LOCUS       NM_001033128            5646 bp    mRNA    linear   ROD 20-OCT-2024
DEFINITION  Mus musculus Bardet-Biedl syndrome 1 (Bbs1), mRNA.
ACCESSION   NM_001033128 XM_355129 XM_902504 XM_902505 XM_902506 XM_902507
            XM_902508 XM_907591 XM_920481 XM_920493 XM_920494 XM_920497
            XM_920501
VERSION     NM_001033128.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5646)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5646)
  AUTHORS   Freke,G.M., Martins,T., Davies,R.J., Beyer,T., Seda,M., Peskett,E.,
            Haq,N., Prasai,A., Otto,G., Jeyabalan Srikaran,J., Hernandez,V.,
            Diwan,G.D., Russell,R.B., Ueffing,M., Huranova,M., Boldt,K.,
            Beales,P.L. and Jenkins,D.
  TITLE     De-Suppression of Mesenchymal Cell Identities and Variable
            Phenotypic Outcomes Associated with Knockout of Bbs1
  JOURNAL   Cells 12 (22), 2662 (2023)
   PUBMED   37998397
  REMARK    GeneRIF: De-Suppression of Mesenchymal Cell Identities and Variable
            Phenotypic Outcomes Associated with Knockout of Bbs1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5646)
  AUTHORS   Hassan,S., Hsu,Y., Mayer,S.K., Thomas,J., Kothapalli,A., Helms,M.,
            Baker,S.A., Laird,J.G., Bhattarai,S. and Drack,A.V.
  TITLE     A visually guided swim assay for mouse models of human retinal
            disease recapitulates the multi-luminance mobility test in humans
  JOURNAL   Saudi J Ophthalmol 37 (4), 313-320 (2023)
   PUBMED   38155679
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5646)
  AUTHORS   Stump,M., Guo,D.F. and Rahmouni,K.
  TITLE     T cell-specific deficiency in BBSome component BBS1 interferes with
            selective immune responses
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 324 (2), R161-R170 (2023)
   PUBMED   36534590
  REMARK    GeneRIF: T cell-specific deficiency in BBSome component BBS1
            interferes with selective immune responses.
REFERENCE   5  (bases 1 to 5646)
  AUTHORS   Stubbs,T., Bingman,J.I., Besse,J. and Mykytyn,K.
  TITLE     Ciliary signaling proteins are mislocalized in the brains of
            Bardet-Biedl syndrome 1-null mice
  JOURNAL   Front Cell Dev Biol 10, 1092161 (2023)
   PUBMED   36699005
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5646)
  AUTHORS   Nachury,M.V., Loktev,A.V., Zhang,Q., Westlake,C.J., Peranen,J.,
            Merdes,A., Slusarski,D.C., Scheller,R.H., Bazan,J.F.,
            Sheffield,V.C. and Jackson,P.K.
  TITLE     A core complex of BBS proteins cooperates with the GTPase Rab8 to
            promote ciliary membrane biogenesis
  JOURNAL   Cell 129 (6), 1201-1213 (2007)
   PUBMED   17574030
REFERENCE   7  (bases 1 to 5646)
  AUTHORS   Forti,E., Aksanov,O. and Birk,R.Z.
  TITLE     Temporal expression pattern of Bardet-Biedl syndrome genes in
            adipogenesis
  JOURNAL   Int J Biochem Cell Biol 39 (5), 1055-1062 (2007)
   PUBMED   17379567
REFERENCE   8  (bases 1 to 5646)
  AUTHORS   Laurier,V., Stoetzel,C., Muller,J., Thibault,C., Corbani,S.,
            Jalkh,N., Salem,N., Chouery,E., Poch,O., Licaire,S., Danse,J.M.,
            Amati-Bonneau,P., Bonneau,D., Megarbane,A., Mandel,J.L. and
            Dollfus,H.
  TITLE     Pitfalls of homozygosity mapping: an extended consanguineous
            Bardet-Biedl syndrome family with two mutant genes (BBS2, BBS10),
            three mutations, but no triallelism
  JOURNAL   Eur J Hum Genet 14 (11), 1195-1203 (2006)
   PUBMED   16823392
REFERENCE   9  (bases 1 to 5646)
  AUTHORS   Ross,A.J., May-Simera,H., Eichers,E.R., Kai,M., Hill,J.,
            Jagger,D.J., Leitch,C.C., Chapple,J.P., Munro,P.M., Fisher,S.,
            Tan,P.L., Phillips,H.M., Leroux,M.R., Henderson,D.J., Murdoch,J.N.,
            Copp,A.J., Eliot,M.M., Lupski,J.R., Kemp,D.T., Dollfus,H., Tada,M.,
            Katsanis,N., Forge,A. and Beales,P.L.
  TITLE     Disruption of Bardet-Biedl syndrome ciliary proteins perturbs
            planar cell polarity in vertebrates
  JOURNAL   Nat Genet 37 (10), 1135-1140 (2005)
   PUBMED   16170314
  REMARK    Erratum:[Nat Genet. 2005 Dec;37(12):1381]
REFERENCE   10 (bases 1 to 5646)
  AUTHORS   Kulaga,H.M., Leitch,C.C., Eichers,E.R., Badano,J.L., Lesemann,A.,
            Hoskins,B.E., Lupski,J.R., Beales,P.L., Reed,R.R. and Katsanis,N.
  TITLE     Loss of BBS proteins causes anosmia in humans and defects in
            olfactory cilia structure and function in the mouse
  JOURNAL   Nat Genet 36 (9), 994-998 (2004)
   PUBMED   15322545
  REMARK    GeneRIF: deletions of Bbs1 or Bbs4 affected the olfactory
            epithelium, causing severe reduction of the ciliated border,
            disorganization of the dendritic microtubule network and trapping
            of olfactory ciliary proteins in dendrites and cell bodies.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY063920.1, BC076577.1 and AK045850.1.
            
            On Oct 31, 2009 this sequence version replaced NM_001033128.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC076577.1, AK045850.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                BY063920.1         2-12
            12-2745             BC076577.1         1-2734
            2746-3737           AK045850.1         2744-3735
            3738-5646           BC076577.1         3727-5635
FEATURES             Location/Qualifiers
     source          1..5646
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.14 cM"
     gene            1..5646
                     /gene="Bbs1"
                     /gene_synonym="D19Ertd609e"
                     /note="Bardet-Biedl syndrome 1"
                     /db_xref="GeneID:52028"
                     /db_xref="MGI:MGI:1277215"
     exon            1..72
                     /gene="Bbs1"
                     /gene_synonym="D19Ertd609e"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..1807
                     /gene="Bbs1"
                     /gene_synonym="D19Ertd609e"
                     /note="Bardet-Biedl syndrome 1 homolog; Bardet-Biedl
                     syndrome 1 protein homolog"
                     /codon_start=1
                     /product="BBSome complex member BBS1"
                     /protein_id="NP_001028300.1"
                     /db_xref="CCDS:CCDS29442.1"
                     /db_xref="GeneID:52028"
                     /db_xref="MGI:MGI:1277215"
                     /translation="MAAASSSDSDSGRAESNEANSKWLDAHYDPMANIHTFSSCLSLA
                     DLHGDGEYKLVVGDLGPGGQQPRLKVLKGPTVLTESPLPALPASAATFLMDQHEPRTP
                     ALALASGPCVYVYKNLRPYFKFSLPQLPPNPLEQDVWNQAKEDQIDPLTLKEMLEDIR
                     EKADVPLSVQSLRFLQLELSEMEAFVNQHKSKVIKRQTVITTMTTLKKNLADEDAASC
                     LVLGTESKELLVLDPEAFTILAKMSLPSVPVFLEVSGQFDVEFRLTAACRNGSIYILR
                     RDSKHPKYCIELSAQPVGLVRVHKVLVVGSTQESLHGFTHKGKKLWTVQMPAAILTMN
                     LLEQRSRGLQAVMAALANGEVRIYRDKALLNVIHAPDAVTSLCFGRYGREDNTLIMTT
                     RGGGLIIKILKRTAVFVEGTGEVGPPLAQTTKLSVPRKTRLYVDQTLREREAGTAMHR
                     TFQTDLYLLRLRAARAYVQALESSLSPMSTTAREPLKLHAVVQGLGPTFKLTLHLQNT
                     STARPVLGLHVCFLYNKALYALPQAFFKVPLLVPGLSYPLETFVESLSSKGISDMIKV
                     LVLREGQSAPLLSAHINMPVSEGLAAA"
     exon            73..149
                     /gene="Bbs1"
                     /gene_synonym="D19Ertd609e"
                     /inference="alignment:Splign:2.1.0"
     exon            150..184
                     /gene="Bbs1"
                     /gene_synonym="D19Ertd609e"
                     /inference="alignment:Splign:2.1.0"
     exon            185..457
                     /gene="Bbs1"
                     /gene_synonym="D19Ertd609e"
                     /inference="alignment:Splign:2.1.0"
     exon            458..504
                     /gene="Bbs1"
                     /gene_synonym="D19Ertd609e"
                     /inference="alignment:Splign:2.1.0"
     exon            505..543
                     /gene="Bbs1"
                     /gene_synonym="D19Ertd609e"
                     /inference="alignment:Splign:2.1.0"
     exon            544..616
                     /gene="Bbs1"
                     /gene_synonym="D19Ertd609e"
                     /inference="alignment:Splign:2.1.0"
     exon            617..748
                     /gene="Bbs1"
                     /gene_synonym="D19Ertd609e"
                     /inference="alignment:Splign:2.1.0"
     exon            749..855
                     /gene="Bbs1"
                     /gene_synonym="D19Ertd609e"
                     /inference="alignment:Splign:2.1.0"
     exon            856..976
                     /gene="Bbs1"
                     /gene_synonym="D19Ertd609e"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1135
                     /gene="Bbs1"
                     /gene_synonym="D19Ertd609e"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1205
                     /gene="Bbs1"
                     /gene_synonym="D19Ertd609e"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1364
                     /gene="Bbs1"
                     /gene_synonym="D19Ertd609e"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1498
                     /gene="Bbs1"
                     /gene_synonym="D19Ertd609e"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1633
                     /gene="Bbs1"
                     /gene_synonym="D19Ertd609e"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1720
                     /gene="Bbs1"
                     /gene_synonym="D19Ertd609e"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..5597
                     /gene="Bbs1"
                     /gene_synonym="D19Ertd609e"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggttgccaag gcgacgcctg ggaaaatggc tgcggcgtct tcatcggatt ctgacagcgg
       61 gcgagctgag agcaacgaag ccaattctaa atggctggac gcacactacg accccatggc
      121 caacatccac accttctcct cctgcctgtc actggcagat ttgcatggcg atggggagta
      181 caagctggtg gtgggagacc ttggcccagg tgggcagcag ccccgcctga aggtgctcaa
      241 aggacccaca gtgctgacgg agagcccact gcctgccctg ccagcctcgg ctgccacctt
      301 cctcatggac caacacgagc ccaggacacc tgccctggca ctcgcctcag ggccttgtgt
      361 ctatgtttat aagaacctta gaccctactt caagttcagc ctgccccagt tacctccaaa
      421 ccctttggaa caggacgttt ggaaccaagc caaagaggac cagattgacc ccttaaccct
      481 gaaggagatg ctggaggaca tcagggaaaa ggcagacgtg cctttgtctg tgcagtcact
      541 caggtttctg cagctggagc tgagtgaaat ggaggcgttt gtgaaccagc acaagtccaa
      601 ggttatcaag cgccagacag tcatcaccac catgaccacc ctgaagaaga acctggcaga
      661 tgaggacgca gcgtcctgtc tggtgctagg cactgagagc aaggaactcc tagtgctgga
      721 ccctgaggcc ttcaccattt tggccaagat gagcctgccc agtgtccctg tcttcctgga
      781 ggtttccggc cagtttgatg tggagttccg gttgactgct gcctgccgaa atgggagcat
      841 ctatatcctg agaagagact ccaaacaccc caagtactgc atcgagttga gtgcccagcc
      901 agtggggctg gtccgggtac acaaggtcct ggtggtgggc agcacccaag agagtctgca
      961 tggcttcacc cacaagggta agaagctgtg gacagtgcag atgcctgcag ccatcctgac
     1021 catgaacctc ctggagcagc gatcccgagg cctgcaagct gtcatggctg ctctggccaa
     1081 tggggaagtc cgaatttacc gagacaaggc cctgctcaat gtcatccatg ccccggatgc
     1141 agtaaccagc ctgtgctttg gccgatacgg gcgagaagac aacaccctca tcatgactac
     1201 tagaggtggc ggcctgatca tcaagatcct gaagcgcaca gcagtgtttg tggaagggac
     1261 gggtgaggtg ggcccaccgc tagcacagac cacaaaactc agtgtgcccc gaaagacccg
     1321 gctgtatgtg gatcagaccc tgcgggagcg ggaagctggc acagccatgc accggacctt
     1381 ccagaccgac ctctacctgc tgcgcctgcg agctgccaga gcctatgtcc aggccctgga
     1441 gtccagcctg agccccatgt caaccacagc tcgcgagccc ctcaagctgc atgctgtggt
     1501 tcaaggcctg ggccccacct ttaagctcac acttcacctg cagaatacct caacggctcg
     1561 acccgttctg gggctgcatg tctgcttcct gtacaacaag gcgctctatg ccctgcctca
     1621 ggctttcttt aaggttccct tgctggtacc aggactcagt tacccactgg aaacctttgt
     1681 ggagagtctc agtagcaagg gcatctcaga catgatcaag gtgctagtgc ttcgggaagg
     1741 ccagagtgct cccctgctga gtgcccacat caacatgcct gtgagtgagg gtctggcagc
     1801 tgcctgagcc ctgcgccagc attcaagtct ccacaaacaa aatggagcct ttcggattca
     1861 gtgacttcca gtattgccag actacttccc ccggtagcaa tgtagtgaga cagcagctcc
     1921 ctgttcttct ctgacacagt cccttgctcc ccacctctgc cagtgacctg agcaacaaga
     1981 cacggggtgc tcggaatcag ctcctcctcc tcggaaccca ctcaagccct gtccctcagt
     2041 tccggctgcc tgctactccc caggtcccag gaagagatgt gaggtggtca gggcgagcat
     2101 agcctcagtc cgtccgtcct tccttccact cacctctttc agatcaagag cacagttgat
     2161 cgagggctta gatgtcggct ggtactgatc ctctgctgtc ctttgaagtt gcaggggtgt
     2221 gggtgctgcc agcttggttt ataggcacat gtgctaagct ttctcaactg aagaggggct
     2281 ccactttcta ccctgaagcc caggagtcat ggggctctgt ccccaggtcc tagacgagcc
     2341 acagagattg ccagaggagc tggtgccaga agtagacggg gtccgtgtga ggagctagag
     2401 ccacacagcc agcagctgct cccgacatgg gtgctcatgg ccagaggcac tgttctgaaa
     2461 tggaatgcgg agctagatag cggagctggg gctggtggca ctgggagagg tctggacctg
     2521 ggacctggga agtgacccaa gaggcagatg ccgacaagag cctgtcagag tgcacttagg
     2581 tccaggagcc cgagatggtc ctgagggtgg aatgttcact gtgcagtggc cagaagatgc
     2641 ctgagctcac ggaaaaggtg cacaccaggg gtgtggcata aagccgaaga ctgaaggtag
     2701 atgtgcttag atctcaaggg tcagggcccc tggccctcct cagaggctgt tctgaatcac
     2761 ttgagaagca ggagccctgc tccatggaga gcaacatttt ccccagtctg atcaggttca
     2821 gcctggtgtg tggcacccag cttaggcttg caagcttcca cctcctctcc agtacaagag
     2881 acttgcctgg attaactcta agccgttgtc agctctggca ccattagagc ttggcagctc
     2941 ctcaggagaa agggaagcat tgctccaaga aggcgagact caactgcaca gctttgtcca
     3001 caaaacctaa gctgaccacc actgcccagt aacagcctct gcgcccactc ggggaccagg
     3061 gtgacccttt caaagggtac ttcagggccc aggctaagag acagtgggtc tggaccaaag
     3121 aaacatcctc gttctcatat tgcccatccc cctcaagaca gtactacctg agcaaggaga
     3181 gcaaagggtt ctttgtgcat catccagtga ggcacagctg gaccacgctg gaggtctaac
     3241 tgaagatggg agagggcagg gaatgttgct gtgagtcaca aaccccagcc tatcctgcac
     3301 agtaaacagg aaggcctgtc caagttgttg agcccttgtc actgtgtcat gtgagcgggg
     3361 ctgtgctctc atggggccag gttggatcat gacatcccag tccctttcac ccaagtcatg
     3421 ctgtgaaatc agaacaaaaa tatttgatgt gtgcactctt catagctact catgatgata
     3481 caaggggtga gacatatgac caggtcctac cataaaacac agtgtcatac tatgcttgcc
     3541 tagtaagaaa tgtatgccat gcaccttatg cacataaaag aacatgaagc ataaacggtg
     3601 cagagtgtcc agtactcacg gaagtcagag ttctaggaaa ctgaacctta aggatgagaa
     3661 gagtctatct ttttttaaca taatacttat tttaaaacac acacctatgt aatgacctgg
     3721 aatagactat ttaaagtaaa atgccctctt cccattccac aggaccattc ctgtacaaca
     3781 gccatcttca ttaactattt tattttattt tttggttttt cgagacagag tttctctgtg
     3841 tagccctggc tgtcctggaa ctcaactgta gaccaggctg gcctcgaact cagaaatctg
     3901 cctgcctctg cctcccaagt gctgggatta aaggcgtgcg ccaccaccac ccagccatta
     3961 actattttaa aaaaaaaaaa atatatatat atatatatat atataaagag attcttttaa
     4021 aattatgtgt gtgggtggat acaggtgccc aaagaaacca gaaaagggcc ttggattccc
     4081 caggagctgg agttacaggt ggttgtgagc tgcccagtat gggtgctggg tccttggcaa
     4141 gagtccttag acattacctg ttgatccctg ttgcagcaga taagcgtttg gtgctcttga
     4201 gacccctccc ctgctctcca tgctttaggt agtcagtgcc cactgtttac attgctgttt
     4261 atattgattc gtgaaagtct tagtaaagtg agaattaact ataaccattt ttgaactttt
     4321 agatgttttc atggaattgg cacttggttt gacttttctt tctttcattg ctaagttttc
     4381 taatatacca tggaaaatcc ccccatccta tctcagttca tttctcgggc gggacacttc
     4441 ctttctaact tgcttctgtg cagactcccc tagaagagaa ttccttctcc tgttagatcc
     4501 cctgattcct gggtcccatg tcttctttct tcttccgccc tcattgggta aaacgtaccc
     4561 agggtaagat cactctaaaa cccacctgtg atggttattc ctggctgtca cgttgactgt
     4621 acctggcctg agctacagtc cagaattgga gcaccctgtg ctccagagct ggaggctgga
     4681 aggcacgggc tttgatctgg accttggagc acagtgaccg tgagaagctc aggcccaggg
     4741 aaggtgactc ctgcctttca tcccaggaga cagaggctag cagatctctt aagttcaagc
     4801 cagcctggaa cagaacaaat taggtccagg cgtggtggtg cacaccttta atctcagcca
     4861 tactttctgc tggaggcctc cataaataag gacaatggaa gaaggaaggc ttgctgcttc
     4921 tttgcctgct tgcacttacc tgccagcaca tctgttggag cctagttctt caggattcca
     4981 gcttatacaa aagaccagct gaaacaccca gcctcatggg actgagcaac tactagactc
     5041 ttggacttcc cattcacagc tgcccattgt tggttagttg gattgcagcc tgagtcattc
     5101 caataaattc ccataatata tagagacatt ccataagttc tgtgactcta gagaaccctg
     5161 acaagatacc acccaagtct ttatatcact gcttgtctgg acactgttgt gacagtctgg
     5221 gtggtaaaac aagctgggaa cagttttcct gtaggcgaag ctcccatgtc ttctgtgctc
     5281 tgtcccagtt gttactctga ggtgggggta acgggcattc ctcctcaggg ctggctgtta
     5341 ttctctctct ggggctccag ttaagctctg tctgacagat ggtcgctact gagaggactg
     5401 cattgatcct aattttcttc tttcatggtc atctttttgc tttgttttcc aagagtgaga
     5461 attttgtaag cttttcttac gtttcaaact gtttttctta gttcctgtgt tcagttctta
     5521 tattttcttc tctttaagtt ttgcatttgt ttatatgtaa gtagcctaac agcatctaat
     5581 taaacaaaaa ctcataaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     5641 aaaaaa
//
