LOCUS       NM_001360259            3397 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus Bardet-Biedl syndrome 9 (Bbs9), transcript variant 4,
            mRNA.
ACCESSION   NM_001360259 XM_006510415
VERSION     NM_001360259.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3397)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3397)
  AUTHORS   Nakano,Y., Wiechert,S. and Banfi,B.
  TITLE     Overlapping Activities of Two Neuronal Splicing Factors Switch the
            GABA Effect from Excitatory to Inhibitory by Regulating REST
  JOURNAL   Cell Rep 27 (3), 860-871 (2019)
   PUBMED   30995482
REFERENCE   3  (bases 1 to 3397)
  AUTHORS   Zhang,B., Wang,G., Xu,X., Yang,S., Zhuang,T., Wang,G., Ren,H.,
            Cheng,S.Y., Jiang,Q. and Zhang,C.
  TITLE     DAZ-interacting Protein 1 (Dzip1) Phosphorylation by Polo-like
            Kinase 1 (Plk1) Regulates the Centriolar Satellite Localization of
            the BBSome Protein during the Cell Cycle
  JOURNAL   J Biol Chem 292 (4), 1351-1360 (2017)
   PUBMED   27979967
REFERENCE   4  (bases 1 to 3397)
  AUTHORS   Eguether,T., San Agustin,J.T., Keady,B.T., Jonassen,J.A., Liang,Y.,
            Francis,R., Tobita,K., Johnson,C.A., Abdelhamed,Z.A., Lo,C.W. and
            Pazour,G.J.
  TITLE     IFT27 links the BBSome to IFT for maintenance of the ciliary
            signaling compartment
  JOURNAL   Dev Cell 31 (3), 279-290 (2014)
   PUBMED   25446516
REFERENCE   5  (bases 1 to 3397)
  AUTHORS   Chamling,X., Seo,S., Searby,C.C., Kim,G., Slusarski,D.C. and
            Sheffield,V.C.
  TITLE     The centriolar satellite protein AZI1 interacts with BBS4 and
            regulates ciliary trafficking of the BBSome
  JOURNAL   PLoS Genet 10 (2), e1004083 (2014)
   PUBMED   24550735
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3397)
  AUTHORS   Seo,S., Zhang,Q., Bugge,K., Breslow,D.K., Searby,C.C., Nachury,M.V.
            and Sheffield,V.C.
  TITLE     A novel protein LZTFL1 regulates ciliary trafficking of the BBSome
            and Smoothened
  JOURNAL   PLoS Genet 7 (11), e1002358 (2011)
   PUBMED   22072986
REFERENCE   7  (bases 1 to 3397)
  AUTHORS   Loktev,A.V., Zhang,Q., Beck,J.S., Searby,C.C., Scheetz,T.E.,
            Bazan,J.F., Slusarski,D.C., Sheffield,V.C., Jackson,P.K. and
            Nachury,M.V.
  TITLE     A BBSome subunit links ciliogenesis, microtubule stability, and
            acetylation
  JOURNAL   Dev Cell 15 (6), 854-865 (2008)
   PUBMED   19081074
REFERENCE   8  (bases 1 to 3397)
  AUTHORS   Forti,E., Aksanov,O. and Birk,R.Z.
  TITLE     Temporal expression pattern of Bardet-Biedl syndrome genes in
            adipogenesis
  JOURNAL   Int J Biochem Cell Biol 39 (5), 1055-1062 (2007)
   PUBMED   17379567
REFERENCE   9  (bases 1 to 3397)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 3397)
  AUTHORS   Thomas,J.W., Summers,T.J., Lee-Lin,S.Q., Maduro,V.V., Idol,J.R.,
            Mastrian,S.D., Ryan,J.F., Jamison,D.C. and Green,E.D.
  TITLE     Comparative genome mapping in the sequence-based era: early
            experience with human chromosome 7
  JOURNAL   Genome Res 10 (5), 624-633 (2000)
   PUBMED   10810084
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC093926.6, AC113106.9, AC113127.6 and AC164882.2.
            
            On Jan 30, 2018 this sequence version replaced XM_006510415.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849385,
                              SAMN00849388 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-341               AC093926.6         24879-25219         c
            342-464             AC093926.6         9994-10116          c
            465-615             AC093926.6         4075-4225           c
            616-680             AC113106.9         180531-180595       c
            681-794             AC113106.9         170547-170660       c
            795-969             AC113106.9         116761-116935       c
            970-1054            AC113106.9         109445-109529       c
            1055-1238           AC113106.9         105820-106003       c
            1239-1368           AC113106.9         105047-105176       c
            1369-1547           AC113106.9         55520-55698         c
            1548-1624           AC113106.9         48953-49029         c
            1625-1678           AC113106.9         45857-45910         c
            1679-1781           AC113106.9         40793-40895         c
            1782-1886           AC113106.9         38572-38676         c
            1887-1901           AC113106.9         36606-36620         c
            1902-2042           AC113106.9         29275-29415         c
            2043-2138           AC113106.9         25495-25590         c
            2139-2311           AC113106.9         13683-13855         c
            2312-2464           AC113106.9         5576-5728           c
            2465-2647           AC113127.6         183149-183331
            2648-2870           AC164882.2         117129-117351       c
            2871-2978           AC164882.2         41984-42091         c
            2979-3397           AC164882.2         41392-41810         c
FEATURES             Location/Qualifiers
     source          1..3397
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 9.17 cM"
     gene            1..3397
                     /gene="Bbs9"
                     /gene_synonym="E130103I17Rik"
                     /note="Bardet-Biedl syndrome 9"
                     /db_xref="GeneID:319845"
                     /db_xref="MGI:MGI:2442833"
     exon            1..341
                     /gene="Bbs9"
                     /gene_synonym="E130103I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            342..464
                     /gene="Bbs9"
                     /gene_synonym="E130103I17Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             353..3010
                     /gene="Bbs9"
                     /gene_synonym="E130103I17Rik"
                     /note="isoform 2 is encoded by transcript variant 4;
                     protein PTHB1; bardet-Biedl syndrome 9 protein homolog;
                     parathyroid hormone-responsive B1 gene protein homolog;
                     EST 3159894"
                     /codon_start=1
                     /product="protein PTHB1 isoform 2"
                     /protein_id="NP_001347188.1"
                     /db_xref="CCDS:CCDS90520.1"
                     /db_xref="GeneID:319845"
                     /db_xref="MGI:MGI:2442833"
                     /translation="MSLFKARDWWSTVLGEKEEFDQGCLCLADVDNSGNGHDKIIVGS
                     FMGYLRIFSPHSVKAGGGPQAEDLLLEVHLRDPVLQVEVGKFVSGTEMLHLAVLHSRK
                     LCVYSVSGTLGNVEHGNQYQIKLMYEHHLQRTACNMTYGPFGGVKGRDLICIQSLDGM
                     LMVFEQESYAFGRFLPGFLLPGPLAYSPRTDSFITVSSCRQVESYKYQVLAFATDADK
                     KQEMEQQKLGSGKRLVVDWTLNIGEQALDICIFPLNQSASSVFVLGERNFFCLKDNGQ
                     IRFMKKLGYNPSCFLPYCSVSEGTINTLIGNHNHMLHIYQDVTLKWATQLPHVPVAVR
                     VGCFHDLKGVIVTLSDDGHLQCSYLGTDPSLFQAPKVESRELNYDELDVELKELQKII
                     KDVKLQGVWPLTEQEDDLKVSASVSSTLDSVSQATNVEPGADSVPSITVKITLQNRVV
                     LQKVKLSIYVQPPLQLTCDQFTFDFTVPDMTSSVAFSVYLKRNYTPSELEGNAVVSYS
                     RPTDRNPDGIPRVVQCKFRLPLKLICLPGQPSKTASHKLTIDTNKSPVSLLGLFPDFA
                     NPSDDDQVNVMGFRLLGGARVTLLASRTSQRYRIQSEQFEDLWLITNELILRLQEHFE
                     KQGTKDFSCSFSGCVPLQEYFELIDHHFELRINGKKLEELLSERAVQFRAIQRRLLTR
                     FRDKTPAPLQHLDTLLDGTYKQVIALADAIEENQDRLLQSFSGLKSATHLLILLIRLW
                     QRLSADQTAILEAAFLPLQEDTQELGWEETVDAAIAYLLKTCLSKSSKEQALNLSSQL
                     NIPKDTSRLKKHITLLCDRLAKGGRLCVSTDAAAPQAMVVPGGCTPIPESDLEERSLD
                     DSTELFTNHKHLMTEPPMPEVSARQGVLE"
     exon            465..615
                     /gene="Bbs9"
                     /gene_synonym="E130103I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            616..680
                     /gene="Bbs9"
                     /gene_synonym="E130103I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            681..794
                     /gene="Bbs9"
                     /gene_synonym="E130103I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            795..969
                     /gene="Bbs9"
                     /gene_synonym="E130103I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1054
                     /gene="Bbs9"
                     /gene_synonym="E130103I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1238
                     /gene="Bbs9"
                     /gene_synonym="E130103I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1368
                     /gene="Bbs9"
                     /gene_synonym="E130103I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1547
                     /gene="Bbs9"
                     /gene_synonym="E130103I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1624
                     /gene="Bbs9"
                     /gene_synonym="E130103I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1678
                     /gene="Bbs9"
                     /gene_synonym="E130103I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1781
                     /gene="Bbs9"
                     /gene_synonym="E130103I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..1886
                     /gene="Bbs9"
                     /gene_synonym="E130103I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..1901
                     /gene="Bbs9"
                     /gene_synonym="E130103I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..2042
                     /gene="Bbs9"
                     /gene_synonym="E130103I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2043..2138
                     /gene="Bbs9"
                     /gene_synonym="E130103I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2139..2311
                     /gene="Bbs9"
                     /gene_synonym="E130103I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2312..2464
                     /gene="Bbs9"
                     /gene_synonym="E130103I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2465..2647
                     /gene="Bbs9"
                     /gene_synonym="E130103I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2648..2870
                     /gene="Bbs9"
                     /gene_synonym="E130103I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2871..2978
                     /gene="Bbs9"
                     /gene_synonym="E130103I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2979..3397
                     /gene="Bbs9"
                     /gene_synonym="E130103I17Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3373..3378
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bbs9"
                     /gene_synonym="E130103I17Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3397
                     /gene="Bbs9"
                     /gene_synonym="E130103I17Rik"
                     /note="major polyA site"
ORIGIN      
        1 ctccgttgta aaatgctatg acaacagggc gaaggcggtt tggattcagg ctggagtggg
       61 gaggtgtctt ccgcaggctg ttgtcttgca gcctcacccc tcttacagtc tccctggtgg
      121 tttcatcctc tctgtgagca tccggacttg gagtttttct ctcttgtcac ttgtggcttc
      181 cgagggatcc atgtcgtctc ccctgcttgt ctctggggga tgacaagagg gtgcagggga
      241 tcttgggact cacttcacct ccgcggagct tgtgttgctg cttggcagga ttctgtctgc
      301 ttgggaacgt ggaaaacttc gaacacaaac aagaccaaga ggttgaaagg aaatgtcctt
      361 atttaaagcc cgtgactggt ggtctactgt gttgggagaa aaagaagaat ttgaccaggg
      421 ctgcttatgc ttggctgatg tggacaacag tgggaacggc cacgataaaa tcattgtggg
      481 cagcttcatg ggctacctga gaatctttag tccccattct gtaaaagctg gaggtgggcc
      541 tcaggctgaa gatttacttc tagaagtgca tctgcgggac ccagtgctgc aagtggaagt
      601 cgggaagttt gtctcgggca ccgagatgct tcatctggcc gtgctgcact cccggaagct
      661 ctgtgtctac tccgtctcag ggacattggg aaatgtggaa catggaaacc aatatcagat
      721 aaaactaatg tatgagcacc atcttcagag gacggcctgc aatatgacgt atggaccctt
      781 tggtggtgta aaaggtcggg atttaatttg tatccagtct ctggatggga tgctgatggt
      841 gtttgagcag gaaagctatg cgtttgggag gtttctccct ggttttcttc tgcctggccc
      901 tcttgcttac agtccccgca cggattcctt cataactgtg tcttcttgca gacaagtgga
      961 aagttacaag taccaggtac ttgcctttgc cacagatgca gacaagaagc aggagatgga
     1021 acagcaaaaa cttggttctg gaaagcggct agttgtggac tggactctga atattggcga
     1081 gcaagccctt gatatctgta tcttcccttt gaaccaatct gcatcttctg tttttgttct
     1141 tggtgagaga aacttctttt gcctaaagga taatgggcag attcgattca tgaagaagct
     1201 cggttataac cccagttgtt ttctaccgta ctgctcagtt tctgaaggta caataaatac
     1261 tttgattgga aaccataacc acatgctgca tatttaccag gacgtgacac tgaagtgggc
     1321 cacacaactc ccccacgtcc ccgtggccgt cagagtaggc tgttttcatg atttgaaggg
     1381 agtgatagtg actctcagtg atgacggtca cctgcagtgc tcgtatctgg ggacagaccc
     1441 ttctttgttc caggctccaa aagttgaatc aagagagctc aactatgatg aacttgatgt
     1501 ggaattgaaa gaacttcaga aaatcatcaa agatgtaaag ttgcaaggtg tttggccctt
     1561 gactgaacag gaagatgact tgaaagtctc tgcttcagtg tcttctaccc tggattctgt
     1621 gtctcaagcc accaatgtgg aacctggagc tgactctgtc ccgtccatca cagtgaagat
     1681 taccctgcag aaccgagtgg tgttgcagaa ggtcaagctg tctatctatg tgcagcctcc
     1741 actacagttg acttgtgatc agttcacctt tgacttcacg gttccagata tgacgagttc
     1801 agtagcgttt tctgtgtacc tgaagagaaa ctacacacca tccgagttag aaggaaatgc
     1861 tgttgtttct tactccagac cgacagatcg aaatcctgat ggtattcctc gggttgtcca
     1921 atgtaaattt agacttcctc tgaaactgat ttgcctacct ggtcagcctt caaaaactgc
     1981 aagccacaaa ctaactatag acaccaacaa atctcctgtc agtctgctcg gtctcttccc
     2041 agactttgcc aacccatcag atgacgacca agtgaatgta atgggcttcc gtctcctagg
     2101 aggcgctcga gtgactcttc ttgcttccag aacatcccaa cgataccgca ttcagagcga
     2161 acagtttgaa gatctctggc tcataaccaa tgaactcatc ctccgccttc aggaacattt
     2221 tgaaaaacag ggaaccaaag acttttcgtg ttctttttct gggtgtgtgc cccttcaaga
     2281 atattttgag ttgattgatc atcattttga gctgcggata aatggtaaaa aattggaaga
     2341 acttttatct gaaagagctg tacaatttcg ggccattcag cgtcggcttc tgacaagatt
     2401 cagagacaag acccctgccc cactgcagca cctggacacc ctgctggacg ggacatacaa
     2461 gcaggtgatt gctctagcag atgcgatcga ggagaaccag gacaggctgt tgcagtcatt
     2521 ctcaggcctg aagagtgcca cccatttgct gatcctgcta atcaggctgt ggcagaggct
     2581 gagcgctgac cagactgcta ttctggaagc agcatttctg ccactacagg aagacacgca
     2641 ggaactgggc tgggaagaaa ccgtggatgc tgccattgcc taccttttga aaacctgcct
     2701 gtcgaagagt tccaaggagc aggctttgaa cctcagcagc caactgaaca tacccaaaga
     2761 taccagccgg ctgaagaagc acatcaccct gctgtgtgat aggttagcca aaggtgggcg
     2821 tctctgcgtg agcacagatg cagcggcccc gcaggccatg gttgtgccag gtggctgtac
     2881 tccaatccca gagtcagacc tagaggaaag gtcactagat gactccacag agctgtttac
     2941 caaccacaag cacctcatga ccgagccccc catgcctgaa gtctcagccc gccaaggagt
     3001 tttggaatag tctggagtaa tgctaatgag ttgaggggag aggccattac agaggctacc
     3061 ctgtctggac actgtgttcc catcccggtg ctgtgccaag ctcatctctg gaggtgactg
     3121 catgaagatg gggtcagggc tgttggttgc taggagggcg tgggatgtca cagacaggtc
     3181 agctgaaaga caagatttgt cttttcttcc caagaaaatg gttgctgcct ttagtcacat
     3241 gcgcttatag tcaggattta gcaaggtgac gaagtttggg gacagacttt ataatacagg
     3301 gatccagatg taaaataatt tcatagccca tttttttcca caggattctt atgtagtaac
     3361 tgtttcaagt ttaataaagc atcgtattgt caaacaa
//
