LOCUS       NM_001403674            1676 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus BCL2 binding component 3 (Bbc3), transcript variant
            10, mRNA.
ACCESSION   NM_001403674 XM_006539575
VERSION     NM_001403674.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1676)
  AUTHORS   Lin,X., Gupta,D., Vaitsiankova,A., Bhandari,S.K., Leung,K.S.K.,
            Menolfi,D., Lee,B.J., Russell,H.R., Gershik,S., Huang,X., Gu,W.,
            McKinnon,P.J., Dantzer,F., Rothenberg,E., Tomkinson,A.E. and Zha,S.
  TITLE     Inactive Parp2 causes Tp53-dependent lethal anemia by blocking
            replication-associated nick ligation in erythroblasts
  JOURNAL   Mol Cell 84 (20), 3916-3931 (2024)
   PUBMED   39383878
REFERENCE   2  (bases 1 to 1676)
  AUTHORS   Shi,Y., Huang,D., Song,C., Cao,R., Wang,Z., Wang,D., Zhao,L.,
            Xu,X., Lu,C., Xiong,F., Zhao,H., Li,S., Zhou,Q., Luo,S., Hu,D.,
            Zhang,Y., Wang,C., Shen,Y., Su,W., Wu,Y., Schmitz,K., Wei,S. and
            Song,W.
  TITLE     Diphthamide deficiency promotes association of eEF2 with p53 to
            induce p21 expression and neural crest defects
  JOURNAL   Nat Commun 15 (1), 3301 (2024)
   PUBMED   38671004
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1676)
  AUTHORS   Sepulveda-Rincon,L.P., Wang,Y.F., Whilding,C., Moyon,B.,
            Ojarikre,O.A., Maciulyte,V., Hamazaki,N., Hayashi,K., Turner,J.M.A.
            and Leitch,H.G.
  TITLE     Determining the potency of primordial germ cells by injection into
            early mouse embryos
  JOURNAL   Dev Cell 59 (6), 695-704 (2024)
   PUBMED   38359835
REFERENCE   4  (bases 1 to 1676)
  AUTHORS   Valverde-Lopez,J.A., Li-Bao,L., Sierra,R., Santos,E.,
            Giovinazzo,G., Diaz-Diaz,C. and Torres,M.
  TITLE     P53 and BCL-2 family proteins PUMA and NOXA define competitive
            fitness in pluripotent cell competition
  JOURNAL   PLoS Genet 20 (3), e1011193 (2024)
   PUBMED   38489392
  REMARK    GeneRIF: P53 and BCL-2 family proteins PUMA and NOXA define
            competitive fitness in pluripotent cell competition.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1676)
  AUTHORS   Brennan,M.S., Brinkmann,K., Romero Sola,G., Healey,G., Gibson,L.,
            Gangoda,L., Potts,M.A., Lieschke,E., Wilcox,S., Strasser,A.,
            Herold,M.J. and Janic,A.
  TITLE     Combined absence of TRP53 target genes ZMAT3, PUMA and p21 cause a
            high incidence of cancer in mice
  JOURNAL   Cell Death Differ 31 (2), 159-169 (2024)
   PUBMED   38110554
  REMARK    GeneRIF: Combined absence of TRP53 target genes ZMAT3, PUMA and p21
            cause a high incidence of cancer in mice.
REFERENCE   6  (bases 1 to 1676)
  AUTHORS   Hemann,M.T., Zilfou,J.T., Zhao,Z., Burgess,D.J., Hannon,G.J. and
            Lowe,S.W.
  TITLE     Suppression of tumorigenesis by the p53 target PUMA
  JOURNAL   Proc Natl Acad Sci U S A 101 (25), 9333-9338 (2004)
   PUBMED   15192153
  REMARK    GeneRIF: PUMA shRNAs were unable to cooperate with oncogenic ras in
            transformation
REFERENCE   7  (bases 1 to 1676)
  AUTHORS   Villunger,A., Michalak,E.M., Coultas,L., Mullauer,F., Bock,G.,
            Ausserlechner,M.J., Adams,J.M. and Strasser,A.
  TITLE     p53- and drug-induced apoptotic responses mediated by BH3-only
            proteins puma and noxa
  JOURNAL   Science 302 (5647), 1036-1038 (2003)
   PUBMED   14500851
  REMARK    GeneRIF: Puma and Noxa are critical mediators of the apoptotic
            responses induced by p53 and other agents
REFERENCE   8  (bases 1 to 1676)
  AUTHORS   Jeffers,J.R., Parganas,E., Lee,Y., Yang,C., Wang,J., Brennan,J.,
            MacLean,K.H., Han,J., Chittenden,T., Ihle,J.N., McKinnon,P.J.,
            Cleveland,J.L. and Zambetti,G.P.
  TITLE     Puma is an essential mediator of p53-dependent and -independent
            apoptotic pathways
  JOURNAL   Cancer Cell 4 (4), 321-328 (2003)
   PUBMED   14585359
  REMARK    GeneRIF: Puma as a principal mediator of cell death in response to
            diverse apoptotic signals
REFERENCE   9  (bases 1 to 1676)
  AUTHORS   Han,J., Flemington,C., Houghton,A.B., Gu,Z., Zambetti,G.P.,
            Lutz,R.J., Zhu,L. and Chittenden,T.
  TITLE     Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by
            diverse cell death and survival signals
  JOURNAL   Proc Natl Acad Sci U S A 98 (20), 11318-11323 (2001)
   PUBMED   11572983
REFERENCE   10 (bases 1 to 1676)
  AUTHORS   Yu,J., Zhang,L., Hwang,P.M., Kinzler,K.W. and Vogelstein,B.
  TITLE     PUMA induces the rapid apoptosis of colorectal cancer cells
  JOURNAL   Mol Cell 7 (3), 673-682 (2001)
   PUBMED   11463391
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156630.6.
            
            On Apr 1, 2022 this sequence version replaced XM_006539575.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422598.1820843.1,
                                           SRR5286963.547.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               AC156630.6         191117-191224
            109-397             AC156630.6         192812-193100
            398-588             AC156630.6         194313-194503
            589-1676            AC156630.6         197804-198891
FEATURES             Location/Qualifiers
     source          1..1676
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 8.85 cM"
     gene            1..1676
                     /gene="Bbc3"
                     /gene_synonym="PUMA; PUMA/JFY1"
                     /note="BCL2 binding component 3"
                     /db_xref="GeneID:170770"
                     /db_xref="MGI:MGI:2181667"
     exon            1..108
                     /gene="Bbc3"
                     /gene_synonym="PUMA; PUMA/JFY1"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..705
                     /gene="Bbc3"
                     /gene_synonym="PUMA; PUMA/JFY1"
                     /note="isoform b is encoded by transcript variant 10;
                     bcl-2-binding component 3; BH3-only; p53 up-regulated
                     modulator of apoptosis; Bcl-2 binding component 3"
                     /codon_start=1
                     /product="bcl-2-binding component 3 isoform b"
                     /protein_id="NP_001390603.1"
                     /db_xref="GeneID:170770"
                     /db_xref="MGI:MGI:2181667"
                     /translation="MLAFVTRRGVCAPGSAMARARQEGSSPEPVEGLARDSPRPFPLG
                     RLMPSAVSCSLCEPGLPAAPAAPALLPAAYLCAPTAPPAVTAALGGPRWPGGHRSRPR
                     GPRPDGPQPSLSPAQQHLESPVPSAPEALAGGPTQAAPGVRVEEEEWAREIGAQLRRM
                     ADDLNAQYERRRQEEQHRHRPSPWRVMYNLFMGLLPLPRDPGAPEMEPN"
     exon            109..397
                     /gene="Bbc3"
                     /gene_synonym="PUMA; PUMA/JFY1"
                     /inference="alignment:Splign:2.1.0"
     exon            398..588
                     /gene="Bbc3"
                     /gene_synonym="PUMA; PUMA/JFY1"
                     /inference="alignment:Splign:2.1.0"
     exon            589..1676
                     /gene="Bbc3"
                     /gene_synonym="PUMA; PUMA/JFY1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1653..1658
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bbc3"
                     /gene_synonym="PUMA; PUMA/JFY1"
                     /note="hexamer: AATAAA"
     polyA_site      1676
                     /gene="Bbc3"
                     /gene_synonym="PUMA; PUMA/JFY1"
                     /note="major polyA site"
ORIGIN      
        1 gctgtggatc tgcaggtgtc tcgcctgggt gtgtgtgctc gtgtttggct cccgagtttg
       61 tatccctaca ccgagatgtt ggcgtttgtc acccggaggg gtgtctgcgc tccagggagc
      121 gccatggccc gcgcacgcca ggagggcagc tctccggagc ccgtagaggg tctagcccgc
      181 gacagtccgc gccccttccc gctcggccgc ctgatgccct ccgctgtatc ctgcagcctt
      241 tgcgagcccg gcctgcccgc cgcccctgct gcccctgcct tgctgccggc cgcctacctc
      301 tgcgccccca ccgctccacc tgccgtcacc gccgccctgg ggggcccccg ctggcctggg
      361 ggtcaccgca gccggcccag aggcccgcgc ccggacggtc ctcagccctc cctgtcacca
      421 gcccagcagc acttagagtc gcccgtgccc agcgccccgg aggccctggc aggaggcccc
      481 acccaagctg ccccgggagt gcgtgtggag gaggaggagt gggcccggga gatcggggcc
      541 cagctgcggc ggatggcgga cgacctcaac gcgcagtacg agcggcggag acaagaagag
      601 cagcatcgac accgaccctc accctggagg gtcatgtaca atctcttcat gggactcctc
      661 cccttaccca gggatcctgg agccccagaa atggagccca actaggtgcc tacacccgcc
      721 cgggggacgt cggagacttg gggggcagga ccccctccgc cttctgacac cctggccagc
      781 gcgggggact ttttctgcac catgtagcat actggactgc cagccttgcc cgtcccaggg
      841 gcaggcaagg gatgccactc gagcccgggc agcctgggtg cactgatgga gatacggact
      901 tggggggacc ctggcctccc gaaagccagg gaagggaggg ctgaaggact catggtgact
      961 gagggggtgg ggaccgagcc gcccgcctct gccgcccacc accatctcag gaaaggctgc
     1021 tggtgctggc tgcccgttcc agctgcaggg gggacgctgg gggtgtcccc agtgcgcctt
     1081 cactttgggc ctggcctcag gcccctggtg cttccccccc tcctcctgag gagggggtct
     1141 gtgaagagca tatgagccaa acctgaccac tagcctcctg gagccagaga atggggggcg
     1201 tgtgaaggcc ttcttaaccc agtgcccagc catcttccct gagccgccgg cgggcggtga
     1261 acgatgcctg cctcaccttc atctgggggt gtccaggagg ggtccagact gtgaatcctg
     1321 tgctctgccc gggaccaccc cccccccccc aatccccatc catctcattg cataggttta
     1381 gagagagcac gtgtgaccac tggcattcat ttggggggtg ggagatattg gcggaagcca
     1441 ccccagcctt agtccccagg gcaaagcgct ggggaggaag atggggagtc agggaggggg
     1501 gaagtctcag aagagggagg agtctgggag cggggaggga cggcccagcc tgtaagatac
     1561 tgtacatgca ctgctgtaga tatactggaa tgaattttct gtacatgttt ggttaatttt
     1621 ttttgtacat gatttttgta tgtttccttt tcaataaaat cagattgaac agtgaa
//
