LOCUS       NM_027810               2598 bp    mRNA    linear   ROD 20-OCT-2024
DEFINITION  Mus musculus Bardet-Biedl syndrome 7 (Bbs7), mRNA.
ACCESSION   NM_027810
VERSION     NM_027810.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2598)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2598)
  AUTHORS   Krause,F., Mohebian,K., Delpero,M., Hesse,D., Kuhn,R., Arends,D.
            and Brockmann,G.A.
  TITLE     A deletion containing a CTCF-element in intron 8 of the Bbs7 gene
            is partially responsible for juvenile obesity in the Berlin Fat
            Mouse
  JOURNAL   Mamm Genome 33 (3), 465-470 (2022)
   PUBMED   34910225
  REMARK    GeneRIF: A deletion containing a CTCF-element in intron 8 of the
            Bbs7 gene is partially responsible for juvenile obesity in the
            Berlin Fat Mouse.
REFERENCE   3  (bases 1 to 2598)
  AUTHORS   Hsu,Y., Garrison,J.E., Seo,S. and Sheffield,V.C.
  TITLE     The absence of BBSome function decreases synaptogenesis and causes
            ectopic synapse formation in the retina
  JOURNAL   Sci Rep 10 (1), 8321 (2020)
   PUBMED   32433491
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2598)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2598)
  AUTHORS   Robichaux,M.A., Potter,V.L., Zhang,Z., He,F., Liu,J., Schmid,M.F.
            and Wensel,T.G.
  TITLE     Defining the layers of a sensory cilium with STORM and cryoelectron
            nanoscopy
  JOURNAL   Proc Natl Acad Sci U S A 116 (47), 23562-23572 (2019)
   PUBMED   31690665
REFERENCE   6  (bases 1 to 2598)
  AUTHORS   Yen,H.J., Tayeh,M.K., Mullins,R.F., Stone,E.M., Sheffield,V.C. and
            Slusarski,D.C.
  TITLE     Bardet-Biedl syndrome genes are important in retrograde
            intracellular trafficking and Kupffer's vesicle cilia function
  JOURNAL   Hum Mol Genet 15 (5), 667-677 (2006)
   PUBMED   16399798
REFERENCE   7  (bases 1 to 2598)
  AUTHORS   Beales,P.L.
  TITLE     Lifting the lid on Pandora's box: the Bardet-Biedl syndrome
  JOURNAL   Curr Opin Genet Dev 15 (3), 315-323 (2005)
   PUBMED   15917208
  REMARK    Review article
REFERENCE   8  (bases 1 to 2598)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   9  (bases 1 to 2598)
  AUTHORS   Blacque,O.E., Reardon,M.J., Li,C., McCarthy,J., Mahjoub,M.R.,
            Ansley,S.J., Badano,J.L., Mah,A.K., Beales,P.L., Davidson,W.S.,
            Johnsen,R.C., Audeh,M., Plasterk,R.H., Baillie,D.L., Katsanis,N.,
            Quarmby,L.M., Wicks,S.R. and Leroux,M.R.
  TITLE     Loss of C. elegans BBS-7 and BBS-8 protein function results in
            cilia defects and compromised intraflagellar transport
  JOURNAL   Genes Dev 18 (13), 1630-1642 (2004)
   PUBMED   15231740
REFERENCE   10 (bases 1 to 2598)
  AUTHORS   Badano,J.L., Ansley,S.J., Leitch,C.C., Lewis,R.A., Lupski,J.R. and
            Katsanis,N.
  TITLE     Identification of a novel Bardet-Biedl syndrome protein, BBS7, that
            shares structural features with BBS1 and BBS2
  JOURNAL   Am J Hum Genet 72 (3), 650-658 (2003)
   PUBMED   12567324
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117584.11.
            
            On Mar 21, 2008 this sequence version replaced NM_027810.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031505.1, AK132661.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-140               AC117584.11        77021-77160
            141-206             AC117584.11        78333-78398
            207-269             AC117584.11        79782-79844
            270-445             AC117584.11        80055-80230
            446-632             AC117584.11        82703-82889
            633-705             AC117584.11        84654-84726
            706-822             AC117584.11        85888-86004
            823-953             AC117584.11        87451-87581
            954-1038            AC117584.11        90987-91071
            1039-1141           AC117584.11        92042-92144
            1142-1334           AC117584.11        95850-96042
            1335-1409           AC117584.11        97971-98045
            1410-1475           AC117584.11        99693-99758
            1476-1615           AC117584.11        107645-107784
            1616-1780           AC117584.11        111850-112014
            1781-1890           AC117584.11        114558-114667
            1891-1994           AC117584.11        114762-114865
            1995-2118           AC117584.11        114993-115116
            2119-2598           AC117584.11        116788-117267
FEATURES             Location/Qualifiers
     source          1..2598
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 17.72 cM"
     gene            1..2598
                     /gene="Bbs7"
                     /gene_synonym="8430406N16Rik"
                     /note="Bardet-Biedl syndrome 7"
                     /db_xref="GeneID:71492"
                     /db_xref="MGI:MGI:1918742"
     exon            1..140
                     /gene="Bbs7"
                     /gene_synonym="8430406N16Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..2252
                     /gene="Bbs7"
                     /gene_synonym="8430406N16Rik"
                     /note="bardet-Biedl syndrome 7 protein homolog; BBS2-like
                     protein 1"
                     /codon_start=1
                     /product="BBSome complex member BBS7"
                     /protein_id="NP_082086.2"
                     /db_xref="CCDS:CCDS17314.2"
                     /db_xref="GeneID:71492"
                     /db_xref="MGI:MGI:1918742"
                     /translation="MDLTLSRADYLQVGVTSQKTMKLLPTSRQRATQKVVVGDQDGVV
                     ICFGVKKGEAVPVFKTLPGQKISRLELGGAVNTPQEKIFIAAGSEIRGFTKRGKQFLS
                     FETNLTESIKAMYISGSDLFLSASYIYNHYCDCKDQNYYLSGDKINDVICLPVEKLSR
                     VTPVLACQDRVLRVLQGSDVMYEIEVPGPPTVLALHNGDGGDSGEGLLFGTSDGRLGL
                     IQITTSKPIHKWEIRNDKKRGGILCVDSFDIMGDGVKDLLVGRDDGMVEVYSFENANE
                     PVLRFDQMLSESVTSIQGGCVGKDGYDEIVLATYSGWVTGLTTEPTHKESGPGEELKL
                     NQEMQNKISSLRSEIEHLQFKVLQERENYQQSSQSSQAKSTVPSFSINDKFTLNKEDA
                     SYSLVLEVRTAIDNVLIQSDVPIDLLDVDKNSAVVSFSSCDTESNDNFLLATYRCQAN
                     TTRLELKIRSIEGQYGTLQAYVTPRIQPKTCQVRQYHIKPLSLHQRTHFIDHDRPMNT
                     LTLTGQFSFAEVHSWVVFCLPEVPEKPPAGECATFYFQNTFLDTQLECVYRKGEGVFK
                     SDNISTISILKDVLSKEATKRKINLNISYEINEVSVKHTLKLIHPKLEYQLLLAKKVQ
                     LIDALKELQVHEGNTDFLTPEYRCILEEADHLQEEYKKQPAHLERLYGMITDLFIDKF
                     KFKGTNVKTKVPMLLEILDSYDQNTLISFFDAA"
     exon            141..206
                     /gene="Bbs7"
                     /gene_synonym="8430406N16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            207..269
                     /gene="Bbs7"
                     /gene_synonym="8430406N16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            270..445
                     /gene="Bbs7"
                     /gene_synonym="8430406N16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            446..632
                     /gene="Bbs7"
                     /gene_synonym="8430406N16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            633..705
                     /gene="Bbs7"
                     /gene_synonym="8430406N16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            706..822
                     /gene="Bbs7"
                     /gene_synonym="8430406N16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            823..953
                     /gene="Bbs7"
                     /gene_synonym="8430406N16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1038
                     /gene="Bbs7"
                     /gene_synonym="8430406N16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1141
                     /gene="Bbs7"
                     /gene_synonym="8430406N16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1334
                     /gene="Bbs7"
                     /gene_synonym="8430406N16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1409
                     /gene="Bbs7"
                     /gene_synonym="8430406N16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1475
                     /gene="Bbs7"
                     /gene_synonym="8430406N16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1615
                     /gene="Bbs7"
                     /gene_synonym="8430406N16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1780
                     /gene="Bbs7"
                     /gene_synonym="8430406N16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..1890
                     /gene="Bbs7"
                     /gene_synonym="8430406N16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..1994
                     /gene="Bbs7"
                     /gene_synonym="8430406N16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..2118
                     /gene="Bbs7"
                     /gene_synonym="8430406N16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2119..2598
                     /gene="Bbs7"
                     /gene_synonym="8430406N16Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2574..2579
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bbs7"
                     /gene_synonym="8430406N16Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2597
                     /gene="Bbs7"
                     /gene_synonym="8430406N16Rik"
                     /note="major polyA site"
ORIGIN      
        1 gttgctgggc gccgctgccc tgacgcaggc cggctcgtca gtctagtggt gggctctccg
       61 agggaaggct tccacagcgg gtcccgcctc tccgtgcggc cgccatggat ctgacgttaa
      121 gccgggcaga ctacctccag gtcggagtga cctctcagaa aactatgaag ttgcttccta
      181 cctcaagaca aagggctaca caaaaggtgg ttgttggaga tcaagatggg gtagtgatat
      241 gcttcggcgt gaagaaagga gaagctgtgc cagtgttcaa gactttacca gggcagaaga
      301 tctcgaggct ggaactagga ggggccgtca acacgcctca ggagaaaatc ttcattgctg
      361 cagggtccga gattagaggc tttacaaaga gagggaaaca gtttctctct tttgaaacta
      421 acctcacgga aagcattaaa gctatgtaca tatctggctc tgacctcttc ctcagtgcaa
      481 gctacatcta taatcactac tgtgattgca aagaccaaaa ttattacctt tctggggaca
      541 aaatcaatga tgtcatctgc cttcctgtgg aaaagttatc tcgcgtgaca ccggtgttgg
      601 cctgccagga ccgggtgctc cgagtcttac agggatctga tgtgatgtat gaaattgagg
      661 ttcctggtcc acccaccgtc ttagcactgc ataatggaga tggaggtgac tctggagaag
      721 gacttctgtt cggcacatca gatggaagac ttgggcttat tcagatcaca acatccaaac
      781 caatacacaa atgggaaatt cgaaatgaca aaaagcgggg aggtatcttg tgtgttgaca
      841 gctttgatat catgggtgat ggggttaaag atttacttgt tgggagagat gatggaatgg
      901 tggaagtata tagttttgaa aatgcaaatg aacctgtgct acgatttgat cagatgctgt
      961 ctgaaagcgt cacctccatc cagggtggct gtgtgggaaa agatggctat gatgaaattg
     1021 tgctggccac atattcaggc tgggtgacag ggctgactac agagccaact cataaagaaa
     1081 gtggaccagg agaagaacta aaacttaatc aggaaatgca gaataagatt tcttctttaa
     1141 ggtctgaaat agaacacctg cagtttaagg tgcttcagga gagagaaaat taccaacagt
     1201 cttcacagtc aagccaagca aagtcaacag tcccttcatt cagtataaat gacaagttca
     1261 cattgaataa agaagatgct agctacagcc tcgtcttaga ggtgcggact gcaatagaca
     1321 atgtcctaat acagagtgat gttccaatag atctacttga tgtggacaag aattctgctg
     1381 ttgtgagctt cagcagctgt gacacagagt caaacgacaa ctttcttctt gctacttatc
     1441 ggtgccaggc aaataccacc aggctggagc tcaagattcg ttcaattgaa ggccagtatg
     1501 gcacactcca ggcatatgtg actccaagaa tccaaccaaa aacctgtcag gttcgccaat
     1561 accacatcaa acctctatca ctccatcaaa gaactcactt tattgaccat gacaggccta
     1621 tgaacacact gactctaaca ggccagttca gctttgctga agttcactcc tgggtggtgt
     1681 tctgcctgcc tgaagttcct gaaaagcctc cagcagggga atgtgcaaca ttttactttc
     1741 agaatacctt tctggataca caacttgagt gtgtatacag gaaaggagaa ggagttttta
     1801 aatctgacaa catttctaca atatccatcc taaaagatgt gctttctaaa gaagctacaa
     1861 aaaggaaaat taatctcaac atatcatacg agataaacga ggtgtctgtc aagcacactt
     1921 taaagctaat tcacccgaag ctggagtatc agctgcttct ggctaagaaa gtgcagttaa
     1981 tcgatgccct gaaggaattg caggttcatg agggaaatac agactttctg actccagagt
     2041 accgatgtat tctagaagag gcagatcatc tacaagagga atacaaaaag cagcctgcac
     2101 atcttgaaag actctatggt atgattactg atctttttat agataaattt aagttcaaag
     2161 gcactaatgt aaaaaccaaa gtacccatgc tcctggagat tctcgacagc tacgaccaga
     2221 acacactgat ttctttcttc gatgcagcat gaaagataaa caaggtaggc caacaggaca
     2281 gccgaagaag caagcagagc ctgatcagac ccgaggcacc tcagatggac gtcccacatg
     2341 taatcagaag agtgacggcc tctaagcatc cccctacgag tacccatgaa agtccttttt
     2401 attgtgtact tgaggggaaa agaagatctt ttagtcattc atttcagggg aatattgcat
     2461 tgaaagtttt agaatactat taaataagag caaataagct gtcttttgtt ttcaaagggt
     2521 agttatgaaa acaatgatta cattttatta tattttatgt atgattctta actattaaat
     2581 gtgaacattt aaggtaat
//
