LOCUS       NM_027395               1855 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus brain abundant, membrane attached signal protein 1
            (Basp1), mRNA.
ACCESSION   NM_027395 XM_979955
VERSION     NM_027395.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1855)
  AUTHORS   Guo,Y., Xiang,P., Sun,X., Liu,W., Zhou,J., Yin,B., Hou,L.,
            Qiang,B., Li,H., Shu,P. and Peng,X.
  TITLE     Docking protein 6 (DOK6) selectively docks the neurotrophic
            signaling transduction to restrain peripheral neuropathy
  JOURNAL   Signal Transduct Target Ther 9 (1), 32 (2024)
   PUBMED   38351062
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1855)
  AUTHORS   Meng,Z., Zhou,L., Hong,S., Qiu,X., Chen,Z., Liu,T., Inoki,K. and
            Lin,J.D.
  TITLE     Myeloid-specific ablation of Basp1 ameliorates diet-induced NASH in
            mice by attenuating pro-inflammatory signaling
  JOURNAL   Hepatology 79 (2), 409-424 (2024)
   PUBMED   37505219
  REMARK    GeneRIF: Myeloid-specific ablation of Basp1 ameliorates
            diet-induced NASH in mice by attenuating pro-inflammatory
            signaling.
REFERENCE   3  (bases 1 to 1855)
  AUTHORS   Anuj,A., Reuven,N., Roberts,S.G.E. and Elson,A.
  TITLE     BASP1 down-regulates RANKL-induced osteoclastogenesis
  JOURNAL   Exp Cell Res 431 (1), 113758 (2023)
   PUBMED   37619639
  REMARK    GeneRIF: BASP1 down-regulates RANKL-induced osteoclastogenesis.
REFERENCE   4  (bases 1 to 1855)
  AUTHORS   Yin,L., Gao,W., Tang,H. and Yin,Z.
  TITLE     BASP1 knockdown suppresses chondrocyte apoptosis and extracellular
            matrix degradation in vivo and in vitro: A possible therapeutic
            approach for osteoarthritis
  JOURNAL   Exp Cell Res 429 (1), 113648 (2023)
   PUBMED   37207971
  REMARK    GeneRIF: BASP1 knockdown suppresses chondrocyte apoptosis and
            extracellular matrix degradation in vivo and in vitro: A possible
            therapeutic approach for osteoarthritis.
REFERENCE   5  (bases 1 to 1855)
  AUTHORS   Sun,F., Liu,J., Wang,Y., Yang,H., Song,D., Fu,H. and Feng,X.
  TITLE     BASP1 promotes high glucose-induced endothelial apoptosis in
            diabetes via activation of EGFR signaling
  JOURNAL   J Diabetes Investig 14 (4), 535-547 (2023)
   PUBMED   36756695
  REMARK    GeneRIF: BASP1 promotes high glucose-induced endothelial apoptosis
            in diabetes via activation of EGFR signaling.
REFERENCE   6  (bases 1 to 1855)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 1855)
  AUTHORS   Laux,T., Fukami,K., Thelen,M., Golub,T., Frey,D. and Caroni,P.
  TITLE     GAP43, MARCKS, and CAP23 modulate PI(4,5)P(2) at plasmalemmal
            rafts, and regulate cell cortex actin dynamics through a common
            mechanism
  JOURNAL   J Cell Biol 149 (7), 1455-1472 (2000)
   PUBMED   10871285
REFERENCE   8  (bases 1 to 1855)
  AUTHORS   Frey,D., Laux,T., Xu,L., Schneider,C. and Caroni,P.
  TITLE     Shared and unique roles of CAP23 and GAP43 in actin regulation,
            neurite outgrowth, and anatomical plasticity
  JOURNAL   J Cell Biol 149 (7), 1443-1454 (2000)
   PUBMED   10871284
REFERENCE   9  (bases 1 to 1855)
  AUTHORS   Wiederkehr,A., Staple,J. and Caroni,P.
  TITLE     The motility-associated proteins GAP-43, MARCKS, and CAP-23 share
            unique targeting and surface activity-inducing properties
  JOURNAL   Exp Cell Res 236 (1), 103-116 (1997)
   PUBMED   9344590
REFERENCE   10 (bases 1 to 1855)
  AUTHORS   Caroni,P., Aigner,L. and Schneider,C.
  TITLE     Intrinsic neuronal determinants locally regulate extrasynaptic and
            synaptic growth at the adult neuromuscular junction
  JOURNAL   J Cell Biol 136 (3), 679-692 (1997)
   PUBMED   9024697
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161537.7.
            
            On Mar 6, 2009 this sequence version replaced NM_027395.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK046868.1, AK011545.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-213               AC161537.7         180040-180252       c
            214-1855            AC161537.7         129765-131406       c
FEATURES             Location/Qualifiers
     source          1..1855
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 9.16 cM"
     gene            1..1855
                     /gene="Basp1"
                     /gene_synonym="2610024P12Rik; CAP-23; CAP23; Ckap3;
                     NAP-22; NAP22"
                     /note="brain abundant, membrane attached signal protein 1"
                     /db_xref="GeneID:70350"
                     /db_xref="MGI:MGI:1917600"
     exon            1..213
                     /gene="Basp1"
                     /gene_synonym="2610024P12Rik; CAP-23; CAP23; Ckap3;
                     NAP-22; NAP22"
                     /inference="alignment:Splign:2.1.0"
     exon            214..1855
                     /gene="Basp1"
                     /gene_synonym="2610024P12Rik; CAP-23; CAP23; Ckap3;
                     NAP-22; NAP22"
                     /inference="alignment:Splign:2.1.0"
     CDS             223..903
                     /gene="Basp1"
                     /gene_synonym="2610024P12Rik; CAP-23; CAP23; Ckap3;
                     NAP-22; NAP22"
                     /note="neuronal axonal membrane protein NAP-22; 22 kDa
                     neuronal tissue-enriched acidic protein; cytoskeleton
                     associated protein 3"
                     /codon_start=1
                     /product="brain acid soluble protein 1"
                     /protein_id="NP_081671.1"
                     /db_xref="CCDS:CCDS27398.1"
                     /db_xref="GeneID:70350"
                     /db_xref="MGI:MGI:1917600"
                     /translation="MGGKLSKKKKGYNVNDEKAKDKDKKAEGAGTEEEGTPKESEPQA
                     AADATEVKESTEEKPKDAADGEAKAEEKEADKAAAAKEEAPKAEPEKSEGAAEEQPEP
                     APAPEQEAAAPGPAAGGEAPKAGEASAESTGAADGAAPEEGEAKKTEAPAAAGPEAKS
                     DAAPAASDSKPSSAEPAPSSKETPAASEAPSSAAKAPAPAAPAAAEPQAEAPAAAASS
                     EQSVAVKE"
     regulatory      1831..1836
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Basp1"
                     /gene_synonym="2610024P12Rik; CAP-23; CAP23; Ckap3;
                     NAP-22; NAP22"
                     /note="hexamer: AATAAA"
     polyA_site      1855
                     /gene="Basp1"
                     /gene_synonym="2610024P12Rik; CAP-23; CAP23; Ckap3;
                     NAP-22; NAP22"
                     /note="major polyA site"
ORIGIN      
        1 aaatgcagag gctgcagcgg cggcggcagt agcggcagcg gcgacggcgg tggcggcagc
       61 gctccaactc gctccacgct ccgggctccg ccgtcgagcc gggagagaga gagcctttgc
      121 tgagcgacca gccacccggc cggacgacac cagccacccg ggccccttgg aggcaccgcg
      181 ctcacccagg gccgccacag gcacccaaag ccgaactcca agatgggagg caagctgagc
      241 aagaagaaga agggctacaa tgtgaacgac gagaaggcca aggacaaaga caagaaggcc
      301 gaaggcgcgg gcaccgagga ggaggggacc ccgaaggaga gcgaacccca ggcggccgcc
      361 gacgccaccg aggtcaagga gagcacggag gagaagccca aggacgcggc ggacggcgag
      421 gccaaggcag aggagaagga ggccgacaag gcagcggcgg ccaaggagga ggcgcccaag
      481 gccgagcccg agaagagcga gggcgccgcg gaggagcagc ccgagcccgc gccggcgccc
      541 gagcaggagg cggccgcgcc cgggcccgct gcgggcggcg aggcccccaa ggccggcgaa
      601 gcgagcgccg agagcacggg cgcggccgac ggcgcggccc cggaggaggg cgaggccaaa
      661 aagactgagg ctcccgccgc cgccggcccc gaggcgaaaa gcgacgcggc cccggcggct
      721 tcagactcta aacctagcag cgcggagccc gcgccctcgt ccaaggagac gcccgccgcc
      781 tccgaggcgc ccagttccgc ggccaaggcc cccgcgcccg ccgcgcccgc agccgccgag
      841 ccccaggccg aggcacccgc cgccgccgcc agctccgagc aaagcgtggc cgtcaaagag
      901 taaccgggac agccaaccag aaccgacgcc actcgcaaac gacctgtctt ctcacgctct
      961 ctctctctct gtttctcact ctgtcctctc tctgtctcta tcctatacta acttgtttca
     1021 aattggaagt gaggatatgt attgcccaag ggattaaata aacaaaagaa aagaaaagag
     1081 aaaaaaaata aagaggatgt gtcccatcag gggagggagg gggcggggag aatccaaata
     1141 gtatttttgt ggggaaatat ctaatatacc ttcagtcaac ttgaccagtc agtcctggat
     1201 tttcgagatc attgtctgaa agtacatcat ctgtaccctg aaccgctgtc ccctaggctc
     1261 catccttaaa aaccccagca tctctcccgc gatgcagctg gggagggagg cgtttgattc
     1321 tgcccacagg accagtgcca aggcaatcag atctttatga aagcagtatt ttctgtgttt
     1381 cctttttaat ttacagcctt tttcttaatt tttttggtat ttttttaaac gttcgtggat
     1441 gaatgccaac tttcagacgg agcccactta gcttgtccac atgtatctca atgccaaccc
     1501 tccatttttc ctctccagat atttttggga gtgacaaaca ttctctcatc atacttagcc
     1561 tacctagatt tctcacgacg agtaatgcat gtccgtggtt gggtgcacct gtagttctgt
     1621 ttattggtca gtggaaatga aaataaaaaa aaataaaaaa taaaaaaaaa agaagtctgc
     1681 gttcactgca gcgccagttt tcttccatct gtgtctcaga caccaacaca ccacccattg
     1741 gaaaaatgga aaaaaaataa ataaaaaaat aaaaaaaatg tacaatggat gcattgaaat
     1801 tatatgtaat tgtataaatg gtgcaacagt aataaagtta aacaattaaa aagta
//
