LOCUS       NM_054078               8369 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus bromodomain adjacent to zinc finger domain, 2A
            (Baz2a), mRNA.
ACCESSION   NM_054078 XM_003945867 XM_003945868 XM_003945869 XM_003945870
            XM_003945871 XM_003945872
VERSION     NM_054078.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8369)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 8369)
  AUTHORS   Jia,Y., Li,L., Lin,Y.H., Gopal,P., Shen,S., Zhou,K., Yu,X.,
            Sharma,T., Zhang,Y., Siegwart,D.J., Ready,J.M. and Zhu,H.
  TITLE     In vivo CRISPR screening identifies BAZ2 chromatin remodelers as
            druggable regulators of mammalian liver regeneration
  JOURNAL   Cell Stem Cell 29 (3), 372-385 (2022)
   PUBMED   35090595
  REMARK    GeneRIF: In vivo CRISPR screening identifies BAZ2 chromatin
            remodelers as druggable regulators of mammalian liver regeneration.
REFERENCE   3  (bases 1 to 8369)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8369)
  AUTHORS   Dalcher,D., Tan,J.Y., Bersaglieri,C., Pena-Hernandez,R.,
            Vollenweider,E., Zeyen,S., Schmid,M.W., Bianchi,V., Butz,S.,
            Roganowicz,M., Kuzyakiv,R., Baubec,T., Marques,A.C. and Santoro,R.
  TITLE     BAZ2A safeguards genome architecture of ground-state pluripotent
            stem cells
  JOURNAL   EMBO J 39 (23), e105606 (2020)
   PUBMED   33433018
  REMARK    GeneRIF: BAZ2A safeguards genome architecture of ground-state
            pluripotent stem cells.
REFERENCE   5  (bases 1 to 8369)
  AUTHORS   Pietrzak,K., Kuzyakiv,R., Simon,R., Bolis,M., Bar,D.,
            Aprigliano,R., Theurillat,J.P., Sauter,G. and Santoro,R.
  TITLE     TIP5 primes prostate luminal cells for the oncogenic transformation
            mediated by PTEN-loss
  JOURNAL   Proc Natl Acad Sci U S A 117 (7), 3637-3647 (2020)
   PUBMED   32024754
  REMARK    GeneRIF: TIP5 is critical for the initiation of prostate cancer of
            luminal origin mediated by Pten-loss whereas it is dispensable once
            Pten-loss mediated transformation is established.
REFERENCE   6  (bases 1 to 8369)
  AUTHORS   Santoro,R., Li,J. and Grummt,I.
  TITLE     The nucleolar remodeling complex NoRC mediates heterochromatin
            formation and silencing of ribosomal gene transcription
  JOURNAL   Nat Genet 32 (3), 393-396 (2002)
   PUBMED   12368916
REFERENCE   7  (bases 1 to 8369)
  AUTHORS   Zhou,Y., Santoro,R. and Grummt,I.
  TITLE     The chromatin remodeling complex NoRC targets HDAC1 to the
            ribosomal gene promoter and represses RNA polymerase I
            transcription
  JOURNAL   EMBO J 21 (17), 4632-4640 (2002)
   PUBMED   12198165
  REMARK    GeneRIF: Overexpression of TIP5, the large subunit of NoRC,
            mediates deacetylation of nucleosomes near the rDNA promoter. TIP5
            associates with HDAC1 in vivo & in vitro. Deletion of the
            C-terminal PHD finger & bromodomain abolishes the interaction of
            TIP5 & HDAC1.
REFERENCE   8  (bases 1 to 8369)
  AUTHORS   Bozhenok,L., Wade,P.A. and Varga-Weisz,P.
  TITLE     WSTF-ISWI chromatin remodeling complex targets heterochromatic
            replication foci
  JOURNAL   EMBO J 21 (9), 2231-2241 (2002)
   PUBMED   11980720
  REMARK    Erratum:[EMBO J 2002 Jun 17;21(12):3212]
REFERENCE   9  (bases 1 to 8369)
  AUTHORS   Strohner,R., Nemeth,A., Jansa,P., Hofmann-Rohrer,U., Santoro,R.,
            Langst,G. and Grummt,I.
  TITLE     NoRC--a novel member of mammalian ISWI-containing chromatin
            remodeling machines
  JOURNAL   EMBO J 20 (17), 4892-4900 (2001)
   PUBMED   11532953
REFERENCE   10 (bases 1 to 8369)
  AUTHORS   Jones,M.H., Hamana,N., Nezu,Ji. and Shimane,M.
  TITLE     A novel family of bromodomain genes
  JOURNAL   Genomics 63 (1), 40-45 (2000)
   PUBMED   10662543
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC131120.4 and AC166817.3.
            
            On or before Oct 10, 2012 this sequence version replaced
            XM_003945867.1, XM_003945868.1, XM_003945869.1, XM_003945870.1,
            XM_003945871.1, XM_003945872.1, NM_054078.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849382,
                              SAMN00849383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                AC131120.4         212804-212871
            69-153              AC131120.4         216460-216544
            154-291             AC166817.3         96543-96680
            292-885             AC166817.3         98404-98997
            886-1071            AC166817.3         100231-100416
            1072-1290           AC166817.3         101112-101330
            1291-1740           AC166817.3         101983-102432
            1741-1801           AC166817.3         102674-102734
            1802-1910           AC166817.3         103710-103818
            1911-2012           AC166817.3         103955-104056
            2013-2223           AC166817.3         104196-104406
            2224-2324           AC166817.3         106204-106304
            2325-2390           AC166817.3         106604-106669
            2391-2621           AC166817.3         106919-107149
            2622-2876           AC166817.3         107273-107527
            2877-3091           AC166817.3         108760-108974
            3092-3166           AC166817.3         109240-109314
            3167-3347           AC166817.3         109449-109629
            3348-3407           AC166817.3         109717-109776
            3408-3552           AC166817.3         109955-110099
            3553-4184           AC166817.3         110673-111304
            4185-4407           AC166817.3         111415-111637
            4408-4563           AC166817.3         111756-111911
            4564-4715           AC166817.3         111984-112135
            4716-5005           AC166817.3         112542-112831
            5006-5138           AC166817.3         112918-113050
            5139-5285           AC166817.3         113148-113294
            5286-5509           AC166817.3         113667-113890
            5510-5653           AC166817.3         113975-114118
            5654-8369           AC166817.3         114237-116952
FEATURES             Location/Qualifiers
     source          1..8369
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 76.4 cM"
     gene            1..8369
                     /gene="Baz2a"
                     /gene_synonym="C030005G16Rik; mKIAA0314; Tip5; Walp3"
                     /note="bromodomain adjacent to zinc finger domain, 2A"
                     /db_xref="GeneID:116848"
                     /db_xref="MGI:MGI:2151152"
     exon            1..68
                     /gene="Baz2a"
                     /gene_synonym="C030005G16Rik; mKIAA0314; Tip5; Walp3"
                     /inference="alignment:Splign:2.1.0"
     exon            69..153
                     /gene="Baz2a"
                     /gene_synonym="C030005G16Rik; mKIAA0314; Tip5; Walp3"
                     /inference="alignment:Splign:2.1.0"
     exon            154..291
                     /gene="Baz2a"
                     /gene_synonym="C030005G16Rik; mKIAA0314; Tip5; Walp3"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..5819
                     /gene="Baz2a"
                     /gene_synonym="C030005G16Rik; mKIAA0314; Tip5; Walp3"
                     /note="TTF-I-interacting protein 5; transcription
                     termination factor I-interacting protein 5"
                     /codon_start=1
                     /product="bromodomain adjacent to zinc finger domain
                     protein 2A"
                     /protein_id="NP_473419.2"
                     /db_xref="CCDS:CCDS36088.1"
                     /db_xref="GeneID:116848"
                     /db_xref="MGI:MGI:2151152"
                     /translation="MEANDHFNFTGLPPAPAASGLKPSPSSGEGLYTNGSPMNFPQQG
                     KSLNGDVNVNGLSTVSHTTTSGILNSAPHSSSTSHLHHPNVAYDCLWNYSQYPSANPG
                     NNLKDPPLLSQFPGGQYPLNGILGGNRQPSSPSHNTNLRAGSQEFWANGTQSPMGLNF
                     DSQELYDSFPDQNFEVMPNGPPSFFTSPQTSPMLGSSIQTFAPSQDVSSDIHPDEAAE
                     KELTSVVAENGTGLVGSLELEEEQPELKMCGYNGSVSSVESLHQEVSVLVPDPTVSCL
                     DDPSHLPDQLEDTPILSEDSLEPFDSLAAEPVSGSLYGIDDAELMGAEDKLPLEGNPV
                     ISALDCPALSNANAFSLLADDSQTSASIFVSPTSPPVLGESVLQDNSFGLNSCSDSEQ
                     EEIETQSSNFQRPLTEPAPDQPPSTQLHPAVSPTASPAASLTASAEISPAVSPVASSP
                     VPPEVFVAVSPASSPALPAISLEASMTTPVTSPQGSPEPSPAAAFQTVSPARKNVSSA
                     PKARADREETTGGAVAVSGSGDVLKRRIATPEEVRLPLQHGWRREVRIKKGSHRWQGE
                     TWYYGPCGKRMKQFPEVIKYLSRNVVHSVRREHFSFSPRMPVGDFFEERDTPEGLQWV
                     QLSAEEIPSRIQAITGKRGRPRNNEKAKNKEVPKVKRGRGRPPKIKMPELLNKTDNRL
                     PKKLETQEILSEDDKAKMTKNKKKMRQKVQRGESQTPVQGQARNKRKQDTKSLKQKDT
                     KKKLKAEKEKMKTKQEKLKEKVKREKKEKVKAKGKEGPRARPSCRADKTLATQKRLEE
                     QQRQQAILEEMKKPTEDMCLSDHQPLPDFTRIPGLTLSSRAFSDCLTIVEFLHSFGKV
                     LGFDLTKDVPSLGVLQEGLLCQGDSLDKVQDLLVRLLKAALHDPGLPPYCQSLKILGE
                     KMSEIPLTRDNVSEILRCFLMAYRVEPSFCDSLRTQPFQAQPPQQKAAILAFLVHELN
                     SSTIIINEIDKTLESVSSCRKNKWIVEGRLRRLKTALAKRTGRPEVMMEGAEDGLGRR
                     RSSRIMEETSGIEEEEEEENTTAVHGRRGRKEGEIDVAASSIPELERHIEKLSKRQLF
                     FRKKLLHSSQMLRAVSLGQDRYRRHYWVLPYLAGIFVEGSEGSTVTEDEIKQETESLM
                     EVVTSTPSSARASVKRELTGSNASTSPARSRGRPRKPKPGSLQPQHLQSTIRECDSEQ
                     AQTQVHPEPQPQLQAPTQPHLQPSSGFLEPEGSPFSLGQSQHDLSQSAFLSWLSQTQS
                     HNSLLSSSVLTPDSSPGKLDSAPSQSLEEPEPDEAQSCPGPQGPWFNFSAQIPCDAAP
                     TPPPAVSEDQPTPSLQLLASSKPMNTPGAANPCSPVQLSSTHLPGGTPKRLSGDSEEM
                     SQSPTGLGQPKRRGRPPSKFFKQVEQHYLTQLTAQPIPPEMCSGWWWIRDPETLDVLL
                     KALHPRGIREKALHKHLSKHKDFLQEVCLQPLTDPIFEPNELPALEEGVMSWSPKEKT
                     YETDLAVLQWVEELEQRVVLSDLQIRGWTCPTPDSTREDLTYCEHLPDSPEDIPWRGR
                     GREGTVPQRQNNNPLDLAVMRLAVLEQNVERRYLREPLWAAHEVVVEKALLSTPNGAP
                     DGTSTEISYEITPRVRVWRQTLERCRSAAQVCLCMGQLERSIAWEKSVNKVTCLVCRK
                     GDNDEFLLLCDGCDRGCHIYCHRPKMEAVPEGDWFCAVCLSQQVEEEYTQRPGFPKRG
                     QKRKSSFPLTFPEGDSRRRMLSRSRDSPAVPRYPEDGLSPPKRRRHSMRSHHSDLTFC
                     EIILMEMESHDAAWPFLEPVNPRLVSGYRRVIKNPMDFSTMRERLLRGGYTSSEEFAA
                     DALLVFDNCQTFNEDDSEVGKAGHVMRRFFESRWEEFYQGKQANL"
     exon            292..885
                     /gene="Baz2a"
                     /gene_synonym="C030005G16Rik; mKIAA0314; Tip5; Walp3"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1071
                     /gene="Baz2a"
                     /gene_synonym="C030005G16Rik; mKIAA0314; Tip5; Walp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1290
                     /gene="Baz2a"
                     /gene_synonym="C030005G16Rik; mKIAA0314; Tip5; Walp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1740
                     /gene="Baz2a"
                     /gene_synonym="C030005G16Rik; mKIAA0314; Tip5; Walp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1801
                     /gene="Baz2a"
                     /gene_synonym="C030005G16Rik; mKIAA0314; Tip5; Walp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1802..1910
                     /gene="Baz2a"
                     /gene_synonym="C030005G16Rik; mKIAA0314; Tip5; Walp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..2012
                     /gene="Baz2a"
                     /gene_synonym="C030005G16Rik; mKIAA0314; Tip5; Walp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..2223
                     /gene="Baz2a"
                     /gene_synonym="C030005G16Rik; mKIAA0314; Tip5; Walp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2224..2324
                     /gene="Baz2a"
                     /gene_synonym="C030005G16Rik; mKIAA0314; Tip5; Walp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2325..2390
                     /gene="Baz2a"
                     /gene_synonym="C030005G16Rik; mKIAA0314; Tip5; Walp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2391..2621
                     /gene="Baz2a"
                     /gene_synonym="C030005G16Rik; mKIAA0314; Tip5; Walp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2622..2876
                     /gene="Baz2a"
                     /gene_synonym="C030005G16Rik; mKIAA0314; Tip5; Walp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2877..3091
                     /gene="Baz2a"
                     /gene_synonym="C030005G16Rik; mKIAA0314; Tip5; Walp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3092..3166
                     /gene="Baz2a"
                     /gene_synonym="C030005G16Rik; mKIAA0314; Tip5; Walp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3167..3347
                     /gene="Baz2a"
                     /gene_synonym="C030005G16Rik; mKIAA0314; Tip5; Walp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3348..3407
                     /gene="Baz2a"
                     /gene_synonym="C030005G16Rik; mKIAA0314; Tip5; Walp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3408..3552
                     /gene="Baz2a"
                     /gene_synonym="C030005G16Rik; mKIAA0314; Tip5; Walp3"
                     /inference="alignment:Splign:2.1.0"
     exon            3553..4184
                     /gene="Baz2a"
                     /gene_synonym="C030005G16Rik; mKIAA0314; Tip5; Walp3"
                     /inference="alignment:Splign:2.1.0"
     exon            4185..4407
                     /gene="Baz2a"
                     /gene_synonym="C030005G16Rik; mKIAA0314; Tip5; Walp3"
                     /inference="alignment:Splign:2.1.0"
     exon            4408..4563
                     /gene="Baz2a"
                     /gene_synonym="C030005G16Rik; mKIAA0314; Tip5; Walp3"
                     /inference="alignment:Splign:2.1.0"
     exon            4564..4715
                     /gene="Baz2a"
                     /gene_synonym="C030005G16Rik; mKIAA0314; Tip5; Walp3"
                     /inference="alignment:Splign:2.1.0"
     exon            4716..5005
                     /gene="Baz2a"
                     /gene_synonym="C030005G16Rik; mKIAA0314; Tip5; Walp3"
                     /inference="alignment:Splign:2.1.0"
     exon            5006..5138
                     /gene="Baz2a"
                     /gene_synonym="C030005G16Rik; mKIAA0314; Tip5; Walp3"
                     /inference="alignment:Splign:2.1.0"
     exon            5139..5285
                     /gene="Baz2a"
                     /gene_synonym="C030005G16Rik; mKIAA0314; Tip5; Walp3"
                     /inference="alignment:Splign:2.1.0"
     exon            5286..5509
                     /gene="Baz2a"
                     /gene_synonym="C030005G16Rik; mKIAA0314; Tip5; Walp3"
                     /inference="alignment:Splign:2.1.0"
     exon            5510..5653
                     /gene="Baz2a"
                     /gene_synonym="C030005G16Rik; mKIAA0314; Tip5; Walp3"
                     /inference="alignment:Splign:2.1.0"
     exon            5654..8369
                     /gene="Baz2a"
                     /gene_synonym="C030005G16Rik; mKIAA0314; Tip5; Walp3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6263..6268
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Baz2a"
                     /gene_synonym="C030005G16Rik; mKIAA0314; Tip5; Walp3"
                     /note="hexamer: AGTAAA"
     polyA_site      6285
                     /gene="Baz2a"
                     /gene_synonym="C030005G16Rik; mKIAA0314; Tip5; Walp3"
                     /note="major polyA site"
     regulatory      7665..7670
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Baz2a"
                     /gene_synonym="C030005G16Rik; mKIAA0314; Tip5; Walp3"
                     /note="hexamer: CATAAA"
     polyA_site      7689
                     /gene="Baz2a"
                     /gene_synonym="C030005G16Rik; mKIAA0314; Tip5; Walp3"
ORIGIN      
        1 ggaggaggcg ccgccgcccg gctcggccac ctgcgccgcc gccgccgccc ggcccggccc
       61 tgcttcagga ttctctccaa cgaccaaggt cctgcagatg acaccaggaa agcagtgatc
      121 caggcaggac caggttgtcc ctacaggaca tagaaatgga ggcaaacgac cattttaact
      181 ttactggcct tcctcctgca ccagctgcct caggactgaa accctctcct tcctcggggg
      241 agggcctcta cactaacggg tctcccatga acttccccca gcaagggaaa agtttgaatg
      301 gggatgtgaa tgttaatggc ttatctactg tatctcacac tactacttca gggattttga
      361 actctgctcc ccactcctct agcacctcac acctccatca ccctaacgtg gcctacgact
      421 gtctttggaa ctactcacag tacccatctg ccaatcctgg caacaacctc aaggacccac
      481 cccttctttc tcagttccct gggggacaat acccgctcaa cggtatcctt gggggcaacc
      541 gacaaccttc atccccaagt cacaacacta atcttcgagc tgggagccaa gagttctggg
      601 ccaatggtac ccagagtccc atggggctta acttcgattc acaggaactg tatgattctt
      661 ttcctgatca gaattttgag gtgatgccca atggaccccc aagttttttc acctcccctc
      721 agacttctcc aatgttgggg tctagtatcc agacctttgc accttcccag gatgtaagca
      781 gtgacatcca tcctgatgaa gcagcagaaa aggagctgac ttcagttgtg gcagaaaatg
      841 gcactggctt ggtaggcagc ctggagctgg aggaagagca gccagaacta aagatgtgtg
      901 gctacaatgg ttctgtctcc tctgtggagt ctttacacca agaagtctcc gtcctggtcc
      961 ctgatcccac agtgagctgt ctagatgatc cttcacatct tcctgatcaa ctggaagaca
     1021 ctccaattct cagtgaagac tccctggagc cctttgactc tctggcagca gagccagtga
     1081 gtggcagtct ttatggtata gatgatgcgg agctgatggg tgcagaagac aagttgcctc
     1141 tggagggcaa ccctgtgatc tctgccctcg attgccctgc tctcagtaat gctaatgcct
     1201 tcagtctcct ggcagacgac agccagacat cagcctccat ctttgtcagc cctacctccc
     1261 cacctgtctt aggggagtct gtcttgcaag ataacagctt tggactgaac agttgcagtg
     1321 actctgaaca ggaagaaata gagacccagt cttcaaactt ccaacgtccc ctgactgagc
     1381 cagctcctga ccagccacct agtactcaac tacatccagc agtttcacca acagcctccc
     1441 cagcagcctc cttgacagca tctgcagaaa tctctccagc tgtctctcca gtagcatcct
     1501 cgcctgtccc tcctgaagtc tttgtagcag tctctccagc ttcctcacct gctctgccag
     1561 ccatctcttt ggaagcctct atgacaactc cagtaacttc tcctcaaggt tcccctgaac
     1621 cttctccagc agctgccttc cagactgtct ccccagcaag gaaaaatgtc agcagtgctc
     1681 ctaaagcgcg tgctgatcga gaagagacga ctggaggagc agttgcagtc tctggtagtg
     1741 gtgatgtact gaagagacgt attgctaccc cagaagaagt tcgtcttccc ctccagcatg
     1801 ggtggcgaag agaagtgcgc atcaagaagg gcagccatcg gtggcagggg gagacttggt
     1861 actatggccc ctgtgggaag agaatgaagc aatttccaga agttatcaag tacctgagcc
     1921 gaaatgtggt gcacagtgtc cgccgtgagc acttcagctt cagtccccgc atgcctgttg
     1981 gagatttctt tgaagaaaga gatacaccag agggcttgca gtgggtccag ttatcagcag
     2041 aggagattcc ttccagaatt caagcaatca ctggcaaacg aggccgacct cgaaacaatg
     2101 agaaggctaa gaacaaggaa gttcccaaag tgaagcgggg ccgaggtcgg cctcctaaga
     2161 tcaaaatgcc tgagctgttg aataaaacag ataaccgact tccaaagaaa ctggaaaccc
     2221 aagaaatact gagtgaggac gataaagcaa agatgactaa aaacaaaaag aagatgaggc
     2281 agaaggtcca acggggagaa agtcagactc ctgtccaagg gcaggccaga aacaagagga
     2341 agcaagacac caagagcttg aagcagaagg acactaagaa gaaattgaag gctgagaaag
     2401 agaagatgaa gacaaagcag gaaaagctga aggaaaaggt aaagcgagaa aagaaagaaa
     2461 aggtaaaagc gaaggggaag gaagggccca gagccaggcc atcctgtaga gcagacaaga
     2521 cccttgccac acagaagcgg ctagaggagc agcagaggca gcaggctatc ctggaggaga
     2581 tgaagaagcc cacagaggat atgtgtctgt ctgaccacca gcccctgcct gacttcacac
     2641 gcatccctgg tttgacactg tccagtaggg ctttctcaga ttgcttgacc atcgtggagt
     2701 tccttcacag ttttggcaaa gtgctaggct ttgaccttac caaagatgtt cctagtctag
     2761 gagtcctgca ggagggactc ttatgtcaag gtgacagctt ggacaaagtg caggacctgc
     2821 tggtgcgact gctgaaggct gcactccatg atcctggtct gcccccctac tgtcagtccc
     2881 tgaagatatt gggggagaag atgtcagaga tcccattgac cagagataat gtgtctgaga
     2941 tactgcgctg cttcctcatg gcatatagag tggagccatc cttctgtgac agtctgcgta
     3001 cccagccttt tcaggcccag ccacctcaac agaaggctgc tattctagcc ttccttgtgc
     3061 atgagcttaa cagctccacc attatcatca atgagattga caagactctg gaaagtgtgt
     3121 ctagctgcag gaagaacaag tggattgttg aaggccgact ccggagactg aaaactgctc
     3181 tggccaagcg aactgggcgg cctgaggtta tgatggaagg ggcagaagac ggcctaggac
     3241 ggaggcgcag ttctcggatc atggaggaaa ccagtggcat agaagaggag gaagaggaag
     3301 aaaatacaac agctgtccat ggccgcaggg gtcgaaaaga aggagagatt gatgttgcag
     3361 catctagcat tccagagcta gagcgccata tagaaaaact cagtaagcgt cagctcttct
     3421 ttagaaaaaa gctgcttcac tcatcccaga tgcttcgggc agtgtccttg ggtcaagacc
     3481 gctatagacg ccattactgg gtattaccgt atcttgctgg tatctttgtg gaaggatcgg
     3541 aagggagcac agttactgaa gatgaaataa agcaagaaac tgagtccttg atggaagtag
     3601 tcacttcaac acccagctct gcccgagcct ctgtaaagag agaattaact ggctccaatg
     3661 cctctacttc tcctgcccgg tcccgaggcc gacctcgaaa acctaagcct gggtctctgc
     3721 agcctcagca ccttcagtcc accattaggg aatgtgattc agagcaagcc cagactcaag
     3781 ttcacccaga accccagcct cagcttcagg cccctaccca gccccatctt cagccaagta
     3841 gtgggttcct agagccagaa ggttcccctt tctctctggg tcagagccag catgacctca
     3901 gccagtctgc cttcttgtct tggctgagcc agactcagag ccacaactcc ctgttgagca
     3961 gctcagtcct cacgccggac agcagcccag ggaaactaga ctctgctccg tctcagtcct
     4021 tggaggagcc cgagcctgat gaggctcagt cctgccctgg tcctcaaggt ccctggttta
     4081 acttctcagc ccagataccc tgtgatgctg ctcctacacc acctcctgca gtctctgagg
     4141 accaacctac tccctccctc cagctgctgg cctcctctaa accaatgaat acacccggtg
     4201 ctgccaatcc ttgttcccca gtgcagctct cttccactca cttgcctgga gggaccccta
     4261 agaggctatc aggggactct gaagaaatgt cacagagtcc cactgggctg gggcaaccaa
     4321 agcggagggg gagaccccct agcaagttct tcaagcaggt ggagcagcat tacttaaccc
     4381 agctgacagc ccagcctatc ccccctgaga tgtgctcggg ctggtggtgg atccgagacc
     4441 ctgagacact ggatgtcctg ctcaaggcac tgcatccccg aggcatccgg gagaaggcgc
     4501 ttcacaaaca tcttagcaag cacaaggact ttttgcagga agtttgttta cagcccttaa
     4561 ctgatcccat ctttgagcct aatgagctcc ctgccttgga agaaggcgtt atgagctggt
     4621 cccccaaaga gaagacgtac gagacagacc tagctgtgct ccagtgggtg gaggagctgg
     4681 agcagcgggt tgtcctctcc gatctgcaga ttcggggctg gacatgccct accccagact
     4741 ccaccagaga agacttgacc tactgtgagc atctgcctga ctccccggag gatatccctt
     4801 ggaggggtcg gggcagggaa ggaacagtac ctcagcggca gaacaacaac cctctggacc
     4861 tcgctgtgat gcgattggct gttctggagc aaaatgtgga gcggcggtac ttgcgggagc
     4921 ccctctgggc agcccatgag gtggtagtgg agaaggccct actgagcaca cccaatggtg
     4981 cccctgatgg cacctcaact gagatatcct atgagatcac ccctcgtgtc cgagtttggc
     5041 ggcagacact tgaaaggtgc cgtagtgcag cccaagtgtg cttgtgcatg ggccagctag
     5101 aaaggtccat cgcgtgggag aagtctgtca acaaagtgac ctgcctggtc tgccggaagg
     5161 gcgataatga tgagtttctc ctgctgtgtg atgggtgtga ccgaggctgc cacatttact
     5221 gtcatcggcc caagatggag gctgttccag aaggagattg gttctgtgct gtctgtctgt
     5281 cccagcaggt agaggaagag tacactcaga ggcctggttt tccaaaacga ggtcagaagc
     5341 ggaaaagtag ttttccactg accttcccag aaggtgacag ccggcggcgg atgttgtcaa
     5401 ggagccgaga tagtccagca gtgcctcggt acccagaaga cgggctgtct ccccccaaaa
     5461 gacggcgaca ttcgatgaga agtcaccaca gtgatctcac attttgcgag attatcctga
     5521 tggagatgga gtcccatgat gcagcctggc ctttcctaga gcctgtgaac cctcgcttgg
     5581 tgagtggata ccgacgtgtc atcaagaacc ctatggattt ttccaccatg cgagaacgcc
     5641 tgctccgtgg agggtacact agctcagaag agtttgcagc tgatgctctg ctggtttttg
     5701 acaactgcca gaccttcaat gaggatgact ctgaagtggg caaggctggg cacgtcatgc
     5761 gacgcttctt tgagagccgc tgggaggaat tttatcaggg aaaacaggcc aatctgtgag
     5821 gcaaggaagt tgggagtcac tttgtggcat cttctccaac cttccaaaca aaaacctgcc
     5881 gttctcacct gctgatggct gccctgggtg gactcaagtc agacaatgct gactcttgac
     5941 tctgcccttg gcagcaccca catcctcttg ttccgaatcc cttttctccc ttcctcctct
     6001 ggctcctcaa ataagagatg cagagatgag gtccttctgg atggaaagcc aaaaaagaaa
     6061 aaattttcct gtctctcctc ctcctccccc ccccccccat taaaatggag agagacaaag
     6121 aagtcctcct tccccttccc agcttcctcc cctccctgtc catgcctcag catcctgggg
     6181 ctatttaaca atagcaatag ttctagtgaa tgtgtgaaac tgagaaacac tctgtactgt
     6241 gtgcggaccc gcagtgacgg ccagtaaagt ggacttaact cccaagtgtg tcgagccgga
     6301 caccgggccc tgaacatgct gcttccatgt tcagtcccct ccctgcttct cacttcctct
     6361 cactcattct gttctaactc ctccctattt ttaaggtttt gtctcaccca gtaatgtaaa
     6421 actatcgtgt acgggttctt taccttccct cccagtcttt ttcccttatg tggaaaacaa
     6481 agttgagagc tctcctgtct ttctgtcctc atcttctgcc tcccttctag ttaaccctct
     6541 aaggtgttgg ctcctcctca catgctgagt ttctgtgagt ctctagcctt ttctgaagct
     6601 cggtggctgg ggagcggaca ggcaggcagt gccctaggcc ttccagcctc cttcccctgc
     6661 ttcccaaacc tccctcttgg gaactcctca gggacaacta ctgctgagtt tgagtgctcc
     6721 tccgagatgg gggccaggta gcaattgact ggcctcagag agaggaggag agagaggtgg
     6781 gtgtgggtgt gtgttttgtg tctgtgtgtg tgcacgtgca cagatgagag ttgtgattgt
     6841 gaccctgtag tgtgatggga ctcattgttc cccacatgtg tttattcccg ccttcccatt
     6901 gtttcacacc atcaaccttt tgtctttggg aaaacacaag aacaagggtt ctctggggac
     6961 aaggctgtct ctcctcatgg tcatttcttt tccagcctct tcaaactgtg caatcttttc
     7021 agcaggaact ccctctccct tcactagctt tgagtttttg ctggtagggg ggtagaactg
     7081 gatctttcct aaaccatgag tgtctgggtt tagctgtgtt ttccttcctt acaccgactt
     7141 catgtcccag gacccctttc ttccccagca gcagagaccc tggagcacag aatgggcaga
     7201 gaggaggatt tgggtctacc actgccctgt gtgtgactga gcccaggtta gcccccagca
     7261 tgagaggaca gctgctaact ccaagctgta gccatgggcc actggcccct gctttcctgc
     7321 tcagccaagc ccctcccatc agaaattacg ggtacttgca ctggggaggt ggctgctagc
     7381 tgacctaagc agggagccaa ggcatccaag caatgttcca tgggtgggcg gaggatgcca
     7441 ggtgaggtgt agcattcctt gtactccagc agtactaaag agtggggcag tgcgggttcc
     7501 tgggcagccc tgactcctcg acccaccctc accgcactcc cggttgcctg tttctaaagt
     7561 cgccttttct gtcgatgaac ctcaaaactt aattttattt gagaattttt tttcttttaa
     7621 ataagaggtg gattgaagaa tatttgaatt gactttatat tatgcataaa tatttatatt
     7681 ttatctaaat aactgcgctg taacaaactt tgtgttagtc agatgtttgg aactgtttcc
     7741 cctggcataa agtgtactgg agtcattcgc tactggaggt gcgggaggag ggagagtgga
     7801 gcctctgctc tgctctgtgc tcctctccca gccccacctc tgccctcggg accaggcact
     7861 cagaaggagg aggtcccaga cttgattgta gaaatgggga ctgaagggat tgtgggcagg
     7921 atgtgatcaa aggggccatt tctcactttt ctttcctcat cctcactgcc cctcaagcta
     7981 ggtggatttt tctcttgttg acaaagagta tttggtaggg aaagcaggtt aaaaataaag
     8041 acagcccttc cctgcccttt gtgtcccctt cctggtgaca gcaagaaacc atcaacacca
     8101 acaagtttcc acgttccttt tacagcaaaa gggacttttt atataaccaa atgtggtgtc
     8161 ttagtgactt tttgataatg tacagttttt tgtgaattta aatttatttc tttctatatt
     8221 tttaggacca atctcatttt taataaggtt taaaaaaagg aaaaaaagtc tagagaaaaa
     8281 aaaatacctt gtttttgcca tgtgatgttc cacaggtgcg gctgtagaaa agtgcttgtc
     8341 attgaataaa aaccacattt gataaaaga
//
