LOCUS       NM_016767                904 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus basic leucine zipper transcription factor, ATF-like
            (Batf), mRNA.
ACCESSION   NM_016767
VERSION     NM_016767.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 904)
  AUTHORS   Burton,O.T., Bricard,O., Tareen,S., Gergelits,V., Andrews,S.,
            Biggins,L., Roca,C.P., Whyte,C., Junius,S., Brajic,A., Pasciuto,E.,
            Ali,M., Lemaitre,P., Schlenner,S.M., Ishigame,H., Brown,B.D.,
            Dooley,J. and Liston,A.
  TITLE     The tissue-resident regulatory T cell pool is shaped by transient
            multi-tissue migration and a conserved residency program
  JOURNAL   Immunity 57 (7), 1586-1602 (2024)
   PUBMED   38897202
REFERENCE   2  (bases 1 to 904)
  AUTHORS   Canaria,D.A., Rodriguez,J.A., Wang,L., Yeo,F.J., Yan,B., Wang,M.,
            Campbell,C., Kazemian,M. and Olson,M.R.
  TITLE     Tox induces T cell IL-10 production in a BATF-dependent manner
  JOURNAL   Front Immunol 14, 1275423 (2023)
   PUBMED   38054003
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 904)
  AUTHORS   Khatun,A., Wu,X., Qi,F., Gai,K., Kharel,A., Kudek,M.R., Fraser,L.,
            Ceicko,A., Kasmani,M.Y., Majnik,A., Burns,R., Chen,Y.G.,
            Salzman,N., Taparowsky,E.J., Fang,D., Williams,C.B. and Cui,W.
  TITLE     BATF is Required for Treg Homeostasis and Stability to Prevent
            Autoimmune Pathology
  JOURNAL   Adv Sci (Weinh) 10 (28), e2206692 (2023)
   PUBMED   37587835
  REMARK    GeneRIF: BATF is Required for Treg Homeostasis and Stability to
            Prevent Autoimmune Pathology.
REFERENCE   4  (bases 1 to 904)
  AUTHORS   Cui,W., Nagano,Y., Morita,S., Tanoue,T., Yamane,H., Ishikawa,K.,
            Sato,T., Kubo,M., Hori,S., Taniguchi,T., Hatakeyama,M., Atarashi,K.
            and Honda,K.
  TITLE     Diet-mediated constitutive induction of novel IL-4+ ILC2 cells
            maintains intestinal homeostasis in mice
  JOURNAL   J Exp Med 220 (8) (2023)
   PUBMED   37163450
REFERENCE   5  (bases 1 to 904)
  AUTHORS   Tikka,C., Beasley,L., Xu,C., Yang,J., Cooper,S., Lechner,J.,
            Gutch,S., Kaplan,M.H., Capitano,M. and Yang,K.
  TITLE     BATF sustains homeostasis and functionality of bone marrow Treg
            cells to preserve homeostatic regulation of hematopoiesis and
            development of B cells
  JOURNAL   Front Immunol 14, 1026368 (2023)
   PUBMED   36911703
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 904)
  AUTHORS   Thornton,T.M., Zullo,A.J., Williams,K.L. and Taparowsky,E.J.
  TITLE     Direct manipulation of activator protein-1 controls thymocyte
            proliferation in vitro
  JOURNAL   Eur J Immunol 36 (1), 160-169 (2006)
   PUBMED   16380965
REFERENCE   7  (bases 1 to 904)
  AUTHORS   Rasmussen,M.H., Sorensen,A.B., Morris,D.W., Dutra,J.C.,
            Engelhard,E.K., Wang,C.L., Schmidt,J. and Pedersen,F.S.
  TITLE     Tumor model-specific proviral insertional mutagenesis of the
            Fos/Jdp2/Batf locus
  JOURNAL   Virology 337 (2), 353-364 (2005)
   PUBMED   15913695
  REMARK    GeneRIF: Fos/Jdp2/Batf locus is associated with SL3-3 mouse
            leukemia virus B cell lymphoma.
REFERENCE   8  (bases 1 to 904)
  AUTHORS   Williams,K.L., Zullo,A.J., Kaplan,M.H., Brutkiewicz,R.R.,
            Deppmann,C.D., Vinson,C. and Taparowsky,E.J.
  TITLE     BATF transgenic mice reveal a role for activator protein-1 in NKT
            cell development
  JOURNAL   J Immunol 170 (5), 2417-2426 (2003)
   PUBMED   12594265
REFERENCE   9  (bases 1 to 904)
  AUTHORS   Senga,T., Iwamoto,T., Humphrey,S.E., Yokota,T., Taparowsky,E.J. and
            Hamaguchi,M.
  TITLE     Stat3-dependent induction of BATF in M1 mouse myeloid leukemia
            cells
  JOURNAL   Oncogene 21 (53), 8186-8191 (2002)
   PUBMED   12444555
  REMARK    GeneRIF: Stat3 mediates cellular growth by modulating AP-1 activity
            through the induction of BATF
REFERENCE   10 (bases 1 to 904)
  AUTHORS   Williams,K.L., Nanda,I., Lyons,G.E., Kuo,C.T., Schmid,M.,
            Leiden,J.M., Kaplan,M.H. and Taparowsky,E.J.
  TITLE     Characterization of murine BATF: a negative regulator of activator
            protein-1 activity in the thymus
  JOURNAL   Eur J Immunol 31 (5), 1620-1627 (2001)
   PUBMED   11466704
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC115037.16
            and AC117240.4.
            
            On Nov 17, 2006 this sequence version replaced NM_016767.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF017021.1, AK018587.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-254               AC115037.16        203272-203525
            255-359             AC115037.16        205820-205924
            360-904             AC117240.4         85595-86139         c
FEATURES             Location/Qualifiers
     source          1..904
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 39.78 cM"
     gene            1..904
                     /gene="Batf"
                     /gene_synonym="B-ATF; SFA-2"
                     /note="basic leucine zipper transcription factor,
                     ATF-like"
                     /db_xref="GeneID:53314"
                     /db_xref="MGI:MGI:1859147"
     exon            1..254
                     /gene="Batf"
                     /gene_synonym="B-ATF; SFA-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             192..569
                     /gene="Batf"
                     /gene_synonym="B-ATF; SFA-2"
                     /note="activating transcription factor B; basic leucine
                     zipper transcription factor-like; B-cell-activating
                     transcription factor"
                     /codon_start=1
                     /product="basic leucine zipper transcriptional factor
                     ATF-like"
                     /protein_id="NP_058047.1"
                     /db_xref="CCDS:CCDS26061.1"
                     /db_xref="GeneID:53314"
                     /db_xref="MGI:MGI:1859147"
                     /translation="MPHSSDSSDSSFSRSPPPGKQDSSDDVRKVQRREKNRIAAQKSR
                     QRQTQKADTLHLESEDLEKQNAALRKEIKQLTEELKYFTSVLSSHEPLCSVLASGTPS
                     PPEVVYSAHAFHQPHISSPRFQP"
     exon            255..359
                     /gene="Batf"
                     /gene_synonym="B-ATF; SFA-2"
                     /inference="alignment:Splign:2.1.0"
     exon            360..904
                     /gene="Batf"
                     /gene_synonym="B-ATF; SFA-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      882..887
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Batf"
                     /gene_synonym="B-ATF; SFA-2"
                     /note="hexamer: AATAAA"
     polyA_site      904
                     /gene="Batf"
                     /gene_synonym="B-ATF; SFA-2"
                     /note="major polyA site"
ORIGIN      
        1 gcagtccctc tgcacccgag agagaggagg acgcaggggt ctgtcagagg ttgctgttgg
       61 gcaagcaggg gaggtacctg tggaaggtgg tgtgctggtg gccccctagc agtcaagaag
      121 gggagccagc tagtgagaag atcgcccaga ggcatctggg acggtgtggg agagcccgga
      181 agattagaac catgcctcac agctccgaca gcagtgactc cagcttcagc cgctctcctc
      241 cccctggcaa acaggactca tctgatgatg tgaggaaagt tcagaggaga gagaagaatc
      301 gcatcgctgc ccagaagagc cgacagagac agacacagaa agccgacacc cttcacctgg
      361 agagtgagga cctggagaaa cagaacgcag ctctccgcaa agagatcaaa cagctcaccg
      421 aggagctcaa gtacttcaca tcagtgctga gcagccacga gcccctgtgc tccgtgctgg
      481 ccagtggcac cccctcgccc cccgaggtgg tatacagtgc ccatgccttc caccagcctc
      541 acatcagctc gccacgcttc cagccctgac cttctggaca agaagggcga tgctactccc
      601 gtgatccctt ggaggggcat gtaaactgag gccgggctgc cctcatacct ctacccagag
      661 gcccagtggc agaggcctgg acaagtattg aacacaagaa ctgtagtggt cagagggact
      721 taaggcctcc cagggaagta tagtcaatgt actggactct cccagggaag tcgagccaat
      781 gtactggacc caaaaaatga caagtcaacc ctggactgtc atgaatgatg cccaaaatac
      841 acagcacaga gggaggaggg cagggggtgg atagttttct aaataaatat tttctaaaaa
      901 acca
//
