LOCUS       NM_001033350            3268 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus B cell scaffold protein with ankyrin repeats 1
            (Bank1), transcript variant 1, mRNA.
ACCESSION   NM_001033350 XM_143587
VERSION     NM_001033350.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3268)
  AUTHORS   Georg,I., Diaz-Barreiro,A., Morell,M., Pey,A.L. and
            Alarcon-Riquelme,M.E.
  TITLE     BANK1 interacts with TRAF6 and MyD88 in innate immune signaling in
            B cells
  JOURNAL   Cell Mol Immunol 17 (9), 954-965 (2020)
   PUBMED   31243359
  REMARK    GeneRIF: BANK1 interacts with TRAF6 and MyD88 in innate immune
            signaling in B cells.
REFERENCE   2  (bases 1 to 3268)
  AUTHORS   Alkaissi,H., Havarinasab,S., Nielsen,J.B., Soderkvist,P. and
            Hultman,P.
  TITLE     Bank1 and NF-kappaB as key regulators in anti-nucleolar antibody
            development
  JOURNAL   PLoS One 13 (7), e0199979 (2018)
   PUBMED   30016332
  REMARK    GeneRIF: Bank1 and NF-kappaB as key regulators in anti-nucleolar
            antibody development
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3268)
  AUTHORS   Yang,J., Ren,J., Yang,Y., Sun,J., Zhou,X., Zheng,S., Xuan,D.,
            Xue,Y., Fan,H., Zhang,J., Zou,H., Wan,W. and Kong,N.
  TITLE     BANK1 alters B cell responses and influences the interactions
            between B cells and induced T regulatory cells in mice with
            collagen-induced arthritis
  JOURNAL   Arthritis Res Ther 20 (1), 9 (2018)
   PUBMED   29370826
  REMARK    GeneRIF: B cell responses were enhanced due to decreased B cell
            scaffold protein with ankyrin repeats 1 (BANK1) levels in
            collagen-induced arthritis (CIA) mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3268)
  AUTHORS   Hiratsuka,T., Takei,Y., Ohmori,R., Imai,Y., Ozeki,M., Tamaki,K.,
            Haga,H., Nakamura,T. and Tsuruyama,T.
  TITLE     ZFP521 contributes to pre-B-cell lymphomagenesis through modulation
            of the pre-B-cell receptor signaling pathway
  JOURNAL   Oncogene 35 (25), 3227-3238 (2016)
   PUBMED   26522721
  REMARK    GeneRIF: The pre-B-cell receptor (pre-BCR) signaling molecules
            BLNK, BTK and BANK1 were positively regulated by the ZFP521 gene,
            leading to enhancement of the pre-BCR signaling pathway.
REFERENCE   5  (bases 1 to 3268)
  AUTHORS   Wu,Y.Y., Kumar,R., Iida,R., Bagavant,H. and Alarcon-Riquelme,M.E.
  TITLE     BANK1 Regulates IgG Production in a Lupus Model by Controlling
            TLR7-Dependent STAT1 Activation
  JOURNAL   PLoS One 11 (5), e0156302 (2016)
   PUBMED   27228057
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3268)
  AUTHORS   Kozyrev,S.V., Abelson,A.K., Wojcik,J., Zaghlool,A., Linga
            Reddy,M.V., Sanchez,E., Gunnarsson,I., Svenungsson,E., Sturfelt,G.,
            Jonsen,A., Truedsson,L., Pons-Estel,B.A., Witte,T., D'Alfonso,S.,
            Barizzone,N., Danieli,M.G., Gutierrez,C., Suarez,A., Junker,P.,
            Laustrup,H., Gonzalez-Escribano,M.F., Martin,J., Abderrahim,H. and
            Alarcon-Riquelme,M.E.
  TITLE     Functional variants in the B-cell gene BANK1 are associated with
            systemic lupus erythematosus
  JOURNAL   Nat Genet 40 (2), 211-216 (2008)
   PUBMED   18204447
  REMARK    Erratum:[Nat Genet. 2008 Apr;40(4):484. Barrizzone, Nadia
            [corrected to Barizzone, Nadia]]
REFERENCE   7  (bases 1 to 3268)
  AUTHORS   Aiba,Y., Yamazaki,T., Okada,T., Gotoh,K., Sanjo,H., Ogata,M. and
            Kurosaki,T.
  TITLE     BANK negatively regulates Akt activation and subsequent B cell
            responses
  JOURNAL   Immunity 24 (3), 259-268 (2006)
   PUBMED   16546095
  REMARK    GeneRIF: BANK attenuates CD40-mediated Akt activation, thereby
            preventing hyperactive B cell responses.
REFERENCE   8  (bases 1 to 3268)
  AUTHORS   Dalton,T.P., He,L., Wang,B., Miller,M.L., Jin,L., Stringer,K.F.,
            Chang,X., Baxter,C.S. and Nebert,D.W.
  TITLE     Identification of mouse SLC39A8 as the transporter responsible for
            cadmium-induced toxicity in the testis
  JOURNAL   Proc Natl Acad Sci U S A 102 (9), 3401-3406 (2005)
   PUBMED   15722412
REFERENCE   9  (bases 1 to 3268)
  AUTHORS   Papin,J. and Subramaniam,S.
  TITLE     Bioinformatics and cellular signaling
  JOURNAL   Curr Opin Biotechnol 15 (1), 78-81 (2004)
   PUBMED   15102471
  REMARK    Review article
REFERENCE   10 (bases 1 to 3268)
  AUTHORS   Yokoyama,K., Su Ih,I.H., Tezuka,T., Yasuda,T., Mikoshiba,K.,
            Tarakhovsky,A. and Yamamoto,T.
  TITLE     BANK regulates BCR-induced calcium mobilization by promoting
            tyrosine phosphorylation of IP(3) receptor
  JOURNAL   EMBO J 21 (1-2), 83-92 (2002)
   PUBMED   11782428
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC101978.6, BY235799.1, AK041242.1, BY107051.1, AK041071.1,
            AA177599.1, BE848854.1, AK041039.1, AA178225.1 and AA175345.1.
            
            On Jul 18, 2015 this sequence version replaced NM_001033350.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY178734.1, AK156201.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AC101978.6         87175-87194         c
            21-61               BY235799.1         3-43
            62-314              AK041242.1         3-255
            315-474             BY107051.1         180-339
            475-1283            AK041242.1         416-1224
            1284-1330           AK041071.1         522-568
            1331-1690           AK041242.1         1272-1631
            1691-1994           AA177599.1         206-509
            1995-2108           BE848854.1         128-241
            2109-2759           AK041039.1         107-757
            2760-3046           AA178225.1         106-392
            3047-3268           AA175345.1         72-293
FEATURES             Location/Qualifiers
     source          1..3268
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 63.04 cM"
     gene            1..3268
                     /gene="Bank1"
                     /gene_synonym="A530094C12Rik; AVIEF; BANK"
                     /note="B cell scaffold protein with ankyrin repeats 1"
                     /db_xref="GeneID:242248"
                     /db_xref="MGI:MGI:2442120"
     exon            1..197
                     /gene="Bank1"
                     /gene_synonym="A530094C12Rik; AVIEF; BANK"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..2479
                     /gene="Bank1"
                     /gene_synonym="A530094C12Rik; AVIEF; BANK"
                     /note="isoform 1 is encoded by transcript variant 1;
                     B-cell scaffold protein with ankyrin repeats 1 delta 2
                     transcript"
                     /codon_start=1
                     /product="B-cell scaffold protein with ankyrin repeats
                     isoform 1"
                     /protein_id="NP_001028522.2"
                     /db_xref="CCDS:CCDS38645.1"
                     /db_xref="GeneID:242248"
                     /db_xref="MGI:MGI:2442120"
                     /translation="MLPVASGTRGSTQDLFQVGLAPPGNAKDILLLYEEDAEEWALYL
                     REIFMRVVEREAILLYPLHSFSSSHLEMLNFYAYKCKLLIISNSLLKDLTPKKCQFLE
                     KILHSTGNVVTLLCGMESSDPFYQLLSIPRKRWEISTEQDPDGYISVIRQILDQGPED
                     YLEVSIPTDSRAKYPEDTSGQKGTDVLASLRPSVPRVLVLPGEIPCEKPGEIFILLKD
                     ELIGEILEVEFISTNKRLRARPARWNKSVWHMKAADFPAGSVTVNIHCDGIIKATTEI
                     KYCSAAKATESPFRVSDPGKSLCQKSIEELDNVLASIFKREIPYYEFKHLQAETYPQK
                     ERTHTTELPTLLHCAAKFGLKNLALHLLQCSGATRAARMKATDGSDLLHIAERHGHEE
                     LKEVFEDFLSQNTGRNSKQENDYEEDVISFSTYSPSMPSPASLHELRKTHRRNTDRSE
                     EPERSVEMKEEEAGAEARRSLSEGERESSENQYDDLYVFIPGFDTEGNSEEPLPHCRP
                     PLLPPRPGTAASQLERPHFTSQGKVLEDQMERSQNWNDLNARPETREESSREEKKEEA
                     QEEEEEEENPYAFAETEDNEYDLILASKSVKKRTGNRSFIINRPPAPTPRPTHIPPKE
                     ETTPYIAQVFQQKAARRQSDGDKFYSLPKKPDKTRMEGPTFPSTRDYLTTGQEELILL
                     QERVKNGKMSVDEALEKFKHWQMGKSGLEMIQQEKLRQLRDNIIGKRPEDENAYDKLT
                     IVHHPSGNTAHNENMLYNSPFNSKFPARIQVEKEFGFCCKKDH"
     exon            198..596
                     /gene="Bank1"
                     /gene_synonym="A530094C12Rik; AVIEF; BANK"
                     /inference="alignment:Splign:2.1.0"
     exon            597..748
                     /gene="Bank1"
                     /gene_synonym="A530094C12Rik; AVIEF; BANK"
                     /inference="alignment:Splign:2.1.0"
     exon            749..887
                     /gene="Bank1"
                     /gene_synonym="A530094C12Rik; AVIEF; BANK"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1027
                     /gene="Bank1"
                     /gene_synonym="A530094C12Rik; AVIEF; BANK"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1133
                     /gene="Bank1"
                     /gene_synonym="A530094C12Rik; AVIEF; BANK"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1330
                     /gene="Bank1"
                     /gene_synonym="A530094C12Rik; AVIEF; BANK"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1409
                     /gene="Bank1"
                     /gene_synonym="A530094C12Rik; AVIEF; BANK"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1718
                     /gene="Bank1"
                     /gene_synonym="A530094C12Rik; AVIEF; BANK"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..2024
                     /gene="Bank1"
                     /gene_synonym="A530094C12Rik; AVIEF; BANK"
                     /inference="alignment:Splign:2.1.0"
     exon            2025..2093
                     /gene="Bank1"
                     /gene_synonym="A530094C12Rik; AVIEF; BANK"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..2272
                     /gene="Bank1"
                     /gene_synonym="A530094C12Rik; AVIEF; BANK"
                     /inference="alignment:Splign:2.1.0"
     exon            2273..2336
                     /gene="Bank1"
                     /gene_synonym="A530094C12Rik; AVIEF; BANK"
                     /inference="alignment:Splign:2.1.0"
     exon            2337..2366
                     /gene="Bank1"
                     /gene_synonym="A530094C12Rik; AVIEF; BANK"
                     /inference="alignment:Splign:2.1.0"
     exon            2367..2419
                     /gene="Bank1"
                     /gene_synonym="A530094C12Rik; AVIEF; BANK"
                     /inference="alignment:Splign:2.1.0"
     exon            2420..2484
                     /gene="Bank1"
                     /gene_synonym="A530094C12Rik; AVIEF; BANK"
                     /inference="alignment:Splign:2.1.0"
     exon            2485..3268
                     /gene="Bank1"
                     /gene_synonym="A530094C12Rik; AVIEF; BANK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3248..3253
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Bank1"
                     /gene_synonym="A530094C12Rik; AVIEF; BANK"
                     /note="hexamer: ATTAAA"
     polyA_site      3268
                     /gene="Bank1"
                     /gene_synonym="A530094C12Rik; AVIEF; BANK"
                     /note="major polyA site"
ORIGIN      
        1 aacctcgggc cacaatcccc agagtaggaa gcaagctgca gggccacaga ccatcggaac
       61 taaaggtctg caggggaagt tgcaggcagg gctggccact gcagctccca ggctccaacc
      121 tcccgcaatg cttcctgtgg cttctggcac taggggtagc acccaggatc tgttccaggt
      181 tggcctagca cctccaggaa atgcaaaaga tatcctgttg ctatatgaag aagatgctga
      241 ggaatgggct ctatacttga gagaaatatt tatgcgtgtt gtagaaagag aagcaatcct
      301 gttatatccc ttgcacagtt tttcttcttc acatttggaa atgctaaact tctatgctta
      361 caaatgtaaa cttctgataa tatccaatag tctacttaaa gacctgacgc caaagaagtg
      421 tcagtttctg gagaagatac ttcactcaac aggaaatgta gtgactttgc tttgtgggat
      481 ggagagctca gatcctttct atcagttatt aagtatcccc agaaagagat gggagatctc
      541 aacagagcag gatccggatg gttacatctc tgtcatcaga cagatcttag accaaggtcc
      601 tgaagactac cttgaggtca gcattccaac agactcaaga gccaagtatc ctgaggacac
      661 aagtggacag aagggaactg acgtcctagc atctctgaga ccatctgtgc ctcgggtact
      721 agtgcttcct ggggaaattc catgtgagaa acctggtgag atattcattc tgttgaaaga
      781 tgaactaatt ggcgaaattc tagaggttga atttatatca accaacaagc gcctcagagc
      841 acggccagca cgttggaata agagtgtctg gcatatgaaa gctgcagatt ttccagctgg
      901 ctcggtcact gtcaatatcc actgtgatgg aatcatcaag gccacaacag agattaaata
      961 ctgttcagca gcaaaagcaa cagaaagtcc atttagagtg tcagacccgg gcaagagttt
     1021 gtgccagaaa agcatcgaag aacttgataa tgttcttgca tctatattca agcgtgagat
     1081 accatattat gaattcaaac atctccaagc tgaaacttac cctcaaaaag aacgtactca
     1141 caccacagag ctcccaacac ttcttcactg tgcagcaaaa tttggcttaa agaatctggc
     1201 tcttcatctg ctgcagtgtt caggagcaac cagggcagct agaatgaagg cgacagatgg
     1261 ttcagacctg ctgcatattg ctgaaaggca tggtcatgaa gaactcaagg aagtctttga
     1321 agactttctc agccaaaaca ctggcagaaa tagcaagcaa gaaaatgact atgaagaaga
     1381 tgtaatctca ttttccacat attcaccctc catgccgtct ccggcatccc ttcatgaact
     1441 caggaagaca cacaggcgga acacagacag atctgaggag cctgaaaggt ctgtggagat
     1501 gaaggaggaa gaagcaggtg ctgaggcaag acgcagcctg tcagagggtg aaagggaaag
     1561 ctccgagaac cagtatgacg atctgtatgt tttcatccct gggtttgaca ccgaaggcaa
     1621 ctctgaagag cctctcccac actgcaggcc acctctgctg ccaccacgac caggcactgc
     1681 tgcctcccag ctagaaagac ctcactttac ctcacaagga aaagtactgg aagaccaaat
     1741 ggaaagaagt caaaactgga atgatctcaa tgcaagacca gagacaagag aggaatccag
     1801 cagagaagaa aagaaagaag aagcccagga ggaggaggaa gaagaagaaa acccatatgc
     1861 atttgcagag actgaagaca atgagtatga cctgatactg gccagtaaga gtgtcaagaa
     1921 aagaactgga aatcggtctt tcattataaa cagaccaccg gctcccacac cccggcccac
     1981 gcacatccct cccaaagaag aaacaacacc ttacatagct caagtgttcc aacaaaaggc
     2041 agcccgaaga caatctgatg gtgataagtt ctacagtcta cctaagaaac ccgacaaaac
     2101 tcggatggag ggcccaacct tccctagtac aagggattat ctgactactg ggcaggaaga
     2161 actgatcctc ctgcaggaga gagtcaagaa tgggaaaatg tctgtggatg aagctctgga
     2221 gaaatttaaa cattggcaga tgggaaagag tggtctggaa atgattcagc aggaaaagct
     2281 acggcaacta cgagacaaca ttattgggaa aaggccagaa gatgaaaatg cctatgataa
     2341 actgaccatt gtgcaccatc caagtggtaa tactgcccac aatgaaaata tgttgtacaa
     2401 cagtccattc aacagtaagt ttcctgctcg aatccaagtt gaaaaggagt ttggtttctg
     2461 ctgcaaaaaa gatcattaaa aaagactatt ataatcaaac tcaagaatct gccaacatgt
     2521 tgcgcctcgg tgaagccagc ctgcttctgg aatacctggt ctccagggct aatctgcatg
     2581 gacacaggac acaagtgtgc ctttggattt caaagtgtgt tagcaccaca atttattggt
     2641 actgtaccac ttcagatgga tacaacaaaa gatggagact catagcattc tctgaaaatc
     2701 cattcatttt taccacaact tttgccacca gagcacctca ttctcccatc ttgaaaatta
     2761 aagaaaaaaa atcagcaaag ttaaatgcag aatagcaaaa ttaaggaccc aaactatata
     2821 ggttattctt cctattcttc ctccttcaac taagaacgtt ttgcatattt gctctttaaa
     2881 tgaccatctt ctgtctgcct ttctcacatt cagagccata atgttcttgt gatgccatgt
     2941 tttcagatag cttcttttat ttactgccta tttgcatgta cctttgaaat gtacttttat
     3001 tcgcagtttt cgttagttga tggtgttttg tatttgggtg ataagcaagc actctaccag
     3061 tgcccaagtc ttcagccctc tacacggatt cctgaagtca tgttaattct atcaattaat
     3121 gacgtgcaca gtaatatttc agaacatgga tgcctcgcac attgcctgtg ctcatcctct
     3181 gctcttctgg aaggtatttc cccatgcttc cctgtcccca aggacttact aaatgtcttt
     3241 ctctcaaatt aaaaagtact tttgcaaa
//
