LOCUS       NM_028377               2190 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus basal body orientation factor 1 (Bbof1), mRNA.
ACCESSION   NM_028377
VERSION     NM_028377.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2190)
  AUTHORS   Liu,C., Wang,Q., Gu,L., Wang,X., Yin,Y., Huang,T., Xiao,S.,
            Zhang,S., Wang,F., Zhou,T., Xu,G., Wang,L., Dong,F., Jiang,J.,
            Luo,M., Li,J., Zhang,H., Zi-Jiang,Chen., Ji,W., Ji,B., Liu,H. and
            Li,W.
  TITLE     CCDC176 stabilizes microtubule doublets 1 and 9 to ensure proper
            sperm movement
  JOURNAL   Curr Biol 33 (16), 3371-3388 (2023)
   PUBMED   37494937
  REMARK    GeneRIF: CCDC176 stabilizes microtubule doublets 1 and 9 to ensure
            proper sperm movement.
REFERENCE   2  (bases 1 to 2190)
  AUTHORS   Cao,H., Xu,H., Zhou,Y., Xu,W., Lu,Q., Jiang,L., Rong,Y., Zhang,Q.
            and Yu,C.
  TITLE     BBOF1 is required for sperm motility and male fertility by
            stabilizing the flagellar axoneme in mice
  JOURNAL   Cell Mol Life Sci 80 (6), 152 (2023)
   PUBMED   37198331
  REMARK    GeneRIF: BBOF1 is required for sperm motility and male fertility by
            stabilizing the flagellar axoneme in mice.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK013494.1, BC151103.1 and AK133381.1.
            
            On Nov 18, 2009 this sequence version replaced NM_028377.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133381.1, BC151099.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-444               AK013494.1         2-445
            445-1922            BC151103.1         367-1844
            1923-2190           AK133381.1         1878-2145
FEATURES             Location/Qualifiers
     source          1..2190
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 39.2 cM"
     gene            1..2190
                     /gene="Bbof1"
                     /gene_synonym="2900006K08Rik; Ccdc176"
                     /note="basal body orientation factor 1"
                     /db_xref="GeneID:72873"
                     /db_xref="MGI:MGI:1920123"
     exon            1..188
                     /gene="Bbof1"
                     /gene_synonym="2900006K08Rik; Ccdc176"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..1716
                     /gene="Bbof1"
                     /gene_synonym="2900006K08Rik; Ccdc176"
                     /note="coiled-coil domain-containing protein 176;
                     coiled-coil domain containing 176"
                     /codon_start=1
                     /product="basal body-orientation factor 1"
                     /protein_id="NP_082653.2"
                     /db_xref="CCDS:CCDS36492.1"
                     /db_xref="GeneID:72873"
                     /db_xref="MGI:MGI:1920123"
                     /translation="MPAKDKRKDKRKDKRKGKNKGKEPKKIIKSDEPAIERAKANASL
                     WEARLEVTELSRIEYRDTSRRLAKNNEDLKKQQYNMEKDIMSVLSYLKKQDQEKDNMI
                     EKLKQQLAKTKEKAQEEKEKLEQKYALQVSELEGQFHQKAKEIGMIQTELKTIKQFQK
                     RKIQVEKELDDLKENLRNSEKNYQETLRRLESRFFEEKHRLEQEAEKRIIMLAERAHH
                     EAVVQLNTAGRNVFKENVYLHKALAYHLKEAEILQQNSKKIEENHSCLLQQKEINDLL
                     VKEKIMQLTQQKSQIQTLQKKVVSLENALTYMTTEFEAEVLKLQQKAIIENQAGLVEI
                     DKLQQLLQMKDREMNRVKRLAKNILDERTEVEQFFLDALYEVKQQILASRKHYKQIAQ
                     AAFNLKMRAACAGKTEYPRIRTFDGKEQSTNSVNQDLLEAEKWPTTQKNVDIRDLTWE
                     QKEKVLRLLFAKMNGFAARKYSQSSKPPVPDHIIYGSGEMKETGDENNLLDQTFITQQ
                     APVSDSNRMVSPDVIPQGLQDSDIA"
     exon            189..417
                     /gene="Bbof1"
                     /gene_synonym="2900006K08Rik; Ccdc176"
                     /inference="alignment:Splign:2.1.0"
     exon            418..483
                     /gene="Bbof1"
                     /gene_synonym="2900006K08Rik; Ccdc176"
                     /inference="alignment:Splign:2.1.0"
     exon            484..627
                     /gene="Bbof1"
                     /gene_synonym="2900006K08Rik; Ccdc176"
                     /inference="alignment:Splign:2.1.0"
     exon            628..708
                     /gene="Bbof1"
                     /gene_synonym="2900006K08Rik; Ccdc176"
                     /inference="alignment:Splign:2.1.0"
     exon            709..779
                     /gene="Bbof1"
                     /gene_synonym="2900006K08Rik; Ccdc176"
                     /inference="alignment:Splign:2.1.0"
     exon            780..924
                     /gene="Bbof1"
                     /gene_synonym="2900006K08Rik; Ccdc176"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1418
                     /gene="Bbof1"
                     /gene_synonym="2900006K08Rik; Ccdc176"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1520
                     /gene="Bbof1"
                     /gene_synonym="2900006K08Rik; Ccdc176"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1595
                     /gene="Bbof1"
                     /gene_synonym="2900006K08Rik; Ccdc176"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1710
                     /gene="Bbof1"
                     /gene_synonym="2900006K08Rik; Ccdc176"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..2190
                     /gene="Bbof1"
                     /gene_synonym="2900006K08Rik; Ccdc176"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2173..2178
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bbof1"
                     /gene_synonym="2900006K08Rik; Ccdc176"
ORIGIN      
        1 ctcaacggcg cggaggacgt tagcccttcg gcgtggtggt ttccttagag acggagtcgg
       61 cccaggtggc ggccaccagg acaccagcac ggtgagactc ccgcagaagt caagatgccg
      121 gcgaaggaca agaggaaaga caagaggaaa gacaagagga aaggcaaaaa caaaggcaaa
      181 gaaccaaaga aaataatcaa atcagatgaa cctgcaattg aaagagccaa agccaatgcc
      241 tctctttggg aggccagatt ggaagtcaca gaactctcta ggattgaata tcgtgatact
      301 tcccgaagac tggcaaaaaa taatgaagac ttaaagaaac agcaatataa catggaaaaa
      361 gacattatgt ctgtattaag ctacttgaag aagcaggatc aagagaaaga taatatgata
      421 gaaaaactga agcagcagtt ggctaaaaca aaggaaaaag cccaggaaga gaaggaaaaa
      481 ttggaacaaa agtatgctct gcaagtgagt gagttggagg gacagtttca tcaaaaagcc
      541 aaggaaatcg gcatgattca gacagagcta aagacaataa aacaattcca gaagagaaaa
      601 atacaagtgg agaaagaatt agatgatctg aaagaaaatt taaggaactc agagaagaac
      661 tatcaggaga ctcttagaag actagaaagc agattttttg aagaaaagca ccgtttggag
      721 caagaggctg agaagaggat cataatgctg gcagagagag ctcaccatga agctgtagtg
      781 cagttgaaca ctgctggaag aaatgttttc aaagagaatg tttatcttca caaggcgctt
      841 gcataccact tgaaggaagc tgaaattctc cagcaaaact ccaagaagat tgaagaaaac
      901 cattcctgcc ttttacaaca aaaggaaatc aatgatctgt tggttaagga aaagattatg
      961 caactcaccc agcagaaatc acaaatccaa actctccaga agaaggtggt aagcttggag
     1021 aacgctctga cctacatgac cacagagttt gaggctgaag tgttgaaact gcagcaaaag
     1081 gcaatcatag agaaccaagc aggcttggta gagattgaca agctgcagca acttcttcag
     1141 atgaaggaca gggagatgaa ccgagtgaag aggctggcta agaacatact ggatgagagg
     1201 acagaagtgg aacagttctt tctagacgct ctctacgaag tgaagcaaca gattctggcc
     1261 agcaggaagc attataagca gatagcacaa gctgctttca atttaaaaat gagagcagca
     1321 tgtgcgggaa aaacagaata tcccagaatc aggacctttg atggcaaaga acaaagtacc
     1381 aatagtgtga accaggatct cttggaggct gaaaaatggc caactactca aaaaaatgtg
     1441 gatattagag atttgacctg ggagcagaag gaaaaggtct taagattgct ctttgcaaaa
     1501 atgaatggtt ttgctgctag gaaatacagt cagagttcta agcctcctgt tccagaccat
     1561 attatttatg gcagtggaga aatgaaagaa actggggatg aaaataacct tctagatcaa
     1621 accttcatca cccagcaagc gccagtatca gactccaata gaatggtgtc acccgatgtt
     1681 attcctcaag gattacagga ctctgacata gcctaggaag tagagcagca cagcagatga
     1741 ctccacagta gatgcaggaa gacccttgtg tatgtaacct tgctctgaac atgttcaaga
     1801 cagtttctca aagaaaaaga caattccagc tcaaaggtta cctgtttgcc atagaaattg
     1861 gtgtctcccc tgaaggaaga gcgagagccg gtgaaggaaa acatcggcaa aggcactgga
     1921 atggggacat tcacacccac ctaaagagaa caaacacaca tcagtgtccc agagtatccc
     1981 tcaaaggact cgaacacagt gtcctgcagg acaaaggcaa cagagagtca ttttattttt
     2041 gctttgattt ttagattttg tttggcttgg gttttttttg ggggggagat atcaatttta
     2101 agtagtcatc ttgcacctgt gctctaccct aagaactttt attcctgagg aagagatggg
     2161 gaattgtggg taattaaagg ggcagtgttc
//
