LOCUS       NM_001360258            3517 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus Bardet-Biedl syndrome 9 (Bbs9), transcript variant 3,
            mRNA.
ACCESSION   NM_001360258 XM_006510419
VERSION     NM_001360258.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3517)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3517)
  AUTHORS   Nakano,Y., Wiechert,S. and Banfi,B.
  TITLE     Overlapping Activities of Two Neuronal Splicing Factors Switch the
            GABA Effect from Excitatory to Inhibitory by Regulating REST
  JOURNAL   Cell Rep 27 (3), 860-871 (2019)
   PUBMED   30995482
REFERENCE   3  (bases 1 to 3517)
  AUTHORS   Zhang,B., Wang,G., Xu,X., Yang,S., Zhuang,T., Wang,G., Ren,H.,
            Cheng,S.Y., Jiang,Q. and Zhang,C.
  TITLE     DAZ-interacting Protein 1 (Dzip1) Phosphorylation by Polo-like
            Kinase 1 (Plk1) Regulates the Centriolar Satellite Localization of
            the BBSome Protein during the Cell Cycle
  JOURNAL   J Biol Chem 292 (4), 1351-1360 (2017)
   PUBMED   27979967
REFERENCE   4  (bases 1 to 3517)
  AUTHORS   Eguether,T., San Agustin,J.T., Keady,B.T., Jonassen,J.A., Liang,Y.,
            Francis,R., Tobita,K., Johnson,C.A., Abdelhamed,Z.A., Lo,C.W. and
            Pazour,G.J.
  TITLE     IFT27 links the BBSome to IFT for maintenance of the ciliary
            signaling compartment
  JOURNAL   Dev Cell 31 (3), 279-290 (2014)
   PUBMED   25446516
REFERENCE   5  (bases 1 to 3517)
  AUTHORS   Chamling,X., Seo,S., Searby,C.C., Kim,G., Slusarski,D.C. and
            Sheffield,V.C.
  TITLE     The centriolar satellite protein AZI1 interacts with BBS4 and
            regulates ciliary trafficking of the BBSome
  JOURNAL   PLoS Genet 10 (2), e1004083 (2014)
   PUBMED   24550735
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3517)
  AUTHORS   Seo,S., Zhang,Q., Bugge,K., Breslow,D.K., Searby,C.C., Nachury,M.V.
            and Sheffield,V.C.
  TITLE     A novel protein LZTFL1 regulates ciliary trafficking of the BBSome
            and Smoothened
  JOURNAL   PLoS Genet 7 (11), e1002358 (2011)
   PUBMED   22072986
REFERENCE   7  (bases 1 to 3517)
  AUTHORS   Loktev,A.V., Zhang,Q., Beck,J.S., Searby,C.C., Scheetz,T.E.,
            Bazan,J.F., Slusarski,D.C., Sheffield,V.C., Jackson,P.K. and
            Nachury,M.V.
  TITLE     A BBSome subunit links ciliogenesis, microtubule stability, and
            acetylation
  JOURNAL   Dev Cell 15 (6), 854-865 (2008)
   PUBMED   19081074
REFERENCE   8  (bases 1 to 3517)
  AUTHORS   Forti,E., Aksanov,O. and Birk,R.Z.
  TITLE     Temporal expression pattern of Bardet-Biedl syndrome genes in
            adipogenesis
  JOURNAL   Int J Biochem Cell Biol 39 (5), 1055-1062 (2007)
   PUBMED   17379567
REFERENCE   9  (bases 1 to 3517)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 3517)
  AUTHORS   Thomas,J.W., Summers,T.J., Lee-Lin,S.Q., Maduro,V.V., Idol,J.R.,
            Mastrian,S.D., Ryan,J.F., Jamison,D.C. and Green,E.D.
  TITLE     Comparative genome mapping in the sequence-based era: early
            experience with human chromosome 7
  JOURNAL   Genome Res 10 (5), 624-633 (2000)
   PUBMED   10810084
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC093926.6, AC113106.9, AC113127.6 and AC164882.2.
            
            On Jan 30, 2018 this sequence version replaced XM_006510419.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028200.1, SRR1660813.139766.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-476               AC093926.6         24744-25219         c
            477-599             AC093926.6         9994-10116          c
            600-750             AC093926.6         4075-4225           c
            751-815             AC113106.9         180531-180595       c
            816-929             AC113106.9         170547-170660       c
            930-1104            AC113106.9         116761-116935       c
            1105-1189           AC113106.9         109445-109529       c
            1190-1373           AC113106.9         105820-106003       c
            1374-1503           AC113106.9         105047-105176       c
            1504-1682           AC113106.9         55520-55698         c
            1683-1759           AC113106.9         48953-49029         c
            1760-1813           AC113106.9         45857-45910         c
            1814-1916           AC113106.9         40793-40895         c
            1917-2021           AC113106.9         38572-38676         c
            2022-2162           AC113106.9         29275-29415         c
            2163-2258           AC113106.9         25495-25590         c
            2259-2431           AC113106.9         13683-13855         c
            2432-2584           AC113106.9         5576-5728           c
            2585-2767           AC113127.6         183149-183331
            2768-2990           AC164882.2         117129-117351       c
            2991-3098           AC164882.2         41984-42091         c
            3099-3517           AC164882.2         41392-41810         c
FEATURES             Location/Qualifiers
     source          1..3517
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 9.17 cM"
     gene            1..3517
                     /gene="Bbs9"
                     /gene_synonym="E130103I17Rik"
                     /note="Bardet-Biedl syndrome 9"
                     /db_xref="GeneID:319845"
                     /db_xref="MGI:MGI:2442833"
     exon            1..476
                     /gene="Bbs9"
                     /gene_synonym="E130103I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            477..599
                     /gene="Bbs9"
                     /gene_synonym="E130103I17Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             488..3130
                     /gene="Bbs9"
                     /gene_synonym="E130103I17Rik"
                     /note="isoform 1 is encoded by transcript variant 3;
                     protein PTHB1; bardet-Biedl syndrome 9 protein homolog;
                     parathyroid hormone-responsive B1 gene protein homolog;
                     EST 3159894"
                     /codon_start=1
                     /product="protein PTHB1 isoform 1"
                     /protein_id="NP_001347187.1"
                     /db_xref="CCDS:CCDS22928.1"
                     /db_xref="GeneID:319845"
                     /db_xref="MGI:MGI:2442833"
                     /translation="MSLFKARDWWSTVLGEKEEFDQGCLCLADVDNSGNGHDKIIVGS
                     FMGYLRIFSPHSVKAGGGPQAEDLLLEVHLRDPVLQVEVGKFVSGTEMLHLAVLHSRK
                     LCVYSVSGTLGNVEHGNQYQIKLMYEHHLQRTACNMTYGPFGGVKGRDLICIQSLDGM
                     LMVFEQESYAFGRFLPGFLLPGPLAYSPRTDSFITVSSCRQVESYKYQVLAFATDADK
                     KQEMEQQKLGSGKRLVVDWTLNIGEQALDICIFPLNQSASSVFVLGERNFFCLKDNGQ
                     IRFMKKLGYNPSCFLPYCSVSEGTINTLIGNHNHMLHIYQDVTLKWATQLPHVPVAVR
                     VGCFHDLKGVIVTLSDDGHLQCSYLGTDPSLFQAPKVESRELNYDELDVELKELQKII
                     KDVKLQGVWPLTEQEDDLKVSASVSSTLDSVSQATNVEPGADSVPSITVKITLQNRVV
                     LQKVKLSIYVQPPLQLTCDQFTFDFTVPDMTSSVAFSVYLKRNYTPSELEGNAVVSYS
                     RPTGIPRVVQCKFRLPLKLICLPGQPSKTASHKLTIDTNKSPVSLLGLFPDFANPSDD
                     DQVNVMGFRLLGGARVTLLASRTSQRYRIQSEQFEDLWLITNELILRLQEHFEKQGTK
                     DFSCSFSGCVPLQEYFELIDHHFELRINGKKLEELLSERAVQFRAIQRRLLTRFRDKT
                     PAPLQHLDTLLDGTYKQVIALADAIEENQDRLLQSFSGLKSATHLLILLIRLWQRLSA
                     DQTAILEAAFLPLQEDTQELGWEETVDAAIAYLLKTCLSKSSKEQALNLSSQLNIPKD
                     TSRLKKHITLLCDRLAKGGRLCVSTDAAAPQAMVVPGGCTPIPESDLEERSLDDSTEL
                     FTNHKHLMTEPPMPEVSARQGVLE"
     exon            600..750
                     /gene="Bbs9"
                     /gene_synonym="E130103I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            751..815
                     /gene="Bbs9"
                     /gene_synonym="E130103I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            816..929
                     /gene="Bbs9"
                     /gene_synonym="E130103I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1104
                     /gene="Bbs9"
                     /gene_synonym="E130103I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1189
                     /gene="Bbs9"
                     /gene_synonym="E130103I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1373
                     /gene="Bbs9"
                     /gene_synonym="E130103I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1503
                     /gene="Bbs9"
                     /gene_synonym="E130103I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1682
                     /gene="Bbs9"
                     /gene_synonym="E130103I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1759
                     /gene="Bbs9"
                     /gene_synonym="E130103I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..1813
                     /gene="Bbs9"
                     /gene_synonym="E130103I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..1916
                     /gene="Bbs9"
                     /gene_synonym="E130103I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..2021
                     /gene="Bbs9"
                     /gene_synonym="E130103I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2162
                     /gene="Bbs9"
                     /gene_synonym="E130103I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2163..2258
                     /gene="Bbs9"
                     /gene_synonym="E130103I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2259..2431
                     /gene="Bbs9"
                     /gene_synonym="E130103I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2432..2584
                     /gene="Bbs9"
                     /gene_synonym="E130103I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2585..2767
                     /gene="Bbs9"
                     /gene_synonym="E130103I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2768..2990
                     /gene="Bbs9"
                     /gene_synonym="E130103I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2991..3098
                     /gene="Bbs9"
                     /gene_synonym="E130103I17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3099..3517
                     /gene="Bbs9"
                     /gene_synonym="E130103I17Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3493..3498
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bbs9"
                     /gene_synonym="E130103I17Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3517
                     /gene="Bbs9"
                     /gene_synonym="E130103I17Rik"
                     /note="major polyA site"
ORIGIN      
        1 ctccgttgta aaatgctatg acaacagggc gaaggcggtt tggattcagg ctggagtggg
       61 gaggtgtctt ccgcaggctg ttgtcttgca gcctcacccc tcttacagtc tccctggtgg
      121 tttcatcctc tctgtgagca tccggacttg gagtttttct ctcttgtcac ttgtggcttc
      181 cgagggatcc atgtcgtctc ccctgcttgt ctctggggga tgacaagagg gtgcagggga
      241 tcttgggact cacttcacct ccgcggagct tgtgttgctg cttggcagga ttctgtctgc
      301 ttgggaacgt ggaaaacttc gaacacaaac aagaccaaga ggtactagtg gtgttaagtg
      361 ttgtttttcc ttgcacggct gttacttctg ttccagcact ggattctcat ccggagggaa
      421 gtctgtggat agtgggttcg tagcaaggcg agtcaaagcc cacttgttgg catcaggttg
      481 aaaggaaatg tccttattta aagcccgtga ctggtggtct actgtgttgg gagaaaaaga
      541 agaatttgac cagggctgct tatgcttggc tgatgtggac aacagtggga acggccacga
      601 taaaatcatt gtgggcagct tcatgggcta cctgagaatc tttagtcccc attctgtaaa
      661 agctggaggt gggcctcagg ctgaagattt acttctagaa gtgcatctgc gggacccagt
      721 gctgcaagtg gaagtcggga agtttgtctc gggcaccgag atgcttcatc tggccgtgct
      781 gcactcccgg aagctctgtg tctactccgt ctcagggaca ttgggaaatg tggaacatgg
      841 aaaccaatat cagataaaac taatgtatga gcaccatctt cagaggacgg cctgcaatat
      901 gacgtatgga ccctttggtg gtgtaaaagg tcgggattta atttgtatcc agtctctgga
      961 tgggatgctg atggtgtttg agcaggaaag ctatgcgttt gggaggtttc tccctggttt
     1021 tcttctgcct ggccctcttg cttacagtcc ccgcacggat tccttcataa ctgtgtcttc
     1081 ttgcagacaa gtggaaagtt acaagtacca ggtacttgcc tttgccacag atgcagacaa
     1141 gaagcaggag atggaacagc aaaaacttgg ttctggaaag cggctagttg tggactggac
     1201 tctgaatatt ggcgagcaag cccttgatat ctgtatcttc cctttgaacc aatctgcatc
     1261 ttctgttttt gttcttggtg agagaaactt cttttgccta aaggataatg ggcagattcg
     1321 attcatgaag aagctcggtt ataaccccag ttgttttcta ccgtactgct cagtttctga
     1381 aggtacaata aatactttga ttggaaacca taaccacatg ctgcatattt accaggacgt
     1441 gacactgaag tgggccacac aactccccca cgtccccgtg gccgtcagag taggctgttt
     1501 tcatgatttg aagggagtga tagtgactct cagtgatgac ggtcacctgc agtgctcgta
     1561 tctggggaca gacccttctt tgttccaggc tccaaaagtt gaatcaagag agctcaacta
     1621 tgatgaactt gatgtggaat tgaaagaact tcagaaaatc atcaaagatg taaagttgca
     1681 aggtgtttgg cccttgactg aacaggaaga tgacttgaaa gtctctgctt cagtgtcttc
     1741 taccctggat tctgtgtctc aagccaccaa tgtggaacct ggagctgact ctgtcccgtc
     1801 catcacagtg aagattaccc tgcagaaccg agtggtgttg cagaaggtca agctgtctat
     1861 ctatgtgcag cctccactac agttgacttg tgatcagttc acctttgact tcacggttcc
     1921 agatatgacg agttcagtag cgttttctgt gtacctgaag agaaactaca caccatccga
     1981 gttagaagga aatgctgttg tttcttactc cagaccgaca ggtattcctc gggttgtcca
     2041 atgtaaattt agacttcctc tgaaactgat ttgcctacct ggtcagcctt caaaaactgc
     2101 aagccacaaa ctaactatag acaccaacaa atctcctgtc agtctgctcg gtctcttccc
     2161 agactttgcc aacccatcag atgacgacca agtgaatgta atgggcttcc gtctcctagg
     2221 aggcgctcga gtgactcttc ttgcttccag aacatcccaa cgataccgca ttcagagcga
     2281 acagtttgaa gatctctggc tcataaccaa tgaactcatc ctccgccttc aggaacattt
     2341 tgaaaaacag ggaaccaaag acttttcgtg ttctttttct gggtgtgtgc cccttcaaga
     2401 atattttgag ttgattgatc atcattttga gctgcggata aatggtaaaa aattggaaga
     2461 acttttatct gaaagagctg tacaatttcg ggccattcag cgtcggcttc tgacaagatt
     2521 cagagacaag acccctgccc cactgcagca cctggacacc ctgctggacg ggacatacaa
     2581 gcaggtgatt gctctagcag atgcgatcga ggagaaccag gacaggctgt tgcagtcatt
     2641 ctcaggcctg aagagtgcca cccatttgct gatcctgcta atcaggctgt ggcagaggct
     2701 gagcgctgac cagactgcta ttctggaagc agcatttctg ccactacagg aagacacgca
     2761 ggaactgggc tgggaagaaa ccgtggatgc tgccattgcc taccttttga aaacctgcct
     2821 gtcgaagagt tccaaggagc aggctttgaa cctcagcagc caactgaaca tacccaaaga
     2881 taccagccgg ctgaagaagc acatcaccct gctgtgtgat aggttagcca aaggtgggcg
     2941 tctctgcgtg agcacagatg cagcggcccc gcaggccatg gttgtgccag gtggctgtac
     3001 tccaatccca gagtcagacc tagaggaaag gtcactagat gactccacag agctgtttac
     3061 caaccacaag cacctcatga ccgagccccc catgcctgaa gtctcagccc gccaaggagt
     3121 tttggaatag tctggagtaa tgctaatgag ttgaggggag aggccattac agaggctacc
     3181 ctgtctggac actgtgttcc catcccggtg ctgtgccaag ctcatctctg gaggtgactg
     3241 catgaagatg gggtcagggc tgttggttgc taggagggcg tgggatgtca cagacaggtc
     3301 agctgaaaga caagatttgt cttttcttcc caagaaaatg gttgctgcct ttagtcacat
     3361 gcgcttatag tcaggattta gcaaggtgac gaagtttggg gacagacttt ataatacagg
     3421 gatccagatg taaaataatt tcatagccca tttttttcca caggattctt atgtagtaac
     3481 tgtttcaagt ttaataaagc atcgtattgt caaacaa
//
