LOCUS       NM_007527                801 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus BCL2-associated X protein (Bax), transcript variant 1,
            mRNA.
ACCESSION   NM_007527
VERSION     NM_007527.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 801)
  AUTHORS   Kaminski,C.L., Banik,D.D., Schmitd,L.B. and Pierchala,B.A.
  TITLE     Identification of a postnatal period of interdependent neurogenesis
            and apoptosis in peripheral neurons
  JOURNAL   Biol Open 13 (11) (2024)
   PUBMED   39527572
REFERENCE   2  (bases 1 to 801)
  AUTHORS   Song,C., Chen,Q., Xu,J., He,K., Guo,Q., Teng,X., Xue,H., Xiao,L.,
            Tian,D., Jin,S., An,C. and Wu,Y.
  TITLE     H2S alleviated sepsis-induced acute kidney injury by inhibiting
            PERK/Bax-Bcl2 pathway
  JOURNAL   Nitric Oxide 152, 11-18 (2024)
   PUBMED   39271041
  REMARK    GeneRIF: H2S alleviated sepsis-induced acute kidney injury by
            inhibiting PERK/Bax-Bcl2 pathway.
REFERENCE   3  (bases 1 to 801)
  AUTHORS   Sheibani,N., Sang,Y., Wang,S. and Sorenson,C.M.
  TITLE     Bax expression impacts postnatal retinal vascular development and
            hyperoxia sensitivity
  JOURNAL   Exp Eye Res 248, 110107 (2024)
   PUBMED   39307450
REFERENCE   4  (bases 1 to 801)
  AUTHORS   Luo,X., Zhang,D., Zheng,J., Liu,H., Sun,L., Guo,H., Wang,L. and
            Cui,S.
  TITLE     Casein kinase 1alpha mediates estradiol secretion via CYP19A1
            expression in mouse ovarian granulosa cells
  JOURNAL   BMC Biol 22 (1), 176 (2024)
   PUBMED   39183304
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 801)
  AUTHORS   Shi,Y., Huang,D., Song,C., Cao,R., Wang,Z., Wang,D., Zhao,L.,
            Xu,X., Lu,C., Xiong,F., Zhao,H., Li,S., Zhou,Q., Luo,S., Hu,D.,
            Zhang,Y., Wang,C., Shen,Y., Su,W., Wu,Y., Schmitz,K., Wei,S. and
            Song,W.
  TITLE     Diphthamide deficiency promotes association of eEF2 with p53 to
            induce p21 expression and neural crest defects
  JOURNAL   Nat Commun 15 (1), 3301 (2024)
   PUBMED   38671004
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 801)
  AUTHORS   Knudson,C.M., Tung,K.S., Tourtellotte,W.G., Brown,G.A. and
            Korsmeyer,S.J.
  TITLE     Bax-deficient mice with lymphoid hyperplasia and male germ cell
            death
  JOURNAL   Science 270 (5233), 96-99 (1995)
   PUBMED   7569956
REFERENCE   7  (bases 1 to 801)
  AUTHORS   Chao,D.T., Linette,G.P., Boise,L.H., White,L.S., Thompson,C.B. and
            Korsmeyer,S.J.
  TITLE     Bcl-XL and Bcl-2 repress a common pathway of cell death
  JOURNAL   J Exp Med 182 (3), 821-828 (1995)
   PUBMED   7650488
REFERENCE   8  (bases 1 to 801)
  AUTHORS   Broome,H.E., Dargan,C.M., Krajewski,S. and Reed,J.C.
  TITLE     Expression of Bcl-2, Bcl-x, and Bax after T cell activation and
            IL-2 withdrawal
  JOURNAL   J Immunol 155 (5), 2311-2317 (1995)
   PUBMED   7650367
REFERENCE   9  (bases 1 to 801)
  AUTHORS   Gillardon,F., Wickert,H. and Zimmermann,M.
  TITLE     Up-regulation of bax and down-regulation of bcl-2 is associated
            with kainate-induced apoptosis in mouse brain
  JOURNAL   Neurosci Lett 192 (2), 85-88 (1995)
   PUBMED   7675327
REFERENCE   10 (bases 1 to 801)
  AUTHORS   Lotem,J. and Sachs,L.
  TITLE     Regulation of bcl-2, bcl-XL and bax in the control of apoptosis by
            hematopoietic cytokines and dexamethasone
  JOURNAL   Cell Growth Differ 6 (6), 647-653 (1995)
   PUBMED   7669718
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC151602.4.
            
            On Sep 13, 2022 this sequence version replaced NM_007527.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053380.1, AK159233.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                AC151602.4         123627-123722
            97-148              AC151602.4         124193-124244
            149-295             AC151602.4         124341-124487
            296-431             AC151602.4         125140-125275
            432-536             AC151602.4         126961-127065
            537-801             AC151602.4         128498-128762
FEATURES             Location/Qualifiers
     source          1..801
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.32 cM"
     gene            1..801
                     /gene="Bax"
                     /note="BCL2-associated X protein"
                     /db_xref="GeneID:12028"
                     /db_xref="MGI:MGI:99702"
     exon            1..96
                     /gene="Bax"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..641
                     /gene="Bax"
                     /note="isoform 1 is encoded by transcript variant 1;
                     apoptosis regulator BAX"
                     /codon_start=1
                     /product="apoptosis regulator BAX isoform 1"
                     /protein_id="NP_031553.1"
                     /db_xref="CCDS:CCDS21246.1"
                     /db_xref="GeneID:12028"
                     /db_xref="MGI:MGI:99702"
                     /translation="MDGSGEQLGSGGPTSSEQIMKTGAFLLQGFIQDRAGRMAGETPE
                     LTLEQPPQDASTKKLSECLRRIGDELDSNMELQRMIADVDTDSPREVFFRVAADMFAD
                     GNFNWGRVVALFYFASKLVLKALCTKVPELIRTIMGWTLDFLRERLLVWIQDQGGWEG
                     LLSYFGTPTWQTVTIFVAGVLTASLTIWKKMG"
     exon            97..148
                     /gene="Bax"
                     /inference="alignment:Splign:2.1.0"
     exon            149..295
                     /gene="Bax"
                     /inference="alignment:Splign:2.1.0"
     exon            296..431
                     /gene="Bax"
                     /inference="alignment:Splign:2.1.0"
     exon            432..536
                     /gene="Bax"
                     /inference="alignment:Splign:2.1.0"
     exon            537..801
                     /gene="Bax"
                     /inference="alignment:Splign:2.1.0"
     regulatory      780..785
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bax"
                     /note="hexamer: AATAAA"
     polyA_site      801
                     /gene="Bax"
                     /note="major polyA site"
ORIGIN      
        1 agtcacgtga ccgtggtgcg ccgcagccgc cggggcgcac ccggcgagag gcagcggcag
       61 tgatggacgg gtccggggag cagcttggga gcggcgggcc caccagctct gaacagatca
      121 tgaagacagg ggcctttttg ctacagggtt tcatccagga tcgagcaggg aggatggctg
      181 gggagacacc tgagctgacc ttggagcagc cgccccagga tgcgtccacc aagaagctga
      241 gcgagtgtct ccggcgaatt ggagatgaac tggacagcaa tatggagctg cagaggatga
      301 ttgctgacgt ggacacggac tccccccgag aggtcttctt ccgggtggca gctgacatgt
      361 ttgctgatgg caacttcaac tggggccgcg tggttgccct cttctacttt gctagcaaac
      421 tggtgctcaa ggccctgtgc actaaagtgc ccgagctgat cagaaccatc atgggctgga
      481 cactggactt cctccgtgag cggctgcttg tctggatcca agaccagggt ggctgggaag
      541 gcctcctctc ctacttcggg acccccacat ggcagacagt gaccatcttt gtggctggag
      601 tcctcaccgc ctcgctcacc atctggaaga agatgggctg aggcctccca ctgccttgga
      661 ctgtgtcttt tcttcataaa ttatgacatt ttcctgggat gaatggggga aggggaaagg
      721 catttttctt acttttgtaa ttattgggag gggtgggaat ggtggcctgg ggaggcgcca
      781 ataaacctca ggtccacttt g
//
