LOCUS       NM_007525               5448 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus BRCA1 associated RING domain 1 (Bard1), transcript
            variant 1, mRNA.
ACCESSION   NM_007525
VERSION     NM_007525.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5448)
  AUTHORS   Georgieva,D., Wang,N., Taglialatela,A., Jerabek,S., Reczek,C.R.,
            Lim,P.X., Sung,J., Du,Q., Horiguchi,M., Jasin,M., Ciccia,A.,
            Baer,R. and Egli,D.
  TITLE     BRCA1 and 53BP1 regulate reprogramming efficiency by mediating DNA
            repair pathway choice at replication-associated double-strand
            breaks
  JOURNAL   Cell Rep 43 (4), 114006 (2024)
   PUBMED   38554279
REFERENCE   2  (bases 1 to 5448)
  AUTHORS   Shakri,A.R., James Zhong,T., Ma,W., Coker,C., Hegde,R., Scholze,H.,
            Chin,V., Szabolcs,M., Hibshoosh,H., Tanji,K., Baer,R., Kumar
            Biswas,A. and Acharyya,S.
  TITLE     Aberrant Zip14 expression in muscle is associated with cachexia in
            a Bard1-deficient mouse model of breast cancer metastasis
  JOURNAL   Cancer Med 9 (18), 6766-6775 (2020)
   PUBMED   32730698
  REMARK    GeneRIF: Aberrant Zip14 expression in muscle is associated with
            cachexia in a Bard1-deficient mouse model of breast cancer
            metastasis.
REFERENCE   3  (bases 1 to 5448)
  AUTHORS   Mohiuddin,M., Rahman,M.M., Sale,J.E. and Pearson,C.E.
  TITLE     CtIP-BRCA1 complex and MRE11 maintain replication forks in the
            presence of chain terminating nucleoside analogs
  JOURNAL   Nucleic Acids Res 47 (6), 2966-2980 (2019)
   PUBMED   30657944
REFERENCE   4  (bases 1 to 5448)
  AUTHORS   Peng,Y., Liao,Q., Tan,W., Peng,C., Hu,Z., Chen,Y., Li,Z., Li,J.,
            Zhen,B., Zhu,W., Li,X., Yao,Y., Song,Q., Liu,C., Qi,X., He,F. and
            Pei,H.
  TITLE     The deubiquitylating enzyme USP15 regulates homologous
            recombination repair and cancer cell response to PARP inhibitors
  JOURNAL   Nat Commun 10 (1), 1224 (2019)
   PUBMED   30874560
  REMARK    GeneRIF: Study reports that USP15 affects cancer cell response to
            PARP inhibitors by regulating homologous recombination repair.
            USP15 is recruited to DNA double-strand breaks (DSBs) by MDC1.
            USP15 deubiquitinates BARD1 BRCT domain, and promotes
            BARD1-HP1gamma interaction, resulting in BRCA1/BARD1 retention at
            DSBs. Cancer-associated USP15 mutations, with decreased USP15-BARD1
            interaction, increases PARP inhibitor sensitivity.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5448)
  AUTHORS   Dai,Y., Lin,X., Xu,W., Lin,X., Huang,Q., Shi,L., Pan,Y., Zhang,Y.,
            Zhu,Y., Li,C., Liu,L. and Zhang,S.
  TITLE     MiR-210-3p protects endometriotic cells from oxidative
            stress-induced cell cycle arrest by targeting BARD1
  JOURNAL   Cell Death Dis 10 (2), 144 (2019)
   PUBMED   30760709
  REMARK    GeneRIF: Results demonstrate that endometriotic cells inhibit
            BARD1/BRCA1 function by upregulating miR-210-3p, which might be the
            underlying mechanism for endometriotic cell maintenance of growth
            in oxidative stress.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5448)
  AUTHORS   Mallery,D.L., Vandenberg,C.J. and Hiom,K.
  TITLE     Activation of the E3 ligase function of the BRCA1/BARD1 complex by
            polyubiquitin chains
  JOURNAL   EMBO J 21 (24), 6755-6762 (2002)
   PUBMED   12485996
REFERENCE   7  (bases 1 to 5448)
  AUTHORS   Ganesan,S., Silver,D.P., Greenberg,R.A., Avni,D., Drapkin,R.,
            Miron,A., Mok,S.C., Randrianarison,V., Brodie,S., Salstrom,J.,
            Rasmussen,T.P., Klimke,A., Marrese,C., Marahrens,Y., Deng,C.X.,
            Feunteun,J. and Livingston,D.M.
  TITLE     BRCA1 supports XIST RNA concentration on the inactive X chromosome
  JOURNAL   Cell 111 (3), 393-405 (2002)
   PUBMED   12419249
REFERENCE   8  (bases 1 to 5448)
  AUTHORS   Irminger-Finger,I., Leung,W.C., Li,J., Dubois-Dauphin,M., Harb,J.,
            Feki,A., Jefford,C.E., Soriano,J.V., Jaconi,M., Montesano,R. and
            Krause,K.H.
  TITLE     Identification of BARD1 as mediator between proapoptotic stress and
            p53-dependent apoptosis
  JOURNAL   Mol Cell 8 (6), 1255-1266 (2001)
   PUBMED   11779501
  REMARK    GeneRIF: identification of BARD1 as mediator between proapoptotic
            stress and p53-dependent apoptosis
REFERENCE   9  (bases 1 to 5448)
  AUTHORS   Sutherland,H.G., Mumford,G.K., Newton,K., Ford,L.V., Farrall,R.,
            Dellaire,G., Caceres,J.F. and Bickmore,W.A.
  TITLE     Large-scale identification of mammalian proteins localized to
            nuclear sub-compartments
  JOURNAL   Hum Mol Genet 10 (18), 1995-2011 (2001)
   PUBMED   11555636
REFERENCE   10 (bases 1 to 5448)
  AUTHORS   Ayi,T.C., Tsan,J.T., Hwang,L.Y., Bowcock,A.M. and Baer,R.
  TITLE     Conservation of function and primary structure in the
            BRCA1-associated RING domain (BARD1) protein
  JOURNAL   Oncogene 17 (16), 2143-2148 (1998)
   PUBMED   9798686
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104747.23.
            
            On Mar 1, 2008 this sequence version replaced NM_007525.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145528.1, AF057157.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-305               AC104747.23        175175-175479       c
            306-362             AC104747.23        161978-162034       c
            363-505             AC104747.23        160616-160758       c
            506-1443            AC104747.23        147050-147987       c
            1444-1524           AC104747.23        139615-139695       c
            1525-1697           AC104747.23        137986-138158       c
            1698-1806           AC104747.23        126120-126228       c
            1807-1939           AC104747.23        120147-120279       c
            1940-2032           AC104747.23        119185-119277       c
            2033-2130           AC104747.23        103866-103963       c
            2131-5448           AC104747.23        100042-103359       c
FEATURES             Location/Qualifiers
     source          1..5448
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 35.67 cM"
     gene            1..5448
                     /gene="Bard1"
                     /note="BRCA1 associated RING domain 1"
                     /db_xref="GeneID:12021"
                     /db_xref="MGI:MGI:1328361"
     exon            1..305
                     /gene="Bard1"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..2463
                     /gene="Bard1"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1;
                     BRCA1-associated RING domain protein 1; BARD-1; RING-type
                     E3 ubiquitin transferase BARD1"
                     /codon_start=1
                     /product="BRCA1-associated RING domain protein 1 isoform
                     1"
                     /protein_id="NP_031551.1"
                     /db_xref="CCDS:CCDS15029.1"
                     /db_xref="GeneID:12021"
                     /db_xref="MGI:MGI:1328361"
                     /translation="MPRRPPRVCSGNQPAPVPAMEPATDGLWAHSRAALARLEKLLRC
                     SRCANILKEPVCLGGCEHIFCSGCISDCVGSGCPVCYTPAWILDLKINRQLDSMIQLS
                     SKLQNLLHDNKDSKDNTSRASLFGDAERKKNSIKMWFSPRSKKVRYVVTKVSVQTQPQ
                     KAKDDKAQEASMYEFVSATPPVAVPKSAKTASRTSAKKHPKKSVAKINREENLRPETK
                     DSRFDSKEELKEEKVVSCSQIPVMERPRVNGEIDLLASGSVVEPECSGSLTEVSLPLA
                     EHIVSPDTVSKNEETPEKKVCVKDLRSGGSNGNRKGCHRPTTSTSDSCGSNIPSTSRG
                     IGEPALLAENVVLVDCSSLPSGQLQVDVTLRRKSNASDDPLSLSPGTPPPLLNNSTHR
                     QMMSSPSTVKLSSGMPARKRNHRGETLLHIASIKGDIPSVEYLLQNGNDPNVKDHAGW
                     TPLHEACSHGHLKVVELLLQHNALVNTPGYQNDSPLHDAVKSGHIDIVKVLLSHGASR
                     NAVNIFGVRPVDYTDNENIRSLLLLPEENESFSTSQCSIVNTGQRKNGPLVFIGSGLS
                     SQQQKMLSKLETVLKAKKCMEFDSTVTHVIVPDEEAQSTLKCMLGILSGCWILKFDWV
                     KACLDSKVREQEEKYEVPGGPQRSRLNREQLLPKLFDGCYFFLGGNFKHHPRDDLLKL
                     IAAAGGKVLSRKPKPDSDVTQTINTVAYHAKPESDQRFCTQYIVYEDLFNCHPERVRQ
                     GKVWMAPSTWLISCIMAFELLPLDS"
     exon            306..362
                     /gene="Bard1"
                     /inference="alignment:Splign:2.1.0"
     exon            363..505
                     /gene="Bard1"
                     /inference="alignment:Splign:2.1.0"
     exon            506..1443
                     /gene="Bard1"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1524
                     /gene="Bard1"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1697
                     /gene="Bard1"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1806
                     /gene="Bard1"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..1939
                     /gene="Bard1"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..2032
                     /gene="Bard1"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..2130
                     /gene="Bard1"
                     /inference="alignment:Splign:2.1.0"
     exon            2131..5448
                     /gene="Bard1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5427..5432
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bard1"
                     /note="hexamer: ATTAAA"
     polyA_site      5448
                     /gene="Bard1"
                     /note="major polyA site"
ORIGIN      
        1 agggcgtggc ctaaagccgg gtccttccat ctctgagttt taccgcgttt cagcctccga
       61 gccggaggcg tccgaccaat tcagagactc cgcacgcagc aggatccggc ggtgaccagc
      121 ggggtgcggc gctagagcaa acctgacctc ccctcctctg tgggaatgcc acgccggccg
      181 ccgagggtct gctctgggaa ccagcctgct cccgtgcccg ccatggagcc ggctaccgac
      241 gggctttggg cccacagccg cgcggcgctt gcccgcctgg agaagctgct gcgctgctcc
      301 cgctgtgcta atattctgaa ggagcccgtg tgcttaggag gatgtgagca catcttctgt
      361 agtggttgta taagtgactg tgttggctca ggatgcccag tgtgttacac cccagcctgg
      421 atcctagacc tcaagataaa ccgacaattg gacagcatga tccagctttc tagtaagctc
      481 caaaatttgc tccatgacaa taaagattca aaagacaaca catctagggc aagtttattt
      541 ggtgatgcag aaaggaagaa gaattcaata aaaatgtggt ttagtcctcg aagtaagaag
      601 gttagatatg ttgtgactaa agtgtcagta caaacacagc ctcaaaaggc aaaggacgac
      661 aaagcccagg aagcctcaat gtatgaattt gtttccgcaa ctccccctgt agctgttcct
      721 aagagtgcta aaacagcttc tagaacatct gcaaaaaagc atccaaagaa atctgtagct
      781 aagatcaaca gggaggagaa tttaaggcca gaaacaaagg atagtagatt tgattccaaa
      841 gaggagctga aggaagagaa ggttgtctcc tgtagccaaa taccagttat ggagagacca
      901 cgggtaaatg gtgaaataga cttattagca agtggttctg ttgtagaacc tgaatgttct
      961 ggaagcttga ctgaagtctc tttaccattg gctgagcata tagtgtctcc agacactgtg
     1021 agcaagaatg aagagactcc ggagaagaag gtctgtgtaa aagatcttcg ttcaggaggg
     1081 agtaatggaa atcgtaaagg ctgccacagg cctaccactt ctacttctga cagttgtggg
     1141 agcaacattc cgagcaccag cagaggcatc ggtgagccag cattgcttgc agaaaacgta
     1201 gtgttggttg actgctcttc actgccttca ggccagctac aggttgatgt cacactcagg
     1261 agaaagagta acgcatcaga tgaccccctt agcctttcac cgggcacacc cccacctctg
     1321 ctgaacaatt caactcacag acaaatgatg tcaagcccct ccacagtgaa gctgtcttct
     1381 ggtatgccag ccaggaaaag aaatcacaga ggagagacct tacttcatat tgcttctatt
     1441 aagggtgata taccttctgt tgaatacctc ttgcaaaatg gaaacgaccc aaatgttaaa
     1501 gaccatgctg gatggacacc gttgcatgaa gcctgcagtc atgggcacct gaaggtagtg
     1561 gagttgctgc tccagcataa tgccctggtg aacacccctg gctatcagaa tgactcgcca
     1621 ctccacgatg ccgtcaagag tggccacatc gatatagtca aggtgttact gtcccacggt
     1681 gcttccagga atgctgttaa catatttggt gtgcggcctg tggactatac agacaatgag
     1741 aatataagat cattattgct gctgccagag gagaatgaat cattctcaac tagccagtgc
     1801 tctatcgtga acaccgggca gcgaaagaat gggccgctgg tatttatagg cagtgggctt
     1861 tcttcacagc agcagaaaat gctcagcaaa cttgagacag ttcttaaggc taaaaagtgt
     1921 atggaatttg acagtacagt aactcatgtc attgttcctg atgaggaagc gcagagtact
     1981 ctgaagtgta tgcttgggat tctcagtgga tgctggatcc tgaagtttga ttgggtgaaa
     2041 gcctgtctgg acagcaaagt acgtgagcag gaagaaaagt atgaagttcc tggaggtcca
     2101 cagaggagca ggctcaacag agagcagctg ttgccaaagc tgtttgatgg atgctacttc
     2161 tttttggggg gaaacttcaa gcatcatcca agggatgacc tccttaagct cattgctgca
     2221 gcaggaggca aagtcctgag tcgcaagccc aagccagaca gtgatgtgac tcagaccatc
     2281 aacacggttg cataccatgc caagcctgag tcggatcagc gcttctgtac gcagtacatc
     2341 gtctacgaag acctgtttaa ctgtcaccca gagagggttc ggcagggcaa agtctggatg
     2401 gctccgtcca cctggcttat cagctgtata atggcctttg aattgcttcc tcttgacagc
     2461 tgaatgtcat accaggtgaa cattttaagt tggacatgca tggtttgtaa gaacaacggc
     2521 cattgtgata tttctggtca ttcatgtttt tatgaatagg tagaaccatt catatttctt
     2581 ccccctttga attgcaaaat aaaacaattg atagtagatt aggaattcat tttgatgcct
     2641 aaactgcttt taagatattt ttgttgttgt tcttttttaa gggtgggggc tataactcaa
     2701 gtcttagggt cttcatcacc tatgtgggag gcacaggttc cacactagga acttatttta
     2761 catgtggcct gtgttttttt tttttttttt ttttttgatt gatcatgtct ttcagctttc
     2821 tcaacatctg tcgaagatta ataagtgaga tagcatcaaa ctacttgtta aatccacgtg
     2881 gtgtattatt aatttagcat cctttagtaa acagaatatc atcatatgat ttattctgcc
     2941 ctttttataa tgataataga gcatttatgt aaatgtgcca gtgtaggcaa aaagctctat
     3001 ctggagttat ccttttctta tgttgtattt tagtttcttg tgttttcttg gctttccatt
     3061 gtgttttttt tttttattta tttaaaaata atcttgtgta tgcattagga aatcatgatt
     3121 cgaagcactg aatgttagtg gtaaaatcag cggtatgctc tcactgtgta catttgctgt
     3181 ctgcctactg tgcgctgtgc acaccttttt tctgtaactt attttagcgt cactgcttag
     3241 aatgtcttgc cagtttagaa cactgacaaa tgttaactca ttagattata agcaatctgg
     3301 ttttggtaaa tctttctgga aattactaaa ataagtcctt gaaggtttta atcccttctc
     3361 tcattccctt tctccctcct tccctccctc cctccctccc tccctccctc cctccctccc
     3421 ttccttcctt ccttcctttt cctctctcct ttcctccctt ttatttgtgc tactgggtat
     3481 ggaagtcagg atcatgtgca tgctaggcaa ttacctacta cataactata tccaactttg
     3541 agacaatctt gctaagttag ccaagctagc cctgatctca cccagcttta attttttata
     3601 cagcctctag attggtgggt aggcaaaagt tggagattgc ttgatttact acatttttac
     3661 catatccgac acaaaccctg tagcaggaaa tcaggcagtg ggagtgagaa gagcttcttc
     3721 ttgttacaga agcagcccca gcaggggtgt ggggggcact cctgagcctg cgcacactgc
     3781 agcttactct gcctgttctg taggtcctca ttgtgagtgg acagggtcta tacttgtaaa
     3841 tggtcttaaa gaagaggatt cttccatgca tcatcccaga aggtaaagag ttggcagcat
     3901 tatggtttgc agaaggaagt cctaagacaa ccatcagctc tgtttttagg agaagagggc
     3961 agcttgacaa gccctgggtg gagttgcccc agctcagaac accaggaagc tgggatgcca
     4021 gtcatttcaa gatccactta ctaggaaagt ttgagattct gttgatcatt tgaaagtgca
     4081 ccttgcataa atccttcttt gacatactat tttttcatgc caataggcat gttgacgtga
     4141 acacaatgtt tccccatgct ggcttcccag gatcaatagt taggacagtc taataaggtt
     4201 ttgtctgtgt ttgacacaca gttccttctg catctagggg tgggtagaag ggtgccatgt
     4261 ggattaagcc atttaggcct ggggttgggg tgtagggata gttttccctt tacttcacac
     4321 acacatgttg agctccttcc tgttgcgtgt ggcgtctcac ccctgcccag ggtcacagcc
     4381 tcgttgctgt gaagcctttg aggttcctgt tcctattttt ttttttattt ttaatttatt
     4441 acgtattttc ctcaattaca tttccaatgc tatcccaaaa gtctcccata ccctcccccc
     4501 ccccccactt ccctccccac ccattcccat ttttttggcc ctggcgttcc cctgtactgg
     4561 ggcatataaa gtttacgttt taatctcttg cctcacctcc tctcggtttc ccttctttcc
     4621 tactagtatt atttttgaat gctctgaatg ctggttttta aaaaaaattg tctgaaacag
     4681 aaatgtattt tcagaataat tcacaaaagc gcaggtctca cactgaaact tcaactcctt
     4741 cttccccttt ctcctcctcc tcttctctga atgccaggga gaatgcagtt gaaggagatg
     4801 cgcagtcaca atgaccaact ctaaagacaa aagccctcag cattacgtat ccggttatgt
     4861 gaacagcttg actgagtagg gttaagatgt tgcagatgtc ctgcttcttt aaggtggctt
     4921 ttcagggctg ctcagggagg taaggatgga gtgcaagtgg gagacatctt tggcccactc
     4981 cctgagctta aggctaaagt cacacagttg tgcatccatt ttagggacag ctcatcagtg
     5041 tcctcatagt ggcagtgctg ccaggctgtt tgcctttgtt ttcttcagct gctcgctgtc
     5101 tcacgcacta cccttcagct ccattactgc tttcttccca cactgctgct tgctgccgag
     5161 acttggcatc aagggcttcc aagtgctctg tttgctcttc tctccattta gggatactcc
     5221 agtctctgat cgcagtagac ctgcttctga gatagccgaa taactgtttg ttggcccatt
     5281 actttcctgg tagtattcgc cattttcctt ccatcagcag catcagcagt tggtttatgt
     5341 tagcttttaa cacttgaggc tgtactttct tttatagaaa tgtgtgtaat ttttattttt
     5401 tcctaatgga tttaaactta taaatcatta aaactatttg tgcttgta
//
