LOCUS       NM_027088               3406 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus Brca1 associated protein 1 (Bap1), mRNA.
ACCESSION   NM_027088 XM_354802
VERSION     NM_027088.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3406)
  AUTHORS   Xu,L., Tan,C., Barr,J., Talaba,N., Verheyden,J., Chin,J.S.,
            Gaboyan,S., Kasaraneni,N., Elgamal,R.M., Gaulton,K.J., Lin,G.,
            Afshar,K., Golts,E., Meier,A., Crotty Alexander,L.E., Borok,Z.,
            Shen,Y., Chung,W.K., McCulley,D.J. and Sun,X.
  TITLE     Context-dependent roles of mitochondrial LONP1 in orchestrating the
            balance between airway progenitor versus progeny cells
  JOURNAL   Cell Stem Cell 31 (10), 1465-1483 (2024)
   PUBMED   39181129
REFERENCE   2  (bases 1 to 3406)
  AUTHORS   Schneider,S., Anderson,J.B., Bradley,R.P., Beigel,K., Wright,C.M.,
            Maguire,B.A., Yan,G., Taylor,D.M., Harbour,J.W. and Heuckeroth,R.O.
  TITLE     BAP1 is required prenatally for differentiation and maintenance of
            postnatal murine enteric nervous system
  JOURNAL   J Clin Invest 134 (9), e177771 (2024)
   PUBMED   38690732
  REMARK    GeneRIF: BAP1 is required prenatally for differentiation and
            maintenance of postnatal murine enteric nervous system.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3406)
  AUTHORS   Liang,Y., Wang,H., Seija,N., Lin,Y.H., Tung,L.T., Di Noia,J.M.,
            Langlais,D. and Nijnik,A.
  TITLE     B-cell intrinsic regulation of antibody mediated immunity by
            histone H2A deubiquitinase BAP1
  JOURNAL   Front Immunol 15, 1353138 (2024)
   PUBMED   38529289
  REMARK    GeneRIF: B-cell intrinsic regulation of antibody mediated immunity
            by histone H2A deubiquitinase BAP1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3406)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 3406)
  AUTHORS   Luo,S., Gong,J., Zhao,S., Li,M. and Li,R.
  TITLE     Deubiquitinase BAP1 regulates stability of BRCA1 protein and
            inactivates the NF-kappaB signaling to protect mice from
            sepsis-induced acute kidney injury
  JOURNAL   Chem Biol Interact 382, 110621 (2023)
   PUBMED   37414201
  REMARK    GeneRIF: Deubiquitinase BAP1 regulates stability of BRCA1 protein
            and inactivates the NF-kappaB signaling to protect mice from
            sepsis-induced acute kidney injury.
REFERENCE   6  (bases 1 to 3406)
  AUTHORS   Xu,J., Kadariya,Y., Cheung,M., Pei,J., Talarchek,J., Sementino,E.,
            Tan,Y., Menges,C.W., Cai,K.Q., Litwin,S., Peng,H., Karar,J.,
            Rauscher,F.J. and Testa,J.R.
  TITLE     Germline mutation of Bap1 accelerates development of
            asbestos-induced malignant mesothelioma
  JOURNAL   Cancer Res 74 (16), 4388-4397 (2014)
   PUBMED   24928783
  REMARK    GeneRIF: Drawing parallels to human disease, these unbiased genetic
            findings indicate that BAP1 mutation carriers are predisposed to
            the tumorigenic effects of asbestos and suggest that high
            penetrance of mesothelioma requires such environmental exposure.
REFERENCE   7  (bases 1 to 3406)
  AUTHORS   Dey,A., Seshasayee,D., Noubade,R., French,D.M., Liu,J.,
            Chaurushiya,M.S., Kirkpatrick,D.S., Pham,V.C., Lill,J.R.,
            Bakalarski,C.E., Wu,J., Phu,L., Katavolos,P., LaFave,L.M.,
            Abdel-Wahab,O., Modrusan,Z., Seshagiri,S., Dong,K., Lin,Z.,
            Balazs,M., Suriben,R., Newton,K., Hymowitz,S., Garcia-Manero,G.,
            Martin,F., Levine,R.L. and Dixit,V.M.
  TITLE     Loss of the tumor suppressor BAP1 causes myeloid transformation
  JOURNAL   Science 337 (6101), 1541-1546 (2012)
   PUBMED   22878500
  REMARK    GeneRIF: results identify a potent tumor suppressor function for
            BAP1 in myeloid neoplasia; propose that BAP1 forms a core complex
            with HCF-1 and OGT that can differentially recruit additional
            histone-modifying enzymes to regulate gene expression and preserve
            norm
REFERENCE   8  (bases 1 to 3406)
  AUTHORS   Misaghi,S., Ottosen,S., Izrael-Tomasevic,A., Arnott,D.,
            Lamkanfi,M., Lee,J., Liu,J., O'Rourke,K., Dixit,V.M. and
            Wilson,A.C.
  TITLE     Association of C-terminal ubiquitin hydrolase BRCA1-associated
            protein 1 with cell cycle regulator host cell factor 1
  JOURNAL   Mol Cell Biol 29 (8), 2181-2192 (2009)
   PUBMED   19188440
  REMARK    GeneRIF: Bap1 helps to control cell proliferation by regulating
            HCF-1 protein levels and by associating with genes involved in the
            G(1)-S transition
REFERENCE   9  (bases 1 to 3406)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   10 (bases 1 to 3406)
  AUTHORS   Jensen,D.E., Proctor,M., Marquis,S.T., Gardner,H.P., Ha,S.I.,
            Chodosh,L.A., Ishov,A.M., Tommerup,N., Vissing,H., Sekido,Y.,
            Minna,J., Borodovsky,A., Schultz,D.C., Wilkinson,K.D., Maul,G.G.,
            Barlev,N., Berger,S.L., Prendergast,G.C. and Rauscher,F.J. 3rd.
  TITLE     BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING
            finger and enhances BRCA1-mediated cell growth suppression
  JOURNAL   Oncogene 16 (9), 1097-1112 (1998)
   PUBMED   9528852
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK170576.1.
            
            On Apr 15, 2006 this sequence version replaced NM_027088.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK079374.1, AK170576.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3406              AK170576.1         2-3407
FEATURES             Location/Qualifiers
     source          1..3406
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="NOD"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 19.09 cM"
     gene            1..3406
                     /gene="Bap1"
                     /gene_synonym="2300006C11Rik; mKIAA0272; uch-x4"
                     /note="Brca1 associated protein 1"
                     /db_xref="GeneID:104416"
                     /db_xref="MGI:MGI:1206586"
     exon            1..166
                     /gene="Bap1"
                     /gene_synonym="2300006C11Rik; mKIAA0272; uch-x4"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..2316
                     /gene="Bap1"
                     /gene_synonym="2300006C11Rik; mKIAA0272; uch-x4"
                     /EC_number="3.4.19.12"
                     /note="ubiquitin C-terminal hydrolase X4; BRCA1-associated
                     protein 1"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase BAP1"
                     /protein_id="NP_081364.1"
                     /db_xref="CCDS:CCDS26910.1"
                     /db_xref="GeneID:104416"
                     /db_xref="MGI:MGI:1206586"
                     /translation="MNKGWLELESDPGLFTLLVEDFGVKGVQVEEIYDLQSKCQGPVY
                     GFIFLFKWIEERRSRRKVSTLVDDTSVIDDDIVNNMFFAHQLIPNSCATHALLSVLLN
                     CSNVDLGPTLSRMKDFTKGFSPESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGLS
                     AVRTMEAFHFVSYVPITGRLFELDGLKVYPIDHGPWGEDEEWTDKARRVIMERIGLAT
                     AGEPYHDIRFNLMAVVPDRRIKYETRLHVLKVNRQTVLEALQQLIRVTQPELIQTHKS
                     QESQLPEESKPASSKSPLGLEAGRTPVASECTQTDGAEEVAGSCPQTTTHSPPSKCKL
                     VVKPPGSSLNGVPPNPAPIVQRLPAFLDNHNYAKSPMQEEEDLAAGVGRSRVPVRAPQ
                     QYSEDEDDYEDEDEDVQNTNPAIRYKRKGTGKPGSLSNSSDGQLSVLQPNTINVLTEK
                     LQESQKDLSVPLSIKTSSGAGSPAVAVPTHSQPSPTPSNESTDTASEIGSAFNSPLRS
                     PIRSANPTRPSSPVTSHISKVLFGEDDSLLRVDCIRYNRAVRDLGPVISTGLLHLAED
                     GVLSPLALTEGGKGSSPSTRSSQGSQGSSGLEEKEVVEVTESRDKPGLNRSSEPLSGE
                     KYSPKELLALLKCVEAEIANYEACLKEEVEKRKKFKIDDQRRTHNYDEFICTFISMLA
                     QEGMLANLVEQNISVRRRQGVSIGRLHKQRKPDRRKRSRPYKAKRQ"
     exon            167..196
                     /gene="Bap1"
                     /gene_synonym="2300006C11Rik; mKIAA0272; uch-x4"
                     /inference="alignment:Splign:2.1.0"
     exon            197..251
                     /gene="Bap1"
                     /gene_synonym="2300006C11Rik; mKIAA0272; uch-x4"
                     /inference="alignment:Splign:2.1.0"
     exon            252..384
                     /gene="Bap1"
                     /gene_synonym="2300006C11Rik; mKIAA0272; uch-x4"
                     /inference="alignment:Splign:2.1.0"
     exon            385..504
                     /gene="Bap1"
                     /gene_synonym="2300006C11Rik; mKIAA0272; uch-x4"
                     /inference="alignment:Splign:2.1.0"
     exon            505..566
                     /gene="Bap1"
                     /gene_synonym="2300006C11Rik; mKIAA0272; uch-x4"
                     /inference="alignment:Splign:2.1.0"
     exon            567..709
                     /gene="Bap1"
                     /gene_synonym="2300006C11Rik; mKIAA0272; uch-x4"
                     /inference="alignment:Splign:2.1.0"
     exon            710..788
                     /gene="Bap1"
                     /gene_synonym="2300006C11Rik; mKIAA0272; uch-x4"
                     /inference="alignment:Splign:2.1.0"
     exon            789..912
                     /gene="Bap1"
                     /gene_synonym="2300006C11Rik; mKIAA0272; uch-x4"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1060
                     /gene="Bap1"
                     /gene_synonym="2300006C11Rik; mKIAA0272; uch-x4"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1245
                     /gene="Bap1"
                     /gene_synonym="2300006C11Rik; mKIAA0272; uch-x4"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1376
                     /gene="Bap1"
                     /gene_synonym="2300006C11Rik; mKIAA0272; uch-x4"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1855
                     /gene="Bap1"
                     /gene_synonym="2300006C11Rik; mKIAA0272; uch-x4"
                     /inference="alignment:Splign:2.1.0"
     exon            1856..2016
                     /gene="Bap1"
                     /gene_synonym="2300006C11Rik; mKIAA0272; uch-x4"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2109
                     /gene="Bap1"
                     /gene_synonym="2300006C11Rik; mKIAA0272; uch-x4"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2182
                     /gene="Bap1"
                     /gene_synonym="2300006C11Rik; mKIAA0272; uch-x4"
                     /inference="alignment:Splign:2.1.0"
     exon            2183..3406
                     /gene="Bap1"
                     /gene_synonym="2300006C11Rik; mKIAA0272; uch-x4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3385..3390
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bap1"
                     /gene_synonym="2300006C11Rik; mKIAA0272; uch-x4"
                     /note="putative"
     polyA_site      3406
                     /gene="Bap1"
                     /gene_synonym="2300006C11Rik; mKIAA0272; uch-x4"
                     /note="putative"
ORIGIN      
        1 gagtgacgcg gcgcggcccg ttgtctgtgc ggggctgaga agccctaagg gcggtgggcg
       61 ctcccggttg ggggcggcgc gggtttagca gggcctggac atggcgctga gaggccgctc
      121 cgcgggaaga tgaataaggg ctggctggag ctggagagtg acccaggcct cttcaccctc
      181 ctggtggaag atttcggtgt caaaggggtg caagtggagg agatctatga ccttcagagt
      241 aaatgccagg ggcctgtgta tggatttatc ttcctgttca aatggatcga agagcgcagg
      301 tcccgccgca aggtttctac gttggtggat gacacgtctg tgattgatga tgatattgtg
      361 aataacatgt tctttgctca ccagctgatt cccaactctt gtgccactca cgccttgcta
      421 agcgtgcttc tgaactgcag caatgtggat ctggggccca cgctgagccg aatgaaggat
      481 ttcaccaaag gcttcagtcc tgagagcaaa ggatatgcaa ttggcaatgc ccctgaactg
      541 gccaaggcac ataatagcca tgccaggcca gaaccacgtc accttcctga gaaacagaat
      601 ggcctcagtg cagtgcggac catggaggcg tttcattttg tcagctatgt gcctatcaca
      661 gggaggctct ttgaattgga tggattgaaa gtctacccaa ttgatcatgg gccctgggga
      721 gaggacgagg agtggacaga taaagctcga agggtcatca tggagcgaat cggtcttgct
      781 actgcagggg agccctatca tgacattcgc ttcaacctga tggcagtggt gcctgaccgc
      841 aggattaagt atgagaccag gctacatgta ctgaaggtga accgacaaac agtcctggag
      901 gccctgcagc agctgattag agtaacccag ccggagctga ttcagaccca caaatctcaa
      961 gagtcacagc tgcctgagga gagcaagcca gccagcagca agtcccccct tggactggag
     1021 gcaggcagaa ccccagtggc ctctgagtgc actcagacag atggtgcaga ggaggtggct
     1081 ggttcgtgcc cacaaactac aacccatagt cctcccagca aatgtaagct ggtggtgaag
     1141 cctccaggga gcagcctcaa tggggttccc ccaaaccctg cccctattgt ccagcggctg
     1201 ccagccttcc tagacaatca caattatgcc aaatccccta tgcaggagga ggaagacctg
     1261 gcggcaggag tgggtcgcag ccgcgttccc gtccgagcgc cccagcagta ctctgaagac
     1321 gaggatgact acgaggatga ggacgaggac gtgcagaaca ccaaccctgc catcagatac
     1381 aagcggaagg ggacagggaa gccaggatcg ttgagcaatt cttcagatgg gcagctgtca
     1441 gtgctgcagc ccaacaccat caatgtctta actgagaagc ttcaagagtc tcagaaagac
     1501 ctttcagttc ctctgtccat caagactagc agtggggctg ggagtccagc tgtggctgtg
     1561 cccacacact cgcaaccttc acccacccct agcaatgaga gcacggacac agcctctgag
     1621 attggcagtg ctttcaactc acccttgcgc tcgcccatcc gctcggccaa cccaacacgg
     1681 ccctctagcc ctgtcacctc tcacatctcc aaggtgcttt ttggagaaga tgacagccta
     1741 cttcgtgttg actgcatacg ctacaaccgt gctgtccgtg acctgggtcc tgtcattagc
     1801 acgggcctgc tgcaccttgc tgaagatggt gtactgagtc ccctggcact cacagagggt
     1861 gggaagggtt cctcaccttc taccagatca agccaaggca gccaggggtc cagtggccta
     1921 gaggagaagg aggtggtgga agtcacagag agcagagaca agcctgggct gaacaggtcc
     1981 agtgagccct tgagtggaga gaagtactca cccaaggagc tgctagcact gctaaagtgt
     2041 gtagaagccg agattgcaaa ctatgaggcc tgtctcaagg aggaggtgga gaaaaggaag
     2101 aagttcaaga ttgatgacca gcgaaggacc cacaactatg acgagtttat ctgtaccttc
     2161 atatccatgc tggctcagga aggaatgctg gccaacctag tggaacagaa catctcagtg
     2221 cgccggcgcc aaggggtcag cattgggcgg cttcacaagc agcggaagcc tgaccggcgg
     2281 aaacgctctc gcccctacaa ggccaaacgc cagtgagaac ctctggccct gactctgcag
     2341 cctctcttgc cgcaaggccc tcatcagggc ccttcactgt ccctcttttc caagtattac
     2401 tgagtagttc aacgagagcc caggtcctgg gagtgggagt gacatgtatt ctgcactgtg
     2461 ctctggggtc tggcagggac aaggcagctc ctcaatgctc aggaagcagc agctggaact
     2521 ggagggcatc caccatggcc tccacagcca tctgaggagc agcaggacct ggcctttctg
     2581 cctgggcagc aggatgtaca ttctacctat tggagatgtt taggttttgg gcttttgtcc
     2641 atcttgccac tgtattaaca tggcagcttc ctgactctgc tgtctctccc agcagctgtc
     2701 attctgctgg gccaggtctc ttagaataca tcacagtccc agctgagaaa cacaccacca
     2761 ctagcctgtc ctcgttggga agaagcttgg cctacacttc attcctctgg gagagcacca
     2821 aactcaggga cctggctgct gagctggaat gggcatgggg tatcctaata ggatgtacag
     2881 cctatcaggg tcccacggct atagtggaga caagtgtttg aactgtccca gtggcatgca
     2941 gactgtcctg ttagtgagtc agagcaaggc tctggggctc tttgccttca gtgttgtggc
     3001 cctggccatg ggtctgcctt aggctcctaa tctctgtctc tggggcccag gggagcctcg
     3061 acctagcccc tcagtattac catgtcttct cttaggaata tcagaggcag ggctgcttga
     3121 atggagctgg tactattcaa ttctcccgac tgtgccagct tccttgtcct cttgcaaggt
     3181 actcagggta gggacagggt tgagaggagt tagaacttct gtatccccat agggcttggt
     3241 agtaagtaca gcactgcttc aaaatccagc ccccaaaagc cctgtaccct ctgctagata
     3301 caggcgatcc aagcaggccc cttatctgta catagtgact gtaggggacc cctctagttt
     3361 ctgtaaatat tgaatcagtg agtgaataaa aatgtgctaa taaatg
//
