LOCUS       NM_027444               8742 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus bobby sox HMG box containing (Bbx), transcript variant
            1, mRNA.
ACCESSION   NM_027444 XM_358864
VERSION     NM_027444.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8742)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 8742)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8742)
  AUTHORS   Ihn,H.J., Kim,J.A., Lim,J., Nam,S.H., Hwang,S.H., Kim,Y.K.,
            Kim,J.Y., Kim,J.E., Cho,E.S., Jiang,R. and Park,E.K.
  TITLE     Bobby sox homolog regulates tooth root formation through modulation
            of dentin sialophosphoprotein
  JOURNAL   J Cell Physiol 236 (1), 480-488 (2021)
   PUBMED   32537777
REFERENCE   4  (bases 1 to 8742)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8742)
  AUTHORS   Chen,T., Zhou,L., Yuan,Y., Fang,Y., Guo,Y., Huang,H., Zhou,Q. and
            Lv,X.
  TITLE     Characterization of Bbx, a member of a novel subfamily of the
            HMG-box superfamily together with Cic
  JOURNAL   Dev Genes Evol 224 (4-6), 261-268 (2014)
   PUBMED   25079045
  REMARK    GeneRIF: Immunohistochemistry analysis in mouse brain revealed that
            BBX was weakly expressed in the cerebellum and highly expressed in
            the cortex and hippocampus.
REFERENCE   6  (bases 1 to 8742)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   7  (bases 1 to 8742)
  AUTHORS   Baguet,A., Epler,J., Wen,K.W. and Bix,M.
  TITLE     A Leishmania major response locus identified by interval-specific
            congenic mapping of a T helper type 2 cell bias-controlling
            quantitative trait locus
  JOURNAL   J Exp Med 200 (12), 1605-1612 (2004)
   PUBMED   15596523
REFERENCE   8  (bases 1 to 8742)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 8742)
  AUTHORS   Sanchez-Diaz,A., Blanco,M.A., Jones,N. and Moreno,S.
  TITLE     HBP2: a new mammalian protein that complements the fission yeast
            MBF transcription complex
  JOURNAL   Curr Genet 40 (2), 110-118 (2001)
   PUBMED   11680820
REFERENCE   10 (bases 1 to 8742)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154781.2, AC113067.8, AC109627.8 and CT571273.12.
            
            On Dec 10, 2008 this sequence version replaced NM_027444.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF454943.1, SRR13948564.4991895.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               AC154781.2         153687-153834
            149-220             AC154781.2         157095-157166
            221-294             AC113067.8         163742-163815       c
            295-465             AC109627.8         27778-27948
            466-708             AC109627.8         33528-33770
            709-901             AC109627.8         41948-42140
            902-969             CT571273.12        139686-139753       c
            970-1050            CT571273.12        128584-128664       c
            1051-1125           CT571273.12        125052-125126       c
            1126-1206           CT571273.12        118124-118204       c
            1207-2212           CT571273.12        101558-102563       c
            2213-2348           CT571273.12        100520-100655       c
            2349-2497           CT571273.12        97715-97863         c
            2498-2557           CT571273.12        86355-86414         c
            2558-2755           CT571273.12        79648-79845         c
            2756-2939           CT571273.12        77678-77861         c
            2940-8742           CT571273.12        69114-74916         c
FEATURES             Location/Qualifiers
     source          1..8742
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 31.35 cM"
     gene            1..8742
                     /gene="Bbx"
                     /gene_synonym="5530401J07Rik; 5730403O13Rik"
                     /note="bobby sox HMG box containing"
                     /db_xref="GeneID:70508"
                     /db_xref="MGI:MGI:1917758"
     exon            1..148
                     /gene="Bbx"
                     /gene_synonym="5530401J07Rik; 5730403O13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            149..220
                     /gene="Bbx"
                     /gene_synonym="5530401J07Rik; 5730403O13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            221..294
                     /gene="Bbx"
                     /gene_synonym="5530401J07Rik; 5730403O13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            295..465
                     /gene="Bbx"
                     /gene_synonym="5530401J07Rik; 5730403O13Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             304..3027
                     /gene="Bbx"
                     /gene_synonym="5530401J07Rik; 5730403O13Rik"
                     /note="isoform 1 is encoded by transcript variant 1; HMG
                     box transcription factor BBX; HMG box-containing protein
                     2; bobby sox homolog"
                     /codon_start=1
                     /product="HMG box transcription factor BBX isoform 1"
                     /protein_id="NP_081720.2"
                     /db_xref="CCDS:CCDS37354.1"
                     /db_xref="GeneID:70508"
                     /db_xref="MGI:MGI:1917758"
                     /translation="MKGSNRNKDHSTEGEGDGKRPKRKCLQWHPLLAKKLLDFSEEEE
                     EDEEEEDIDKVQLLEADGLEQDVAETEDDESPEQRARRPMNAFLLFCKRHRSLVRQEH
                     PRLDNRGATKILADWWAVLDPKEKQKYTDMAKEYKDAFMKANPGYRWCPTTNKPVKSP
                     TPTVNPRKKLWAFPPDSSRDLPTPKKAKTEVPQLNFGMADPTQMGGLSMLLLAGEHAL
                     GTPEASSGTCRPDISESPELRQKSPLFQFAEISSRTSHPDAPSKQCQASALFQFAEIS
                     SSTSQLGGTEPVKRCGNSALFQLAEMCLASEGVKMEDTKLIKSKESDGGRIEEIEKGK
                     EERGTEVEKTTETSFQKEAEFGKSAKGNVRESKDLRDIEQLQMDNVMAIKVEDPKEIR
                     KEPEDDQKYSHFPDFSYSASSKIIISGVPSRKDHMCHPHGIMIIEDPTTLNKPEKIKK
                     KKKKNKLDRHGNDKSTPKKTCKKRQSSESDIESVMYTIEAVAKGDWGVDKLGETPRKK
                     VRPSSSGKGGILDAKPPKKKVKSKEKKVSKEKCSDITKESRPPDFLSISASKSVPGEV
                     PEGIKAEPLTPTEDALPPSLPGQAKPEDSDCHRKTETCGSRKSERSCKGALYKTLVSE
                     GMLTSLRANVDRGKRSSGKGNSSDHEGCWSEESWTFNQSGTSGSKKFKKKLREDSFLG
                     SAKLDEEFEKKFNSLPQYSPITFDRKCVSTPRKKKKTGNMSSESTKTSKGSGDKWSHK
                     QFFLDAIHPTEAIFSEDKSTTEPAFKVKNALSIPNTPEPTTMQEPLVGSQKRKARKTK
                     ITHLVRTADGRVSPAGGTLDDKPKEQLQRSLPKVPGTYCGDNCSHSTVEEPRSSTPDM
                     PAVSAFFSLAALAEVAAMENVHRGQRSTPLTHDGQPKEMPQAPVLISCADQ"
     exon            466..708
                     /gene="Bbx"
                     /gene_synonym="5530401J07Rik; 5730403O13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            709..901
                     /gene="Bbx"
                     /gene_synonym="5530401J07Rik; 5730403O13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            902..969
                     /gene="Bbx"
                     /gene_synonym="5530401J07Rik; 5730403O13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1050
                     /gene="Bbx"
                     /gene_synonym="5530401J07Rik; 5730403O13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1125
                     /gene="Bbx"
                     /gene_synonym="5530401J07Rik; 5730403O13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1206
                     /gene="Bbx"
                     /gene_synonym="5530401J07Rik; 5730403O13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..2212
                     /gene="Bbx"
                     /gene_synonym="5530401J07Rik; 5730403O13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2213..2348
                     /gene="Bbx"
                     /gene_synonym="5530401J07Rik; 5730403O13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2349..2497
                     /gene="Bbx"
                     /gene_synonym="5530401J07Rik; 5730403O13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2498..2557
                     /gene="Bbx"
                     /gene_synonym="5530401J07Rik; 5730403O13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2558..2755
                     /gene="Bbx"
                     /gene_synonym="5530401J07Rik; 5730403O13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2756..2939
                     /gene="Bbx"
                     /gene_synonym="5530401J07Rik; 5730403O13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2940..8742
                     /gene="Bbx"
                     /gene_synonym="5530401J07Rik; 5730403O13Rik"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3066
                     /gene="Bbx"
                     /gene_synonym="5530401J07Rik; 5730403O13Rik"
                     /note="major polyA site"
     regulatory      8516..8521
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bbx"
                     /gene_synonym="5530401J07Rik; 5730403O13Rik"
                     /note="hexamer: AATAAA"
     polyA_site      8540
                     /gene="Bbx"
                     /gene_synonym="5530401J07Rik; 5730403O13Rik"
                     /note="major polyA site"
     regulatory      8715..8720
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bbx"
                     /gene_synonym="5530401J07Rik; 5730403O13Rik"
                     /note="hexamer: AATAAA"
     polyA_site      8742
                     /gene="Bbx"
                     /gene_synonym="5530401J07Rik; 5730403O13Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggttgcatgt actgtatgtg gagcagtgta cagtggagcg gaggcagcgc ggctccgcaa
       61 gctcctctcc actttcccat agagagcccc tgactggccg ctgagggcga gccacacaca
      121 cgccctcgcg ccgcggcgag cccgcgaggt cactatcgtc tgacaaaggc tttgctgcag
      181 ttcatcttcc ttcctgtgtg cctcccattt accttccagg aatcctgctg catcacagaa
      241 gctggaagtt ctgatgttcc attgaaatca caatggacag tcttgacctg actggtcaca
      301 gtaatgaaag gcagtaatag aaataaagac cattcaacag aaggagaagg ggacggaaaa
      361 cgaccaaaac ggaagtgtct tcagtggcat ccgttgctag ctaagaaact tctggacttt
      421 tcagaggagg aggaggaaga cgaggaagag gaagatattg ataaagttca acttcttgag
      481 gcggatggcc tagagcaaga tgttgctgag actgaagatg atgagtcacc tgagcagcga
      541 gcccggagac caatgaatgc atttctttta ttttgcaagc gccaccgctc ccttgtccga
      601 caggaacacc caaggcttga taaccgaggt gctaccaaga tactagctga ttggtgggct
      661 gttcttgatc ctaaggaaaa gcagaaatat acagacatgg ccaaggagta taaagatgca
      721 tttatgaaag caaatcctgg ctacagatgg tgccctacca caaacaagcc tgtgaaatcg
      781 ccaacaccca ctgtcaatcc acggaagaaa ctttgggcct tcccacctga ctcttcaaga
      841 gacttgccaa cccccaagaa ggcaaagaca gaagttcctc agctcaactt tggaatggca
      901 gatcctactc agatgggggg cctgagcatg ttgctgctag ctggagagca cgctcttggg
      961 acaccagagg catcctctgg gacttgcagg cctgatattt cagaatcacc tgagttgcgt
     1021 cagaagtcac cattgtttca gtttgccgag atatcttcaa ggacatcgca ccccgatgcg
     1081 ccttcaaaac agtgtcaagc gtcagccttg tttcagtttg cagagatctc ttcaagcact
     1141 tcgcagttgg gtggcactga gcctgtgaaa cgctgtggaa attctgcact ctttcaactg
     1201 gcagagatgt gtctggcatc agagggggtg aaaatggaag acacaaaact aataaaatca
     1261 aaagagtcag atggaggaag aattgaggaa atagaaaagg ggaaggaaga gagaggcaca
     1321 gaagtggaga aaaccactga aacttcgttc cagaaggaag cagaatttgg gaagtcagct
     1381 aagggcaacg tgagagagtc taaggactta agagacatcg aacagctaca gatggataat
     1441 gtcatggcta tcaaagtgga agaccccaaa gaaattagga aggagccaga ggatgatcag
     1501 aaatacagtc acttccctga tttttcttac tctgccagta gcaagataat aattagtggt
     1561 gtccccagta gaaaggacca catgtgccat cctcacggaa ttatgatcat tgaggaccca
     1621 accacgctaa acaaaccaga gaagataaag aagaaaaaga agaaaaacaa actggatcga
     1681 cacggaaatg acaaatccac acccaagaag acgtgcaaga agaggcagtc ttcagaatct
     1741 gacatcgaga gtgtcatgta caccatcgaa gctgtggcaa aaggagactg gggtgttgac
     1801 aaactcggag aaaccccaag aaagaaagtc cgcccctcct caagtggcaa gggaggcatt
     1861 ttggatgcca agccaccaaa gaaaaaagtg aaatccaagg agaagaaagt ttccaaggag
     1921 aagtgctcag acatcaccaa agagtctcga cctccagatt tccttagcat ttctgccagc
     1981 aagagtgttc ctggggaggt gccagagggc ataaaagcag aacccttgac ccctaccgag
     2041 gatgcactgc cacctagcct accaggacag gctaagcctg aggatagtga ttgtcacaga
     2101 aaaacggaga cctgtggctc caggaaatct gagaggtctt gcaaaggtgc tctttataaa
     2161 accctggtgt ccgagggcat gctcacctct ctccgagcta atgttgacag agggaaacga
     2221 agctcaggaa aaggaaactc ctctgatcat gaagggtgtt ggagtgaaga gagctggaca
     2281 tttaatcaga gtgggaccag tgggagcaag aagtttaaga agaaactaag ggaagactcc
     2341 ttccttggtt ctgcgaagct ggatgaagaa tttgaaaaga aattcaacag cctccctcaa
     2401 tatagtccta ttacatttga ccggaaatgc gtatctactc caagaaaaaa gaagaagact
     2461 ggaaacatgt cctcagaatc gactaaaacc agcaaaggaa gtggggataa atggtcacac
     2521 aagcaatttt tcttggatgc cattcaccct acagaagcca tattttccga agataaaagc
     2581 accacagagc ctgcttttaa ggttaaaaat gccctatcca ttcccaacac tccagagcca
     2641 acaacaatgc aagaaccttt ggttggcagc caaaagagaa aagcaaggaa aaccaagatc
     2701 acacaccttg tcaggactgc agatggccga gtatcaccag caggaggtac tttggatgac
     2761 aaaccaaagg agcaactgca gaggagtctc cccaaagtcc ctgggacata ctgcggtgac
     2821 aattgctcac acagcacggt tgaggagcca cggagcagca ctccagacat gcctgctgtg
     2881 tctgcgttct tcagcctcgc tgcactggct gaggttgcgg ccatggagaa tgtgcacaga
     2941 ggccagagat caactccgct cacccatgat ggacagccaa aagaaatgcc gcaggctcct
     3001 gtacttattt cttgtgctga ccagtgacgc gccctttaat tgtaaaacat tgtgcttcac
     3061 cttctaccct agccttgtct ttaccaggga tgctagcgag tccatgcagt gggaagcaca
     3121 gactgcagac aagtgcttgg tgccccacac agcccagaac cacttgaagc agaacttagc
     3181 attctgggcc catgtgttgt ttcagaagcc acggtttctg agggcagtgc tactgtgtga
     3241 tactgagtga aagcccggtg gcctagacct ttgctttgca tggaaggaag gcttttgatg
     3301 gtgaccagtg gtgacttggt aaaaggctgc ctttgctgta gctcatccag cacctctttt
     3361 accaaccaga gagcgtgaaa ctagtttcat atattatcta gttattcttt caaaacaaac
     3421 aagaaaaccc tgacgcactg cactagttat tattagatat tcttagcctt ttgtacatga
     3481 agatttaagt tctaagatgg tttatataat aggttatacc tacatttata ttgtagaata
     3541 aatataaaaa gcctgtacca gagcctccca agcagcacgg gcaggcagac gtaccattgt
     3601 tagcggtgta tgctcggcct cgtggtccat atattctgca cttttatatt tgccaccaga
     3661 gtggtagtgg tagtttgctg gcagagagag agagagagag agagagagag agagagagag
     3721 agagagagag agagagacag actgactgac tgtgactgac tgagaaagag aatattacaa
     3781 ttcttacaat ctgaattttt ttcttagcct tgagtgacca agaagaattt gcttggggca
     3841 aattgtggca aatattttcc cagacagggg aagcatcctg cagattacag attactgatg
     3901 ttttcatgcc ttgaggattc ttttattttt acacaggggt ctaagtgacc aatggatcgt
     3961 tcatataaac aaacaaaaaa aaagacaaaa atattattca gaagtgacct tagtattact
     4021 tcattattct aaacacattg aagatgctca cttcatatgg acttggagct tcagaccttt
     4081 tacatccatc acacacagac cagacgggtg gtgattgcta tgcacggcct aataggcact
     4141 gcaggtttta ggagccattt ggagtttgta ttgttgagga agtattgagt aaacgagggg
     4201 ggaggtgtgt ctgaagcacg cctctcagtc agatccacct acaagtttct gtttcctttt
     4261 tatgttttgt tgcttttaag cataaaacca accatatgcc agtgccaagt ggatttaact
     4321 ggcttacaac attcaacata ttgacttaac cacctgatgt tcacagtgtc ttgtttccta
     4381 gcaacagatg caaagtgata catcaaaatt aatctgaggc tacagacttt acagggtatt
     4441 tgttccatag cacaaagtat ttccccactc ttgcatcaca gcacaaacta ccaaattttg
     4501 attttttgga tcccagcaat aatttttaat agttttcaaa ctggtggaat tttgatagtg
     4561 ctagctggag tttgaagctt ttgaattaga tctctaaatg gtgacagttt acatggtttt
     4621 atctagcttt cttatttata cttgactgaa ttgtaatgtt ttttttttct aattgtaatt
     4681 tgacctaata gccatataaa atgactctat taatactgtc taggtctagc ttctcacggt
     4741 tgtagatatt acttcagttc cggtgctgga aaatatgtac aacaatacta acagcattga
     4801 aaaacataga ggtttgtttt gtttgttgtt gtttttccaa agcaggtggg gagggcagca
     4861 aagtattaga attatgtcct cagactttgt ttcttgtggg gatgacggaa gcaggaagtg
     4921 gtgaaaggtg aatcagtagg gatagcttaa ccccattcgc gtgaagagcc ccagatttta
     4981 gcatactatt tttactatga taacttttaa taatattttc taaatttcaa aacaaaaacc
     5041 tgaatgattg aaaattgctg ggtcctgatg ttggtggctg ttggcgtttg gaccacttgc
     5101 tagcagtgat ttaaacatga taattagcta accccccaaa aataataaca aaaatagaaa
     5161 accaacaatt gcattggtgc agaacatgca tcttgacaat ggtactaact tgttattctc
     5221 tagaacacat tagaatagat ctatttttgc cagagcaccc tccctcagtc ctccgataca
     5281 tttcactaga gtcctttaag agattgctgt atattcctga aagttttttt ttttaagaag
     5341 caaacaagag ataacttttt tctacatggt taatatctta cctggtctgc ttttcctaaa
     5401 ccccaatggc ttttacttta gtcagggtgg gaaggggagg gacttactgg atatgactgt
     5461 tttcagattc tttaaaaaca aacctttttt gtagaaatgc ttaattttta agcggttagg
     5521 cactgagagt agcagaaatc ctgcaaagct ttatagttct ccaagtgagg tcttgatttc
     5581 agtagctgtg cttcttatgc cccggctctg ctggagaggg gtgttggtat tttcaggtaa
     5641 catttgttag cacaaatctt tcggtctgtt acgttgtcct tcttcactct atccgtgttg
     5701 tcatctccat ttcacgtctc tccttctgga aactggcgtt gctgtgttgc tctgatgtgt
     5761 acttgcgatc cgccagcaag caccatccac actaatattc gtctcacagc atcctcatga
     5821 agacaagtcg ttgcacctta tgtatatctc aagcaaacca aaatgcaatc ttctgctttg
     5881 ttctgttcta aatcattgta gttatatctt tctgaaacca ttttgcattt agttgaaatt
     5941 gtcagtattt atgcttttaa ccttctggat tcaagcctgt atataaaatg ttgaaagaag
     6001 cccttgccct tcgctgcagg gctgggagtg gaaggctctg tctcaggtgc acacttagta
     6061 ctcttccagc attctttagc cctttattta ttttaggtat tctggtattt ccgatgtaat
     6121 tttgaagtgt ctagagtata ttatagtaac taaaactgca gctctgaagc tgagtgaaag
     6181 aagaaaatac tgtaagatgt ccttgaagtt ttgtttgggt actgtaaatg agatcgggaa
     6241 gaggaaaaat gtctcacagc cacattggaa gctacaggtt cttgtcccca aattaggcta
     6301 gtctcagatg gtggatcaaa actctaactt catttaaccc ccttcttgag tgatcttgtc
     6361 accccggcag cctattcccc acaagtatga gaaatcattt tatcagatgt tgcctggaag
     6421 ccatactgaa ataattccca catgatcact gttgtgctcc ttctggtcct tacaattgct
     6481 ggaggaaaat gatgacaaca ctatgagtgg aaggggcatc tgaaccatca gggttggagt
     6541 ctgacgtgtt gaatcccttg ttttcttact aggtcagatg ctttgctaag tcataaaaaa
     6601 tgtgtttgca ctctgcaatc tttggctcag tgtatggaag tgtttgcact gatgtaaatg
     6661 cccaagcaca tgataaattg ctatggaaca gacattagct gaaaactgaa taatgcgttc
     6721 tgtttatagg gtggggtggg gaataccgca taactctgct ctaagcttgg tatttgatgt
     6781 taatgtgaag cagtgggtcc atgctgcctg ctaaactact gtatgcgtca taagtgttgt
     6841 gaagaccagc agctgaaggc tggaggacag cagccattga acagaggaga agcaccactg
     6901 gcttatcggg ggagaggaag aaaatcagaa gaggcccaga gtcaccattt gtaagagaaa
     6961 tgttagggtg ttacatgacg ctgttgagag ccacacttga ttgcactgct ccacagagcc
     7021 ctcagataag gccaatcctc atgggctacc tcggctttca aagttaactt cagtaagtct
     7081 ttcacctcta ccttcagtgc cacgattttc cactgcagtg tttcaacttc acaaaaccga
     7141 cttctccgga gagaacaaca ccttgctgcg atgggcagta gaagcaagtg cttaccacat
     7201 ttgacctgta aagtgtttgg agtgatggct aggtggaaat tggatttagc ttctccccac
     7261 acatccttgt tttgcacttt atgcaaagtg tactaattgc taattagatg ttgtttctgt
     7321 tcatacaggc attcccaaag agttagactg gacttggttt tgagtttggg gattgttaaa
     7381 gtcttactta gattaactaa caacatgtgt ctaatgaaga cagaagcagc tctgtagttc
     7441 acggacccat gtatctgaag aagcgtcagg gtttcatgga ctacttggct tgtgtttgaa
     7501 agtgatagct aagttggtat tactccatgc cgagtgactg tccttttcca tggggacatt
     7561 gttaccttct tacatttcag aacaaagaag caacagaagt aaatgacata tgtttgactt
     7621 ctttgtatat ctgcacctat ctgtgctact ctttccttca aatataaaaa tacacattta
     7681 tgagggagga aaaggttcct cttttgacca aattttatat gtggtggtgt gatttttact
     7741 gataaattca caggaggaac tttgtagtca aaagttctgt ggctactgtt ttgctttgtt
     7801 cttttttggc ttttttctgt tttgttttgt tttttgttgt tttttttttt gttttttact
     7861 ttctttcttg gcagccagcg gtcaaactga tcatgccttc agatttattt tcatacacag
     7921 aactagtttt tgtgaacatt gttactactt ccaaagattt tctcatacct tgggccagga
     7981 ctggtgaccg agtaacaaga gtctgactga acgcctccaa acccacccac agcacgaatc
     8041 ttacctcaca agctcttacc taaatcatag agaaactcat gttccatgca atgtcactga
     8101 cttctctgtt gctctccaga aggtgtttgc tagctcttgt ctcctgacac ctcacattag
     8161 tgcctgggct ctcagagcag cagaacctag ggtctggaag gctggggacc ttgagctttt
     8221 agcaagtgtt cagccacatt ttcatgtcat tagcactaac aagcctctgg ctctcaggaa
     8281 tttgtcaaaa ggttgatgaa acctcctgag gttccacaca ccaggttata aactggttca
     8341 cgtaggtttg aactgcttac attcatgtca taaattaacc atagcttcat ttgaccccag
     8401 gtcttaagtc tgttgacagt ttcagcatga ctgattcgct cattttattt ttttattttt
     8461 ttttgctttg gaaattggct tggttctctt tagagttggt gtaaacatgc catgtaataa
     8521 atgatttcca gttaatggta caagagaatt attgctttct tagatgtatg tgtagtaaaa
     8581 gtcaatatac acatttatat aatttcttca aaatcttata cctaatttga tatttctaaa
     8641 aattgcacat gtaagtcatg tgtataacat gctaaagtac tttaactgtg atcttaaaac
     8701 tgaataaaat atttaataaa aatttgaaat attttaaaga ta
//
