LOCUS       NP_001005477             384 aa            linear   ROD 03-DEC-2024
DEFINITION  barH-like 2 homeobox protein [Mus musculus].
ACCESSION   NP_001005477 XP_144466
VERSION     NP_001005477.1
DBSOURCE    REFSEQ: accession NM_001005477.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 384)
  AUTHORS   Wutikeli,H., Yu,Y., Zhang,T., Cao,J., Nawy,S. and Shen,Y.
  TITLE     Role of Elavl-like RNA-binding protein in retinal development and
            signal transduction
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1871 (1), 167518 (2025)
   PUBMED   39307290
REFERENCE   2  (residues 1 to 384)
  AUTHORS   Shu,M., Hong,D., Lin,H., Zhang,J., Luo,Z., Du,Y., Sun,Z., Yin,M.,
            Yin,Y., Liu,L., Bao,S., Liu,Z., Lu,F., Huang,J. and Dai,J.
  TITLE     Single-cell chromatin accessibility identifies enhancer networks
            driving gene expression during spinal cord development in mouse
  JOURNAL   Dev Cell 57 (24), 2761-2775 (2022)
   PUBMED   36495874
REFERENCE   3  (residues 1 to 384)
  AUTHORS   Wheaton,B.J., Haggstrom,S.L., Muppavarapu,M.,
            Gonzalez-Castrillon,L.M. and Wilson,S.I.
  TITLE     Alternative LIM homeodomain splice variants are dynamically
            regulated at key developmental steps in vertebrates
  JOURNAL   Dev Dyn 251 (7), 1223-1243 (2022)
   PUBMED   35247020
REFERENCE   4  (residues 1 to 384)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 384)
  AUTHORS   Wu,M., Deng,Q., Lei,X., Du,Y. and Shen,Y.
  TITLE     Elavl2 Regulates Retinal Function Via Modulating the
            Differentiation of Amacrine Cells Subtype
  JOURNAL   Invest Ophthalmol Vis Sci 62 (7), 1 (2021)
   PUBMED   34061953
REFERENCE   6  (residues 1 to 384)
  AUTHORS   Saba,R., Johnson,J.E. and Saito,T.
  TITLE     Commissural neuron identity is specified by a homeodomain protein,
            Mbh1, that is directly downstream of Math1
  JOURNAL   Development 132 (9), 2147-2155 (2005)
   PUBMED   15788459
  REMARK    Erratum:[Development. 2005 Aug;132(15):3573]
REFERENCE   7  (residues 1 to 384)
  AUTHORS   Li,S., Mo,Z., Yang,X., Price,S.M., Shen,M.M. and Xiang,M.
  TITLE     Foxn4 controls the genesis of amacrine and horizontal cells by
            retinal progenitors
  JOURNAL   Neuron 43 (6), 795-807 (2004)
   PUBMED   15363391
REFERENCE   8  (residues 1 to 384)
  AUTHORS   Mo,Z., Li,S., Yang,X. and Xiang,M.
  TITLE     Role of the Barhl2 homeobox gene in the specification of
            glycinergic amacrine cells
  JOURNAL   Development 131 (7), 1607-1618 (2004)
   PUBMED   14998930
  REMARK    GeneRIF: Data suggest that Barhl2 may function to specify the
            identity of glycinergic amacrine cells from competent progenitors
            during retinogenesis.
REFERENCE   9  (residues 1 to 384)
  AUTHORS   Saba,R., Nakatsuji,N. and Saito,T.
  TITLE     Mammalian BarH1 confers commissural neuron identity on dorsal cells
            in the spinal cord
  JOURNAL   J Neurosci 23 (6), 1987-1991 (2003)
   PUBMED   12657654
REFERENCE   10 (residues 1 to 384)
  AUTHORS   Bulfone,A., Menguzzato,E., Broccoli,V., Marchitiello,A.,
            Gattuso,C., Mariani,M., Consalez,G.G., Martinez,S., Ballabio,A. and
            Banfi,S.
  TITLE     Barhl1, a gene belonging to a new subfamily of mammalian homeobox
            genes, is expressed in migrating neurons of the CNS
  JOURNAL   Hum Mol Genet 9 (9), 1443-1452 (2000)
   PUBMED   10814725
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK053799.1, BC078444.1 and BC055789.1.
            
            On Dec 20, 2004 this sequence version replaced XP_144466.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK053799.1, SRR1660813.259367.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..384
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 51.43 cM"
     Protein         1..384
                     /product="barH-like 2 homeobox protein"
                     /note="BarH-class homeodomain transcription factor;
                     homeobox protein B-H1; bar-class homeodomain protein MBH1"
                     /calculated_mol_wt=41328
     Region          1..134
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VIB5.2)"
     Region          154..235
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VIB5.2)"
     Region          230..286
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          364..384
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VIB5.2)"
     CDS             1..384
                     /gene="Barhl2"
                     /gene_synonym="E130309B19Rik; MBH1"
                     /coded_by="NM_001005477.1:326..1480"
                     /db_xref="CCDS:CCDS19497.1"
                     /db_xref="GeneID:104382"
                     /db_xref="MGI:MGI:1859314"
ORIGIN      
        1 mtamegasgs sfgidtilsg agsgspgmmn gdfrslgear ttdfrsqatp spcseidtvg
       61 tapsspisvt leppephlvt dgpqhhhhlh hsqqppppsa vpaqslqpsp qqqpppqpqs
      121 aaqqlgsaaa aprtstssfl ikdilgdskp laacapysts vssphhtpkq esnaahesfr
      181 pkleqedgkt kldkredpqs dikchgtkee gdreitssre sppvrakkpr kartafsdhq
      241 lnqlersfer qkylsvqdrm dlaaalnltd tqvktwyqnr rtkwkrqtav glellaeagn
      301 ysalqrmfps pyfyhpsllg smdsttaaaa aaamyssmyr tppaphpqlq rplvprvlih
      361 glgpggqpal nplsnpipgt phpr
//
