LOCUS       NM_016812               5498 bp    mRNA    linear   ROD 02-JUL-2024
DEFINITION  Mus musculus BTG3 associated nuclear protein (Banp), transcript
            variant 2, mRNA.
ACCESSION   NM_016812
VERSION     NM_016812.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5498)
  AUTHORS   Huang,Z., Zhang,R., Teng,Y., Guo,J., Zhang,H., Wang,L., Tang,L.V.,
            Shi,W., Wu,Q. and Xia,L.
  TITLE     Nuclear Matrix-associated Protein SMAR1 Attenuated Acute
            Graft-versus-host Disease by Targeting JAK-STAT Signaling in CD4 +
            T Cells
  JOURNAL   Transplantation 108 (3), e23-e35 (2024)
   PUBMED   37817309
  REMARK    GeneRIF: Nuclear Matrix-associated Protein SMAR1 Attenuated Acute
            Graft-versus-host Disease by Targeting JAK-STAT Signaling in CD4 +
            T Cells.
REFERENCE   2  (bases 1 to 5498)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5498)
  AUTHORS   Bao,P., Li,P., Zhou,X., Zhang,H., You,S., Xu,Z. and Wu,Q.
  TITLE     SMAR1 inhibits proliferation, EMT and Warburg effect of bladder
            cancer cells by suppressing the activity of the Wnt/beta-catenin
            signaling pathway
  JOURNAL   Cell Cycle 22 (2), 229-241 (2023)
   PUBMED   35980125
  REMARK    GeneRIF: SMAR1 inhibits proliferation, EMT and Warburg effect of
            bladder cancer cells by suppressing the activity of the
            Wnt/beta-catenin signaling pathway.
REFERENCE   4  (bases 1 to 5498)
  AUTHORS   Pant,R., Alam,A., Choksi,A., Shah,V.K., Firmal,P. and
            Chattopadhyay,S.
  TITLE     Chromatin remodeling protein SMAR1 regulates adipogenesis by
            modulating the expression of PPARgamma
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1866 (12), 159045 (2021)
   PUBMED   34450266
  REMARK    GeneRIF: Chromatin remodeling protein SMAR1 regulates adipogenesis
            by modulating the expression of PPARgamma.
REFERENCE   5  (bases 1 to 5498)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5498)
  AUTHORS   Jalota-Badhwar,A., Kaul-Ghanekar,R., Mogare,D., Boppana,R.,
            Paknikar,K.M. and Chattopadhyay,S.
  TITLE     SMAR1-derived P44 peptide retains its tumor suppressor function
            through modulation of p53
  JOURNAL   J Biol Chem 282 (13), 9902-9913 (2007)
   PUBMED   17229733
  REMARK    GeneRIF: A short SMAR1 peptide efficiently activates p53 protein by
            mediating its phosphorylation at serine 15, resulting in the
            activation of p21 and in effect regulating cell cycle checkpoint.
REFERENCE   7  (bases 1 to 5498)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   8  (bases 1 to 5498)
  AUTHORS   Kaul-Ghanekar,R., Majumdar,S., Jalota,A., Gulati,N., Dubey,N.,
            Saha,B. and Chattopadhyay,S.
  TITLE     Abnormal V(D)J recombination of T cell receptor beta locus in SMAR1
            transgenic mice
  JOURNAL   J Biol Chem 280 (10), 9450-9459 (2005)
   PUBMED   15623522
REFERENCE   9  (bases 1 to 5498)
  AUTHORS   Chattopadhyay,S., Kaul,R., Charest,A., Housman,D. and Chen,J.
  TITLE     SMAR1, a novel, alternatively spliced gene product, binds the
            Scaffold/Matrix-associated region at the T cell receptor beta locus
  JOURNAL   Genomics 68 (1), 93-96 (2000)
   PUBMED   10950932
REFERENCE   10 (bases 1 to 5498)
  AUTHORS   Birot,A., Duret,L., Bartholin,L., Santalucia,B., Tigaud,I.,
            Magaud,J. and Rouault,J.
  TITLE     Identification and molecular analysis of BANP
  JOURNAL   Gene 253 (2), 189-196 (2000)
   PUBMED   10940556
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX207431.1, BC062641.1 and AC116772.6.
            
            On Oct 26, 2013 this sequence version replaced NM_016812.3.
            
            Transcript Variant: This variant (2) represents the longest
            transcript and encodes the longest protein (isoform 2).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062641.1, SRR10223969.8518.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                CX207431.1         1-55
            56-2192             BC062641.1         1-2137
            2193-5498           AC116772.6         198826-202131
FEATURES             Location/Qualifiers
     source          1..5498
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 70.82 cM"
     gene            1..5498
                     /gene="Banp"
                     /gene_synonym="SMAR1"
                     /note="BTG3 associated nuclear protein"
                     /db_xref="GeneID:53325"
                     /db_xref="MGI:MGI:1889023"
     exon            1..157
                     /gene="Banp"
                     /gene_synonym="SMAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            158..296
                     /gene="Banp"
                     /gene_synonym="SMAR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             227..1873
                     /gene="Banp"
                     /gene_synonym="SMAR1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     protein BANP; scaffold/matrix-associated region-1-binding
                     protein"
                     /codon_start=1
                     /product="protein BANP isoform 2"
                     /protein_id="NP_058092.2"
                     /db_xref="CCDS:CCDS40502.1"
                     /db_xref="GeneID:53325"
                     /db_xref="MGI:MGI:1889023"
                     /translation="MMSEQDLADVVQIAVEDLSPDHPVVLENHVVTDDDEPALKRQRL
                     EINCQDPSIKSFLYSINQTICLRLDSIEAKLQALEATCKSLEEKLDLVTNKQHSPIQV
                     PMVAGSPLGATQTCNKVRCVVPQTTVILNNDRQNAIVAKMEDPLSNRAPDSLENIISN
                     AVPGRRQNTIVVKVPGQDDSHNEDGESGSEASDSVSNCGQPGSQNIGSNVTLITLNSE
                     EDYPNGTWLGDENNPEMRVRCAIIPSDMLHISTNCRTAEKMALTLLDYLFHREVQAVS
                     NLSGQGKHGKKQLDPLTIYGIRCHLFYKFGITESDWYRIKQSIDSKCRTAWRRKQRGQ
                     SLAVKSFSRRTPSSSSYSASETMMGTPPPTSELQQSQPQALHYALANAQQVQIHQIGE
                     DGQVQVIPQGHLHIAQVPQGEQVQITQDSEGNLQIHHVGQDGQSWGLCQNPIPVSGDS
                     VAQANPSQLWPLGGDTLDLPAGNEMIQVLQGAQLIAVASSDPAATGVDGSPLQGSDIQ
                     VQYVQLAPVSDHTAAAQTAEALQPTLQPDMQLEHGAIQIQ"
     exon            297..388
                     /gene="Banp"
                     /gene_synonym="SMAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            389..588
                     /gene="Banp"
                     /gene_synonym="SMAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            589..705
                     /gene="Banp"
                     /gene_synonym="SMAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            706..881
                     /gene="Banp"
                     /gene_synonym="SMAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1121
                     /gene="Banp"
                     /gene_synonym="SMAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1289
                     /gene="Banp"
                     /gene_synonym="SMAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1420
                     /gene="Banp"
                     /gene_synonym="SMAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1492
                     /gene="Banp"
                     /gene_synonym="SMAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1531
                     /gene="Banp"
                     /gene_synonym="SMAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1657
                     /gene="Banp"
                     /gene_synonym="SMAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1801
                     /gene="Banp"
                     /gene_synonym="SMAR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1802..5498
                     /gene="Banp"
                     /gene_synonym="SMAR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2396..2401
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Banp"
                     /gene_synonym="SMAR1"
                     /note="hexamer: AATAAA"
     polyA_site      2416
                     /gene="Banp"
                     /gene_synonym="SMAR1"
                     /note="major polyA site"
     regulatory      5473..5478
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Banp"
                     /gene_synonym="SMAR1"
                     /note="hexamer: AATAAA"
     polyA_site      5497
                     /gene="Banp"
                     /gene_synonym="SMAR1"
ORIGIN      
        1 cttgagccgg gagcccaggg agcctgcgct gagggcgggg cgcaggccgt ggggaggcgc
       61 tcgcggcgcc tgcgcagagc ggctgcttct ctcgcgagga cggacgccat tatcgcagct
      121 ccccgacaaa caccacgaga attccgcagc ccacacggtg acagaaaccg cataccctgt
      181 gacttctgga ctcttgctgt cagtgtgccc cttcctcgtg ctctggatga tgtcagagca
      241 ggacctggcg gatgtggttc agattgcagt ggaagacctg agccctgatc acccagttgt
      301 tttggagaat catgtcgtga cagatgatga tgaacctgcc ttgaagcgcc agcgactaga
      361 gatcaattgc caggacccct ctataaagtc tttcctgtac tctattaacc agacgatatg
      421 tttgcggttg gatagcattg aggccaagct gcaagctctc gaggccactt gcaaatctct
      481 ggaagagaag ctagacctgg tcaccaataa acagcacagt cccatccagg tccccatggt
      541 ggcaggttcc ccacttggcg ccacccagac ctgcaacaaa gtgcgatgcg tcgtccccca
      601 gactacagta atactcaaca atgatcggca gaacgccatt gtagccaaga tggaagaccc
      661 attgagcaac agggcaccgg attccctgga aaatatcatt agcaacgctg ttcctgggcg
      721 tcggcagaac accatcgtgg tgaaagtgcc tggtcaggac gacagccaca acgaagatgg
      781 ggagagcggg tcagaggcca gtgactccgt gtctaactgt ggccagccag gaagccagaa
      841 cattggaagc aacgtcacac tcatcaccct gaactccgaa gaggactatc ccaatggcac
      901 ctggctgggc gatgagaata accctgagat gcgggtacgc tgtgccatca tcccttccga
      961 catgttgcac atcagcacca actgtcgcac ggccgagaag atggcgctga cactgctgga
     1021 ctacctgttc caccgtgagg tgcaggctgt gtccaacttg tccggccagg gcaagcacgg
     1081 gaagaagcag ctggaccccc tcaccatcta cggcatccgg tgtcacctct tctataaatt
     1141 tggaatcacg gaatctgact ggtatcggat caagcagagc attgactcca agtgccggac
     1201 agcctggcgg cggaagcagc gaggccagag cctggcggtc aagagcttct ctcggaggac
     1261 gccatcctca tcctcttaca gtgcctcaga gaccatgatg ggaacccctc ctcccaccag
     1321 tgagctacag cagtcacagc cacaggccct acactacgcc ctggccaacg cccagcaggt
     1381 ccagatccac cagattgggg aggatggaca ggtgcaagta atcccacagg gccacctcca
     1441 cattgcccag gtgcctcaag gggagcaggt gcagatcaca caggacagcg agggcaatct
     1501 gcagatccat catgtgggtc aggatggcca gtcgtggggc ctgtgccaga atcccattcc
     1561 tgtcagcggt gactcagtgg cccaggctaa tccctcccag ctttggcctc tgggaggaga
     1621 cacacttgat ctgcctgctg gaaatgaaat gatccaggta ctgcagggtg ctcagctcat
     1681 agccgtggcc tcttcagacc ctgctgctac aggagtagat gggtcgcctc tccagggcag
     1741 tgacattcag gttcagtatg tccagctggc gcctgtgagt gaccacacag ccgcagcgca
     1801 gaccgcagag gccctgcagc ccactctgca gcccgacatg cagcttgaac atggggccat
     1861 ccagatccag tgaggccagg cactgcagga gcaccgcgtc acagctgctc gctgaccctg
     1921 ccccactcgt gccctgctct cttgcttcag caagcaactg caggttctgc tgggcatctg
     1981 agagctgctc ctcccagggg aaggtcctgg ccacccctgc tggaaggcgc ctcagggttg
     2041 gagtctcact actggtcgtc tccaaaggag aagcatagtg cagagtgttg agtgcattca
     2101 gacagacaag aactacgata ttttgtttaa acagcttttt taatttgcta tggtgtttat
     2161 aacaaaaaag aaaatggaaa aaaaaaaaaa aacaaaaaca tccaaccaac caaccaacca
     2221 accaaaccag aggagaaaca caactgtgga gtagtgaaag cctgggccgt gtgctcccct
     2281 tcggggttct gacgtaggtg ttggagccag ctggcgatgc tggagcactt ggacctgctg
     2341 ctaggggagt gctccccagg gagtgctccc cagtgtgagt atgcatttct aatgaaataa
     2401 agtgtattta tggccacaga ggctcagtgt tgttgcaccg tgagaggact tccccatcca
     2461 gggccatgct accagagagt ccctgctttg gctctctctc ctagggagca tgagctgtgg
     2521 gtatcccttg gggcagctgg ctcccacttc atcacagtga gccctcaaag gcaaggtcat
     2581 tgtaacccat cctcttctga atgcttaggc tccattacct gcaacgccag gggtcctgga
     2641 gagtgccgtg tggagaaggc aggactgcag agaaagcagg tgcaaggagt cccatgagca
     2701 gcatgggaaa tgccagtgaa gtccttactg actgacagtg ccgtgtttga cgctttcctg
     2761 ggaggatttc aaagttgtcc cagattctgt ctcatgcctc tgtctcatgc caccacatta
     2821 agaattcctg ggctggttat tcaccagggc acactgaggt agcagaggag agcagctcta
     2881 tggaaaggac aatttgacat ggtggtggcc atcttcttag gagacctgcc actgttagag
     2941 atggctctgt gtggggaaaa tggggacagg cgtggaggct gggttcccaa ggctgtgtaa
     3001 cacatctggg caggatccca ggcaagaatg gagaagaaga atccagagag gagagcacac
     3061 tccaggaaga gcatggcata ggcccatacc cagatacaca agatgggtga tggcagcaga
     3121 cctgtgccct ggaggtcaga gtactggaaa ggaactactt ccagctgagt caggtcttca
     3181 gaaaacatgt tcagaaagct agttgacaat gtaccatacg atggaccctg caggtgtgga
     3241 tcccaggaat gccctgtgtc cgtacacacc tgtgtgccca cattcgcagt agccccattc
     3301 ataatgagct gaggtggaaa tggcctaaag accgagcata tgagcaggtg agcaaaggca
     3361 cacctcttgg tatcggtatc gagggtgagc tgactgccag aggatctgca ctccggcccg
     3421 ctctatggca tgtgaacttg cagacgctag tgagggaaag aaagcagagg gaaggagaca
     3481 gcttaccgga agatgatatg gatgggagga ttcacagaga cagattgtca ggatcatgca
     3541 tcctgcgggg cactgaaact gcgcccggtt ggacagtgga tatttgtctt gcacaccagg
     3601 taatgaccgg tcactcgaaa aggtgaaaca gtcgctgtcc acgaatgctc aaggttattt
     3661 ttgataaatg gatcacattt ggcaagaaca aaaattgaga ttatgcgcta aagatgctca
     3721 caaaaagggg attccagggg attttcaagg ctaggaatgt aggcccagat ggaagttctc
     3781 cagcaagaga ccactggacc acttggaaca gaaaaggatc ttaagtgatc tatataaaat
     3841 tgactctcta agattaaaga catcaaaaca gaggaaaaca tgactatctc ggggcgggca
     3901 agaagagaag taaattattt taaagtattc ttcattgcct tgaagaaaac agaaagttcc
     3961 gtgttcagcc ttcagtatct gagagctgta tagagacctg tcactgttgg tacacaatgc
     4021 ttgctcgcat ggctggtagc cctggccttg tccttgtagg acatgaccca gcagcttgag
     4081 aaaggtctgt tcttagatgt tctctgaggc attgctaaag aactttgctt gccacaggct
     4141 ctgagccatg ttgtgtgttc tctgaccaca tggaattgag gtagatttta atgaggaaaa
     4201 aacttcccat aggtcaagta aaaaaaactt ggattcatga agatgacgtc attgaatgac
     4261 atatgtcaaa atgtggactg catcaggtgt gctgaggaac agctgcagac aagcttgggg
     4321 tggagaatta cgtcgtctcc atccaaagga caaaagcagt gttggtgctc agggaggatt
     4381 acagatagag gagttccatg tataacaatg ttcagttgat gaagtcctgg taccagaagg
     4441 gtgaaggcta caagctgcca ttgtgggcgt ctccacagac gccctcaggc agtagaagat
     4501 gaggttctcc cagatctgta tggatggatc gggaaatgac agatgggatg acatgctgcc
     4561 tggacaccag actcgggtgg gggcagcagg agaaggaagg aggaaagaag aaaagaaaga
     4621 ttgttgttgc ttctgaatgt ctgagctgtc tcagagcaag aacaggctgt gcttggtggc
     4681 aacaagtgat gtgtcaccct accccaggtt gagtcaggtt cagtcatgca tacttggtat
     4741 attttgaaag tcatgtgact taactctggt aataggacca tgtggttatc ttaagcagaa
     4801 aaatagtatg taaaatttac ctgtttatag ttaagagacc tttcagcaaa atcacaatag
     4861 atcggatcag agacatctgt aagaaacctg tgacaaatat cccagaactt ggatttggaa
     4921 agcctggcat gacaaatgaa gatgcctggc accttggtta ttctgagatt ggaaagctag
     4981 gaatgagact gtctatataa tttggattta gacacctgat ggctatccca cacactgacc
     5041 caaaaacctg cgagtgtgct ttgcctgggt gctggctaca ggctacttag aaatcactcc
     5101 catctcaatc agaatgggct cgggtgctct tagctgctgt ttattacaga ctctaagacg
     5161 ctttaaccca cagaagtaaa tttaagggga tgctgaggca aatgttactg aactagagaa
     5221 aaaccaagaa aaaacctcat ctgagaaagt gtgggttctc taaatggtgc agccagtgag
     5281 gttccatgca gaagctaagc agggactcct gtggcactgg acaagtaatg gggactggtt
     5341 ggagagatgg ctcagtggtt agacttcttt ctgctttccc ctccacagtg gggagagctc
     5401 actgcctgta acccgatgcc cctttgattc cccacactcc tcccactccc agggcagacg
     5461 tacacgcaca ggaataaaaa taaatcttta agaatgac
//
