LOCUS       NM_013800               1791 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus BarH-like homeobox 2 (Barx2), mRNA.
ACCESSION   NM_013800
VERSION     NM_013800.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1791)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1791)
  AUTHORS   Yadav,U.S., Biswas,T., Singh,P.N., Gupta,P., Chakraborty,S.,
            Delgado,I., Zafar,H., Capellini,T.D., Torres,M. and
            Bandyopadhyay,A.
  TITLE     Molecular mechanism of synovial joint site specification and
            induction in developing vertebrate limbs
  JOURNAL   Development 150 (13) (2023)
   PUBMED   37272420
REFERENCE   3  (bases 1 to 1791)
  AUTHORS   Chen,S., Lin,X., He,R., Zhang,W., Kang,M. and Xu,R.
  TITLE     PHLDA3 activated by BARX2 transcription, suppresses the malignant
            development of esophageal squamous cell carcinoma by downregulating
            PI3K/AKT levels
  JOURNAL   Exp Cell Res 426 (2), 113567 (2023)
   PUBMED   36965748
  REMARK    GeneRIF: PHLDA3 activated by BARX2 transcription, suppresses the
            malignant development of esophageal squamous cell carcinoma by
            downregulating PI3K/AKT levels.
REFERENCE   4  (bases 1 to 1791)
  AUTHORS   Ye,Q., Bhojwani,A. and Hu,J.K.
  TITLE     Understanding the development of oral epithelial organs through
            single cell transcriptomic analysis
  JOURNAL   Development 149 (16) (2022)
   PUBMED   35831953
REFERENCE   5  (bases 1 to 1791)
  AUTHORS   Qiao,Z., Zhang,S., Hu,T., Lan,F., Yu,D., Ge,G., Li,C., Fang,S. and
            Chen,Q.
  TITLE     Tet2 regulates Barx2 expression in undifferentiated and early
            differentiated mouse embryonic stem cells
  JOURNAL   Biochem Biophys Res Commun 533 (4), 1212-1218 (2020)
   PUBMED   33069358
  REMARK    GeneRIF: Tet2 regulates Barx2 expression in undifferentiated and
            early differentiated mouse embryonic stem cells.
REFERENCE   6  (bases 1 to 1791)
  AUTHORS   Herring,B.P., Kriegel,A.M. and Hoggatt,A.M.
  TITLE     Identification of Barx2b, a serum response factor-associated
            homeodomain protein
  JOURNAL   J Biol Chem 276 (17), 14482-14489 (2001)
   PUBMED   11278942
REFERENCE   7  (bases 1 to 1791)
  AUTHORS   Gould,D.B. and Walter,M.A.
  TITLE     Cloning, characterization, localization, and mutational screening
            of the human BARX1 gene
  JOURNAL   Genomics 68 (3), 336-342 (2000)
   PUBMED   10995576
REFERENCE   8  (bases 1 to 1791)
  AUTHORS   Edelman,D.B., Meech,R. and Jones,F.S.
  TITLE     The homeodomain protein Barx2 contains activator and repressor
            domains and interacts with members of the CREB family
  JOURNAL   J Biol Chem 275 (28), 21737-21745 (2000)
   PUBMED   10781615
REFERENCE   9  (bases 1 to 1791)
  AUTHORS   Krasner,A., Wallace,L., Thiagalingam,A., Jones,C., Lengauer,C.,
            Minahan,L., Ma,Y., Kalikin,L., Feinberg,A.P., Jabs,E.W.,
            Tunnacliffe,A., Baylin,S.B., Ball,D.W. and Nelkin,B.D.
  TITLE     Cloning and chromosomal localization of the human BARX2 homeobox
            protein gene
  JOURNAL   Gene 250 (1-2), 171-180 (2000)
   PUBMED   10854790
REFERENCE   10 (bases 1 to 1791)
  AUTHORS   Jones,F.S., Kioussi,C., Copertino,D.W., Kallunki,P., Holst,B.D. and
            Edelman,G.M.
  TITLE     Barx2, a new homeobox gene of the Bar class, is expressed in neural
            and craniofacial structures during development
  JOURNAL   Proc Natl Acad Sci U S A 94 (6), 2632-2637 (1997)
   PUBMED   9122247
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT030724.7.
            
            On Aug 9, 2007 this sequence version replaced NM_013800.1.
            
            Sequence Note: This RefSeq record was created using genomic
            sequence from the reference strain C57BL/6J, because quality
            transcripts from the reference strain were not available for the
            full length of the gene. The genomic coordinates used for the
            transcript were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012684.1, SRR7345562.5141296.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-381               CT030724.7         114112-114492       c
            382-694             CT030724.7         59938-60250         c
            695-779             CT030724.7         55320-55404         c
            780-1791            CT030724.7         47251-48262         c
FEATURES             Location/Qualifiers
     source          1..1791
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 17.25 cM"
     gene            1..1791
                     /gene="Barx2"
                     /gene_synonym="2310006E12Rik; Barx2b"
                     /note="BarH-like homeobox 2"
                     /db_xref="GeneID:12023"
                     /db_xref="MGI:MGI:109617"
     exon            1..381
                     /gene="Barx2"
                     /gene_synonym="2310006E12Rik; Barx2b"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..1046
                     /gene="Barx2"
                     /gene_synonym="2310006E12Rik; Barx2b"
                     /note="homeodomain transcription factor BARX2"
                     /codon_start=1
                     /product="homeobox protein BarH-like 2"
                     /protein_id="NP_038828.2"
                     /db_xref="CCDS:CCDS52750.1"
                     /db_xref="GeneID:12023"
                     /db_xref="MGI:MGI:109617"
                     /translation="MHCHAELRLSSPGQLKAARRRYKTFMIDEILSKETCDYFEKLSL
                     YSVCPSLVVRPKPLHSCTGSPSLRAYPLLSVITRQPTVISHLVPTGSGLTPVLTRHPV
                     AAAEAAAAAAETPGGEALASSESETEQPTPRQKKPRRSRTIFTELQLMGLEKKFQKQK
                     YLSTPDRLDLAQSLGLTQLQVKTWYQNRRMKWKKMVLKGGQEAPTKPKGRPKKNSIPT
                     SEEIEAEEKMNSQAQSQELLESSERQEEPCDTQEPKACLVPLEVAEPIHQPQELSEAS
                     SEPPPLS"
     exon            382..694
                     /gene="Barx2"
                     /gene_synonym="2310006E12Rik; Barx2b"
                     /inference="alignment:Splign:2.1.0"
     exon            695..779
                     /gene="Barx2"
                     /gene_synonym="2310006E12Rik; Barx2b"
                     /inference="alignment:Splign:2.1.0"
     exon            780..1791
                     /gene="Barx2"
                     /gene_synonym="2310006E12Rik; Barx2b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1769..1774
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Barx2"
                     /gene_synonym="2310006E12Rik; Barx2b"
                     /note="hexamer: ATTAAA"
     polyA_site      1790
                     /gene="Barx2"
                     /gene_synonym="2310006E12Rik; Barx2b"
                     /note="major polyA site"
ORIGIN      
        1 gctgctcggc gggtgggtgt agacgcagca ggcgcgcccg tgccctctct gctttgcgcg
       61 cctccccggg ccccgccgcc cctctggctg ccgaggagcg gggctcaggc cccagccagc
      121 gagccacctc ctgcggtccc ggacggccag gcgctcgccg cgctcaggtc gccaggctct
      181 ggtcccggct caccatgcac tgccacgcgg aactgaggct gagctcaccc ggccagctca
      241 aagcagccag gcggcgctac aagactttca tgatcgatga gatcctctcc aaggagacct
      301 gcgactactt tgagaaactt tccctctact ctgtgtgccc gtcgctggtg gtgcgaccca
      361 agcccctgca ctcttgtacc ggttcccctt ccctacgggc atatcctctc ctgtctgtga
      421 tcacccggca gcccacagtc atctcccacc tggttcccac cggctcggga ctcaccccag
      481 tgttaactcg ccatccagtc gccgctgcgg aggcggcggc tgctgctgct gagacccctg
      541 gtggtgaggc gttagccagc agcgagtcag agacagaaca gcccacgccc aggcagaaga
      601 aaccacgcag aagtcgcacc atcttcaccg agctgcagct catgggccta gagaagaaat
      661 tccagaagca gaagtatttg tctaccccag acaggttgga cttggcccag tctctgggac
      721 tcactcagct gcaagtgaag acttggtatc agaatcgcag gatgaaatgg aagaagatgg
      781 tccttaaagg tggacaggaa gcacccacaa aacctaaggg gcgccctaag aagaattcca
      841 ttcccacatc agaggagatt gaagctgaag agaagatgaa cagccaggct cagagccagg
      901 agctgctgga atcctcggag agacaggagg agccctgtga tacccaggag cccaaagcgt
      961 gccttgtccc cttggaggtg gcagaaccta ttcaccagcc ccaggagtta tcagaagctt
     1021 cctctgaacc cccaccatta agctaaaata aagttctttg aggggaaggg ggagctggga
     1081 agaagggaag agagaggcaa ggagaatgag ggagagaaga cctctaaaga ctagtaacgt
     1141 gggtagagga gcacttctgg tctcccacgt cccagcgtca ttttcatcgg aagcatttga
     1201 tgaagactcg attgtgtggg acttaacctt cttgcaaggc tgtgttaggc acagataccc
     1261 ttctgtaagg gagatagcgc cttggatctg attgcccagg cttgggtgat agctgcaggg
     1321 ctggctacag cagctccgct ggcctgcagc aagggctgct cttctccctc cttgctctcc
     1381 tctgggcaac aggtcagcca agcagagaga ggtaggtgga agtgctcggg agacctgccc
     1441 agactccttg ctgactcggc gcttatttct gtagttttaa gagaattgaa tttttttttt
     1501 tttgagggtg gggtcgggtg gggaaagctg ttaaaggcag acaaaaaaga agaaaaaaag
     1561 aaaagaaaaa aaaaggagtt ggagggagtt gtgagttacg agggacatct cagagccctg
     1621 cttgtctgtt tggagacccc tgtgcctttg cgcctttatg agacggtcag gtgccgacag
     1681 acctgatggt ctttggcttc cctgcttcgt gaagttgccc tcctggaagc tgcaaatgca
     1741 gatatgttaa gataactttt attttttaat taaaaataca tctttcagga g
//
