagctcct gcaggtttgg ggacaggtaa
     2881 ccccagctct gccttgggcc tggtgccctc aactgtccag ggatttgtac atatttatat
     2941 caaggcagga tgtgggatgc ctcctcggag aagctgagga gcccagtagg agtgtaccgt
     3001 gggctgggga tcaccaggat tggtgcacat gggccccaaa cctcagggct ccctgtgaca
     3061 ggcaagtaca gtgtggtgca cacctctgca ccaagaaaaa ccctaaagaa ctatttttca
     3121 ctattgattt ttccaatcat ttgactaata gtctacattt aataaaattt taaaaatgca
     3181 aaaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
