LOCUS       NM_028967               1391 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Mus musculus basic leucine zipper transcription factor, ATF-like 2
            (Batf2), transcript variant 1, mRNA.
ACCESSION   NM_028967
VERSION     NM_028967.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1391)
  AUTHORS   Zong,Y., Chang,Y., Huang,K., Liu,J. and Zhao,Y.
  TITLE     The role of BATF2 deficiency in immune microenvironment
            rearrangement in cervical cancer - New biomarker benefiting from
            combination of radiotherapy and immunotherapy
  JOURNAL   Int Immunopharmacol 126, 111199 (2024)
   PUBMED   37995570
REFERENCE   2  (bases 1 to 1391)
  AUTHORS   van der Geest,R., Penaloza,H.F., Xiong,Z., Gonzalez-Ferrer,S.,
            An,X., Li,H., Fan,H., Tabary,M., Nouraie,S.M., Zhao,Y., Zhang,Y.,
            Chen,K., Alder,J.K., Bain,W.G. and Lee,J.S.
  TITLE     BATF2 enhances proinflammatory cytokine responses in macrophages
            and improves early host defense against pulmonary Klebsiella
            pneumoniae infection
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 325 (5), L604-L616 (2023)
   PUBMED   37724373
  REMARK    GeneRIF: BATF2 enhances proinflammatory cytokine responses in
            macrophages and improves early host defense against pulmonary
            Klebsiella pneumoniae infection.
REFERENCE   3  (bases 1 to 1391)
  AUTHORS   Liu,J., Li,J., Tuo,Z., Hu,W. and Liu,J.
  TITLE     BATF2 inhibits PD-L1 expression and regulates CD8+ T-cell
            infiltration in non-small cell lung cancer
  JOURNAL   J Biol Chem 299 (11), 105302 (2023)
   PUBMED   37777155
  REMARK    GeneRIF: BATF2 inhibits PD-L1 expression and regulates CD8+ T-cell
            infiltration in non-small cell lung cancer.
REFERENCE   4  (bases 1 to 1391)
  AUTHORS   Taniguchi,M., Okumura,R., Matsuzaki,T., Nakatani,A., Sakaki,K.,
            Okamoto,S., Ishibashi,A., Tani,H., Horikiri,M., Kobayashi,N.,
            Yoshikawa,H.Y., Motooka,D., Okuzaki,D., Nakamura,S., Kida,T.,
            Kameyama,A. and Takeda,K.
  TITLE     Sialylation shapes mucus architecture inhibiting bacterial invasion
            in the colon
  JOURNAL   Mucosal Immunol 16 (5), 624-641 (2023)
   PUBMED   37385587
REFERENCE   5  (bases 1 to 1391)
  AUTHORS   Le,D.T., Florez,M.A., Kus,P., Tran,B.T., Kain,B., Zhu,Y.,
            Christensen,K., Jain,A., Malovannaya,A. and King,K.Y.
  TITLE     BATF2 promotes HSC myeloid differentiation by amplifying IFN
            response mediators during chronic infection
  JOURNAL   iScience 26 (2), 106059 (2023)
   PUBMED   36824275
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1391)
  AUTHORS   Guler,R., Roy,S., Suzuki,H. and Brombacher,F.
  TITLE     Targeting Batf2 for infectious diseases and cancer
  JOURNAL   Oncotarget 6 (29), 26575-26582 (2015)
   PUBMED   26376615
  REMARK    GeneRIF: Batf2 has a central role in macrophage activation by
            regulating inflammatory responses during lipopolysaccharides
            stimulation and mycobacterial infection
REFERENCE   7  (bases 1 to 1391)
  AUTHORS   Roy,S., Guler,R., Parihar,S.P., Schmeier,S., Kaczkowski,B.,
            Nishimura,H., Shin,J.W., Negishi,Y., Ozturk,M., Hurdayal,R.,
            Kubosaki,A., Kimura,Y., de Hoon,M.J., Hayashizaki,Y., Brombacher,F.
            and Suzuki,H.
  TITLE     Batf2/Irf1 induces inflammatory responses in classically activated
            macrophages, lipopolysaccharides, and mycobacterial infection
  JOURNAL   J Immunol 194 (12), 6035-6044 (2015)
   PUBMED   25957166
  REMARK    GeneRIF: these results underline the role of Batf2/Irf1 in inducing
            inflammatory responses in M. tuberculosis infection.
REFERENCE   8  (bases 1 to 1391)
  AUTHORS   Satpathy,A.T., Briseno,C.G., Lee,J.S., Ng,D., Manieri,N.A., Kc,W.,
            Wu,X., Thomas,S.R., Lee,W.L., Turkoz,M., McDonald,K.G.,
            Meredith,M.M., Song,C., Guidos,C.J., Newberry,R.D., Ouyang,W.,
            Murphy,T.L., Stappenbeck,T.S., Gommerman,J.L., Nussenzweig,M.C.,
            Colonna,M., Kopan,R. and Murphy,K.M.
  TITLE     Notch2-dependent classical dendritic cells orchestrate intestinal
            immunity to attaching-and-effacing bacterial pathogens
  JOURNAL   Nat Immunol 14 (9), 937-948 (2013)
   PUBMED   23913046
REFERENCE   9  (bases 1 to 1391)
  AUTHORS   Tussiwand,R., Lee,W.L., Murphy,T.L., Mashayekhi,M., KC,W.,
            Albring,J.C., Satpathy,A.T., Rotondo,J.A., Edelson,B.T.,
            Kretzer,N.M., Wu,X., Weiss,L.A., Glasmacher,E., Li,P., Liao,W.,
            Behnke,M., Lam,S.S., Aurthur,C.T., Leonard,W.J., Singh,H.,
            Stallings,C.L., Sibley,L.D., Schreiber,R.D. and Murphy,K.M.
  TITLE     Compensatory dendritic cell development mediated by BATF-IRF
            interactions
  JOURNAL   Nature 490 (7421), 502-507 (2012)
   PUBMED   22992524
REFERENCE   10 (bases 1 to 1391)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ134251.1 and AC131114.3.
            
            On Oct 12, 2017 this sequence version replaced NM_028967.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC024521.1, AK150133.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-414               CJ134251.1         2-415
            415-415             AC131114.3         11584-11584         c
            416-651             CJ134251.1         417-652
            652-1391            AC131114.3         10608-11347         c
FEATURES             Location/Qualifiers
     source          1..1391
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.34 cM"
     gene            1..1391
                     /gene="Batf2"
                     /gene_synonym="B-ATF-2"
                     /note="basic leucine zipper transcription factor, ATF-like
                     2"
                     /db_xref="GeneID:74481"
                     /db_xref="MGI:MGI:1921731"
     exon            1..115
                     /gene="Batf2"
                     /gene_synonym="B-ATF-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..910
                     /gene="Batf2"
                     /gene_synonym="B-ATF-2"
                     /note="isoform 1 is encoded by transcript variant 1; basic
                     leucine zipper transcriptional factor ATF-like 2"
                     /codon_start=1
                     /product="basic leucine zipper transcriptional factor
                     ATF-like 2 isoform 1"
                     /protein_id="NP_083243.1"
                     /db_xref="CCDS:CCDS29497.1"
                     /db_xref="GeneID:74481"
                     /db_xref="MGI:MGI:1921731"
                     /translation="MQLCGSSELLTETDLGESQKQLKKKQKNRVAAQRSRQKHTSKAD
                     ALHQQHESLEKQNHALRKEIQALQTELAGWGRTLHLHERLCRVDCDPCPVLLPSGCPI
                     QAKQPSGQPAPLGYNGCQEQLGLFQTPGSSPRAQHLSPGPCSHESPGLLPSLLPSLAF
                     DPLMVRTPLAQLSPSPVLSASSPSGSSLLGSFSKLDPLIPSPQDQLAPPQPLRQEQPT
                     SGRLASSDSPAALGPECSQNREHLPALPGSSTHWQKSSVAPSPQALMAFPLLSSAKVH
                     F"
     exon            116..220
                     /gene="Batf2"
                     /gene_synonym="B-ATF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            221..1391
                     /gene="Batf2"
                     /gene_synonym="B-ATF-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1365..1370
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Batf2"
                     /gene_synonym="B-ATF-2"
                     /note="hexamer: AATAAA"
     polyA_site      1391
                     /gene="Batf2"
                     /gene_synonym="B-ATF-2"
                     /note="major polyA site"
ORIGIN      
        1 ataggtcact gggaggggac agctgctgag gggacatcca ggaccagact gaacctcttt
       61 tccccttgcc taagccatgc aactctgtgg gagtagcgag ctgctgactg agacagacct
      121 tggggagtct cagaaacagc tgaagaagaa gcagaagaac cgagtggctg cccagcgcag
      181 ccggcagaag cacaccagta aggcggacgc tctgcaccag cagcacgaat ccttggagaa
      241 acagaaccac gcccttcgga aggagatcca ggccttgcag actgagctgg cagggtgggg
      301 ccggacactg cacttgcatg aacgcctgtg cagagtggac tgtgatccct gccctgttct
      361 gctgccctct ggatgcccaa tccaggccaa gcaaccctca ggacaacctg cccctcttgg
      421 atacaatggc tgccaggaac aactgggcct gttccagact ccgggctcat ctccccgagc
      481 ccagcatctc tctccaggtc catgctctca tgagtctcct ggcctcctcc cttccctcct
      541 gccttcactg gcctttgacc ctctcatggt gaggacacct ctagcccagc tctcccccag
      601 ccctgtcctg tctgcatcat caccttctgg ttccagcctg ctggggtctt tctctaagct
      661 tgatcccctc atacccagcc cccaagacca actggcccca ccacaacccc tcaggcagga
      721 gcagcccacc agtgggaggc tggcatcctc tgactctcca gctgctctgg gaccagagtg
      781 ttcacagaac agagagcatt tgccggcact gcctggctcc tccactcatt ggcagaagtc
      841 atctgtggcc cctagcccac aggccctcat ggccttcccc ctgctttctt ctgcaaaagt
      901 ccacttctag cctatgtcta gagaggacct gccttacctg agcacctagg cagctccatt
      961 tctgttcttc ctgagttact gagtgcctac caccgtggac cacacaaagc catcctgtcc
     1021 ctcagcaccg caaaggatga tggaagggcc aagtgcaaga acattgaacc tggctggagc
     1081 attgcctata ccttccttgg cagcactccc aactctgcac agtacctgca caccaacatt
     1141 gggctccccc aaaatggctc cttcatggct cttgggacta ctgaggcagt gacagctagg
     1201 agagtaggta gtaggtggga tctctgaaag ggtggtcatt cacagcaccc cccaagtgcc
     1261 tccagttctt caccaggttt tcacacacag aactgagtga gacggtgtgt gagaactgga
     1321 cccactcctg gatcagagca tggttcttgg cacatgggat ggtaaataaa gtgttccccc
     1381 gcctcttgaa a
//
