LOCUS       NM_001005477            2329 bp    mRNA    linear   ROD 03-DEC-2024
DEFINITION  Mus musculus BarH like homeobox 2 (Barhl2), mRNA.
ACCESSION   NM_001005477 XM_144466
VERSION     NM_001005477.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2329)
  AUTHORS   Wutikeli,H., Yu,Y., Zhang,T., Cao,J., Nawy,S. and Shen,Y.
  TITLE     Role of Elavl-like RNA-binding protein in retinal development and
            signal transduction
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1871 (1), 167518 (2025)
   PUBMED   39307290
REFERENCE   2  (bases 1 to 2329)
  AUTHORS   Shu,M., Hong,D., Lin,H., Zhang,J., Luo,Z., Du,Y., Sun,Z., Yin,M.,
            Yin,Y., Liu,L., Bao,S., Liu,Z., Lu,F., Huang,J. and Dai,J.
  TITLE     Single-cell chromatin accessibility identifies enhancer networks
            driving gene expression during spinal cord development in mouse
  JOURNAL   Dev Cell 57 (24), 2761-2775 (2022)
   PUBMED   36495874
REFERENCE   3  (bases 1 to 2329)
  AUTHORS   Wheaton,B.J., Haggstrom,S.L., Muppavarapu,M.,
            Gonzalez-Castrillon,L.M. and Wilson,S.I.
  TITLE     Alternative LIM homeodomain splice variants are dynamically
            regulated at key developmental steps in vertebrates
  JOURNAL   Dev Dyn 251 (7), 1223-1243 (2022)
   PUBMED   35247020
REFERENCE   4  (bases 1 to 2329)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2329)
  AUTHORS   Wu,M., Deng,Q., Lei,X., Du,Y. and Shen,Y.
  TITLE     Elavl2 Regulates Retinal Function Via Modulating the
            Differentiation of Amacrine Cells Subtype
  JOURNAL   Invest Ophthalmol Vis Sci 62 (7), 1 (2021)
   PUBMED   34061953
REFERENCE   6  (bases 1 to 2329)
  AUTHORS   Saba,R., Johnson,J.E. and Saito,T.
  TITLE     Commissural neuron identity is specified by a homeodomain protein,
            Mbh1, that is directly downstream of Math1
  JOURNAL   Development 132 (9), 2147-2155 (2005)
   PUBMED   15788459
  REMARK    Erratum:[Development. 2005 Aug;132(15):3573]
REFERENCE   7  (bases 1 to 2329)
  AUTHORS   Li,S., Mo,Z., Yang,X., Price,S.M., Shen,M.M. and Xiang,M.
  TITLE     Foxn4 controls the genesis of amacrine and horizontal cells by
            retinal progenitors
  JOURNAL   Neuron 43 (6), 795-807 (2004)
   PUBMED   15363391
REFERENCE   8  (bases 1 to 2329)
  AUTHORS   Mo,Z., Li,S., Yang,X. and Xiang,M.
  TITLE     Role of the Barhl2 homeobox gene in the specification of
            glycinergic amacrine cells
  JOURNAL   Development 131 (7), 1607-1618 (2004)
   PUBMED   14998930
  REMARK    GeneRIF: Data suggest that Barhl2 may function to specify the
            identity of glycinergic amacrine cells from competent progenitors
            during retinogenesis.
REFERENCE   9  (bases 1 to 2329)
  AUTHORS   Saba,R., Nakatsuji,N. and Saito,T.
  TITLE     Mammalian BarH1 confers commissural neuron identity on dorsal cells
            in the spinal cord
  JOURNAL   J Neurosci 23 (6), 1987-1991 (2003)
   PUBMED   12657654
REFERENCE   10 (bases 1 to 2329)
  AUTHORS   Bulfone,A., Menguzzato,E., Broccoli,V., Marchitiello,A.,
            Gattuso,C., Mariani,M., Consalez,G.G., Martinez,S., Ballabio,A. and
            Banfi,S.
  TITLE     Barhl1, a gene belonging to a new subfamily of mammalian homeobox
            genes, is expressed in migrating neurons of the CNS
  JOURNAL   Hum Mol Genet 9 (9), 1443-1452 (2000)
   PUBMED   10814725
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK053799.1, BC078444.1 and BC055789.1.
            
            On Dec 20, 2004 this sequence version replaced XM_144466.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK053799.1, SRR1660813.259367.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-282               AK053799.1         1-282
            283-1822            BC078444.1         1-1540
            1823-1849           BC055789.1         1136-1162
            1850-2329           BC078444.1         1568-2047
FEATURES             Location/Qualifiers
     source          1..2329
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 51.43 cM"
     gene            1..2329
                     /gene="Barhl2"
                     /gene_synonym="E130309B19Rik; MBH1"
                     /note="BarH like homeobox 2"
                     /db_xref="GeneID:104382"
                     /db_xref="MGI:MGI:1859314"
     exon            1..941
                     /gene="Barhl2"
                     /gene_synonym="E130309B19Rik; MBH1"
                     /inference="alignment:Splign:2.1.0"
     CDS             326..1480
                     /gene="Barhl2"
                     /gene_synonym="E130309B19Rik; MBH1"
                     /note="BarH-class homeodomain transcription factor;
                     homeobox protein B-H1; bar-class homeodomain protein MBH1"
                     /codon_start=1
                     /product="barH-like 2 homeobox protein"
                     /protein_id="NP_001005477.1"
                     /db_xref="CCDS:CCDS19497.1"
                     /db_xref="GeneID:104382"
                     /db_xref="MGI:MGI:1859314"
                     /translation="MTAMEGASGSSFGIDTILSGAGSGSPGMMNGDFRSLGEARTTDF
                     RSQATPSPCSEIDTVGTAPSSPISVTLEPPEPHLVTDGPQHHHHLHHSQQPPPPSAVP
                     AQSLQPSPQQQPPPQPQSAAQQLGSAAAAPRTSTSSFLIKDILGDSKPLAACAPYSTS
                     VSSPHHTPKQESNAAHESFRPKLEQEDGKTKLDKREDPQSDIKCHGTKEEGDREITSS
                     RESPPVRAKKPRKARTAFSDHQLNQLERSFERQKYLSVQDRMDLAAALNLTDTQVKTW
                     YQNRRTKWKRQTAVGLELLAEAGNYSALQRMFPSPYFYHPSLLGSMDSTTAAAAAAAM
                     YSSMYRTPPAPHPQLQRPLVPRVLIHGLGPGGQPALNPLSNPIPGTPHPR"
     exon            942..1167
                     /gene="Barhl2"
                     /gene_synonym="E130309B19Rik; MBH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..2314
                     /gene="Barhl2"
                     /gene_synonym="E130309B19Rik; MBH1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2240..2245
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Barhl2"
                     /gene_synonym="E130309B19Rik; MBH1"
                     /note="hexamer: AATAAA"
     polyA_site      2261
                     /gene="Barhl2"
                     /gene_synonym="E130309B19Rik; MBH1"
ORIGIN      
        1 gcatcttagt ctcggtgctg ctctccgctg ccaccgccca cgtgcgcggt ggtccagcgg
       61 agcggagcac accttcccgc ttgtggcatt tgggggcttt cccctcaaat ttttttctct
      121 ttactttttg tataaggggg aaaagttgag tcgaaagtgc ccaccaattg tcacctccca
      181 ttatccttca ttccctcccc actttttttt ttttttaaag cagtgtcaac gctttttagt
      241 gtctattttg ttttacgatc ggtagtttcc cttgcttggt cccggcggcg gctgatccgc
      301 ggagtagcgt ggacctcatg tagaaatgac agcaatggaa ggggccagcg ggtcgagttt
      361 tggaatagac actattttgt ccggtgccgg ttccgggagc cccggcatga tgaacgggga
      421 tttccgatcg ctcggtgaag cgaggacaac ggattttagg agccaggcca ccccgtcacc
      481 ctgttcggag attgataccg tgggaacggc gccctcttca ccgatctcgg tcaccctgga
      541 acccccggag ccgcatcttg tgacagacgg accccagcat caccatcacc tccaccacag
      601 ccaacagccg ccgccaccat ccgcggtccc cgcgcaaagt ttgcagcctt cgccccaaca
      661 gcaaccgccg ccgcagccgc agtcagcagc ccagcagctg ggctcggccg ccgcggcccc
      721 caggacttcc acctcttcct ttttaattaa ggacatcttg ggagacagca aacccctggc
      781 ggcttgtgca ccctacagca ccagcgtttc ttctcctcat cacaccccga agcaggagag
      841 caacgcggca cacgagagct tcaggccaaa gcttgagcag gaggacggca aaaccaagct
      901 ggacaagaga gaagaccccc agagcgacat caaatgccac ggaacaaagg aggaaggaga
      961 ccgggagatt acaagtagcc gagagagtcc ccccgtgaga gccaagaaac ctcgaaaggc
     1021 caggacagct ttctcagacc accagctcaa ccagctggag cgtagctttg agcggcagaa
     1081 gtacctaagt gtccaggacc gaatggacct ggcggccgca ctcaacctca ctgacaccca
     1141 agtcaagacc tggtaccaga accgaagaac caagtggaag cggcagactg cagtgggcct
     1201 ggagctgcta gccgaggccg ggaactactc cgcgctgcag aggatgtttc cgtcgcctta
     1261 tttctatcac ccaagcctgc tggggagcat ggacagcacc acggcggcgg cggcggccgc
     1321 ggccatgtac agcagcatgt accgaactcc tccagcacct catccgcagc tgcagcggcc
     1381 gctggtaccc cgcgtgctca tccacggcct ggggcctggg ggacagccgg ccctcaaccc
     1441 tttgtccaac cccatcccag gcaccccgca tccccggtga ggaaggaggg acaggaggga
     1501 cagtgccaca gccctccagg ttcccacctc accccggacg gctgccccgc ctcttcccgc
     1561 accaaaccaa ctggaataga ggcagaggag taaaaggggg agctcaccgg tgggctgggg
     1621 tccccaagga ccagccagct ctcagatctc catctgccca ctcagaggca gggctgcaaa
     1681 gctccccgag tgtgactgga gaaaatactg aaaagtgcaa ccagtaagtg aaaacaccca
     1741 tccacccaca catacacaca cacacacaca cacacacaca cacacacaca cacacacaca
     1801 cacacacaca aaacgaaccc tcgagttctt tctttctttc tttttttttt cttttaaaca
     1861 aaatgacttt agggacatgc agcagggagg gaggggggag ggcaaagagg ggagagactg
     1921 gatggagagg agccttcggg cagagagaat tgttactgga cagaagcctg aagttcaccc
     1981 ccaggcagaa ggtggtaccc tggacatcca gtctgcctca gagcagagga gggtgatgga
     2041 gaactttgca ctgatttttc atgagctttt tttttttctt ttggaaaagt ggcatgctac
     2101 ataatatgaa aaaaatgtac atttgaaaga ctgagcgatg agtgatatat catatttatt
     2161 atatgttgtc caaaaaagag tcacttatat acgtcagtaa taacatgact tttcttttca
     2221 tgtctttttg attcagtaaa ataaatgctt agacaaaagt atagattttt tgtgattgaa
     2281 aattacaaaa ataaagttta tcttttttta acaaaaaaaa aaaaaaaaa
//
