LOCUS       NM_001038231             766 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus BAF nuclear assembly factor 1 (Banf1), transcript
            variant 2, mRNA.
ACCESSION   NM_001038231
VERSION     NM_001038231.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 766)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 766)
  AUTHORS   Yao,X., Xu,X., Hu,K., Yang,Z. and Deng,S.
  TITLE     BANF1 promotes glutamate-induced apoptosis of HT-22 hippocampal
            neurons
  JOURNAL   Mol Biol Rep 50 (11), 9441-9452 (2023)
   PUBMED   37838622
  REMARK    GeneRIF: BANF1 promotes glutamate-induced apoptosis of HT-22
            hippocampal neurons.
REFERENCE   3  (bases 1 to 766)
  AUTHORS   Ma,H., Qian,W., Bambouskova,M., Collins,P.L., Porter,S.I.,
            Byrum,A.K., Zhang,R., Artyomov,M., Oltz,E.M., Mosammaparast,N.,
            Miner,J.J. and Diamond,M.S.
  TITLE     Barrier-to-Autointegration Factor 1 Protects against a Basal
            cGAS-STING Response
  JOURNAL   mBio 11 (2), e00136-20 (2020)
   PUBMED   32156810
  REMARK    GeneRIF: Barrier-to-Autointegration Factor 1 Protects against a
            Basal cGAS-STING Response.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 766)
  AUTHORS   Halfmann,C.T., Sears,R.M., Katiyar,A., Busselman,B.W., Aman,L.K.,
            Zhang,Q., O'Bryan,C.S., Angelini,T.E., Lele,T.P. and Roux,K.J.
  TITLE     Repair of nuclear ruptures requires barrier-to-autointegration
            factor
  JOURNAL   J Cell Biol 218 (7), 2136-2149 (2019)
   PUBMED   31147383
REFERENCE   5  (bases 1 to 766)
  AUTHORS   Jamin,A., Thunuguntla,P., Wicklund,A., Jones,C. and Wiebe,M.S.
  TITLE     Barrier to auto integration factor becomes dephosphorylated during
            HSV-1 Infection and Can Act as a host defense by impairing viral
            DNA replication and gene expression
  JOURNAL   PLoS One 9 (6), e100511 (2014)
   PUBMED   24945635
  REMARK    GeneRIF: BAF can act in a phosphorylation-regulated manner to
            impair HSV-1 transcription and/or DNA replication.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 766)
  AUTHORS   Forne,I., Carrascal,M., Martinez-Lostao,L., Abian,J.,
            Rodriguez-Sanchez,J.L. and Juarez,C.
  TITLE     Identification of the autoantigen HB as the
            barrier-to-autointegration factor
  JOURNAL   J Biol Chem 278 (50), 50641-50644 (2003)
   PUBMED   14523012
  REMARK    GeneRIF: HB and barrier-to-autointegration factor are the same
            protein
REFERENCE   7  (bases 1 to 766)
  AUTHORS   Wang,X., Xu,S., Rivolta,C., Li,L.Y., Peng,G.H., Swain,P.K.,
            Sung,C.H., Swaroop,A., Berson,E.L., Dryja,T.P. and Chen,S.
  TITLE     Barrier to autointegration factor interacts with the cone-rod
            homeobox and represses its transactivation function
  JOURNAL   J Biol Chem 277 (45), 43288-43300 (2002)
   PUBMED   12215455
REFERENCE   8  (bases 1 to 766)
  AUTHORS   Nili,E., Cojocaru,G.S., Kalma,Y., Ginsberg,D., Copeland,N.G.,
            Gilbert,D.J., Jenkins,N.A., Berger,R., Shaklai,S., Amariglio,N.,
            Brok-Simoni,F., Simon,A.J. and Rechavi,G.
  TITLE     Nuclear membrane protein LAP2beta mediates transcriptional
            repression alone and together with its binding partner GCL
            (germ-cell-less)
  JOURNAL   J Cell Sci 114 (Pt 18), 3297-3307 (2001)
   PUBMED   11591818
REFERENCE   9  (bases 1 to 766)
  AUTHORS   Furukawa,K.
  TITLE     LAP2 binding protein 1 (L2BP1/BAF) is a candidate mediator of
            LAP2-chromatin interaction
  JOURNAL   J Cell Sci 112 (Pt 15), 2485-2492 (1999)
   PUBMED   10393804
REFERENCE   10 (bases 1 to 766)
  AUTHORS   Lee,M.S. and Craigie,R.
  TITLE     A previously unidentified host protein protects retroviral DNA from
            autointegration
  JOURNAL   Proc Natl Acad Sci U S A 95 (4), 1528-1533 (1998)
   PUBMED   9465049
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122861.4 and AK010257.1.
            
            On Nov 8, 2013 this sequence version replaced NM_001038231.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 3. Variants 1-3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU935633.1, AK010257.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AC122861.4         100853-100868       c
            17-756              AK010257.1         3-742
            757-766             AC122861.4         99138-99147         c
FEATURES             Location/Qualifiers
     source          1..766
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.31 cM"
     gene            1..766
                     /gene="Banf1"
                     /gene_synonym="Baf; Bcrp1; L2bp1/Baf"
                     /note="BAF nuclear assembly factor 1"
                     /db_xref="GeneID:23825"
                     /db_xref="MGI:MGI:1346330"
     exon            1..101
                     /gene="Banf1"
                     /gene_synonym="Baf; Bcrp1; L2bp1/Baf"
                     /inference="alignment:Splign:2.1.0"
     exon            102..240
                     /gene="Banf1"
                     /gene_synonym="Baf; Bcrp1; L2bp1/Baf"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..387
                     /gene="Banf1"
                     /gene_synonym="Baf; Bcrp1; L2bp1/Baf"
                     /note="LAP2-binding protein 1; breakpoint cluster region
                     protein 1; barrier to autointegration factor 1"
                     /codon_start=1
                     /product="barrier-to-autointegration factor"
                     /protein_id="NP_001033320.1"
                     /db_xref="CCDS:CCDS29458.1"
                     /db_xref="GeneID:23825"
                     /db_xref="MGI:MGI:1346330"
                     /translation="MTTSQKHRDFVAEPMGEKPVGSLAGIGDVLSKRLEERGFDKAYV
                     VLGQFLVLKKDEDLFREWLKDTCGANAKQSRDCFGCLREWCDAFL"
     exon            241..766
                     /gene="Banf1"
                     /gene_synonym="Baf; Bcrp1; L2bp1/Baf"
                     /inference="alignment:Splign:2.1.0"
     regulatory      740..745
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Banf1"
                     /gene_synonym="Baf; Bcrp1; L2bp1/Baf"
                     /note="hexamer: AATAAA"
     polyA_site      759
                     /gene="Banf1"
                     /gene_synonym="Baf; Bcrp1; L2bp1/Baf"
                     /note="major polyA site"
ORIGIN      
        1 gcgggacctg agaggcgtgg aagaggccgg cagcccgagt gagggcggcg aggctggcga
       61 gagccgcgtg ctgttcctac cacgtgttag ttcccaacgg ggttaagcct gatcacgatg
      121 acaacctccc aaaagcaccg agacttcgtg gcagagccca tgggggaaaa gccagtgggg
      181 agcctggccg ggattggtga cgtcctgagc aagaggctgg aggaaagggg ctttgacaag
      241 gcttatgtgg tccttggcca gtttctggtg ctaaagaaag atgaagacct cttccgagaa
      301 tggctgaagg atacatgtgg tgccaatgcc aagcagtccc gggactgctt tgggtgcctt
      361 cgagaatggt gtgatgcctt cttgtagtgt tctctgggga tccctcatac cccagccaca
      421 gcacagtttc cagagtctgc agcagggcag ggctcctccc tgtcctccat aaaggaaaag
      481 atggctgttg tcaccctcac ctcctatgta ctccagggtc tatggggagt tctctcccct
      541 cagcgtttca atctttctgg gatcgtttcc cttgcatgcc tttcccttcc acctccccct
      601 gcagttccgt ggcagcagtt accaactttc ctgaatggat tcctggcccc cttctccctc
      661 actatctgtt ggatgccctt tggctccttt cctttttttg gcaaaaacag tcactgtcct
      721 tataaaagat ttttaaatta ataaaatcag tggccttcat acttgg
//
