LOCUS       NM_001409547            3002 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus brevican (Bcan), transcript variant 8, mRNA.
ACCESSION   NM_001409547
VERSION     NM_001409547.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3002)
  AUTHORS   Seiler,S., Rudolf,F., Gomes,F.R., Pavlovic,A., Nebel,J.,
            Seidenbecher,C.I. and Foo,L.C.
  TITLE     Astrocyte-derived factors regulate CNS myelination
  JOURNAL   Glia 72 (11), 2038-2060 (2024)
   PUBMED   39092473
REFERENCE   2  (bases 1 to 3002)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3002)
  AUTHORS   Reinhard,J., Mueller-Buehl,C., Wiemann,S., Roll,L., Luft,V.,
            Shabani,H., Rathbun,D.L., Gan,L., Kuo,C.C., Franzen,J.,
            Joachim,S.C. and Faissner,A.
  TITLE     Neural extracellular matrix regulates visual sensory motor
            integration
  JOURNAL   iScience 27 (2), 108846 (2024)
   PUBMED   38318351
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3002)
  AUTHORS   Mueller-Buehl,C., Reinhard,J., Roll,L., Bader,V., Winklhofer,K.F.
            and Faissner,A.
  TITLE     Brevican, Neurocan, Tenascin-C, and Tenascin-R Act as Important
            Regulators of the Interplay Between Perineuronal Nets, Synaptic
            Integrity, Inhibitory Interneurons, and Otx2
  JOURNAL   Front Cell Dev Biol 10, 886527 (2022)
   PUBMED   35721494
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3002)
  AUTHORS   Lee,D.R., Rhodes,C., Mitra,A., Zhang,Y., Maric,D., Dale,R.K. and
            Petros,T.J.
  TITLE     Transcriptional heterogeneity of ventricular zone cells in the
            ganglionic eminences of the mouse forebrain
  JOURNAL   Elife 11, e71864 (2022)
   PUBMED   35175194
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3002)
  AUTHORS   Zhou,X.H., Brakebusch,C., Matthies,H., Oohashi,T., Hirsch,E.,
            Moser,M., Krug,M., Seidenbecher,C.I., Boeckers,T.M., Rauch,U.,
            Buettner,R., Gundelfinger,E.D. and Fassler,R.
  TITLE     Neurocan is dispensable for brain development
  JOURNAL   Mol Cell Biol 21 (17), 5970-5978 (2001)
   PUBMED   11486035
REFERENCE   7  (bases 1 to 3002)
  AUTHORS   Sander,V., Mullegger,J. and Lepperdinger,G.
  TITLE     Xenopus brevican is expressed in the notochord and the brain during
            early embryogenesis
  JOURNAL   Mech Dev 102 (1-2), 251-253 (2001)
   PUBMED   11287204
REFERENCE   8  (bases 1 to 3002)
  AUTHORS   Hirakawa,S., Oohashi,T., Su,W.D., Yoshioka,H., Murakami,T.,
            Arata,J. and Ninomiya,Y.
  TITLE     The brain link protein-1 (BRAL1): cDNA cloning, genomic structure,
            and characterization as a novel link protein expressed in adult
            brain
  JOURNAL   Biochem Biophys Res Commun 276 (3), 982-989 (2000)
   PUBMED   11027579
REFERENCE   9  (bases 1 to 3002)
  AUTHORS   Yamaguchi,Y.
  TITLE     Lecticans: organizers of the brain extracellular matrix
  JOURNAL   Cell Mol Life Sci 57 (2), 276-289 (2000)
   PUBMED   10766023
  REMARK    Review article
REFERENCE   10 (bases 1 to 3002)
  AUTHORS   Rauch,U., Meyer,H., Brakebusch,C., Seidenbecher,C.,
            Gundelfinger,E.D., Beier,D.R. and Fassler,R.
  TITLE     Sequence and chromosomal localization of the mouse brevican gene
  JOURNAL   Genomics 44 (1), 15-21 (1997)
   PUBMED   9286696
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158233.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14777534.678227.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-98                AC158233.2         166998-167095       c
            99-209              AC158233.2         166045-166155       c
            210-581             AC158233.2         165285-165656       c
            582-756             AC158233.2         164839-165013       c
            757-884             AC158233.2         164418-164545       c
            885-1178            AC158233.2         163710-164003       c
            1179-1400           AC158233.2         162412-162633       c
            1401-1988           AC158233.2         161355-161942       c
            1989-2147           AC158233.2         158440-158598       c
            2148-2230           AC158233.2         157468-157550       c
            2231-2375           AC158233.2         156993-157137       c
            2376-2566           AC158233.2         156572-156762       c
            2567-3002           AC158233.2         155832-156267       c
FEATURES             Location/Qualifiers
     source          1..3002
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 38.78 cM"
     gene            1..3002
                     /gene="Bcan"
                     /gene_synonym="Cspg7"
                     /note="brevican"
                     /db_xref="GeneID:12032"
                     /db_xref="MGI:MGI:1096385"
     exon            1..98
                     /gene="Bcan"
                     /gene_synonym="Cspg7"
                     /inference="alignment:Splign:2.1.0"
     exon            99..209
                     /gene="Bcan"
                     /gene_synonym="Cspg7"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..2662
                     /gene="Bcan"
                     /gene_synonym="Cspg7"
                     /note="isoform 4 precursor is encoded by transcript
                     variant 8; brevican core protein"
                     /codon_start=1
                     /product="brevican core protein isoform 4 precursor"
                     /protein_id="NP_001396476.1"
                     /db_xref="GeneID:12032"
                     /db_xref="MGI:MGI:1096385"
                     /translation="MIPLLLSLLAALVLTQAPAALADDLKEDSSEDRAFRVRIGATQL
                     RGVLGGALAIPCHVHHLRPPHSRRAAPGFPRVKWTFLSGDREVEVLVARGLRVKVNEA
                     YRFRVALPAYPASLTDVSLVLSELRPNDSGVYRCEVQHGIDDSSDAVEVKVKGVVFLY
                     REGSARYAFSFAGAQEACARIGARIATPEQLYAAYLGGYEQCDAGWLSDQTVRYPIQN
                     PREACSGDMDGYPGVRNYGVVGPDDLYDVYCYAEDLNGELFLGAPPSKLTWEEARDYC
                     LERGAQIASTGQLYAAWNGGLDRCSPGWLADGSVRYPIITPSQRCGGGLPGVKTLFLF
                     PNQTGFPSKQNRFNVYCFRDSAHPSASSEASSPASDGLEAIVTVTEKLEELQLPQEAM
                     ESESRGAIYSIPISEDGGGGSSTPEDPAEAPRTPLESETQSIAPPTESSEEEGVALEE
                     EERFKDLEALEEEKEQEDLWVWPRELSSPLPTGSETEHSLSQVSPPAQAVLQLGASPS
                     PGPPRVRGPPAETLLPPREGSPTSTPGGAREVGGETGSPELSGVPRESEEAGSSSLED
                     GPSLLPATWAPVGPRELETPSEEKSGRTVLAGTSVQAQPVLPTDSASHGGVAVAPSSG
                     LHFCSPGWEAFQGACYKHFSTRRSWEEAESQCRALGAHLTSICTPEEQDFVNDRYREY
                     QWIGLNDRTIEGDFLWSDGAPLLYENWNPGQPDSYFLSGENCVVMVWHDQGQWSDVPC
                     NYHLSYTCKMGLVSCGPPPQLPLAQIFGRPRLRYAVDTVLRYRCRDGLAQRNLPLIRC
                     QENGLWEAPQISCVPRRPGRALRSMDAPEGPRGQLSRHRKAPLTPPSSL"
     exon            210..581
                     /gene="Bcan"
                     /gene_synonym="Cspg7"
                     /inference="alignment:Splign:2.1.0"
     exon            582..756
                     /gene="Bcan"
                     /gene_synonym="Cspg7"
                     /inference="alignment:Splign:2.1.0"
     exon            757..884
                     /gene="Bcan"
                     /gene_synonym="Cspg7"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1178
                     /gene="Bcan"
                     /gene_synonym="Cspg7"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1400
                     /gene="Bcan"
                     /gene_synonym="Cspg7"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1988
                     /gene="Bcan"
                     /gene_synonym="Cspg7"
                     /inference="alignment:Splign:2.1.0"
     exon            1989..2147
                     /gene="Bcan"
                     /gene_synonym="Cspg7"
                     /inference="alignment:Splign:2.1.0"
     exon            2148..2230
                     /gene="Bcan"
                     /gene_synonym="Cspg7"
                     /inference="alignment:Splign:2.1.0"
     exon            2231..2375
                     /gene="Bcan"
                     /gene_synonym="Cspg7"
                     /inference="alignment:Splign:2.1.0"
     exon            2376..2566
                     /gene="Bcan"
                     /gene_synonym="Cspg7"
                     /inference="alignment:Splign:2.1.0"
     exon            2567..3002
                     /gene="Bcan"
                     /gene_synonym="Cspg7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2981..2986
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bcan"
                     /gene_synonym="Cspg7"
                     /note="hexamer: AATAAA"
     polyA_site      3002
                     /gene="Bcan"
                     /gene_synonym="Cspg7"
                     /note="major polyA site"
ORIGIN      
        1 acaagtcctg gtggagagga agcagaggga gaagccgctg tttcagcagg gttcagtcta
       61 ggaggccctc ctggaagagg aagggttagg aagggaagtt cttccatcag tgtgcagaat
      121 gattccactg cttctgtccc tgctggccgc tctggtcctg acccaagccc ctgccgccct
      181 cgctgatgac ctgaaagaag acagctcgga ggatcgagcc ttccgcgtgc gcatcggtgc
      241 cacgcagctg cggggcgtgc tgggcggtgc cctggccatc ccatgccacg tccaccacct
      301 gcggccgccg cacagtcgcc gggccgcgcc gggttttccc cgggtcaagt ggaccttcct
      361 gtccggggac cgggaggtag aggtactggt ggctcgtggg ctgcgcgtca aggtaaacga
      421 agcctaccgg ttccgcgtgg cgctgcctgc ctaccccgca tcgctcacgg atgtgtctct
      481 agtattgagc gaactgcggc ccaatgattc cggggtctat cgctgcgagg tccagcacgg
      541 tatcgacgac agcagtgatg ctgtggaggt caaggtcaaa ggggtcgtct tcctctacag
      601 agagggctct gcgcgctatg ctttctcctt tgctggagcc caggaagcct gcgctcgcat
      661 aggagcccga atcgccaccc cggagcagct ctatgctgcc tacctcggcg gctatgagca
      721 gtgtgatgca ggctggctgt ccgaccaaac tgtgaggtac cccatccaga acccacgaga
      781 ggcctgctct ggagacatgg atggctatcc tggcgtgcgg aactacggag tggtgggtcc
      841 tgatgatctc tatgatgtct actgttatgc cgaagaccta aatggagaac tgttcctagg
      901 cgcccctccc agcaagctga catgggagga ggctcgggac tactgtctgg aacgtggtgc
      961 acagatcgct agcacaggcc agctgtacgc agcctggaat ggtggcctgg acagatgtag
     1021 ccctggctgg ctggctgatg gcagcgtgcg ctatcccatc atcacaccca gccaacgctg
     1081 tgggggcggc ctgccaggag tcaagaccct cttcctcttt cccaaccaga ctggcttccc
     1141 cagcaagcag aaccgcttca atgtctactg cttccgagac tctgcccatc cctctgcttc
     1201 ctctgaggcc tctagcccag cctcagatgg acttgaggcc attgtcacag tgacagaaaa
     1261 gctggaggaa ctgcagctgc ctcaggaagc gatggagagc gagtctcgtg gggccatcta
     1321 ctccatcccc atctcagaag atgggggagg aggaagctcc accccagaag acccagcaga
     1381 ggcccccagg actccgctag aatcggaaac ccaatccatt gcaccaccta ccgagtcctc
     1441 agaagaggaa ggcgtagccc tggaggaaga agaaagattc aaagacttgg aggctctgga
     1501 ggaagagaag gagcaggagg acctgtgggt gtggcccaga gagctcagca gccctctccc
     1561 tactggctca gaaacagagc attcactctc ccaggtgtcc ccaccagccc aggcagttct
     1621 acagctgggt gcctcacctt ctcctgggcc tccaagggtc cgtggaccgc ctgcagagac
     1681 tttgctcccc ccgagggagg gaagccccac atctactcct ggtggggcaa gagaagtagg
     1741 gggggaaact gggagccctg agctctctgg ggttcctcga gagagcgagg aggcagggag
     1801 ctccagcttg gaggatggcc cttccctact tccagctaca tgggcccctg tgggtcccag
     1861 ggagctggag accccctcag aagagaagtc tggaagaact gtcctggcag gcacctcagt
     1921 gcaggcccag ccagtgctgc ccaccgacag tgccagccac ggtggagtgg ctgtggctcc
     1981 ctcatcaggc cttcatttct gcagccctgg ctgggaggcc ttccagggag cctgctacaa
     2041 gcacttttcc acacgaagga gttgggagga ggcagaaagt cagtgccgag cgctaggtgc
     2101 tcatctgacc agcatctgca cccctgagga gcaagacttt gtcaacgatc gataccggga
     2161 gtaccagtgg attgggctca atgacaggac catcgagggt gacttcttgt ggtcagatgg
     2221 tgcccctctg ctctatgaaa actggaaccc tgggcagcct gacagctact tcctgtctgg
     2281 ggagaactgt gtggtcatgg tgtggcatga ccagggacag tggagtgatg tgccctgcaa
     2341 ctaccatcta tcctacacct gcaagatggg gcttgtgtcc tgtgggcctc caccacagct
     2401 acccctggct caaatatttg gtcgccctcg gctgcgctac gcggtggata ctgtgcttcg
     2461 atatcgatgc cgagacgggc tggctcagcg caacctgccg ttgatccgct gccaggagaa
     2521 tgggctttgg gaggcccctc agatttcctg tgtaccccgg aggcctggcc gtgctctgcg
     2581 ctccatggac gccccagaag gaccacgggg acagctctcg aggcacagga aggcaccgtt
     2641 gacaccgccc tccagtctct agggagcctg gaagactgct gcccccagca ggaccctctc
     2701 acatcaactg ccagtgctct tccccatgat agggggtgac gtgagagggg tgggactgaa
     2761 attcagagga cagcgctcga aggggtttct gggaaacact tgggtggctc cgccccctca
     2821 cacaagggcc tcaggtttta cccggtaagt ccctaagtgc ctcaactgcc ctctcatgtc
     2881 agctgcctcc ttgtccctcg atttcgttag gggacactgt gctattcgtt cttgattttc
     2941 aaagagtttt taggatggag taccagcaaa accaggtgga aataaagttg tctgaaccca
     3001 aa
//
