LOCUS       NM_019446               3674 bp    mRNA    linear   ROD 22-DEC-2022
DEFINITION  Mus musculus BarH like homeobox 1 (Barhl1), transcript variant 1,
            mRNA.
ACCESSION   NM_019446
VERSION     NM_019446.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3674)
  AUTHORS   Xu P, He H, Gao Q, Zhou Y, Wu Z, Zhang X, Sun L, Hu G, Guan Q, You
            Z, Zhang X, Zheng W, Xiong M and Chen Y.
  TITLE     Human midbrain dopaminergic neuronal differentiation markers
            predict cell therapy outcomes in a Parkinson's disease model
  JOURNAL   J Clin Invest 132 (14) (2022)
   PUBMED   35700056
REFERENCE   2  (bases 1 to 3674)
  AUTHORS   Zhang YH, Xu M, Shi X, Sun XL, Mu W, Wu H, Wang J, Li S, Su P, Gong
            L, He M, Yao M and Wu QF.
  TITLE     Cascade diversification directs generation of neuronal diversity in
            the hypothalamus
  JOURNAL   Cell Stem Cell 28 (8), 1483-1499 (2021)
   PUBMED   33887179
REFERENCE   3  (bases 1 to 3674)
  AUTHORS   Zhu Y, Hirata T, Mackay F and Murakami F.
  TITLE     Chemokine receptor CXCR7 non-cell-autonomously controls pontine
            neuronal migration and nucleus formation
  JOURNAL   Sci Rep 10 (1), 11830 (2020)
   PUBMED   32678266
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3674)
  AUTHORS   Maheshwari U, Kraus D, Vilain N, Holwerda SJB, Cankovic V, Maiorano
            NA, Kohler H, Satoh D, Sigrist M, Arber S, Kratochwil CF, Di Meglio
            T, Ducret S and Rijli FM.
  TITLE     Postmitotic Hoxa5 Expression Specifies Pontine Neuron Positional
            Identity and Input Connectivity of Cortical Afferent Subsets
  JOURNAL   Cell Rep 31 (11), 107767 (2020)
   PUBMED   32553152
REFERENCE   5  (bases 1 to 3674)
  AUTHORS   Qin L, Ahn KJ, Wine Lee L, de Charleroy C Jr and Crenshaw EB 3rd.
  TITLE     Analyses with double knockouts of the Bmpr1a and Bmpr1b genes
            demonstrate that BMP signaling is involved in the formation of
            precerebellar mossy fiber nuclei derived from the rhombic lip
  JOURNAL   PLoS One 14 (12), e0226602 (2019)
   PUBMED   31869353
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3674)
  AUTHORS   Li S, Price SM, Cahill H, Ryugo DK, Shen MM and Xiang M.
  TITLE     Hearing loss caused by progressive degeneration of cochlear hair
            cells in mice deficient for the Barhl1 homeobox gene
  JOURNAL   Development 129 (14), 3523-3532 (2002)
   PUBMED   12091321
REFERENCE   7  (bases 1 to 3674)
  AUTHORS   Poggi L, Carl M, Vignali R, Barsacchi G and Wittbrodt J.
  TITLE     Expression of a medaka (Oryzias latipes) Bar homologue in the
            differentiating central nervous system and retina
  JOURNAL   Mech Dev 114 (1-2), 193-196 (2002)
   PUBMED   12175510
REFERENCE   8  (bases 1 to 3674)
  AUTHORS   Bermingham NA, Hassan BA, Wang VY, Fernandez M, Banfi S, Bellen HJ,
            Fritzsch B and Zoghbi HY.
  TITLE     Proprioceptor pathway development is dependent on Math1
  JOURNAL   Neuron 30 (2), 411-422 (2001)
   PUBMED   11395003
REFERENCE   9  (bases 1 to 3674)
  AUTHORS   Bulfone A, Menguzzato E, Broccoli V, Marchitiello A, Gattuso C,
            Mariani M, Consalez GG, Martinez S, Ballabio A and Banfi S.
  TITLE     Barhl1, a gene belonging to a new subfamily of mammalian homeobox
            genes, is expressed in migrating neurons of the CNS
  JOURNAL   Hum Mol Genet 9 (9), 1443-1452 (2000)
   PUBMED   10814725
REFERENCE   10 (bases 1 to 3674)
  AUTHORS   Bulfone A, Gattuso C, Marchitiello A, Pardini C, Boncinelli E,
            Borsani G, Banfi S and Ballabio A.
  TITLE     The embryonic expression pattern of 40 murine cDNAs homologous to
            Drosophila mutant genes (Dres): a comparative and topographic
            approach to predict gene function
  JOURNAL   Hum Mol Genet 7 (13), 1997-2006 (1998)
   PUBMED   9817915
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732526.8.
            
            [WARNING] On May 19, 2023 this sequence was replaced by
            NM_019446.5.
            
            On Aug 14, 2009 this sequence version replaced NM_019446.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a). Variants 1, 2, and 3
            all encode the same isoform (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB043980.1, AK036312.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164141 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1208              AL732526.8         143478-144685       c
            1209-1431           AL732526.8         139606-139828       c
            1432-3674           AL732526.8         135944-138186       c
FEATURES             Location/Qualifiers
     source          1..3674
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 19.38 cM"
     gene            1..3674
                     /gene="Barhl1"
                     /gene_synonym="Dres115; MBH2"
                     /note="BarH like homeobox 1"
                     /db_xref="GeneID:54422"
                     /db_xref="MGI:MGI:1859288"
     exon            1..1208
                     /gene="Barhl1"
                     /gene_synonym="Dres115; MBH2"
                     /inference="alignment:Splign:2.1.0"
     CDS             743..1726
                     /gene="Barhl1"
                     /gene_synonym="Dres115; MBH2"
                     /note="isoform a is encoded by transcript variant 1;
                     barH-like 1 homeobox protein; barH-related homeobox
                     protein 1; bar-class homeodomain protein MBH2"
                     /codon_start=1
                     /product="barH-like 1 homeobox protein isoform a"
                     /protein_id="NP_062319.1"
                     /db_xref="CCDS:CCDS15849.1"
                     /db_xref="GeneID:54422"
                     /db_xref="MGI:MGI:1859288"
                     /translation="MEGSNGFGIDSILSHRAGSPALPKGDPLLGDCRSPLELSPRSES
                     SSDCSSPASPGRDCLETSTSRPGAASGPGLDSHLQPGQLSAPAQSRTVTSSFLIRDIL
                     ADCKPLAACAPYSSSGQPAAPEPGGRLAAKAGEDFRDKLDKSVSSASSDSEYKVKEEG
                     DREISSSRDSPPVRLKKPRKARTAFTDHQLAQLERSFERQKYLSVQDRMELAASLNLT
                     DTQVKTWYQNRRTKWKRQTAVGLELLAEAGNYSALQRMFPSPYFYPQSLVSNLDPGAA
                     LYLYRGPSAPPPALQRPLVPRILIHGLQGASEPPPPLPPLPGVLPRAAQPR"
     exon            1209..1431
                     /gene="Barhl1"
                     /gene_synonym="Dres115; MBH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..3674
                     /gene="Barhl1"
                     /gene_synonym="Dres115; MBH2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaaacaaca acaacaacaa aaaagccagt cctaaagtaa aagtgaccca agttcgattt
       61 tttttttttt aaaggaagtg ggggtggcgg cgaaggcgcg cgcggaggac aggtgagagc
      121 tgcggtggga gccgcagggc gctgtccacg gtgctggcgg ggccgagcag gagctccggg
      181 gccaggtggg gctgctcgat cccggggccg ctgtcgctgt ccgcggtgct gaggcctcca
      241 ggtgcgctct gttctgcctg cccgtaacgc ggccccggcc ggttgctatc ggccgtgctg
      301 acccctgccc tgggctaccg tttgcctgga ggaagcgtgc ggtttggatt ttgttttttc
      361 aaaagacgat ctttattcag attccatcaa cctcgtgttt cttctgtgcc taagggatcc
      421 tcgggccgtt cttctaccct ttggctctcc ccaacttggc gcgccctcct cccattcctc
      481 ctgacactcc caccaccacc ccccctcggc tcggcggctc ggcgcggtgc tgcagaagac
      541 gcgttgagcc cttttggatg taatgcgcag aggaggttgg cccagagctc ccgggctccc
      601 ccaaggctga actccgtcca aggtgcccac aggctccctg cccgccttcc ccatgccagc
      661 ccgcagctag gggcaggggc agcggcggct ggggttgggg gtgggtgggg agcttttggg
      721 gaggacaggt tgcagcttgg ctatggaagg ctctaatggc tttgggattg actccattct
      781 ctcccaccga gcgggcagcc ccgcccttcc caagggggac cccttgcttg gggactgccg
      841 ttcacccctg gagctgagtc cacgctcaga gagcagtagc gactgctctt caccagcctc
      901 gcccggaaga gactgtctgg agaccagtac ctcgcggcct ggtgcagcat ctggcccagg
      961 tttggactct cacctgcaac cggggcagct ttcagcccca gcccagtcgc gaactgtcac
     1021 ctcctccttt ctgatcaggg acatccttgc tgactgcaaa cctctcgcgg cctgtgcacc
     1081 ctactctagc agtgggcagc ctgcagcccc tgagcctggg ggccgccttg cggccaaggc
     1141 cggggaggac tttcgagaca agctggacaa aagtgtcagc agcgcttcat cagactctga
     1201 gtacaaagtg aaggaggagg gcgaccgcga gatctccagc tctcgggaca gtcccccggt
     1261 gcgcctgaaa aagccacgca aagcacgcac cgccttcacc gaccatcagc tggcgcagct
     1321 ggagcgtagc ttcgagcggc agaaatacct gagcgtgcaa gaccgcatgg agctagccgc
     1381 ctcgctcaac ctcaccgaca cgcaggtcaa gacctggtac cagaaccgca ggactaaatg
     1441 gaagcgacag acggccgtgg ggctggagct gctagcggag gcaggcaatt actcggcgct
     1501 ccagagaatg ttcccgtcgc cttatttcta cccgcagagt ctggtttcca atctggaccc
     1561 cggtgccgca ctctatctgt accgcggacc cagcgcgcca cctcctgccc ttcagagacc
     1621 tctggtgccc cgcatcctca tccacggact ccagggcgcc agcgagccgc ccccgccgct
     1681 gcccccgctg cccggcgtcc tcccgcgcgc cgcgcagccc cggtgaagct cccgcttgcc
     1741 ccaaaccatg ctctgggacc cccagctcag gctgggcgtg ggtccctccc ttcgccccgg
     1801 ggcagggctg ctgggctccc ctccgcagcc cagtgtcccc gtgtgggaga aattcactga
     1861 ggctacccct cccctacgtc ctctctcttg gctgctccat ccaggagcta cttacactcg
     1921 ccggatgtac atatgcgtcc ttgcccacct ctcaccaagc cccggatcct tgcggacttc
     1981 cccaggtgcc ccctgtcccc tcagcagcag gtaggggacg ccggtgtccc aggcctgggg
     2041 cccacccttc ttgcacctct gcgggacaga gtgggagcgc tatacggagc ttccctccca
     2101 tttcctttat tcttcctaag ccccgggcta gcagcggagc tgtacataca gtgtgcaaag
     2161 tgtatatgaa gttatttatt cgtgacccat gagcccgtga ccgtgtcagt gaatcagtga
     2221 gtctgtggcc tgtgccctcc ccatcccggg tgggcaggaa ggggccaaga gggcttgccc
     2281 acacatcctg gcccccagtc ccgctccctc cacccaggtc ccagggcagc cagacctctt
     2341 gggttatctt tttttaaatg tgaaaataaa cttcttacaa atgactaggc gcctgtccgc
     2401 gctaccttcc gttggctccc gctcaggccc tccccactcc ttcctccata aataactttg
     2461 gcacctctgg aactacagat cctttcactg gcaagaagag ggagaattcg tctccctctt
     2521 gtcccgttcc ccagttcctg ggtgttgtag tcatgcttag gagacttggg ctggactccc
     2581 aggggtctcc ccgtttccac cccgaggctc ttggccttct catctgattt gtcccgtttc
     2641 cacacggtct taggaggtca cgggcgaggc caacgctcgg cctccctctg ctgcgcgaca
     2701 ggccgcgaag cactcactga gccgactcat ctggctcagg ccagggcgcc ggcagctggt
     2761 gcccggccct gcgggcgcgg ggcagacaga tggactccga ggctgctccc cgttgcccca
     2821 ccctcctccg cccggcgccc cccgctctgg ctacccgcag ctcctagtct ctaatgcctg
     2881 gtaggatccc atgggccttt gcgacgccac gttaggcaac cctttgctct ctctccatcc
     2941 tccccttgtt ccagtcctgg gagaaatagg agcaggggag ggggcagatc aaccacccgc
     3001 ctctggctct gagatttcag gggagtcaga ctccagatca cgttcaaagg gccaaggtca
     3061 tctcctgaca ctggtccgtc tcccgggacc tgggcgcagg tgctcccctc ccccacacca
     3121 cctgcagcac actgacctgc agatggaaga aatgcttggg agtttggata cttgcaagcc
     3181 aagcaccttc ccagcttttc tggcctaacc tgagagaaca aggcagtgga gggagggggc
     3241 gtgttcagaa agacaccccc ccaaccattt tggctactgt ttcctccccc acccactagc
     3301 atcctcgcac ccaggctttt attttctggg atggtggggc tattattcta attttgcaaa
     3361 atgcacagca gctaattaag tcaaggagcc cctcggcttt caagttcttt tgcatgtgaa
     3421 tgcaggctgg taaatccctc gatctggctg tggtggggtg tgagggggac tgtccccaac
     3481 tcagggttaa tgaagtggga aaggagtctc tcatagcctc ctgcaaacaa aaccccccaa
     3541 gcaacaaacc ctgcccaaat cctacacgga ttgacttaaa cccaggggat aagtgcttta
     3601 aattaatctc attgaataag aatgagacca aacaaaactc tttaaaatca tattaaaaat
     3661 ctatcaaagg acaa
//
