LOCUS       NM_020486               2407 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus basal cell adhesion molecule (Bcam), mRNA.
ACCESSION   NM_020486
VERSION     NM_020486.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2407)
  AUTHORS   Soffer,A., Mahly,A., Padmanabhan,K., Cohen,J., Adir,O., Loushi,E.,
            Fuchs,Y., Williams,S.E. and Luxenburg,C.
  TITLE     Apoptosis and tissue thinning contribute to symmetric cell division
            in the developing mouse epidermis in a nonautonomous way
  JOURNAL   PLoS Biol 20 (8), e3001756 (2022)
   PUBMED   35969606
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2407)
  AUTHORS   Miura,Y., Matsui,S., Miyata,N., Harada,K., Kikkawa,Y., Ohmuraya,M.,
            Araki,K., Tsurusaki,S., Okochi,H., Goda,N., Miyajima,A. and
            Tanaka,M.
  TITLE     Differential expression of Lutheran/BCAM regulates biliary tissue
            remodeling in ductular reaction during liver regeneration
  JOURNAL   Elife 7, e36572 (2018)
   PUBMED   30059007
  REMARK    GeneRIF: Lutheran (Lu)/Basal cell adhesion molecule (BCAM)
            regulates the morphogenesis of DR depending on liver disease
            models.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2407)
  AUTHORS   Lin,C., Yao,E., Zhang,K., Jiang,X., Croll,S., Thompson-Peer,K. and
            Chuang,P.T.
  TITLE     YAP is essential for mechanical force production and epithelial
            cell proliferation during lung branching morphogenesis
  JOURNAL   Elife 6, e21130 (2017)
   PUBMED   28323616
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2407)
  AUTHORS   Langen,U.H., Pitulescu,M.E., Kim,J.M., Enriquez-Gasca,R.,
            Sivaraj,K.K., Kusumbe,A.P., Singh,A., Di Russo,J., Bixel,M.G.,
            Zhou,B., Sorokin,L., Vaquerizas,J.M. and Adams,R.H.
  TITLE     Cell-matrix signals specify bone endothelial cells during
            developmental osteogenesis
  JOURNAL   Nat Cell Biol 19 (3), 189-201 (2017)
   PUBMED   28218908
REFERENCE   5  (bases 1 to 2407)
  AUTHORS   Gu,Z., Imai,F., Kim,I.J., Fujita,H., Katayama,Ki., Mori,K.,
            Yoshihara,Y. and Yoshida,Y.
  TITLE     Expression of the immunoglobulin superfamily cell adhesion
            molecules in the developing spinal cord and dorsal root ganglion
  JOURNAL   PLoS One 10 (3), e0121550 (2015)
   PUBMED   25826454
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2407)
  AUTHORS   Bolcato-Bellemin,A.L., Lefebvre,O., Arnold,C., Sorokin,L.,
            Miner,J.H., Kedinger,M. and Simon-Assmann,P.
  TITLE     Laminin alpha5 chain is required for intestinal smooth muscle
            development
  JOURNAL   Dev Biol 260 (2), 376-390 (2003)
   PUBMED   12921739
REFERENCE   7  (bases 1 to 2407)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 2407)
  AUTHORS   Moulson,C.L., Li,C. and Miner,J.H.
  TITLE     Localization of Lutheran, a novel laminin receptor, in normal,
            knockout, and transgenic mice suggests an interaction with laminin
            alpha5 in vivo
  JOURNAL   Dev Dyn 222 (1), 101-114 (2001)
   PUBMED   11507772
REFERENCE   9  (bases 1 to 2407)
  AUTHORS   Parsons,S.F., Lee,G., Spring,F.A., Willig,T.N., Peters,L.L.,
            Gimm,J.A., Tanner,M.J., Mohandas,N., Anstee,D.J. and Chasis,J.A.
  TITLE     Lutheran blood group glycoprotein and its newly characterized mouse
            homologue specifically bind alpha5 chain-containing human laminin
            with high affinity
  JOURNAL   Blood 97 (1), 312-320 (2001)
   PUBMED   11133776
REFERENCE   10 (bases 1 to 2407)
  AUTHORS   Rahuel,C., Colin,Y., Goossens,D., Gane,P., El Nemer,W.,
            Cartron,J.P. and Le Van Kim,C.
  TITLE     Characterization of a mouse liminin receptor gene homologous to the
            human blood group Lutheran gene
  JOURNAL   Immunogenetics 50 (5-6), 271-277 (1999)
   PUBMED   10630290
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF109160.1, AF221507.1, AF346663.1 and BB190832.1.
            
            On Dec 9, 2006 this sequence version replaced NM_020486.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB035511.1, AF109160.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                AF109160.1         1-57
            58-631              AF221507.1         8-581
            632-1945            AF346663.1         570-1883
            1946-2406           AF221507.1         1896-2356
            2407-2407           BB190832.1         190-190
FEATURES             Location/Qualifiers
     source          1..2407
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 9.94 cM"
     gene            1..2407
                     /gene="Bcam"
                     /gene_synonym="1200005K12Rik; B-CAM; Gplu; Lu"
                     /note="basal cell adhesion molecule"
                     /db_xref="GeneID:57278"
                     /db_xref="MGI:MGI:1929940"
     exon            1..126
                     /gene="Bcam"
                     /gene_synonym="1200005K12Rik; B-CAM; Gplu; Lu"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..1931
                     /gene="Bcam"
                     /gene_synonym="1200005K12Rik; B-CAM; Gplu; Lu"
                     /note="lutheran glycoprotein; Lutheran blood group;
                     Auberger b antigen; lutheran antigen; B-CAM cell surface
                     glycoprotein"
                     /codon_start=1
                     /product="basal cell adhesion molecule precursor"
                     /protein_id="NP_065232.1"
                     /db_xref="CCDS:CCDS39803.1"
                     /db_xref="GeneID:57278"
                     /db_xref="MGI:MGI:1929940"
                     /translation="MEPPDARAGLLWLTFLLSGYSGAQAELHVSVPPRVEVMRGEQVA
                     LDCTPREHPEHYVLEWFLVDGTGARHRLASVEPQGSEFLGTVHSLGRVPPYEVDSRGR
                     LVIAKVQVGDGRDYVCVVKAGAAGTSEATSSVRVFATPEDTEVSPNKGTLSVMDQFAQ
                     EIATCSSNNGNPVPRITWYRNGQRLEVPMEVNQKGYITIRTVREASGLYSLTSTLYLR
                     LHKDDRDANFHCAAHYDLPSGQHGRLDSHTFRLTLHYPTEHVEFWVGSPSTTEGWVRE
                     GDAVQLLCQGDGSPSPEYSFFRQQGTQEEQLNVNLKGNLTLERVHRNQSGIYGCRVED
                     YDADEEVQLVKKLKLHVAYLDPLELSVPEELFVFLNSSSTVVNCSARGLPTPTVRWTK
                     DSVTLADGPMLSLQSVTFDSAGTYTCEASTPTVPLLSRTQSFQLIVQGAPELKPNEIM
                     PKSGNSWTEGDEVMLTCSARGFPEPKLTWSQRGDTPAEPPFEGRGWKSSSLMVKVTSA
                     LSREGVSCEASNIHGKKGHVFHFGSVAPQTAQAGVAVMAVAVSVGLLLLVVAAFYCMR
                     RKGRPGCCRRAEKGAPPAREPELSHSGSERPEHTGLLMGGPSGGGRGGSGGFGDEC"
     exon            127..248
                     /gene="Bcam"
                     /gene_synonym="1200005K12Rik; B-CAM; Gplu; Lu"
                     /inference="alignment:Splign:2.1.0"
     exon            249..474
                     /gene="Bcam"
                     /gene_synonym="1200005K12Rik; B-CAM; Gplu; Lu"
                     /inference="alignment:Splign:2.1.0"
     exon            475..545
                     /gene="Bcam"
                     /gene_synonym="1200005K12Rik; B-CAM; Gplu; Lu"
                     /inference="alignment:Splign:2.1.0"
     exon            546..642
                     /gene="Bcam"
                     /gene_synonym="1200005K12Rik; B-CAM; Gplu; Lu"
                     /inference="alignment:Splign:2.1.0"
     exon            643..825
                     /gene="Bcam"
                     /gene_synonym="1200005K12Rik; B-CAM; Gplu; Lu"
                     /inference="alignment:Splign:2.1.0"
     exon            826..962
                     /gene="Bcam"
                     /gene_synonym="1200005K12Rik; B-CAM; Gplu; Lu"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1119
                     /gene="Bcam"
                     /gene_synonym="1200005K12Rik; B-CAM; Gplu; Lu"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1238
                     /gene="Bcam"
                     /gene_synonym="1200005K12Rik; B-CAM; Gplu; Lu"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1380
                     /gene="Bcam"
                     /gene_synonym="1200005K12Rik; B-CAM; Gplu; Lu"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1517
                     /gene="Bcam"
                     /gene_synonym="1200005K12Rik; B-CAM; Gplu; Lu"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1662
                     /gene="Bcam"
                     /gene_synonym="1200005K12Rik; B-CAM; Gplu; Lu"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1807
                     /gene="Bcam"
                     /gene_synonym="1200005K12Rik; B-CAM; Gplu; Lu"
                     /inference="alignment:Splign:2.1.0"
     exon            1808..1925
                     /gene="Bcam"
                     /gene_synonym="1200005K12Rik; B-CAM; Gplu; Lu"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..2407
                     /gene="Bcam"
                     /gene_synonym="1200005K12Rik; B-CAM; Gplu; Lu"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2384..2389
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bcam"
                     /gene_synonym="1200005K12Rik; B-CAM; Gplu; Lu"
                     /note="hexamer: AATAAA"
     polyA_site      2407
                     /gene="Bcam"
                     /gene_synonym="1200005K12Rik; B-CAM; Gplu; Lu"
                     /note="major polyA site"
ORIGIN      
        1 gccagcttca gggcggcgga gagcctcgcc cgggctcagt cactgccgcc actgcaggga
       61 acatggaacc ccctgacgcc cgcgcagggc tgctgtggct caccttcctg ctgtcgggct
      121 actcaggtgc ccaggctgag ctgcacgtgt ccgtgccccc acgggtggag gtgatgcgag
      181 gcgagcaagt cgccctggac tgcactccac gggagcaccc tgagcattac gtgctggaat
      241 ggttcctcgt tgatggtact ggggctcgac accgtctggc ttctgtggaa ccacagggct
      301 cagagttcct gggcacagtc cactctctgg gccgcgtacc cccatacgag gtagactctc
      361 gtgggcgcct ggtgatagca aaggtccagg tgggcgatgg acgggactac gtgtgcgtag
      421 tgaaggctgg ggcagcgggt acctcagagg ccacctcaag tgtccgtgtg tttgcaacac
      481 cagaggatac ggaggtgtct cccaacaaag ggacgctgtc tgtgatggac cagtttgccc
      541 aggagattgc cacctgcagc agcaacaacg gaaaccccgt gcctcggatc acatggtacc
      601 gaaacgggca gcgtctggaa gtacccatgg aggtgaacca aaagggctac ataaccatcc
      661 gtactgtccg ggaagcctca ggcctgtact ccctgaccag caccctctac ctgaggctgc
      721 acaaggatga tcgggatgcc aacttccact gtgctgctca ctacgacttg ccctcaggcc
      781 aacatggccg cctggacagc catacctttc gcctcaccct gcactatccc acggaacatg
      841 tagaattctg ggtggggagc ccgtccacca cggagggctg ggtccgtgag ggtgatgctg
      901 tccagctgct ctgccagggc gatggcagcc ccagcccaga gtattctttt ttccgccagc
      961 agggtaccca ggaggaacag ctgaatgtca acctcaaggg aaacttgacc ctagaacggg
     1021 tgcatcggaa ccagagcggg atctacggct gcagagtgga ggattacgat gccgacgagg
     1081 aagtgcaact tgtcaagaag ctaaagctgc acgtggccta cctggatcca ttggagctga
     1141 gcgtgcctga ggagctcttc gtattcctga acagcagcag cacggtggtg aactgctccg
     1201 ctagaggcct gcctactcct actgtgcgat ggaccaagga ttctgtgacc cttgcagacg
     1261 gccccatgct ctctctccag tctgtgacct ttgactcagc tggcacctat acctgtgagg
     1321 cgtccacacc cacagtcccc ctcctgagcc gcacacagag tttccagctc atcgtccaag
     1381 gagcaccaga gttaaaaccg aatgagataa tgcccaaatc agggaatagc tggacagaag
     1441 gcgatgaagt catgctgacc tgctccgccc ggggcttccc agagcccaaa ctcacctgga
     1501 gtcagcgagg cgatactcca gcagagccgc cctttgaggg tagaggctgg aagagcagct
     1561 cgctgatggt gaaagtgacc agcgccctga gccgagaggg cgtgtcctgt gaagcgtcta
     1621 acatccatgg caagaaaggc catgtcttcc actttggctc tgtggcccct cagactgccc
     1681 aggctggagt ggctgtcatg gctgtagctg tcagcgtcgg tcttttgcta ctcgtggtcg
     1741 ctgctttcta ttgcatgaga cgcaaagggc gccctggctg ctgccggcga gcagagaaag
     1801 gggcgccgcc agccagggaa ccggagttga gccactctgg gtcagagcgg ccagaacaca
     1861 cgggccttct catgggtggg ccctccggag gaggcagagg tggcagtgga ggctttggag
     1921 atgagtgttg aggctgacga cctcccagag gcaatctctg gatctggaac tttgggcatc
     1981 atcggaggac cggctctgag cacgcctccg cctcagcgca cgcctctgcc tccttccttc
     2041 tccagcctcg gccctccctt ccttcctctg cctgctgggc agggacccac agtggccagc
     2101 ggccttgggg agggaaagag ggaggtgggg gctgggaggg ggccttcctc cagggaatgt
     2161 aactctccca ggccccagaa tagctcctgg atccaagccc ggggcccggc ctgggacacg
     2221 gcgctgaggg tcggcaggct ggggctattt ttacctcctg actcccttgc tgggcactac
     2281 ccccccacct gataccctgc tgtgtagtct gacactggag tccccaaccc accccattcc
     2341 tgccctcatc ctcagcccat catttgtgaa cactggactc tgaaataaat gctgcctgtc
     2401 acgtgga
//
